NDA Help Center

Data From Labs

The general public can view experiments, associated studies, publications, and shared data. Additionally, users with access to a Collection's permission group will be able to view and edit the prior mentioned criteria, as well as submissions and permissions.

If you need assistance finding a specific collection or project, accessing Collections, or trouble with access, please contact the Help Desk

Frequently Asked Questions

  • Yes, the appropriate funding source staff have access to your Collection to monitor the project's data sharing progress.

  • Every automated email sent from NDA will include the Collection number and direct link.  You may also use the NDA Search Tool by searching on the name of the PI, a keyword from the title, or the grant number.

  • The Collection Owner or a user with Admin Privilege can provide a user with access to a Collection.  NDA staff can help provide the Privilege if the Collection Owner or a user with Admin Privilege emails the NDA Help Desk (NDAHelp@mail.nih.gov).

  • When a Collection is created by NDA staff and marked as Shared, an email notification will automatically be sent to the PI(s) of the grant(s) associated with the Collection to notify them.

  • Users can view a list of Collections to which they have been provided with a Collection Privilege by navigating to the Collections Tab in their Account information once logged in.

  • The Collection Owner is typically the contact PI listed on a grant; however, another person may be provided this role.

Glossary

  • A Collection is a virtual container into which data will be submitted and shared.  It also provides important information about the project, funding amounts, reported enrollment amounts, data sharing schedule, and results that will help program staff better evaluate the grant.  While the general rule is that one Collection is created for each grant, it may be appropriate to associated multiple grants with a single Collection in the case of collaborative projects or projects submitting data through a single site such as a Data Coordinating Center. 

  • The Collection Phase provides information on data submission as opposed to grant/project completion so while the Collection phase and grant/project phase may be closely related they are often different.  Collection users with Administrative Privileges are encouraged to edit the Collection Phase.  The Program Officer as listed in eRA (for NIH funded grants) may also edit this field. Changes must be saved by clicking the Save button at the bottom of the page.  This field is sortable alphabetically in ascending or descending order. Collection Phase options include: 

    • Pre-Enrollment:  A grant/project has started, but has not yet enrolled subjects.
    • Enrolling:  A grant/project has begun enrolling subjects.  Data submission is likely ongoing at this point.
    • Data Analysis:  A grant/project has completed enrolling subjects and has completed all raw data submissions.
    • Funding Completed:  A grant/project has reached the project end date.
  • An editable field with the title of the Collection, which is often the title of the grant associated with the Collection.

  • A list of NDA Collections.

  • Adds all data from the current Collection or NDA Study to the Filter Cart.

  • This button will reduce the collections available for browsing by applying the selections from the Data Source, Collection Phase, and Funding Source dropdowns to the Filter Cart. 

  • Users who do not necessarily have access to data within an NDA Permission Group or who may not even have an NDA account.

  • The authors of the publication or other public disclosure of analysis results.  The publication's authors are automatically imported when creating a new NDA Study from a Create Study link associated with a Publication listed in a Collection.  The field is editable and uses a last name, first name format with multiple names separated by semicolons.

  • A user who has been provided access to data within an NDA Permission Group.

  • This button clears all current selections on a tab. 

NDA Help Center

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Frequently Asked Questions

Glossary

NDA Help Center

Filter Cart

The Filter Cart provides a powerful way to query and access data for which you may be interested.  

A few points related to the filter cart are important to understand with the NDA Query/Filter implementation: 

First, the filter cart is populated asyncronously.  So, when you run a query, it may take a moment to populate but this will happen in the background so you can define other queries during this time.  

When you are adding your first filter, all data associated with your query will be added to the filter cart (whether it be a collection, a concept, a study, a data structure/elment or subjects). Not all data structures or collections will necessarily be displayed.  For example, if you select the NDA imaging structure image03, and further restrict that query to scan_type fMRI, only fMRI images will appear and only the image03 structure will be shown.  To see other data structures, select "Find All Subject Data" which will query all data for those subjects. When a secord or third filter is applied, an AND condition is used.  A subject must exist in all filters.  If the subject does not appear in any one filter, that subjects data will not be included in your filter cart. If that happens, clear your filter cart, and start over.  

It is best to package more data than you need and access those data using other tools, independent of the NDA (e.g. miNDAR snapshot), to limit the data selected.  If you have any questions on data access, are interested in using avaialble web services, or need help accessing data, please contact us for assistance.  

Frequently Asked Questions

Glossary

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NDAR provides a single access to de-identified autism research data. For permission to download data, you will need an NDAR account with approved access to NDAR or a connected repository (AGRE, IAN, or the ATP). For NDAR access, you need to be a research investigator sponsored by an NIH recognized institution with federal wide assurance. See Request Access for more information.

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This is a U.S. Government computer system, which may be accessed and used only for authorized Government business by authorized personnel. Unauthorized access or use of this computer system may subject violators to criminal, civil, and/or administrative action. All information on this computer system may be intercepted, recorded, read, copied, and disclosed by and to authorized personnel for official purposes, including criminal investigations. Such information includes sensitive data encrypted to comply with confidentiality and privacy requirements. Access or use of this computer system by any person, whether authorized or unauthorized, constitutes consent to these terms. There is no right of privacy in this system.

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The filters you have selected from various query interfaces will be stored here, in the 'Filter Cart'. The database will be queried using filters added to your 'Filter Cart', when multiple filters are defined, each will be executed using 'AND' logic, so with each filter that is applied the result set gets smaller.

From the 'Filter Cart' you can inspect each of the filters that have been defined, and you also have the option to remove filters. The 'Filter Cart' itself will display the number of filters applied along with the number of subjects that are identified by the combination of those filters. For example a GUID filter with two subjects, followed by a GUID filter for just one of those subjects would return only data for the subject that is in both GUID filters.

If you have a question about the filter cart, or underlying filters please contact the help desk at The NDA Help Desk

