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NDAR provides a single access to de-identified autism research data. For permission to download data, you will need an NDAR account with approved access to NDAR or a connected repository (AGRE, IAN, or the ATP). For NDAR access, you need to be a research investigator sponsored by an NIH recognized institution with federal wide assurance. See Request Access for more information.

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Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

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Shared

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For clinical trials, the option to link to the clinical trial in clinicaltrials.gov is optionally provided.

Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Pupillary Light Reflex as a Biomarker for Autism
Gang Yao, Judith H. Miles, Shawn Christ 
Pupillary light reflex, Heart rate variability, medical history.
NDAR
Closed
Shared
$409,050.00
310
200
97
Loading Chart...
NIH - Extramural None

Fan09JADD.pdf Publication results from a preliminary study Qualified Researchers

R21NS070299-01 Validation study of atypical dynamic pupillary light reflex as a biomarker for au 09/30/2009 08/31/2011 200 97 UNIVERSITY OF MISSOURI-COLUMBIA $409,050.00

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Experiments

To create a new Omics, eye tracking, fMRI, or EEG experiment, press the "+ New Experiment" button. Once an experiment is created, then raw files for these types of experiments should be provided, associating the experiment – through Experiment_ID – with the metadata defined in the experiments interface.

IDNameCreated DateStatusType
No records found.

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Shared Data

Data structures with the number of subjects submitted and shared are provided.

Autism Diagnostic Observation Schedule (ADOS) - Module 1 (2007) Clinical Assessments 9
Autism Diagnostic Observation Schedule (ADOS) - Module 2 (2007) Clinical Assessments 10
Autism Diagnostic Observation Schedule (ADOS) - Module 4 Clinical Assessments 7
Autism Diagnostic Observation Schedule (ADOS)- Module 1 Clinical Assessments 5
Autism Diagnostic Observation Schedule (ADOS)- Module 2 Clinical Assessments 9
Autism Diagnostic Observation Schedule (ADOS)- Module 3 Clinical Assessments 38
Autism Diagnostic Observation Schedule (ADOS)- Module 3 (2007) Clinical Assessments 30
Child's Sleep Habits Questionnaire (CSHQ) Clinical Assessments 310
Diagnoses Neurology Clinical Assessments 310
Fever Assessment Clinical Assessments 310
Medication Profile Clinical Assessments 310
Pupillary Light Reflex/Heart Rate Variability Clinical Assessments 310
Sensory Profile (1994) Clinical Assessments 310

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDAR data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed IDStudyTitleJournalAuthorsDateStatus
25528080Study (382)Association between pupillary light reflex and sensory behaviors in children with autism spectrum disorders.Research in developmental disabilitiesDaluwatte, C; Miles, J H; Sun, J; Yao, GFebruary 2015Relevant
23859888Create StudyEffects of cold-pressor and mental arithmetic on pupillary light reflex.Physiological measurementDavis BC, Daluwatte C, Colona NC, Yao DGAugust 2013Not Determined
23248075Create StudyAtypical pupillary light reflex and heart rate variability in children with autism spectrum disorder.Journal of autism and developmental disordersDaluwatte C, Miles JH, Christ SE, Beversdorf DQ, Takahashi TN, Yao GAugust 2013Not Determined
22563002Create StudySimultaneously measured pupillary light reflex and heart rate variability in healthy children.Physiological measurementDaluwatte C, Miles JH, Yao GJune 2012Not Determined
20876003Create StudyModeling transient pupillary light reflex induced by a short light flash.IEEE transactions on bio-medical engineeringFan X, Yao GJanuary 2011Not Determined
help.tab.dataexpected

Relevant Publications
PubMed IDStudyTitleJournalAuthorsDate
No records found.
help.tab.dataexpected.addnew
Data Expected
Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
Childs Sleep Habits Questionnaire (CSHQ) info iconApproved
ADOS info iconApproved
Fever Assessment info iconApproved
Medication List info iconApproved
Neuropsychological Assessment info iconApproved
Sensory Profile info iconApproved
Research Subject and Pedigree info iconApproved
Pupillary Light Reflex with Heart Rate Variability  info iconApproved
Structure not yet defined