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1 Numbers reported are subjects by age
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UIC ACE: Translational Studies of Insistence on Sameness in Autism #1
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
UIC ACE: Translational Studies of Insistence on Sameness in Autism
Ed Cook 
The UIC ACE was focused on the genetics, neurobiology, cognitive and affective processes, and pharmacology of insistence on sameness (IS) in autism spectrum disorders (ASD). A large sample of children with self-reported autism spectrum disorder will be screened by the Assessment Core for further...
NDAR
Funding Completed
Shared
No
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Biological and Information Processing Mechanisms Underlying Autism #6
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Biological and Information Processing Mechanisms Underlying Autism
Nancy Minshew, M.D., Mark Strauss, Ph.D., Kevin Pelphrey, Ph.D., Marcel Just, Ph.D., Thomas Mitchell, Ph.D., and Diane Williams, Ph.D. 
This center focuses on elucidating fundamental information processing and neurobiological mechanisms causing autism with studies of infant siblings, first-diagnosed toddlers, and groups of children, adolescents, and adults with and without autism. Project I: Development of Categorization Knowledge...
NDAR
Funding Completed
Shared
No
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A Comprehensive Approach to Identification of Autism Susceptibility Genes with the AGRE Center for Genomic and Phenomic Studies in Autism #7
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
A Comprehensive Approach to Identification of Autism Susceptibility Genes with the AGRE Center for Genomic and Phenomic Studies in Autism
Clara Lajonchere and Dan Geschwind 
AGRE is a DNA repository and family registry, housing a database of genotypic and phenotypic information that is available to autism researchers worldwide.
NDAR
Funding Completed
Shared
No
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Yale Autism Center of Excellence: Mechanisms of Social Engagement in the Autism Spectrum Disorders #8
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Yale Autism Center of Excellence: Mechanisms of Social Engagement in the Autism Spectrum Disorders
Fred Volkmar 
The Yale ACE consists of 5 project areas and 3 core resources. Projects I, II, and III focus on the same cohort of 12- to 24-month old infants with ASD followed up longitudinally. Project IV involves structural and functional neuroimaging protocols on a group of 10-year-olds with ASD who were...
NDAR
Funding Completed
Shared
No
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Biomarkers of Autism at 12 Months: From Brain Overgrowth to Genes #9
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Biomarkers of Autism at 12 Months: From Brain Overgrowth to Genes
Eric Courchesne, Karen Pierce and others. 
Behavioral data from the UCSD Autism Center of Excellence. This first data deposit will include Mullen Scales of Early Learning Scores from infants ages 12-36 months who are part of the ACE. Infants represent those at risk for an ASD, language delay (LD) and developmental delay (DD). Normal...
NDAR
Funding Completed
Shared
No
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UCLA Sigman/Bookheimer ACE and ARRA #10
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
UCLA Sigman/Bookheimer ACE and ARRA
Sigman M, Geschwind D, Bookheimer S 
ACE Projects: 1) PI Sigman - Infant Sibs. 2) PI Geschwind - Genetics. 3) PI Dapretto - Mirror neuron and imaging. 4) PI Kasari - Optimizing outcomes for toddlers. 5) PI McCracken - Understanding repetitive behaviors. ARRA: PI Bookheimer - Neural and Phenotypic Correlates of Autism Risk...
NDAR
Funding Completed
Shared
No
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Hunterdon Autism Center Data #13
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Hunterdon Autism Center Data
Audrey Mars MD 
Data collection of individuals at center partially funded by the NJ Governer's Council on Autism/Dept. of Health and Senior Services
NDAR
Funding Completed
Shared
No
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Early Pharmacotherapy Guided by Biomarkers in Autism #14
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Early Pharmacotherapy Guided by Biomarkers in Autism
Diane C Chugani 
Clinical trial of buspirone in young children with autism testing a PET scan of serotonin synthesis as a biomarker of drug response
NDAR
Funding Completed
Shared
No
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Measuring QALYs in Children with ASDs #15
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Measuring QALYs in Children with ASDs
John Tilford; Karen Kuhlthau 
Autism spectrum disorders (ASDs) are characterized by impairments in social skills, communication, and cognitive and behavioral functioning. Successful interventions for children with ASDs thus have the potential to not only affect outcomes of the child, but may include substantial health benefits...
NDAR
Funding Completed
Shared
No
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Intensive Intervention for Toddlers With Autism (EARLY STEPS) #16
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Intensive Intervention for Toddlers With Autism (EARLY STEPS)
Sally J. Rogers 
A Multi-Site Randomized Study of Intensive Treatment for Toddlers with Autism
NDAR
Funding Completed
Shared
No
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Aberrant Behavior Checklist in Fragile X Syndrome #18
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Aberrant Behavior Checklist in Fragile X Syndrome
David Hessl, Ph.D. 
This project will combine data from the Aberrant Behavior Checklist for individuals with fragile X syndrome from multiple centers throughout the U.S. in order to examine its factor structure, reliability, and clinical utility, and to examine its potential as an outcome measure for clinical trials. ...
NDAR
Funding Completed
Shared
No
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Longitudinal MRI Study of Infants at Risk for Autism #19
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Longitudinal MRI Study of Infants at Risk for Autism
Joe Piven 
Research data for the IBIS Autism project. Autism Centers of Excellence (ACE) Network is a collaborative effort by investigators at four clinical sites: University of North Carolina (UNC), University of Washington (UW), Washington University (WU), and Yale University; and one data coordinating...
NDAR
Funding Completed
Shared
No
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CBT for Anxiety in Adolescents with Autism #20
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
CBT for Anxiety in Adolescents with Autism
Eric A. Storch, Ph.D. 
The purpose of the research study is to see how well a cognitive-behavioral psychotherapy program works to reduce anxiety in adolescents with autism spectrum disorders. This collection will contain data associated with this project. Including but not limited to the: ADIS, PARS, SACA, ADI-R, ADOS,...
NDAR
Funding Completed
Shared
No
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Induced pluripotent cells in ASD with macrocephaly #1201
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Induced pluripotent cells in ASD with macrocephaly
Flora Vaccarino 
R01MH89176 - This project will develop lines of pluripotent cells (iPSC) from a longitudinally acquired cohort of patients with autism spectrum disorders (ASD) and macrocephaly and their family members, as well as typically developing children, using cells obtained by a skin biopsy. We will produce...
NDAR
Funding Completed
Shared
No
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Treatment as usual and peer engagement in Adolescents with High Functioning Autism #1202
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Treatment as usual and peer engagement in Adolescents with High Functioning Autism
Felice Orlich, PhD 
Multi-site RCT contrasting peer-mediated intervention and typical social skills intervention in teens with HFA.********NOTICE********NOTICE********NOTICE*********Subject ages in these datasets are provided in the unit of months, but are not accurate. They are, instead, approximate ages in...
NDAR
Funding Completed
Shared
No
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Distance to Freeway and Major Road Data #1203
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Distance to Freeway and Major Road Data
Rob McConnell 
This collection contains birth address based measures on distance to interstate highway, state highway, major road, and local road for study subjects enrolled in the CHARGE study. **** NOTICE **** Please note that the subjects for this project were pregnant mothers. The phenotype of the child are...
NDAR
Funding Completed
Shared
No
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Screening and Diagnostic Measures in Toddlers with ASD #1250
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Screening and Diagnostic Measures in Toddlers with ASD
Amy M. Wetherby 
This dataset includes toddlers and controls with red flags of ASD. This includes participants from the FIRSTWORDS Project and the Early Social Interaction Project.
NDAR
Funding Completed
Shared
No
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Behavioral Treatment for Autism in Community Settings Using a Telehealth Network #1300
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Behavioral Treatment for Autism in Community Settings Using a Telehealth Network
Scott Lindgren 
The purpose of this study is to evaluate assessment and treatment procedures for children with autism or a related disorder
NDAR
Funding Completed
Shared
No
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Identifying Brain-Based Biomarkers for ASD and their Biological Subtypes #1356
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Identifying Brain-Based Biomarkers for ASD and their Biological Subtypes
Bradley S. Peterson 
This is a multi-modal brain imaging study of Autism Spectrum Disorders to define biomarkers and subtypes of the disorder.--------------------------------------------------------------------No gradient tables provided for DTI data files. fMRI files headers were cleaned - DOB removed; Spectroscopy...
NDAR
Funding Completed
Shared
No
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Biological Signatures of Autism #1358
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Biological Signatures of Autism
David G. Amaral 
Collection of data associated with the Autism Phenome Project and ARRA grant
NDAR
Funding Completed
Shared
No
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RNA-Seq data from cerebral cortex in control subjects #1360
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
RNA-Seq data from cerebral cortex in control subjects
John Allman 
RNA-Seq studies of Gene Expression in Cells and Networks in FI (fronto-insular) and AC (anterior cingulate) cortex in Autism. We seek to understand the cellular bases of autism by using a new technology, RNA-Seq, to determine differences in gene expression in autopsy brains of subjects with well...
NDAR
Funding Completed
Shared
No
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Pupillary Light Reflex as a Biomarker for Autism #1400
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Pupillary Light Reflex as a Biomarker for Autism
Gang Yao, Judith H. Miles, Shawn Christ 
Pupillary light reflex, Heart rate variability, medical history.
NDAR
Funding Completed
Shared
No
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Systems biology of ASD #1401
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Systems biology of ASD
Lilia Iakoucheva 
Sequencing and building protein-protein interaction network of brain-expressed alternatively spliced isoforms of autism candidate genes
NDAR
Funding Completed
Shared
No
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The Met Signaling System, Autism and Gastrointestinal Dysfunction. #1450
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
The Met Signaling System, Autism and Gastrointestinal Dysfunction.
Pat R. Levitt 
This dataset contains three types of individuals: with ASD and with gastrointestinal dysfunction; with ASD but without gastrointestinal dysfunction; and without ASD but with gastrointestinal dysfunction.
NDAR
Funding Completed
Shared
No
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Autism in the second half of the lifespan #1500
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Autism in the second half of the lifespan
Ruth Carper 
Behavior, daily living, service needs. As a first step toward identifying and understanding the effects of aging in ASD, we propose to examine individuals in middle and later-age (30-70 years) in order to: (1) Characterize current living situations, support needs and available support systems for...
NDAR
Funding Completed
Shared
No
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Neural and Behavioral Outcomes of Social Skills Groups in Children with ASD #1501
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Neural and Behavioral Outcomes of Social Skills Groups in Children with ASD
A. Ting Wang, Latha V. Soorya 
Neuroimaging and phenotypic measures of school-age children undergoing social skills group interventions. The purpose of this investigation is to examine the acute and sustained effects of a CBT-based social skills treatment on social cognition and the neural architecture that supports it....
NDAR
Funding Completed
Shared
No
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Sensory Integration Treatment in ASD #1550
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Sensory Integration Treatment in ASD
Stephen Camarata & Mark Wallace 
Sensory integration deficit is a controversial but widely used diagnostic classification in ASD and sensory integration (SI) based treatment is commonly provided to children with autism spectrum disorder, but has an extremely limited evidence base. The purpose of this proposal will be to complete...
NDAR
Funding Completed
Shared
No
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Neural Dissection of Hyperactivity/Inattention in Autism #1551
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Neural Dissection of Hyperactivity/Inattention in Autism
Francisco Xavier Castellanos 
This data collection is intended to contain neuroimaging and phenotypic and diagnostic data from approximately 100 children with Autism Spectrum Disorder, 50 children with Attention Deficit/Hyperactivity Disorder and 50 typically developing children.
NDAR
Funding Completed
Shared
No
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Early Autism Risk Longitudinal Investigation (EARLI) Network #1600
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Early Autism Risk Longitudinal Investigation (EARLI) Network
Craig Newschaffer 
Descriptive data for EARLI (probands and sibling) ADOS, Vineland, SRS, SCQ
NDAR
Funding Completed
Shared
No
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Imaging Brain and Movement in ASD #1601
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Imaging Brain and Movement in ASD
Jeanne Townsend 
This dataset contains diagnostic information, standardized neuropsychological test measures, EEG, structural MRI, and movement-related measures from adolescents with ASD and control adolescents.
NDAR
Funding Completed
Shared
No
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SFARI - DNA Methylation Analysis Cohort #1650
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
SFARI - DNA Methylation Analysis Cohort
Stephen T Warren 
DNA methylation analysis of peripheral blood cells from siblings discordant for ASD
NDAR
Funding Completed
Shared
No
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UW ACE Extended Family Study #1654
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
UW ACE Extended Family Study
Bryan King 
University of Washington ACE projects
NDAR
Funding Completed
Shared
No
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Gross morphological correlates to the minicolumnopathy of autism (ATP postmortem MRI) #1655
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Gross morphological correlates to the minicolumnopathy of autism (ATP postmortem MRI)
Manuel Casanova 
Proton density weighted scans of fixed, postmortem brain tissue
NDAR
Funding Completed
Shared
No
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Genes disrupted by balanced genomic rearrangements in autism spectrum disorders #1700
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Genes disrupted by balanced genomic rearrangements in autism spectrum disorders
James Gusella 
Sequencing rearrangements in ASD
NDAR
Funding Completed
Shared
No
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Initial Investigation of Prevention of ASD in Infants at Risk #1800
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Initial Investigation of Prevention of ASD in Infants at Risk
Sally J. Rogers  
The project's overall goal is to develop and pilot test a manualized, parent-delivered intervention for symptomatic infants ages 6-11 months of age at high risk for autism that will reduce atypical behaviors and developmental delays and increase developmental rates, thus lessening or preventing...
NDAR
Funding Completed
Shared
No
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CBT for anxiety in adolescents with autism #1850
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
CBT for anxiety in adolescents with autism
Jeffrey Wood 
Collection consists of youth with autism and coexisting anxiety undergoing cognitive-behavioral treatment
NDAR
Funding Completed
Shared
No
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Collaborative Programs of Excellence in Autism (CPEA) #1853
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Collaborative Programs of Excellence in Autism (CPEA)
Dawson, Geraldine; Loveland, Katherine; McMahon, William; Minshew, Nancy; Rodier, Patricia; Rogers, Sally; Sigman,Marian; Tager-Flusberg, Helen; Volkmar, Fred  
The CPEAs link 129 scientists from 23 universities in the United States, Canada, Britain, and five other countries, and more than 2,000 families of people with autism. The clinical data associated with the CPEAs are contained here.
NDAR
Funding Completed
Shared
No
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Studies to Advance Autism Research and Treatment (STAART). #1854
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Studies to Advance Autism Research and Treatment (STAART).
Aylward, Elizabeth; Buxbaum, Joseph; Dawson, Geraldine; Hollander, Eric; Landa, Rebecca; Rodier, Patricia; Sigman, Marian; Tager-Flusberg, Helen  
The STAART Network is comprised of eight centers across the country. Most of these centers are evaluating and treating patients, as well as enrolling them into clinical trials.
NDAR
Funding Completed
Shared
No
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Autism Tissue Program (ATP) Brain Donor Listing #1855
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Autism Tissue Program (ATP) Brain Donor Listing
Jane Pickett Ph.D, ATP Director of Brain Resources and Data 
This is a listing of brain donors, with GUIDs, that are within the Autism Tissue Program (ATP) database. The information in this collection is limited to just a few fields. Additional information is available to authorized researchers with ATP accounts through NDAR or ATPportal.org
NDAR
Funding Completed
Shared
No
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Early Language Development within the Autism Spectrum #1856
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Early Language Development within the Autism Spectrum
Susan Ellis-Weismer 
This project obtained behavioral data focused on early language and communication development in autism spectrum disorders (ASD). These data were obtained from a sample of young children residing in the state of Wisconsin. All children were between 2-3 years when enrolled in the research project...
NDAR
Funding Completed
Shared
No
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Electrophysiologic Studies of Language Impairment in ASD (Years 1-5) #1862
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Electrophysiologic Studies of Language Impairment in ASD (Years 1-5)
Timothy Roberts 
6-15 year old children recruited for MEG studies of auditory processing
NDAR
Funding Completed
Shared
No
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Child-Initiated Interactions and Autism Intervention #1863
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Child-Initiated Interactions and Autism Intervention
Robert Koegel 
Data for a project to examine specific intervention components during language intervention and social communication.
NDAR
Funding Completed
Shared
No
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Gene Expression and Immune Cell Function in Mothers of Children with Autism- Demographics #1864
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Gene Expression and Immune Cell Function in Mothers of Children with Autism- Demographics
Frank Sharp 
To investigate the gene expression profiles of parents of typically developing children and parents of children diagnosed with autism spectrum disorder. Information in this collection includes the demographic profiles for subjects enrolled in the study.
NDAR
Funding Completed
Shared
No
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Development of a Brief Screener for Research in Autism Spectrum Disorders #1865
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Development of a Brief Screener for Research in Autism Spectrum Disorders
Cathy Lord, Ph. D. and Christopher Monk 
This collection contains phenotypic data from subjects diagnosed with ASD as well as subjects with non-ASD diagnoses.
NDAR
Funding Completed
Shared
No
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1/2 Development of a Screening Interview for Research Studies of ASD #1866
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
1/2 Development of a Screening Interview for Research Studies of ASD
Christoper Monk, Somer Bishop and Cathy Lord 
This collection contains phenotypic data on subjects diagnosed with ASD and subjects with non-ASD diagnoses.
NDAR
Funding Completed
Shared
No
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The Effects of Oxytocin on Complex Social Cognition in Autism Spectrum Disorders #1868
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
The Effects of Oxytocin on Complex Social Cognition in Autism Spectrum Disorders
Jennifer Bartz, PhD 
The Effects of Oxytocin on Complex Social Cognition
NDAR
Funding Completed
Shared
No
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NICHD Brain and Tissue Bank for Developmental Disorders #1870
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
NICHD Brain and Tissue Bank for Developmental Disorders
H. Ron Zielke 
The objective of this human tissue repository is to systematically collect, store, and distribute brain and other tissues for research dedicated to the improved understanding, care and treatment of individuals with developmental disorders.
NDAR
Funding Completed
Shared
No
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Elucidating the Genetic Architecture of Autism by Deep Genomic Sequencing #1872
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Elucidating the Genetic Architecture of Autism by Deep Genomic Sequencing
Mark Daly, Richard Gibbs, Joseph Buxbaum, Gerard Schellenberg and James Sutcliffe 
ARRA Autism Sequencing Collaboration
NDAR
Funding Completed
Shared
No
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Genomic Identification of Autism Loci #1878
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Genomic Identification of Autism Loci
Evan E Eichler 
The goal of this grant is to use a targeted approach to identify the genes responsible for autism. Three different approaches were put forward to focus on genomic regions associated with autism, each was a dedicated specific aim.
NDAR
Funding Completed
Shared
No
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Computer Adaptive Testing of Adaptive Behavior of Children and Youth with Autism #1880
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Computer Adaptive Testing of Adaptive Behavior of Children and Youth with Autism
Wendy Coster, PhD 
The PEDI-CAT (ASD) will facilitate significant advances in ASD research and clinical services by providing a brief but precise, psychometrically sound assessment of daily function in home and community. The instrument will greatly improve the quality of information obtained on the adaptive behavior...
NDAR
Funding Completed
Shared
No
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Sex specific dissection of autism genetics #1883
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Sex specific dissection of autism genetics
Lauren A. Weiss 
SRS and SCQ data for females and males with ASDs
NDAR
Funding Completed
Shared
No
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Predicting Useful Speech in Children With Autism #1885
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Predicting Useful Speech in Children With Autism
Paul Yoder 
Predicting Useful Speech in Children with ASD: Analyzing speech processing, word processing, and pre-speech vocalizations
NDAR
Funding Completed
Shared
No
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PDN Screening Data #1886
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
PDN Screening Data
Audrey Thurm 
Data from PDN Screening study
NDAR
Funding Completed
Shared
No
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Restricted Interests and Repetitive Behaviors in Autism #1887
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Restricted Interests and Repetitive Behaviors in Autism
Gabriel Dichter 
Collection of a broad array of phenotyping measures in adolescents with high and low functioning autism spectrum disorders that exhibit repetitive behaviors and restricted interest sets
NDAR
Funding Completed
Shared
No
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Emergence and Stability of Autism in Fragile X Syndrome #1888
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Emergence and Stability of Autism in Fragile X Syndrome
Jane Roberts 
FXS Demographics, General Demographics, and Mullen Scores
NDAR
Funding Completed
Shared
No
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ASD Mathematical Cognition: A Cognitive and Systems Neuroscience Approach #1889
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
ASD Mathematical Cognition: A Cognitive and Systems Neuroscience Approach
Vinod Menon, Stanford University  
Investigation of math abilities in children with ASD via behavioral tests and brain imaging. Study will investigate cognitive and brain processes as well as brain networks involved in mathematical cognition in ASD populations. First submission will include behavioral (WASI) as well as diagnostic...
NDAR
Funding Completed
Shared
No
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Fetal Programming of the Newborn and Infant Human Brain #1890
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Fetal Programming of the Newborn and Infant Human Brain
Claudia Buss and Pathik D. Wadhwa 
We propose to conduct a prospective, longitudinal, follow-up study in a population-based cohort of children born to mothers who will participate in an NIH-funded study of biological and behavioral processes in pregnancy. We will have extensive characterization in this child cohort over the course...
NDAR
Funding Completed
Shared
No
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Early Detection of Autism through Acoustic Analysis of Cry #1891
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Early Detection of Autism through Acoustic Analysis of Cry
Stephen J. Sheinkopf 
This team will work collaboratively to develop a new acoustic analysis system for infant cry based on state of the art acoustical engineering and computer technology. In particular, we will utilize advances in digital signal processing to yield more accurate and robust detection and modeling of...
NDAR
Funding Completed
Shared
No
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Genomic Profiling and Functional Mutation Analysis in Autism Spectrum Disorders #1895
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Genomic Profiling and Functional Mutation Analysis in Autism Spectrum Disorders
Matthew State 
This proposal is in response to a request for applications to address "Genomic Profiling of Mental Disorders", and proposes intensive genomic profiling and functional analysis of Contactin Associated Protein 2 (CNTNAP2) as well as the presynaptic cytomatrix protein Piccolo (PCLO), in an effort to...
NDAR
Funding Completed
Shared
No
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Novel computational methods for higher order diffusion MRI in autism #1896
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Novel computational methods for higher order diffusion MRI in autism
Ragini Verma 
We aim at developing computational methods for processing and analysis of high angular resolution diffusion imaging data that has been fitted with higher order diffusion models (HOMs). Compared to the tensor model in diffusion tensor imaging (DTI), HOMs provide a much richer understanding of...
NDAR
Funding Completed
Shared
No
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Measuring Social Networks among Parents and Autism Heath Care Providers #1897
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Measuring Social Networks among Parents and Autism Heath Care Providers
Stephen Raudenbush 
This study will generate hypotheses, yield a field-tested survey instrument, and provide preliminary evidence about the effects of social networks on parents capacity to manage their child's autism treatment, laying the groundwork for larger-scale research and intervention.
NDAR
Funding Completed
Shared
No
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Cellular Density and Morphology in the Autistic Temporal Human Cerebral Cortex #1898
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Cellular Density and Morphology in the Autistic Temporal Human Cerebral Cortex
Veronica Martinez Cerdeno 
This project will analyze the temporal lobe of 21 autistic postmortem human brains (diagnosed as autistic, not as other autism spectrum disorders) and the temporal lobe of 18 control postmortem human brains. The data obtained from this project will also serve as the basis for future studies...
NDAR
Funding Completed
Shared
No
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Neurobehavioral Research on Infants at Risk for SLI and Autism #1900
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Neurobehavioral Research on Infants at Risk for SLI and Autism
Helen Tager-flusberg 
The specific aims of the research are (1) to identify markers that distinguish between infants at risk for SLI or ASD and low risk controls; (2) to identify the predictors of later SLI and ASD diagnoses (at 36 months of age) from measures collected between 6 and 12 months of age; and (3) to...
NDAR
Funding Completed
Shared
No
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Functional Neuroimaging of Attention in Autism #1904
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Functional Neuroimaging of Attention in Autism
Benjamin Yerys 
The proposed study will use functional MRI and rest state MRI along with novel, data-driven methods to examine brain networks disrupted in children with ASD and ADHD symptoms. This approach has two distinct advantages: 1) a basal ganglia-thalamocortical loop tapped by response inhibition is well-...
NDAR
Funding Completed
Shared
No
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Atypical Late Neurodevelopment in Autism #1906
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Atypical Late Neurodevelopment in Autism
Janet E Lainhart, MD 
Longitudinal neuroimaging and neuropsychological study to understand how brain mechanisms and clinical phenotypes in autism are related.
NDAR
Funding Completed
Shared
No
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Autism Genome Project #1916
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Autism Genome Project
Scherer, S. Devlin, B 
The Autism Genome Project (AGP) Consortium represents more than 50 centers in North America and Europe. In an ongoing effort, the international AGP Consortium is collecting DNA from ASD families for ongoing genetic studies. The first phase of this initiative involved examining genetic linkage and...
NDAR
Funding Completed
Shared
No
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Next Generation Gene Discovery in Familial Autism #1919
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Next Generation Gene Discovery in Familial Autism
Zoran Brkanac 
The goal of this proposal is to identify novel genes that are responsible for autism. To achieve that, we will apply novel analytic approach to identify families from existing UW-ACE and NIH collections where inheritance is most parsimonious with single gene transmission. We will analyze such...
NDAR
Funding Completed
Shared
No
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Visual attention and fine motor coordination in infants at risk for autism #1920
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Visual attention and fine motor coordination in infants at risk for autism
Anjana Narayan Bhat 
The broad objectives of this research are to develop novel tools for early identification of motor, social, and cognitive deficits of Autism Spectrum Disorders (ASD) within the first six months of life. In this proposal, reaching, object exploration, and associative learning tasks are used as ...
NDAR
Funding Completed
Shared
No
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Components of Limited Activity Monitoring in Toddlers with ASD #1923
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Components of Limited Activity Monitoring in Toddlers with ASD
Frederick Shic 
This proposal seeks to understand why toddlers with ASD monitor the activities of others less frequently by examining the social, perceptual, and developmental factors which may influence this ability in 20-month old toddlers with ASD and 14- and 20-month old TD toddlers. In regards to typical...
NDAR
Funding Completed
Shared
No
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Behavioral and Genetic Biomarker Development for Autism and Related Disorders #1932
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Behavioral and Genetic Biomarker Development for Autism and Related Disorders
Linda Brzustowicz, M.D. 
This collection represents a family-based study of Autism Spectrum Disorder (ASD) that consists of (1) behavioral and diagnostic assessments of ASD (including social behavior, language, reading, and cognition measures) used to create behavioral biomarkers and (2) the genetic data used for linkage,...
NDAR
Funding Completed
Shared
No
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Deep sequencing of autism candidate genes in 2000 families from the Simons Simplex Collection (SSC) #1936
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Deep sequencing of autism candidate genes in 2000 families from the Simons Simplex Collection (SSC)
Michael Wigler 
343 families from the Simons Simplex Collection. Each family includes father, mother, a proband and an unaffected sibling.
NDAR
Funding Completed
Shared
No
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Cultural Equivalence of Autism Assessment for Latino Children #1939
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Cultural Equivalence of Autism Assessment for Latino Children
Sandra Magana 
The proposed study will examine the cultural equivalence of the Autism Diagnostic Interview Revised (ADI-R) for a US Latino population. The proposed study builds on an existing study of Latino children on the autism spectrum and their families and will recruit 25 additional children who have...
NDAR
Funding Completed
Shared
No
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Developing a novel treatment for restricted inflexible behavior #1940
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Developing a novel treatment for restricted inflexible behavior
Mark Lewis 
The overall goal of the proposed project is to initiate a program of research to develop a novel treatment approach to restricted, inflexible behavior, a clinically important and highly understudied problem in neurodevelopmental disorders in general and autism in specific. Rather than target a...
NDAR
Funding Completed
Shared
No
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Decoding what and who in the auditory system of children with autism spectrum #1943
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Decoding what and who in the auditory system of children with autism spectrum
Vinod Menon 
To further our understanding of basic auditory function underlying decoding of phonological content ("what" is being said) and speaker identity (who is saying it) in children with ASD, compared to typically developing (TD) children matched on age and language ability. Novel multivariate pattern...
NDAR
Funding Completed
Shared
No
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Autism Risk, Prenatal Environmental Exposures, and Pathophysiologic Markers #1946
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Autism Risk, Prenatal Environmental Exposures, and Pathophysiologic Markers
Irva Hertz-Picciotto 
An extension of the epidemiology project MARBLES (Markers of Autism Risk in Babies Learning Early Signs) to collect 1) extensive behavioral, medical, and exposure data, 2) biologic specimens from the mother and child, and 3) detailed psychometric assessments from birth to 3 years, Exposures of...
NDAR
Funding Completed
Shared
No
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Effectiveness and Implementation of a Mental Health Intervention for ASD #1950
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Effectiveness and Implementation of a Mental Health Intervention for ASD
Lauren Brookman-Frazee 
This collection includes clinical data on children ages 5 to 13 with ASD receiving community mental health services.
NDAR
Funding Completed
Shared