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study Name Description Number of Subjects
Collection / Total
Data Use State
Atypical pupillary light reflex and heart rate variability in children with autism spectrum disorder We investigated pupillary light reflex (PLR) in 152 children with ASD, 116 typically developing (TD) children, and 36 children with non-ASD neurodevelopmental disorders (NDDs). Heart rate variability (HRV) was measured simultaneously to study potential impairments in the autonomic nervous system (ANS) associated with ASD. The results showed that the ASD group had significantly longer PLR latency, reduced relative constriction amplitude, and shorter constriction/redilation time than those of the TD group. Similar atypical PLR parameters were observed in the NDD group. A significant age effect on PLR latency was observed in children younger than 9 years in the TD group, but not in the ASD and NDD groups. Atypical HRV parameters were observed in the ASD and NDD groups. A significant negative correlation existed between the PLR constriction amplitude and average heart rate in children with an ASD, but not in children with typical development. 287 / 287 Primary Analysis Shared
Acetaminophen Use for Fever in Children Associated with Autism Spectrum Disorder Autism Spectrum Disorder (ASD) is characterized by persistent deficits in social communication and restrictive behavior, interests, and activities. Our previous case-control study showed that use of acetaminophen at age 12-18 months is associated with increased likelihood for ASD (OR 8.37, 95% CI 2.08-33.7). In this study, we again show that acetaminophen use is associated with ASD (p = 0.013). Because these children are older than in our first study, the association is reversed; fewer children with ASD vs. non-ASD children use acetaminophen as a “first choice” compared to “never use” (OR 0.165, 95% CI 0.045, 0.599). We found significantly more children with ASD vs. non- ASD children change to the use of ibuprofen when acetaminophen is not effective at reducing fever (p = 0.033) and theorize this change in use is due to endocannabinoid system dysfunction. We also found that children with ASD vs. non-ASD children are significantly more likely to show an increase in sociability when they have a fever (p = 0.037) and theorize that this increase is due to anandamide activation of the endocannabinoid system in ASD children with low endocannabinoid tone from early acetaminophen use. In light of this we recommend that acetaminophen use be reviewed for safety in children. 197 / 197 Secondary Analysis Shared
Association between pupillary light reflex and sensory behaviors in children with autism spectrum disorders. Atypical pupillary light reflexes (PLR) has been observed in children with autism spectrum disorders (ASD), which suggests potential autonomic nervous system (ANS) dysfunction in ASD. ANS is also involved in modulating sensory processing and sensory dysfunction has been widely reported in children with ASD. However, the potential association between physiological measurements of PLR and behavioral observations (e.g. sensory behaviors) has not been examined extensively in literature. In this study, we investigated the potential correlation between PLR and frequently observed sensory behaviors in children with ASD. We found a significant association between PLR constriction amplitude and a set of sensory behaviors in the ASD group but not in typically developing children. Children with ASD who showed more atypical sensory behaviors also had smaller PLR constriction amplitudes. A smaller PLR constriction amplitude suggests lower parasympathetic modulation. This observation implies that some atypical sensory behaviors in children with ASD could be associated with decreased parasympathetic modulation. 256 / 256 Primary Analysis Shared
Rare Inherited and De Novo CNVs Reveal Complex Contributions to ASD Risk in Multiplex families NOTE: NOT ALL DATA HAS BEEN UPLOADED FOR THIS STUDY. Rare mutations, including copy-number variants (CNVs), contribute significantly to autism spectrum disorder (ASD) risk. Although their importance has been established in families with only one affected child (simplex families), the contribution of both de novo and inherited CNVs to ASD in families with multiple affected individuals (multiplex families) is less well understood. We analyzed 1,532 families from the Autism Genetic Resource Exchange (AGRE) to assess the impact of de novo and rare CNVs on ASD risk in multiplex families. We observed a higher burden of large, rare CNVs, including inherited events, in individuals with ASD than in their unaffected siblings (odds ratio [OR] = 1.7), but the rate of de novo events was significantly lower than in simplex families. In previously characterized ASD risk loci, we identified 49 CNVs, comprising 24 inherited events, 19 de novo events, and 6 events of unknown inheritance, a significant enrichment in affected versus control individuals (OR = 3.3). In 21 of the 30 families (71%) in whom at least one affected sibling harbored an established ASD major risk CNV, including five families harboring inherited CNVs, the CNV was not shared by all affected siblings, indicating that other risk factors are contributing. We also identified a rare risk locus for ASD and language delay at chromosomal region 2q24 (implicating NR4A2) and another lower-penetrance locus involving inherited deletions and duplications of WWOX. The genetic architecture in multiplex families differs from that in simplex families and is complex, warranting more complete genetic characterization of larger multiplex ASD cohorts. 3 / 5288 Primary Analysis Shared
* Data not on individual level
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