No
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Synaptic A-to-I RNA editing in autistic and neurotypical cerebella #1951
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Synaptic A-to-I RNA editing in autistic and neurotypical cerebella
Louis Kunkel 
Ultradeep 454 and Illumina sequencing of cDNA from postmortem cerebella of individuals with ASD and matched neurotypical controls
NDAR
Funding Completed
Shared
No
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School-Age Children with Autism with Limited Expressive Language Intervention #1952
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
School-Age Children with Autism with Limited Expressive Language Intervention
Rebecca Landa 
School-Age Children with Autism with Limited Expressive Language Skills: An Intervention Study
NDAR
Funding Completed
Shared
No
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Characterizing mechanistic heterogeneity across ADHD and Autism #1955
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Characterizing mechanistic heterogeneity across ADHD and Autism
Fair, Damien A 
Progress in establishing the etiology of psychiatric illness is limited by the absence of objective biological measures able to detect and discriminate between disorders. This problem is particularly important in developmental disorders, where early identification could eventually assist in...
NDAR
Enrolling
Shared
No
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A Family-Genetic Study of Autism and Fragile X Syndrome #1958
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
A Family-Genetic Study of Autism and Fragile X Syndrome
Molly C. Losh 
Fragile X syndrome (FXS) is associated with an increased risk of autism, with prevalence rates ranging from 25-50%. This translates to an approximate relative risk of over 100, indicating that FMR1 (the gene causing FXS) confers considerable vulnerability to autism. While efforts to uncover the...
NDAR
Enrolling
Shared
No
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Performance Indices of Social Disability in Toddlers with Autism #1959
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Performance Indices of Social Disability in Toddlers with Autism
Ami Klin 
This project - 'Performance Indices of Social Disability in Toddlers with Autism' - addresses Challenge Area '(04) Clinical Research' and Specific Challenge Topic 'Autism: Addressing the Challenge (04-MH-101*)'; and Challenge Area '(01) Behavior, Behavioral Change, and Prevention' and Specific...
NDAR
Funding Completed
Shared
No
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Longitudinal Studies of Autism Spectrum Disorders: From 2 to 23 #1965
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Longitudinal Studies of Autism Spectrum Disorders: From 2 to 23
Cathy Lord, Ph. D 
Longitudinal Studies of Autism Spectrum Disorders (ASD): From 2 to 23 - Increasing Understanding of Nonverbal School-Aged Children and Children with Limited Language Skills
NDAR
Funding Completed
Shared
No
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Dissecting Epistasis and Pleiotropy in Autism towards Personalized Medicine (Autism Traits in the RASopathies) #1966
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Dissecting Epistasis and Pleiotropy in Autism towards Personalized Medicine (Autism Traits in the RASopathies)
Lauren A. Weiss, PhD 
SRS & SCQ data for individuals with RASopathies (NF1, Noonan, CFC, & Costello syndromes) as well as healthy family members.
NDAR
Funding Completed
Shared
No
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Sensor-based technology in the study of motor skills in infants at risk for ASD (Infant motor planning) #1968
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Sensor-based technology in the study of motor skills in infants at risk for ASD (Infant motor planning)
Jana M. Iverson 
Longitudinal and cross-sectional data on motor planning in infants at HR for ASD and comparison infants. This research is designed to examine fine motor and object manipulation skills in HR and comparison infants with no such risk (Low Risk infants; LR) between the ages of 12 and 36 months. The...
NDAR
Funding Completed
Shared
No
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Methylomic and genomic impacts of organic pollutants in Dup15q syndrome #1970
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Methylomic and genomic impacts of organic pollutants in Dup15q syndrome
Janine LaSalle 
This study is designed to test a novel paradigm that the human genome dynamically interacts with the environment and that epigenetic mechanisms are at the interface of genome environment interactions. This study is designed to experimentally determine if PCB-95 and/or BDE-47 play a causal or...
NDAR
Funding Completed
Shared
No
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Rapid Phenotyping for Rare Variant Discovery in Autism #1971
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Rapid Phenotyping for Rare Variant Discovery in Autism
Stanley Nelson 
The project proposed here is to use the combined power of web based recruiting, web-implemented and validated phenotypic measurements, and distributed blood collection to establish a cost-effective recruitment of affected children with ASD. Based on our preliminary analysis where we assessed the...
NDAR
Funding Completed
Shared
No
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Early Brain Development in Twins #1974
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Early Brain Development in Twins
John Gilmore 
Twin studies have been critical in determining the contributions of genetic and environmental factors to normal brain structure and for understanding abnormalities of brain development that underlie neurodevelopmental and neuropsychiatric disorders. In adults and older children, twin studies...
NDAR
Funding Completed
Shared
No
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A Longitudinal 3-D MRSI Study of Infants at High Risk for Autism #1975
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
A Longitudinal 3-D MRSI Study of Infants at High Risk for Autism
Stephen Dager 
The aim of this proposal is to expand the scope of a funded NIH project "A longitudinal MRI Study of Infants at Risk for Autism", (RO1 HD055741- IBIS network) through adding 3-D Proton Echo PlanarSpectroscopic Imaging (3D PEPSI) to allow measurements of brain chemistry in 6 month-old siblings.
NDAR
Funding Completed
Shared
No
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The use of interactive television in identifying autism in young children #1978
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
The use of interactive television in identifying autism in young children
Ronald Matthew Reese 
The long-term research goal is to identify empirically validated practices for early detection of ASD in rural communities and the objective of this study is to identify reliable and valid evaluation procedures for diagnosing children with ASD in rural communities. The main hypothesis is that...
NDAR
Funding Completed
Shared
No
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Preschool Reading and Language Interventions for Children with Autism #1981
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Preschool Reading and Language Interventions for Children with Autism
Roxanne Hudson 
The goal of this proposed project is to determine the immediate (end of preschool) and longer term (end of kindergarten) effects of preschool interventions based on areas that have been previously shown to be important for emergent literacy and improved reading and language outcomes. To investigate...
NDAR
Funding Completed
Shared
No
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Evaluating the Time-Dependent Unfolding of Social Interactions in Children with Autism #1985
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Evaluating the Time-Dependent Unfolding of Social Interactions in Children with Autism
Michael Richardson 
Given the importance of social competence in ASD, the proposed research will evaluate whether social motor coordination can be a marker for social competence in autism across the spectrum of deficits and explore the relationship between motorically-based and cognitively-based conceptions of social...
NDAR
Funding Completed
Shared
No
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Testing the hyperspecificity hypothesis: a neural theory of autism #1986
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Testing the hyperspecificity hypothesis: a neural theory of autism
Robert Schultz 
The current proposal represents the first ever neural test of the "hyperspecificity" hypothesis of ASD. Testing involves application of new methods that our labs developed for implementation with fMRI and ERPs. We predict that fMRI based probe will reveal sparser neural encoding in ASD, and that...
NDAR
Funding Completed
Shared
No
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NIMH Genetics #1999
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
NIMH Genetics
NIMH Genetics 
NIMH Genetics Summary Information
NDAR
Funding Completed
Shared
No
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Networked Cortical Responses to Movement Associated with ASD #2000
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Networked Cortical Responses to Movement Associated with ASD
Michael Murias 
This project examines three different networks (mu, beta, gamma) of brain activity that respond when people view scenes involving motion. We measure these network activities by recording electroencephalographic (EEG) responses to motion, and analyze their temporal, spectral, and spatial...
NDAR
Funding Completed
Shared
No
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Influence of Attention and Arousal on Sensory Abnormalities in ASD #2001
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Influence of Attention and Arousal on Sensory Abnormalities in ASD
Jeanne Townsend 
Based upon our own work and existing evidence, we suggest a model in which basic sensory function is intact in ASD and abnormalities in sensory behavior result instead from the influence of poorly modulated arousal and attention on sensory responsiveness. We propose to address this important issue...
NDAR
Funding Completed
Shared
No
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Autism: Social and Communication Predictors in Siblings (Landa) AND Effects of Active Motor and Social Training on Developmental Trajectories in Infants at High-risk for Autism Spectrum Disorders (Libertus) #2003
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Autism: Social and Communication Predictors in Siblings (Landa) AND Effects of Active Motor and Social Training on Developmental Trajectories in Infants at High-risk for Autism Spectrum Disorders (Libertus)
Rebecca Landa, Klaus Libertus 
The purpose of the proposed study is to identify very early indicators of ASD, beginning in infancy. Specific aims are to: (1) define markers of disrupted neurobehavioral development that appear between 6 and 14 months of age, before clinical signs of ASD; (2) translate ASD clinical indicators...
NDAR
Funding Completed
Shared
No
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Sequencing Autism Spectrum Disorder Extended Pedigrees (1/3, 2/3, and 3/3) #2004
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Sequencing Autism Spectrum Disorder Extended Pedigrees (1/3, 2/3, and 3/3)
Gerard Schellenberg, Hilary Coon and Ellen Wijsman 
We have in hand a unique resource of extended autism spectrum disorder (ASD) pedigrees. We will sequence family members from the most informative pedigrees to study genetic variation contributing to ASD and related phenotypes. We will work to discover new variation, and also use the resource to...
NDAR
Funding Completed
Shared
No
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Pivotal Response Treatment for Infants at Risk for ASD: A Pilot Intervention #2005
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Pivotal Response Treatment for Infants at Risk for ASD: A Pilot Intervention
Katarzyna Chawarska 
The proposed project aims to evaluate the feasibility and acceptability of a novel behavioral intervention, Infant-Toddler Years Pivotal Response Treatment (ITY-PRT), designed to enhance the frequency of communication and social engagement in infant siblings of children with Autism Spectrum...
NDAR
Funding Completed
Shared
No
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Impairments of Theory of Mind disrupt patterns of brain activity #2006
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Impairments of Theory of Mind disrupt patterns of brain activity
Rebecca Saxe 
Humans think constantly about one another's thoughts, for example, in order to communicate, to teach, to learn from, to cooperate with, to compete with, and to deceive one another. This ability to fluently infer what others are thinking is impaired in individuals with Autism Spectrum Disorders...
NDAR
Funding Completed
Shared
No
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Treatment of Autism Symptoms in Children (TASC): Initial RCT with Active Control #2007
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Treatment of Autism Symptoms in Children (TASC): Initial RCT with Active Control
Jeffrey Wood 
Cognitive behavioral therapy (CBT) offers a novel approach for addressing core autism symptoms in higher functioning school-age youngsters. CBT has been successfully adapted to treat emotional problems in school-aged children with ASD (e.g., Wood et al., 2009a). Initial results suggest that CBT...
NDAR
Funding Completed
Shared
No
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Early Biomarkers of Autism Spectrum Disorders in infants with Tuberous Sclerosis #2008
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Early Biomarkers of Autism Spectrum Disorders in infants with Tuberous Sclerosis
Mustafa Sahin 
Autism Spectrum Disorders (ASD) has complex and varying etiologies. A lack of understanding regarding the underlying molecular and cellular mechanisms is a key barrier in finding effective treatments. Single-gene disorders that have a high prevalence of ASD provide unique opportunities to...
NDAR
Enrolling
Shared
No
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Study of Oxytocin in Autism to Improve Reciprocal Social Behaviors (SOARS-B) #2009
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Study of Oxytocin in Autism to Improve Reciprocal Social Behaviors (SOARS-B)
Linmarie Sikich 
This application proposes creation of the ACE SOARS Network and a pivotal clinical trial of sustained oxytocin treatment in children with ASD known as SOARS-B (Study of Oxytocin in ASD to improve Reciprocal Social Behaviors). The ACE SOARS Network consists of five Treatment Sites across the country...
NDAR
Funding Completed
Shared
No
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Toward Outcome Measurement of Anxiety in Youth with Autism Spectrum Disorders #2011
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Toward Outcome Measurement of Anxiety in Youth with Autism Spectrum Disorders
Lawrence D. Scahill 
This four-year multisite project will advance outcome measurement of anxiety in future clinical trials in youth with autism spectrum disorders (ASDs). Program announcement (PAR-11-045) declares that the dearth of outcome measures in developmentally disabled populations is a major impediment for...
NDAR
Funding Completed
Shared
No
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Optimization of Fidelity Procedures for Pivotal Response Training in Autism #2012
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Optimization of Fidelity Procedures for Pivotal Response Training in Autism
Aubyn Stahmer 
To improve the overall quality and effectiveness of mental health intervention, it is essential to identify empirically supported behavioral treatments (ESBTs) and assure the accessibility and usability of these treatments for providers in community settings. Fidelity of implementation (FI), or...
NDAR
Funding Completed
Shared
No
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Magnetoencephalographic studies of lexical processing and abstraction in autism #2013
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Magnetoencephalographic studies of lexical processing and abstraction in autism
David Embick 
Language impairment and communication difficulties are a hallmark of autism spectrum disorders. The central hypothesis underlying this proposal is that children on the autism spectrum manifest difficulties forming and accessing abstract representations and categorizing acoustic distinct but...
NDAR
Funding Completed
Shared
No
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The Neural Substrates of Higher-Level Learning in Autism #2014
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
The Neural Substrates of Higher-Level Learning in Autism
Marjorie Solomon 
Individuals with ASD display a unique pattern of abilities and disabilities in learning and memory. They exhibit intact lower-level learning of items, facts, details, and routines. However, they manifest impairments in higher level learning involving abstraction, problem solving, using information...
NDAR
Funding Completed
Shared
No
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Wireless EEG System for Training Attention and Eye Movement in ASD #2017
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Wireless EEG System for Training Attention and Eye Movement in ASD
Jeanne Townsend 
Autism Spectrum Disorder (ASD) is a lifelong disorder that severely affects the ability to learn and function in a social environment. In typical function, higher level social, language and communication skills develop over the first few years of life and depend upon the critical building blocks of...
NDAR
Funding Completed
Shared
No
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Longitudinal measurements of sleep EEG in adolescence #2018
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Longitudinal measurements of sleep EEG in adolescence
Irwin Feinberg 
Adolescence is now recognized as a period of major brain reorganization as well as rapid endocrine and physical development. Among the most prominent brain changes is a huge decline in the delta (<4 Hz) EEG of NREM sleep. Our ongoing study uses spectral and period-amplitude analyses to examine...
NDAR
Funding Completed
Shared
No
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The Role of Germline Mutation and Parental Age in Autism Spectrum Disorders #2019
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
The Role of Germline Mutation and Parental Age in Autism Spectrum Disorders
Jonathan Sebat 
In the new phase of our project, we will apply a whole genome sequencing-based approach to determine the role of ROHs in ASD. We will investigate the nature intrinsic hypermutability and the extrinsic forces, such as paternal age, that influence rates of germline mutation. We will accomplish these...
NDAR
Funding Completed
Shared
No
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Adaptive Interventions for Minimally Verbal Children with ASD in the Community #2020
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Adaptive Interventions for Minimally Verbal Children with ASD in the Community
Connie Kasari 
An estimated 30-40% of school-aged children with an autism spectrum disorder (ASD) remain minimally verbal even after receiving years of interventions. These children require an intervention approach that simultaneously (a) consolidates early success in treatment and (b) intensifies treatment given...
NDAR
Funding Completed
Shared
No
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Multimodal Developmental Neurogenetics of Females with ASD #2021
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Multimodal Developmental Neurogenetics of Females with ASD
Kevin Pelphrey 
The term autism-spectrum disorders (ASD) exemplifies the tremendous heterogeneity in this developmental disorder at both the phenotypic and underlying genetic levels. It has repeatedly been observed that ASD disproportionately affects males relative to females. Although many hypotheses attempt to...
NDAR
Funding Completed
Shared
No
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The Social Brain in Schizophrenia and Autism Spectrum Disorders #2022
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
The Social Brain in Schizophrenia and Autism Spectrum Disorders
Michal Assaf 
Autism measures, diagnostic measures, EEG and fMRI data
NDAR
Funding Completed
Shared
No
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Multigenerational Familial and Environmental Risk for Autism (MINERvA) Network #2023
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Multigenerational Familial and Environmental Risk for Autism (MINERvA) Network
Abraham Reichenberg 
We will build on an existing research network leveraging established population-based epidemiologic resources from seven countries (USA-California, Australia, Denmark, Finland, Israel, Norway, Sweden) that include individual-level perinatal medical, and demographic information and archived...
NDAR
Funding Completed
Shared
No
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Divergent biases for conspecifics as early markers for Autism Spectum Disorders #2024
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Divergent biases for conspecifics as early markers for Autism Spectum Disorders
Athena Vouloumanos 
Typically developing infants have fundamental perceptual biases that direct their attention to socially relevant stimuli such as voices and faces Children diagnosed with Autism Spectrum Disorder (ASD) show apparent deficits in auditory and visual processing of the voices and faces of their own...
NDAR
Funding Completed
Shared
No
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Minimally Verbal ASD: From Basic Mechanisms to Innovative Interventions #2025
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Minimally Verbal ASD: From Basic Mechanisms to Innovative Interventions
Helen Tager-Flusberg 
Our ACE, located at Boston University, brings together researchers from across the university and collaborators from Harvard Medical School, Northeastern University and Albert Einstein College of Medicine. The interconnected projects in the ACE include: a novel intervention to promote spoken...
NDAR
Enrolling
Shared
No
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Biomarkers of Developmental Trajectories and Treatment in ASD #2026
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Biomarkers of Developmental Trajectories and Treatment in ASD
Susan Bookheimer 
This is a renewal for the UCLA Autism Center of Excellence. The primary focus of the UCLA ACE renewal is to understand the relationship between aberrant brain development and core deficits in autism by identifying mechanisms relating genes to brain structure/function and brain to behavior, and to...
NDAR
Funding Completed
Shared
No
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A Longitudinal MRI Study of Infants at Risk for Autism (ACE 2) #2027
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
A Longitudinal MRI Study of Infants at Risk for Autism (ACE 2)
Joseph Piven 
This application is a competing continuation of an Autism Center of Excellence (ACE) Network grant. The initial grant supported a prospective, longitudinal examination of brain and behavior at 6, 12 and 24 months in infants at high familial risk (HR) for autism. By the completion of this initial...
NDAR
Funding Completed
Shared
No
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Mechanisms of Risk and Resilience in ASD: Ontogeny, Phylogeny and Gene Disruption #2028
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Mechanisms of Risk and Resilience in ASD: Ontogeny, Phylogeny and Gene Disruption
Ami Klin 
The Emory ACE joins 8 laboratories in 3 institutions, creating a center for clinical and translational science built-from its outset--on the expectation of transformative impact on the community. Laboratories from the Marcus Autism Center, Emory University School of Medicine, and Yerkes National...
NDAR
Funding Completed
Shared
No
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Autism genetics: homozygosity mapping and functional validation (Years 1-5) #2029
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Autism genetics: homozygosity mapping and functional validation (Years 1-5)
Christopher A. Walsh 
Although high throughput sequencing (HTS) methods allow systematic analysis of genetic variation across the entire exome, or even the entire genome, the interpretation of this data faces analytical challenges that have by no means been solved. The use of consanguineous pedigrees, in which parents...
NDAR
Funding Completed
Shared
No
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Electrophysiological Response to Executive Control Training in Autism #2030
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Electrophysiological Response to Executive Control Training in Autism
Susan Faja 
Fifty to 96% of children with ASD demonstrate impaired executive control the ability to manage complex or conflicting information in the service of a goal. Development of appropriate executive control is relevant to public health because these skills are critical for success in school, the...
NDAR
Funding Completed
Shared
No
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The Study of Health Outcomes in Children with Autism and their Families #2032
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
The Study of Health Outcomes in Children with Autism and their Families
The Lewin Group 
The National Institute of Mental Health (NIMH) contracted with The Lewin Group to conduct a two-year study from September 2010 to September 2012 entitled "The Study of Health Outcomes in Children with Autism and their Families." This study seeks to address a significant gap in the empirical...
NDAR
Funding Completed
Shared
No
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Genotyping and RNA-Seq in post-mortem brains from autism-affected cases and controls #2034
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Genotyping and RNA-Seq in post-mortem brains from autism-affected cases and controls
Dan E. Arking 
Despite significant heritability of autism spectrum disorders (ASDs), the genetic basis of autism remains elusive. We have genotyped 64 autism-affected cases and controls and carried out RNA-Sequencing (RNA-Seq) on post-mortem cortical brain samples (BA19 ) from these same individuals with our goal...
NDAR
Funding Completed
Shared
No
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Autism Genetics, Phase II: Increasing Representation of Human Diversity #2035
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Autism Genetics, Phase II: Increasing Representation of Human Diversity
Daniel Geschwind 
Autism Spectrum Disorder (ASD) is a common, often devastating neuropsychiatric condition with largely unknown pathophysiology. Although ASD has a multifactorial etiology, it encompasses a large genetic component. The investigators in this proposal aim to continue and enhance our collaborative...
NDAR
Funding Completed
Shared
No
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Intervention effects of intensity and delivery style for toddlers with ASD #2036
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Intervention effects of intensity and delivery style for toddlers with ASD
Sally Rogers 
High quality, intensive early intervention is a powerful treatment for ASD, improving IQ and language markedly in randomized controlled clinical trials (RCTs), though little long term follow-up data exists. Few core characteristics that affect child change have been tested. Two potential core...
NDAR
Enrolling
Shared
No
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Gender and Cognitive Profile as Predictors of Functional Outcomes in School-Aged Children #2038
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Gender and Cognitive Profile as Predictors of Functional Outcomes in School-Aged Children
Jennifer Moriuchi 
The vast variability of symptoms and symptom severity in autism spectrum disorders (ASD) has been one of the greatest obstacles for research on its causes and treatment. This project aims to enhance understanding of the phenotypic heterogeneity in the disorder by identifying social learning styles...
NDAR
Funding Completed
Shared
No
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Autism Brain Imaging Data Exchange #2039
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Autism Brain Imaging Data Exchange
Michael Milham, MD, Ph.D. 
Autism spectrum disorders (ASD) are characterized by qualitative impairment in reciprocal social communication, as well as by repetitive, restricted, and stereotyped behaviors. Previously considered rare, ASD are now recognized to occur in more than 1% of children, causing immense suffering to...
NDAR
Funding Completed
Shared
No
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SSC total recall project #2042
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
SSC total recall project
Eichler, Evan 
This collection consists of sequencing and variation data resulting from the reanalysis of Whole Exome Sequences from 9047 individual subjects belonging to the Simons Simplex Collection (SSC). Original data were contributed by a collaboration between NDAR Collections 1878 (Eichler Lab, University...
NDAR
Funding Completed
Shared
No
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Autism Spectrum Disorder - Inflammatory Subtype: Molecular Characterization #2043
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Autism Spectrum Disorder - Inflammatory Subtype: Molecular Characterization
Harumi Jyonouchi 
Previously, we have reported that some of those 'poor responders' are characterized by fluctuating behavioral symptoms following immune insults (typically microbial infection), and persistent gastrointestinal (GI) symptoms. We have also found that peripheral blood (PB) monocytes...
NDAR
Funding Completed
Shared
No
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Development of a new autism screening tool for traditionally underserved families #2046
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Development of a new autism screening tool for traditionally underserved families
Yvette Janvier, MD 
The goal of this study is to improve identification of young children with autism spectrum disorders (ASD) from traditionally underserved populations by refining and testing the utility of a new ASD screening tool designed for use in families with low English literacy and comprehension challenges. ...
NDAR
Enrolling
Shared
No
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Efficacy of Relationship Development Intervention and Parent-Implemented Applied Behavior #2049
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Efficacy of Relationship Development Intervention and Parent-Implemented Applied Behavior
Mary Louise Kerwin Ph.D.  
Relationship Development Intervention (RDI) is a relationship-based intervention focusing on recreating developmental milestones through meaningful interactions with parents. The primary goal of RDI is to increase the child's response to parents bid for JA and the child's initiation of JA with the...
NDAR
Funding Completed
Shared
No
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Peers, Play and Performance to Improve Social Interaction in Autism #2052
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Peers, Play and Performance to Improve Social Interaction in Autism
Blythe Corbett 
Current psychosocial interventions in autism generally target only specific aspects of social knowledge or functioning. Moreover, promising initial gains often fail to maintain or generalize. Our goal is to address the need for the development of interventions for older children and adolescents...
NDAR
Funding Completed
Shared
No
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Autism Spectrum Disorder: Birth Cohort 1976-2000, Epidemiology and Adult #2053
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Autism Spectrum Disorder: Birth Cohort 1976-2000, Epidemiology and Adult
Slavica Katusic 
Autism Spectrum Disorders (ASDs) are lifelong neurodevelopmental conditions with mostly unknown etiology that have a huge impact on affected individuals and their families, and are a major public health concern. This proposal, Autism Spectrum Disorder: Birth Cohort 1976-2000, Epidemiology and Adult...
NDAR
Funding Completed
Shared
No
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Silvio O. Conte Center for Oxytocin and Social Cognition #2055
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Silvio O. Conte Center for Oxytocin and Social Cognition
Larry Young 
The oxytocin (OT) system is arguably the most viable target for pharmacologically enhancing social cognition in psychiatric disorders with compromised social cognition, including autism spectrum disorder (ASD). Central OT enhances key aspects of social behavior in animals, and intranasal (IN) OT...
NDAR
Funding Completed
Shared
No
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Reduced NADH Production in the Presence of Tryptophan as a Biomarker of ASD #2058
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Reduced NADH Production in the Presence of Tryptophan as a Biomarker of ASD
Charles Schwartz 
Autism Spectrum Disorders (ASDs) affect 1/110 children in the United States, but physicians do not yethave an effective laboratory test which can confirm the clinical diagnosis. This proposal aims to develop aquick and reliable metabolic array to identify individuals with ASD.Using Phenotype...
NDAR
Funding Completed
Shared
No
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Family Outcomes in Autism Spectrum Disorders #2059
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Family Outcomes in Autism Spectrum Disorders
Sigan L. Hartley 
It is now estimated that 1 in 88 children in the U.S. are diagnosed with an autism spectrum disorder (ASD).Few disabilities are more stressful on parents than ASD. There is theoretical and empirical evidence to suggest that chronic parenting stress affects marital adjustment. The overarching goal...
NDAR
Enrolling
Shared
No
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Dysfunction of Sensory Inhibition in Autism #2060
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Dysfunction of Sensory Inhibition in Autism
Richard Edden 
Autism Spectrum Disorder (ASD) is a group of developmental disorders which affects approximately 1% of children, a prevalence rate that is increasing annually. The molecular basis of ASD is likely to be complex and heterogeneous, but given the central role of the inhibitory neurotransmitter GABA...
NDAR
Funding Completed
Shared
No
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Verbal/non-verbal asynchrony in adolescents with high-functioning Autism #2062
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Verbal/non-verbal asynchrony in adolescents with high-functioning Autism
Ruth B. Grossman 
Adolescents with high-functioning autism (HFA) have significant deficits in non-verbal social communication, which often lead to depression and social withdrawal. These deficits are particularly apparent in their ability to process and produce qualitatively appropriate facial expressions. It has...
NDAR
Funding Completed
Shared
No
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Epidemiological Research on Autism in Jamaica - Phase II #2063
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Epidemiological Research on Autism in Jamaica - Phase II
Mohammad Rahbar 
Autism Spectrum Disorders (ASDs) are complex lifelong neurodevelopmental and behavioral disorders manifesting in infancy or early childhood, characterized by impairments in social interaction and communication, and by repetitive, stereotyped behavior. Although the causes of ASD are unknown, the...
NDAR
Enrolling
Shared
No
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The CCS: A Treatment Outcome Measure for Individuals with Severe ID #2064
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
The CCS: A Treatment Outcome Measure for Individuals with Severe ID
Nancy Brady 
This application is in response to FOA PAR-11-045, Outcome Measures for Use in Treatment trials for Individuals with Intellectual and Developmental Disabilities. We propose to further develop and validate an endpoint measure of communication for use in clinical trials research. We created a scale...
NDAR
Enrolling
Shared
No
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The CHARGE Study: Childhood Autism Risks From Genetics and the Environment #2066
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
The CHARGE Study: Childhood Autism Risks From Genetics and the Environment
Irva Hertz-Picciotto 
Few rigorous epidemiologic studies have addressed the environmental causes and biologic underpinnings of autism spectrum disorder (ASD). The CHARGE (CHildhood Autism Risks from Genetics and Environment) Study is a large, population-based case-control investigation of environmental risk factors,...
NDAR
Funding Completed
Shared
No
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Targeting GABA-A for the Treatment of Social Disability in Young Adults with Autism Spectrum Disorders: A Phase II Proof of Mechanism Trial #2067
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Targeting GABA-A for the Treatment of Social Disability in Young Adults with Autism Spectrum Disorders: A Phase II Proof of Mechanism Trial
James T. McCracken 
Autism Spectrum Disorders (ASD) (DSM-V, APA 2013) include the Pervasive Developmental Disorders (PDDs) previously referred to as Autistic Disorder, Asperger's disorder and PDD-Not Otherwise Specified (NOS). ASD are chronic neurodevelopmental disorders of early childhood onset that are associated...
NDAR
Funding Completed
Shared
No
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Eyeblink conditioning in school-aged children with ASD #2070
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Eyeblink conditioning in school-aged children with ASD
John Welsh 
Our project seeks to apply an objective behavioral measure of brain function that may identify sites of neural dysfunction in autism spectrum disorder (ASD). Our paradigm will be a robust measure of associative learning- Pavlovian eyeblink conditioning (EBC) to assess how fundamental...
NDAR
Enrolling
Shared
No
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Intrinsic Brain Architecture of Young Children with Autism While Awake and Asleep #2072
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Intrinsic Brain Architecture of Young Children with Autism While Awake and Asleep
Adriana DiMartino 
Functional neuroimaging is increasingly enhancing our understanding of autism spectrum disorders (ASD) as disconnection syndromes, but because of its demands, most studies have focused on adults or older children. Conducting functional neuroimaging during natural sleep permits the study of young...
NDAR
Funding Completed
Shared
No
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Mapping Thalamocortical Networks Across Development in ASD #2075
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Mapping Thalamocortical Networks Across Development in ASD
Carissa Cascio 
Autism spectrum disorders (ASD) are a group of pervasive developmental disorders characterized by deficits in social interaction and communication, and rigid or stereotypical behaviors. These complex behavioral problems arise, in part, from deficits in more basic sensory and motor systems. The...
NDAR
Funding Completed
Shared
No
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Treatment of anxiety in autism spectrum disorder #2076
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Treatment of anxiety in autism spectrum disorder
Jeffrey Wood, Eric Storch and Philip Kendall 
Comorbid anxiety disorders affect 40 to 50% of children with ASD, causing substantial distress and impairmentover and above that caused by ASD alone. High anxiety is associated with increased severity of ASDsymptoms and social maladjustment in affected youth. Further, parents of children with ASD...
NDAR
Funding Completed
Shared
No
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Gaze Modification Strategies for Toddlers with ASD #2077
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Gaze Modification Strategies for Toddlers with ASD
Frederick Shic 
Recent eye tracking studies have shown that 20 month old toddlers with autism spectrum disorders (ASD), as compared to typically developing (TD) and developmentally delayed (DD) toddlers, attend less to the shared activities of others 1 as well as to faces trying to engage them using direct eye...
NDAR
Funding Completed
Shared
No
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Modifiable Behavior & Dietary Predictors of Overweight in Children with ASD #2079
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Modifiable Behavior & Dietary Predictors of Overweight in Children with ASD
Susana Patton 
Pediatric overweight has reached epidemic levels and, at 36%, children with autism spectrum disorder (ASD)have a higher rate of overweight than typically developing children. Pediatric overweight is a major health problem because it is linked to childhood onset of dyslipidemia, hypertension, high...
NDAR
Funding Completed
Shared
No
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Smart Early Screening for Autism and Communication Disorders in Primary Care #2080
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Smart Early Screening for Autism and Communication Disorders in Primary Care
Amy Wetherby 
There is a pressing need to build the capacity of communities to follow the guidelines of the American Academy of Pediatrics to screen all children for ASD at 18 and 24 months (Johnson & Myers, 2007) as research indicates that earlier intervention maximizes outcomes. In response to PA-10-158, the...
NDAR
Enrolling
Shared
No
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A Randomized Controlled Trial of Intranasal Oxytocin as an Adjunct to Behavioral Therapy for Autism Spectrum Disorder #2087
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
A Randomized Controlled Trial of Intranasal Oxytocin as an Adjunct to Behavioral Therapy for Autism Spectrum Disorder
John Gabrieli and Aude Henin 
The primary objectives of this clinical study are threefold. First, we aim to test the hypothesis that cognitive behavioral therapy (CBT) will be efficacious at targeting core social deficits and enhancing social function in young adults with autism spectrum disorder (ASD). Second, we aim to...
NDAR
Enrolling
Shared
No
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Early Quantitative Characterization of Reciprocal Social Behavior #2089
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Early Quantitative Characterization of Reciprocal Social Behavior
John Constantino 
This project is focused on the development, validation, and standardization of quantitative methods to measure core components of variation in the social development of young children.This is critical for understanding autism and will inform the development and evaluation of early interventions for...
NDAR
Funding Completed
Shared
No
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Genotypes of Swedish subjects used in "Most genetic risk for autism resides with common variation" study #2092
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Genotypes of Swedish subjects used in "Most genetic risk for autism resides with common variation" study
Joseph D. Buxbaum, Trent Gaugler, Lambertus Klei, Stephan J. Sanders, Corneliu A. Bodea, Arthur P. Goldberg, Ann B. Lee, Yudi Pawitan, Stephan Ripke, Sven Sandin, Pamela Sklar, Oscar Svantesson, Abraham Reichenberg, Christina M. Hultman, Bernie Devlin, Kathryn Roeder 
Genotypes of Swedish subjects used in "Most genetic risk for autism resides with common variation" study
NDAR
Funding Completed
Shared
No
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Sporadic Mutations and Autism Spectrum Disorders #2093
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Sporadic Mutations and Autism Spectrum Disorders
Evan E Eichler 
Sporadic Mutations and Autism Spectrum Disorders
NDAR
Funding Completed
Shared
No
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Decoding Affective Prosody and Communication Circuits in Autism #2094
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Decoding Affective Prosody and Communication Circuits in Autism
Vinod Menon 
Understanding the emotional state of a communication partner stands at the center of meaningful and successful human interaction, and speech serves as a conduit for conveying critical emotional information in everyday communication. Social communication deficits constitute a core characteristic of...
NDAR
Enrolling
Shared
No
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The neurophysiology of sensory processing and multisensory integration in ASD #2095
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
The neurophysiology of sensory processing and multisensory integration in ASD
Natalie Russo 
Sensory atypicalities represent a cardinal feature of Autism Spectrum Disorders (ASD) and have been established as the source of much behavioral aggression, frustration, and functional impairment over the course of the lifespan within this population[1-3]. Research in this area generally has been...
NDAR
Enrolling
Shared
No
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Phenotypic Characterization of Gene Disrupting Mutations in ASD #2101
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Phenotypic Characterization of Gene Disrupting Mutations in ASD
Raphael Bernier 
Autism spectrum disorder (ASD) is a genetically and phenotypically heterogeneous disorder. Efforts to identifying subtypes based on the behavioral and neural phenotypes have been unsuccessful, and the rarity of specific genetic events renders subtyping at the CNV or exonic mutation level...
NDAR
Enrolling
Shared
No
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Neural Phenotypes of Females with Autism Spectrum Disorder #2108
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Neural Phenotypes of Females with Autism Spectrum Disorder
Christine Wu Nordahl 
Autism spectrum disorder (ASD) affects 1 in 88 children in the United States, but the disorder is much more common in boys than in girls. The prevalence of ASD in boys is 5 times higher than in girls, with a rate of 1 in 54 for boys and 1 in 252 for girls. Although this disparate sex ratio is among...
NDAR
Enrolling
Shared
No
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Supported Employment, Cognitive Enhancement, Social Skills Program for ASD Adult #2111
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Supported Employment, Cognitive Enhancement, Social Skills Program for ASD Adult
Mary J. Baker 
The increasing population of adults with ASD is described as a challenging public health issue. Longitudinal studies of intellectually able adults with autism have shown consistent and persistent deficits across cognitive, social, and vocational domains, indicating a significant need for effective...
NDAR
Funding Completed
Shared
No
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Services to enhance social functioning in adults with autism spectrum disorder #2112
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Services to enhance social functioning in adults with autism spectrum disorder
Edward S. Brodkin 
This application is submitted in response to RFA-MH-14-102 (Pilot Studies of Services Strategies for Adults with ASD), and seeks support to develop and test a service strategy to enhance social functioning in adults with autism spectrum disorder (ASD). Social cognition and social interaction...
NDAR
Funding Completed
Shared
No
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Addressing systemic health disparities in early ASD identification and treatment #2113
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Addressing systemic health disparities in early ASD identification and treatment
Alice S. Carter 
The goal of the proposed work is to implement a system-level intervention to (a) improve early detection of autism spectrum disorders (ASD) and (b) increase early access to autism specific early intervention services, especially for children who often are not given the known benefits of early...
NDAR
Enrolling
Shared
No
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Early identification and service linkage for urban children with autism #2114
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Early identification and service linkage for urban children with autism
Emily Feinberg 
Emerging evidence demonstrates that Autism Spectrum Disorder (ASD) can be reliably diagnosed by age two, and that early identification and intervention can improve outcomes. Low-income and minority children with ASD, however, are diagnosed later and experience greater delays in service provision...
NDAR
Enrolling
Shared
No
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Detection of ASD at the 1st birthday as standard of care: The Get SET Early Model #2115
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Detection of ASD at the 1st birthday as standard of care: The Get SET Early Model
Karen L. Pierce 
We previously demonstrated that our early intervention model system, which was centered on using the CSBS to screen all babies at the 1-year check-up as standard of care, resulted in a mean age of 12 months for screening, 14 months for evaluation, and 18 months for treatment participation. These...
NDAR
Enrolling
Shared
No
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Improving Transition Outcomes in ASD using COMPASS #2116
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Improving Transition Outcomes in ASD using COMPASS
Lisa A. Ruble 
This application responds to the identified need for developing and testing a model for transition to adult supports and services for individuals with autism spectrum disorders (ASD) that prevents lapses in services and enhances functional life outcomes. The proposal also addresses concerns raised...
NDAR
Funding Completed
Shared
No
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Transition to Medication Self-Management for Youth with ASD & Co-Occurring ADHD #2117
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Transition to Medication Self-Management for Youth with ASD & Co-Occurring ADHD
Laura P. Shone 
Autism Spectrum Disorder (ASD) affects roughly 1 in 88 US children. Service delivery can be complicated during transition from youth to adulthood, when youth must begin to manage their own healthcare. Essential skills include making appointments, communicating with providers, and understanding and...
NDAR
Funding Completed
Shared
No
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Multi-family Group Psychoeducation for Young Adults with ASD #2118
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Multi-family Group Psychoeducation for Young Adults with ASD
Leann Smith 
Autism spectrum disorders (ASDs) are developmental disabilities that affect approximately 1 in 88 children in the US (CDC, 2012). Although there is evidence of reduction in severity of symptoms from childhood to adulthood, ASD is a lifelong disability requiring ongoing support. Following high...
NDAR
Funding Completed
Shared
No
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A Screen-Refer-Treat (SRT) Model to Promote Earlier Access to ASD Intervention #2119
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
A Screen-Refer-Treat (SRT) Model to Promote Earlier Access to ASD Intervention
Wendy L. Stone 
Although caregivers often become concerned about their child by 17-19 months of age, children do not typically receive a diagnosis of autism spectrum disorder (ASD) until they are 4.5 years old, or older for Hispanic families. It is now well documented that early participation in ASD-specialized...
NDAR
Enrolling
Shared
No
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Adapting a Parent Advocacy Program to Improve Transition for Youth With Autism #2120
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Adapting a Parent Advocacy Program to Improve Transition for Youth With Autism
Julie L. Taylor 
In the proposed research, we first adapt an existing parent advocacy training program (the Volunteer Advocacy Project, or VAP) to meet the needs of families of youth with autism spectrum disorders (ASD) who are transitioning to adulthood. In a randomly assigned, wait-list control design with 6- and...
NDAR
Funding Completed
Shared
No
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Mobilizing Community Systems to Engage Families in Early ASD Detection & Services #2121
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Mobilizing Community Systems to Engage Families in Early ASD Detection & Services
Amy Wetherby 
The American Academy of Pediatrics recommends screening all children for autism spectrum disorder (ASD) at 18 and 24 months because research indicates that earlier intervention maximizes children's outcomes. The earliest signs of ASD are delays in social communication milestones that appear in the...
NDAR
Enrolling
Shared
No
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STEPS: Stepped Transition in Education Program for Students with ASD #2122
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
STEPS: Stepped Transition in Education Program for Students with ASD
Susan W. White 
Young adults who have Autism Spectrum Disorder (ASD) without co-occurring intellectual impairment face a fairly unique set of challenges as they transition out of secondary school. These students are often quite capable of succeeding in higher education and many of them have interest in pursuing...
NDAR
Funding Completed
Shared
No
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Longitudinal Study of Genetic Influences on Cognition (LOGIC) #2123
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Longitudinal Study of Genetic Influences on Cognition (LOGIC)
Alysa E. Doyle, Ellen B. Braaten, Steven McCarroll, Michael Talkowski 
This project aims to collect DNA and cognitive and psychiatric phenotypes on 3,000 clinically-referred youth enriched for neurocognitive dysfunction. Its goal is to reveal complex trajectories to adult psychiatric illness and provide an evidence base by which to improve early identification and...
NDAR
Funding Completed
Shared
Yes
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Biological Determinants of Brain Variation in Autism #2129
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Biological Determinants of Brain Variation in Autism
Janet Lainhart 
The goal of this research is to generate a genetic architecture of brain development. We aim to achieve this goal in two solid steps. We first utilize our existing brain MR imaging measurements (traditional MRI volumetry, brain connectivity, resting state activity) of 235 individuals, 125 with...
NDAR
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No
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Recurrent de novo mutations implicate novel genes underlying simplex autism risk #2130
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Recurrent de novo mutations implicate novel genes underlying simplex autism risk
Evan Eichler 
Autism spectrum disorder (ASD) is a common disorder with a strong and complex genetic component. Here, we resequence 64 candidate neurodevelopmental disorder risk genes in almost 6,000 samples and identify novel genes associated with ASD.
NDAR
Funding Completed
Shared
No
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Derived and Evaluated Data #2161
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Derived and Evaluated Data
Multiple 
The contents of this collection include NDA derived and evaluated Data. The NIMH Data Archive currently provides infrastructure to run established pipelines and processes making derived results available for querying. Those investigators using data contained here for purposes other than query...
NDAR
Funding Completed
Shared
No
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Multi-Site, Randomized, Controlled Implementation Trial of an Evidence-Based, Adult & Peer-Mediated Social Skills Intervention for Elementary School Children with ASD #2168
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Multi-Site, Randomized, Controlled Implementation Trial of an Evidence-Based, Adult & Peer-Mediated Social Skills Intervention for Elementary School Children with ASD
Jill Locke 
With the rising cost of educational services for children with autism and fiscal challenges that school districts face, it is imperative that cost-effective autism-related interventions are easily implemented and sustained in schools. Social impairment represents the most challenging core deficit...
NDAR
Funding Completed
Shared
No
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Human Clinical Trial of IGF-1 in Children with Idiopathic ASD #2169
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Human Clinical Trial of IGF-1 in Children with Idiopathic ASD
Alexander Kolevzon 
A double-blind, randomized, placebo controlled, phase 2 human clinical trial of Insulin-Like Growth Factor-1 (IGF-1) in children with a genetic cause of autism (Phelan McDermid Syndrome) is currently underway at the Seaver Autism Center for Research and Treatment at Mount Sinai. That study builds...
NDAR
Enrolling
Shared
No
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Neural markers of shared gaze during simulated social interactions in ASD \-Modal Automated Assessment of Behavior during Social Interactions in Children with ASD #2179
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Neural markers of shared gaze during simulated social interactions in ASD \-Modal Automated Assessment of Behavior during Social Interactions in Children with ASD
James McPartland and Adam Naples 
(1) Individuals with autism spectrum disorder (ASD) experience profound difficulty in social interactions. Problems maintaining eye contact, or shared gaze, emerge early in life and persist throughout development. The social challenges experienced by people with ASD are most evident in dynamic,...
NDAR
Funding Completed
Shared
No
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Partners in Schools: A Program for Parents and Teachers of Children with Autism #2180
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Partners in Schools: A Program for Parents and Teachers of Children with Autism
Gazi Azad 
The goal of Partners In School is to develop and test a program that will improve parent-teacher communication about interventions for diverse children with autism attending public schools. With support from this enhancement grant, I will compensate parents and teachers for their participation,...
NDAR
Funding Completed
Shared
No
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Sex Differences in the Neural Mechanisms of Treatment Response #2181
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Sex Differences in the Neural Mechanisms of Treatment Response
Pamela Ventola 
Because of the skewed sex ratio in autism, prior treatment studies have not permitted inference regarding differential treatment response in boys and girls. Here we study how girls respond to an empirically supported behavioral treatment approach, Pivotal Response Training (PRT), to foster...
NDAR
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Identifying Biomarkers for Early Detection of Prosody Disorders in ASD using Electroglottography #2183
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Identifying Biomarkers for Early Detection of Prosody Disorders in ASD using Electroglottography
Shweta Ghai and Gordon Ramsay 
Atypical prosody is a characteristic feature of the communication deficit in autism spectrum disorders (ASD). Investigating disorders of prosody in autism is clinically important because disordered expressive prosody is an obstacle to social integration and communication for individuals with ASD...
NDAR
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Organization of Excitatory and Inhibitory Circuits in ASD #2189
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Organization of Excitatory and Inhibitory Circuits in ASD
Vasileios Zikopoulos 
The goal of the proposed project is to investigate the largely unexplored issue of the integrity of neural elements that underlie excitatory and inhibitory control within prefrontal networks. Experiments will be conducted on post-mortem brain tissue from children, using the robustly interconnected...
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Mitochondrial and Channelopathy Disorders and Dysfunction in Autism Spectrum Disorders: Genotypic and Phenotypic Correlations #2190
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Mitochondrial and Channelopathy Disorders and Dysfunction in Autism Spectrum Disorders: Genotypic and Phenotypic Correlations
Mark Mintz 
Our study enrolled individuals with moderate to severe ASDs associated with intellectual disabilities and/or epilepsy. Subjects underwent extensive clinical testing including brain wave testing, neuropsychological testing (including IQ and other testing), observations of behavior, measurements of...
NDAR
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Piloting Treatment with Insulin-Like Growth Factor-1 in Phelan-McDermid Syndrome #2192
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Piloting Treatment with Insulin-Like Growth Factor-1 in Phelan-McDermid Syndrome
Alexander Kolevzon 
Autism spectrum disorders (ASD) can now be conceived of as having multiple distinct genetic risk genes and one example is SHANK3 deficiency, characterized by global developmental delay, motor skills deficits, delayed or absent speech, and ASD. According to the Interagency Autism Coordinating...
NDAR
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No
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The role of vasopressin in the social deficits of autism #2197
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
The role of vasopressin in the social deficits of autism
Karen J. Parker and Antonio Hardan 
Autism is characterized by core social impairments which limit patients ability to form and maintain meaningful social relationships. At present, antipsychotic medications are the only pharmacotherapeutic option approved to treat autism. However, these agents mainly target associated symptoms...
NDAR
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No
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Pivotal Response Treatment Package for Young Children with Autism #2198
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Pivotal Response Treatment Package for Young Children with Autism
Antonio Hardan 
Over the last decade, considerable progress has been made to increase our understanding of the pathophysiology of autism spectrum disorder (ASD), but limited progress has been made in identifying effective interventions. The goal of this investigation is to build on our preliminary findings and...
NDAR
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No
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Change-sensitive Measurement of Emotion Dysregulation in ASD #2203
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Change-sensitive Measurement of Emotion Dysregulation in ASD
Carla Mazefsky 
Individuals with autism spectrum disorder (ASD) are often in need of psychiatric care due to poor emotion regulation and emotional distress. Only two psychotropic medications have been approved for use in ASD, both to treat irritability expressed as tantrums, outbursts, and aggression. However, the...
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A feasibility study for prevention and safety training for children with autism #2250
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
A feasibility study for prevention and safety training for children with autism
Nathan Call 
Children with autism spectrum disorder (ASD) are much more likely to wander or run away from supervision than their typically developing peers; a behavior referred to as elopement. The prevalence of elopement among children with ASD has contributed to the fact that accidents are the leading cause...
NDAR
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Developmental Synaptopathies Associated with TSC, PTEN and SHANK3 Mutations #2251
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Developmental Synaptopathies Associated with TSC, PTEN and SHANK3 Mutations
Mustafa Sahin 
Autism spectrum disorder and intellectual disability (ASD/ID) are severe neurodevelopmental conditions with early childhood onset. Advances in genetics have illustrated that ASD/ID represent a spectrum of rare disorders and that mutations in hundreds of genes may result in susceptibility to ASD/ID....
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Neurophenotypic Trajectories and Behavioral Outcomes in Autism Spectrum Disorder #2253
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Neurophenotypic Trajectories and Behavioral Outcomes in Autism Spectrum Disorder
David G. Amaral 
Autism spectrum disorder (ASD) has a common set of diagnostic features that nonetheless vary substantially in severity in different individuals. There are also many co-morbid features ranging from developmental delay to epilepsy to gastrointestinal disturbances that further complicate the...
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The neurobiological basis of heterogeneous social and motor deficits in ASD #2254
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
The neurobiological basis of heterogeneous social and motor deficits in ASD
Lisa Aziz-Zadeh 
While social communication deficits are considered the hallmark of Autism Spectrum Disorders (ASD), there is increasing evidence that sensorimotor deficits are also common in individuals with ASD diagnoses. A large body of research suggests that brain systems for execution and observation of...
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Serotonin Receptor Subtypes as Pharmacotherapeutic Targets in Autism #2255
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Serotonin Receptor Subtypes as Pharmacotherapeutic Targets in Autism
Gene Blatt 
Social-emotional and social-communicative behaviors are core features of autism and two of the key affected substrates are the cingulate cortices and fusiform gyrus. There is neuropathology within cortical lamina as well as changes in GABA-A receptors and associated benzodiazepine binding sites in...
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Effects of Social Gaze Training on Brain and Behavior in Fragile X Syndrome #2260
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Effects of Social Gaze Training on Brain and Behavior in Fragile X Syndrome
Scott S. Hall 
While research progress pertaining to autism spectrum disorder (ASD) has been extraordinary in some areas, many critical gaps in knowledge remain, particularly with respect to the development of treatments that address primary neurobiological abnormalities in affected individuals. For example,...
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Comparing Behavioral Assessments Using Telehealth for Children with Autism #2262
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Comparing Behavioral Assessments Using Telehealth for Children with Autism
Scott David Lindgren 
Managing challenging behavior in autism spectrum disorders (ASD) can profoundly improve quality of life for children and families. However, many families lack access to research-based treatment, such as applied behavior analysis (ABA). This study is a randomized trial comparing outcomes of...
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Inhibitory dysfunction in autism #2266
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Inhibitory dysfunction in autism
Scott Murray 
Autism spectrum disorder (ASD) is a complex disorder of brain development characterized by difficulties in social interaction, communication, and repetitive behaviors and is often accompanied by disruptions of sensory processing. One recent and potentially unifying neurobiological explanation...
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No
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Epigenetic regulation of social impairments and treatment response in autism #2268
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Epigenetic regulation of social impairments and treatment response in autism
Karen J. Parker 
Autism spectrum disorder (ASD) is characterized by core social impairments and affects 1 in 68 US children, but remains poorly understood. ASD is currently diagnosed on the basis of behavioral criteria because no robust biomarkers have been identified, nor are there any pharmacotherapies that...
NDAR
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Developing an Automated Emotion Training System #2272
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Developing an Automated Emotion Training System
Susan Williams White 
Problems with nonverbal social interaction are characteristic of autism spectrum disorder (ASD). Such problems include impaired ability to detect as well as express emotions, termed facial emotion recognition (FER) and emotion expression (EE), respectively. Computer-based, automated training...
NDAR
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Neural Effects of Sustained Oxytocin Treatment in Children with Autism #2279
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Neural Effects of Sustained Oxytocin Treatment in Children with Autism
Ting Wang 
This project aims to investigate the impact of oxytocin treatment on the neural systems underlying social impairments in children with ASD. We are participating in an NIH ACE network grant to conduct a definitive randomized, double-blind, placebo-controlled clinical trial of sustained intranasal...
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Predictors of Cognitive Development in Autism Spectrum Disorder #2281
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Predictors of Cognitive Development in Autism Spectrum Disorder
Marjorie Solomon 
Existing studies of middle childhood suggest that some children with ASD show significant improvements in IQ and other aspects of cognitive functioning during this period, while others stabilize or fall further behind. With the increased availability of intensive early intervention, it is not clear...
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Cognitive Enhancement Therapy for Adult Autism Spectrum Disorder #2282
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Cognitive Enhancement Therapy for Adult Autism Spectrum Disorder
Shaun Eack 
Autism spectrum disorder (ASD) is characterized by marked impairments in social and non-social cognitive ability that persist well into adulthood and contribute to significant functional disability. The treatment of ASD has focused almost exclusively on children, and few empirically supported...
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No
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Integrity and Dynamic Processing Efficiency of Networks in ASD #2285
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Integrity and Dynamic Processing Efficiency of Networks in ASD
Ralph-Axel Mueller 
A growing functional connectivity MRI (fcMRI) and diffusion tensor imaging (DTI) literature suggests that cognitive, socio communicative, and sensori motor impairments in autism spectrum disorders (ASD) are associated with impaired brain network connectivity. However few ASD studies to date have...
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FMRI and EEG approaches to the resting state in ASD #2286
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
FMRI and EEG approaches to the resting state in ASD
Ralph-Axel Mueller and Thomas T. Liu 
In the context of increasing prevalence the brain bases of autism spectrum disorder (ASD) remain incompletely understood. There is growing consensus that ASD is a disorder of brain connectivity, but functional connectivity findings are inconsistent. Resting state functional MRI (rs-fMRI) data,...
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Whole Genome Sequencing of Autistic Children and Families from Serbia and the U.S. #2287
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Whole Genome Sequencing of Autistic Children and Families from Serbia and the U.S.
Brock Peters 
This project uses Complete Genomics' LFR and standard sequencing techniques to identify causal variants linked to autism
NDAR
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No
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The Autism Biomarkers Consortium for Clinical Trials #2288
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
The Autism Biomarkers Consortium for Clinical Trials
James McPartland 
The goal of this consortium is to establish tools that can be used as biomarkers and/or sensitive and reliable objective assays of social impairment in autism spectrum disorder (ASD) clinical trials. Specifically, we aim to accelerate the development of effective treatments for social impairment in...
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Early Identification of ASD: Translating Eye Tracking into Practice (Years 6-10) #2290
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Early Identification of ASD: Translating Eye Tracking into Practice (Years 6-10)
Karen Pierce 
Currently, parent report screening tools (e.g., M-CHAT, CSBS) are the only standardized screening options available to pediatricians for the early detection of autism. As demonstrated in our previous work (the 1-Year Well-Baby Check-Up Approach, Pierce et al., 2011), such screens have valuable...
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No
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The Autistic Brain Over 45: The Anatomic, Functional, and Cognitive Phenotype #2291
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
The Autistic Brain Over 45: The Anatomic, Functional, and Cognitive Phenotype
Ralph-Axel Mueller 
The behavioral and neuroscientific literature on children and adolescents with autism spectrum disorder (ASD) has grown dramatically over the past decades. In contrast, almost nothing is known about ASD later in life. This is problematic in view of preliminary findings suggesting that some older...
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Molecular Mechanisms of Atypical Habituation in Autism Spectrum Disorders #2292
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Molecular Mechanisms of Atypical Habituation in Autism Spectrum Disorders
Natalia Kleinhans 
This project is designed to evaluate the efficacy of a novel imaging, biochemical, and behavioral approach for detecting autism spectrum disorder (ASD) and discovering mechanisms associated with ASD symptomology. Although considerable knowledge has been gained, the lack of reliable predictors...
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No
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Components of Emotional Processing in Toddlers with ASD #2293
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Components of Emotional Processing in Toddlers with ASD
Katarzyna Chawarska 
Older individuals with ASD show deficits in the pragmatic and spontaneous use of emotional information, but little is known about emotional processing in the early stages of ASD. Our preliminary work suggests that deficits in emotion processing are present as early as at 12 months in the affected...
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Change in social adaptive action and brain connectivity in infants first 6 months #2301
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Change in social adaptive action and brain connectivity in infants first 6 months
Warren Jones 
The current project will identify maturational changes in the infant brain that accompany important transitions in social behavior in the first 6 months of life. This work is motivated by a surprising feature of a recent study in which we identified the earliest known indicators of social...
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Dissecting recurrent microdeletion syndromes using dual-guide genome editing #2304
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Dissecting recurrent microdeletion syndromes using dual-guide genome editing
James Gusella 
Recurrent microdeletion syndromes (rMDS), such as those associated with 16p11.2, 1q21 and 22q11.2, represent a major component (10-15%) of the genetic etiology of neurodevelopmental disorders, including autism spectrum disorder (ASD). In each rMDS, a distinct set of genes is reproducibly reduced to...
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No
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Multimodel Assessment of Social Process Systems across Neurodevelopmental Disorders #2312
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Multimodel Assessment of Social Process Systems across Neurodevelopmental Disorders
James McPartland 
Disruption of social process systems is a hallmark of multiple neurodevelopmental disorders, resulting in significant functional impairment for affected individuals and substantial public health costs. This project proposes to examine the relationship between social performance and Reception of...
NDAR
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No
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Quantitative Measurements of Cortical Excitability in Neurodevelopmental Disorder #2316
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Quantitative Measurements of Cortical Excitability in Neurodevelopmental Disorder
Antonio Hardan 
Neurodevelopmental disorders, such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), are characterized by abnormalities in baseline cortical excitability that are believed to be caused by an abnormal, system-wide balance between excitation and inhibition....
NDAR
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Efficacy of Parent-implemented Treatment in Infant Siblings of Children With ASD #2321
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Efficacy of Parent-implemented Treatment in Infant Siblings of Children With ASD
Paul Yoder 
One way to prevent or reduce the severity of social and linguistic communication disorders in children at high risk for these disorders (e.g., younger siblings of children with autism spectrum disorders, Sibs-ASD) is to treat them at an age when the brain is still developing (i.e., infancy)....
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Electrophysiologic Studies of Language Impairment in ASD (Years 6-10) #2322
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Electrophysiologic Studies of Language Impairment in ASD (Years 6-10)
Timothy Roberts 
"Magnetoencephalographic (MEG) studies examining brain activity in children with autism spectrum disorders (ASD), including published studies from this R01s previous funding period, have identified functional markers
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Simons Simplex Collection (SSC) Genome Studies #2328
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Simons Simplex Collection (SSC) Genome Studies
Evan Eichler 
This Collection contains the following projects: (1) Maternal Modifiers and parent-of-origin bias of the autism 16p11.2 CNV: We assessed the presence of additional CNVs in 126 families where at least one individual carried the 16p11.2 CNV. (2) Genome Sequencing Pilot of Simons Simplex Collection...
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Infant Vocal Communication: Typical Development and Autism Risk #2332
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Infant Vocal Communication: Typical Development and Autism Risk
D. Kimbrough Oller 
Research is now tracking early infant vocal communication using all-day recordings evaluated with human coding and in limited cases with automated analysis at very large scales. Results reveal unexpected features of development, illustrating foundations of language. Much of this work conducted at...
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Early Intervention With Fluoxetine in Autism #2333
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Early Intervention With Fluoxetine in Autism
Linmarie Sikich 
Autism, a brain disorder that affects a small percentage of Americans, often results in a lifetime of impaired thinking, feeling, and social functioning. The disorder generally becomes apparent in children by the age of 3. Autism typically affects a person's ability to communicate, form...
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No
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Citalopram for Children With Autism and Repetitive Behavior (STAART Study 1) #2334
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Citalopram for Children With Autism and Repetitive Behavior (STAART Study 1)
Bryan King 
For children with autism spectrum disorders (ASD, also known as Pervasive Developmental Disorders - PDDs), repetitive behaviors are common and frequently interfere with functioning in the home as well as in social and educational settings. These behaviors may involve repetitive movements, rigid...
NDAR
Funding Completed
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No
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The role of parent phenotype in parent-mediated language interventions for autism #2335
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
The role of parent phenotype in parent-mediated language interventions for autism
Megan Roberts 
High dosage of early intervention is critical to language skill development in young children with autism spectrum disorders (ASD) (Dawson et al., 2010) and including parents is a cost-effective approach to maximize intervention dosage. However, parent-mediated interventions have inconsistent...
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No
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Multimodal Imaging of Early Neural Signature in Autism Spectrum Disorder #2338
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Multimodal Imaging of Early Neural Signature in Autism Spectrum Disorder
Inna Fishman 
The high and rapidly increasing prevalence of autism spectrum disorder (ASD) presents a major public health challenge, as costs of care and the need for more effective interventions are growing. While classified as a brain development disorder, its diagnostic criteria remain entirely behavioral...
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Cognitive and Neural Flexibility in Autism #2342
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Cognitive and Neural Flexibility in Autism
Lucina Qazi Uddin 
Autism spectrum disorder (ASD) is a complex neurodevelopment disorder of largely unknown etiology affecting 1 in 68 children. While much progress has been made towards understanding the neurobiology of social and communication deficits associated with the disorder, very little is known regarding...
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Arousal Tendencies and Individual Differences in Children with Autism Spectrum Disorder #2351
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Arousal Tendencies and Individual Differences in Children with Autism Spectrum Disorder
Jason Baker 
Children with autism spectrum disorder (ASD) demonstrate significant variation in the degree and patterning of core symptomatology as well as high rates of comorbid externalizing behavior problems that can exacerbate impairment in functioning and impede learning. Few factors have been identified as...
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Perception and central coherence in autism: A family genetic eye-tracking study #2353
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Perception and central coherence in autism: A family genetic eye-tracking study
Molly Losh 
Autism Spectrum Disorder (ASD) is a neurogenetic disorder characterized by social-communication deficits as well as restricted and repetitive interests and behaviors. Differences in perceptual coherence, including a local perceptual bias at the expense of global processing and perseverative visual...
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Neurodevelopment of cognitive control in autism: adolescence to young adulthood #2354
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Neurodevelopment of cognitive control in autism: adolescence to young adulthood
Marjorie Solomon 
A tsunami of adolescents with ASD has begun to transition to adulthood. Despite enormous societal expenditures, many of them continue to experience extremely poor social and role functioning and life satisfaction in early adulthood. There is a great need for more in-depth research to investigate...
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Neurobehavioral Research on Infants at Risk for Language Delay and ASD #2355
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Neurobehavioral Research on Infants at Risk for Language Delay and ASD
Helen Tager-Flusberg 
Searching for biomarkers and behavioral signs of early risk for neurodevelopmental disorders has emerged as an important line of clinical research in an effort to improve diagnosis and develop the most effective treatments and preventive interventions. In our current award period we identified...
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Neural networks for attention to internal and external sensory cues in ASD #2358
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Neural networks for attention to internal and external sensory cues in ASD
Carissa Cascio 
Altered responsiveness to basic sensory input is an under-studied symptom in autism spectrum disorders (ASD) that likely has far-reaching effects on development, although these effects are not well understood. While the term sensory typically connotes stimuli external to the body, there is copious...
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Studying Biology and Behavior of Autism at 1-Year: The Well-Baby Check-Up Approach (Years 1-5) #2365
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Studying Biology and Behavior of Autism at 1-Year: The Well-Baby Check-Up Approach (Years 1-5)
Karen L. Pierce 
There is a paucity of behavioral data and an absence of biological data on autism at 12 months of age. The reason for these major gaps in vital information is because autism remains behaviorally, not biologically, defined and diagnosed. Prospective, hypothesis-driven studies of behavior and biology...
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Clinical and Immunological Investigations of Subtypes of Autism #2368
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Clinical and Immunological Investigations of Subtypes of Autism
Susan Swedo 
This was a longitudinal observational study of children with autistic disorder, non-autism developmental delay, or typical development.
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Mechanisms of neocortical and sensory hyperexcitability in Fragile X Syndrome #2373
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Mechanisms of neocortical and sensory hyperexcitability in Fragile X Syndrome
Kimberly Huber 
Sensory hypersensitivity is commonly seen in FXS patients and the FXS mouse model - the Fmr1 knockout KO. Recent data suggests that this abnormality stems from hyperexcitability in sensory circuits. We have established that cortical microcircuits are hyperexcitable in the Fmr1 KO mouse model, and...
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Modifiers of FMR1-associated Disorders: Appplication of High Throughput Technologies #2380
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Modifiers of FMR1-associated Disorders: Appplication of High Throughput Technologies
Stephen T. Warren 
The goals of our Center, "Modifiers of FMR1-associated disorders: application of high throughput technologies", are targeted to the RFA research area to Advance the understanding of the pathophysiology of FMR1 Related Conditions. The completion of the proposed aims from the three research projects...
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Phenotype and Genetic Factors in Autism Spectrum Disorders: Autism Consortium #2382
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Phenotype and Genetic Factors in Autism Spectrum Disorders: Autism Consortium
Jordan Smoller 
The objective of this study was to collect comprehensive behavioral and medical data on individuals with autism, their parents, and one or more unaffected siblings for inclusion in the Autism Consortium data respository maintained in the Psychiatric and Neurodevelopmental Genetics Unit at...
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Early Brain Development in Twins #2384
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Early Brain Development in Twins
John Gilmore 
Twin studies have provided fundamental information about how genes and environment contribute to individual differences in brain structure and cognitive function in health and psychiatric disease and how these influences change during development. Previous twin studies in older children,...
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Efficacy of the Direct Instruction Language for Learning Program to Promote Expressive and Receptive Language in Children with Autism Spectrum Disorder #2386
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Efficacy of the Direct Instruction Language for Learning Program to Promote Expressive and Receptive Language in Children with Autism Spectrum Disorder
Lawrence Scahill 
This study will test the efficacy of DI-LL in young school-age children with ASD and moderate language delay. 100 participants, ages 5 to 7 years, 11 months, will be randomly assigned to either DI-LL or Treatment as Usual (TAU). Children randomly assigned to DI-LL will be allowed to continue in...
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Rett syndrome, MECP2 Duplications, and Rett-related Disorders Natural History #2388
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Rett syndrome, MECP2 Duplications, and Rett-related Disorders Natural History
Alan Percy 
This Collection is from a multi-institutional group of investigators with longstanding interest in Rett syndrome (RTT) and RTT-related disorders continues a Rare Disease Clinical Research Center (RDCRC) within the Rare Diseases Clinical Research Network. This RDCRC will focus on three distinct...
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Brain Network Dynamics Contributing to Atypical Social Interaction in Autism #2394
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Brain Network Dynamics Contributing to Atypical Social Interaction in Autism
Elizabeth Redcay 
Atypical reciprocal social interaction is a core diagnostic feature of autism spectrum disorder ASD, but the brain network dynamics contributing to difficulties with social interactions remain unclear. Dominant theories suggest a role for social-motivational and social-cognitive brain networks....
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A Multimodal Investigation of Inhibitory Dysfunction in Autism Spectrum Disorder #2398
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
A Multimodal Investigation of Inhibitory Dysfunction in Autism Spectrum Disorder
Nicolaas Puts 
It is thought that impairments in the main inhibitory neurotransmitter GABA underlie Autism, at least to some degree. Children with Autism often show abnormal touch processing as well as abnormal motor control, which have a large impact on social interactions and quality of life. GABA plays an...
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Immune regulation and neurodevelopmental disorders #2399
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Immune regulation and neurodevelopmental disorders
Paul Ashwood 
Autism Spectrum Disorders ASD are behaviorally defined by deficits in communication, social reciprocity, and repetitive stereotypic behaviors. While genetic and environmental factors are likely contributors to these disorders, little is known about the pathophysiology in ASD. Many in vitro studies,...
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Atypical Late Neurodevelopment in Autism: A Longitudinal Clinical Phenotype and Multimodal Brain Imaging Study #2400
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Atypical Late Neurodevelopment in Autism: A Longitudinal Clinical Phenotype and Multimodal Brain Imaging Study
Janet Lainhart 
The goal of the proposed project is to determine how individual variation in brain development from childhood to adulthood is associated with variation in clinical course and outcome in autism. We will achieve this goal in three steps. We will first quantify individual whole and regional brain...
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Sensory Integration Therapy in Autism: Mechanisms and Effectiveness #2415
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Sensory Integration Therapy in Autism: Mechanisms and Effectiveness
Sophie Molholm and Roseann Schaaf 
Autism Spectrum Disorders ASD are one of the most commonly occurring neurodevelopmental disorders, affecting 1 in 68 children, frequently resulting in impairments in the functional skills necessary for independent living, and presenting a significant impact on families and society. Up to 90 percent...
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Autism Spectrum Disorder - Inflammatory Subtype: Biomarker Analysis #2419
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Autism Spectrum Disorder - Inflammatory Subtype: Biomarker Analysis
Harumi Jyonouchi, M.D. (CO-PIs: Richard Frye M.D., Ph.D., and James J. Dermody, Ph.D.) 
We hypothesize 1 Altered monocyte functions detected by changes in cytokine production and miRNA expression can be biomarkers for ASD subjects suffering from immune mediated chronic inflammation. We estimate that these changes can be detected in the newly diagnosed ASD population up to 30 percent...
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Predicting Voice Quality in ASD from Early Markers of Vocal Development #2420
Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Predicting Voice Quality in ASD from Early Markers of Vocal Development
Shweta Ghai 
The goal of this project is to test the hypothesis that the emergence of atypical voice quality in children with autism is an attribute of core impairments in social interaction against the hypothesis that voice quality disorders are an early outcome of comorbid motor deficits in vocal production...
NDAR
Funding Completed
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Optimizing Prediction of Social Deficits in Autism Spectrum Disorders #2421
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Collection Title Collection Investigators Collection Description
Optimizing Prediction of Social Deficits in Autism Spectrum Disorders
Matthew Lerner 
Autism spectrum disorders ASDs are characterized by vast neural and behavioral phenotypic heterogeneity. However, little is yet known about how variability in these processes impacts functional outcomes this, in turn, hampers development of highly effective and targeted interventions. As children...
NDAR
Enrolling
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