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NDAR provides a single access to de-identified autism research data. For permission to download data, you will need an NDAR account with approved access to NDAR or a connected repository (AGRE, IAN, or the ATP). For NDAR access, you need to be a research investigator sponsored by an NIH recognized institution with federal wide assurance. See Request Access for more information.

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Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

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SelectExperiment IdExperiment NameExperiment Type
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  • EEG
  • EGG
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Created On
912Task and emotional content driven visual competitionEEG04/23/2018
911Resting StatefMRI04/20/2018
910Modified Monetary Incentive Delay fMRI04/20/2018
908Resting State Pre-Stress Visit 1fMRI04/20/2018
907Montreal Imaging Stress Task Visit 1fMRI04/18/2018
9062-back Post-Stress Visit 1fMRI04/18/2018
9051-back Post-Stress Visit 1fMRI04/18/2018
9040-back Post-Stress Visit 1fMRI04/18/2018
9032-back Pre-Stress Visit 1fMRI04/18/2018
9021-back Pre-Stress Visit 1fMRI04/18/2018
9010-back Pre-Stress Visit 1fMRI04/18/2018
900DTIfMRI04/11/2018
899Investigating a Neurobehavioral Mechanism of Paranoia - Resting State ScansfMRI04/06/2018
898FAST-POMAfMRI04/03/2018
897parvizi_eeg_109EEG03/19/2018
896parvizi_eeg_107EEG03/19/2018
895parvizi_eeg_106EEG03/19/2018
894Dot ProbeEye Tracking03/07/2018
893Startle Habituation and Shock Sensitivity EvaluationEEG03/03/2018
892NPU EEG Task EEG03/03/2018
891Duke ACE ETEye Tracking03/02/2018
888Emotion 1.1 Determining context effects during potential threatfMRI02/26/2018
886RestfMRI02/14/2018
885SARTfMRI02/14/2018
884Plasma metabolic profileOmics02/05/2018
878Social Challenge AssessmentEye Tracking01/26/2018
877PRV-005-EEGEEG01/22/2018
876Mixed Anti and Pro (vgs) saccade mixed blocked (EyeTracking)Eye Tracking01/22/2018
875Attention modulation taskEye Tracking01/17/2018
874ruthldopa resting 17 and 18fMRI01/16/2018
873ruthldopa resting 15 and 16fMRI01/16/2018
872ruthldopa resting 13 and 14fMRI01/16/2018
871ruthldopa resting 11 and 12fMRI01/16/2018
870Resting State fMRIfMRI01/12/2018
869cyberballfMRI01/12/2018
868MDD_PilotfMRI01/12/2018
867Velten Mood Induction State-ItemfMRI01/12/2018
866Emotional Hemifield Task (EHT)EEG01/12/2018
865Genome EditingOmics01/12/2018
864parvizi_eeg_118EEG01/12/2018
863parvizi_eeg_117EEG01/12/2018
862parvizi_eeg_116EEG01/12/2018
861parvizi_eeg_115EEG01/12/2018
860parvizi_eeg_114EEG01/12/2018
859parvizi_eeg_113EEG01/12/2018
858PRV-003-EEGEEG01/12/2018
857PRV-004-EEGEEG01/12/2018
856PRV-007-EEGEEG01/12/2018
855Regulating Emotional Responses to Visual Images Across the Affective Instability SpectrumfMRI01/12/2018
854PRV-002-EEGEEG01/12/2018
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Shared

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Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Pupillary Light Reflex as a Biomarker for Autism
Gang Yao, Judith H. Miles, Shawn Christ 
Pupillary light reflex, Heart rate variability, medical history.
NDAR
Funding Completed
Shared
$409,050.00
310
200
97
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NIH - Extramural None

Fan09JADD.pdf Publication results from a preliminary study Qualified Researchers

R21NS070299-01 Validation study of atypical dynamic pupillary light reflex as a biomarker for au 09/30/2009 08/31/2011 200 97 UNIVERSITY OF MISSOURI-COLUMBIA $409,050.00

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Experiments

To create a new Omics, eye tracking, fMRI, or EEG experiment, press the "+ New Experiment" button. Once an experiment is created, then raw files for these types of experiments should be provided, associating the experiment – through Experiment_ID – with the metadata defined in the experiments interface.

IDNameCreated DateStatusType
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Shared Data

Data structures with the number of subjects submitted and shared are provided.

Autism Diagnostic Observation Schedule (ADOS) - Module 1 (2007) Clinical Assessments 9
Autism Diagnostic Observation Schedule (ADOS) - Module 2 (2007) Clinical Assessments 10
Autism Diagnostic Observation Schedule (ADOS) - Module 4 Clinical Assessments 7
Autism Diagnostic Observation Schedule (ADOS)- Module 1 Clinical Assessments 5
Autism Diagnostic Observation Schedule (ADOS)- Module 2 Clinical Assessments 9
Autism Diagnostic Observation Schedule (ADOS)- Module 3 Clinical Assessments 38
Autism Diagnostic Observation Schedule (ADOS)- Module 3 (2007) Clinical Assessments 30
Child's Sleep Habits Questionnaire (CSHQ) Clinical Assessments 310
Diagnoses Neurology Clinical Assessments 310
Fever Assessment Clinical Assessments 310
Medication Profile Clinical Assessments 310
Pupillary Light Reflex/Heart Rate Variability Clinical Assessments 310
Sensory Profile (1994) Clinical Assessments 310

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Publications

Publications relevant to NDAR data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed IDStudyTitleJournalAuthorsDateStatus
25528080Study (382)Association between pupillary light reflex and sensory behaviors in children with autism spectrum disorders.Research in developmental disabilitiesDaluwatte, C; Miles, J H; Sun, J; Yao, GFebruary 2015Relevant
23859888Create StudyEffects of cold-pressor and mental arithmetic on pupillary light reflex.Physiological measurementDavis BC, Daluwatte C, Colona NC, Yao DGAugust 2013Not Determined
23248075Create StudyAtypical pupillary light reflex and heart rate variability in children with autism spectrum disorder.Journal of autism and developmental disordersDaluwatte C, Miles JH, Christ SE, Beversdorf DQ, Takahashi TN, Yao GAugust 2013Not Determined
22563002Create StudySimultaneously measured pupillary light reflex and heart rate variability in healthy children.Physiological measurementDaluwatte C, Miles JH, Yao GJune 2012Not Determined
20876003Create StudyModeling transient pupillary light reflex induced by a short light flash.IEEE transactions on bio-medical engineeringFan X, Yao GJanuary 2011Not Determined
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Relevant Publications
PubMed IDStudyTitleJournalAuthorsDate
No records found.
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Data Expected
Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
Childs Sleep Habits Questionnaire (CSHQ) info iconApproved
Neuropsychological Assessment info iconApproved
ADOS info iconApproved
Research Subject and Pedigree info iconApproved
Sensory Profile info iconApproved
Medication List info iconApproved
Pupillary Light Reflex with Heart Rate Variability  info iconApproved
Fever Assessment info iconApproved
Structure not yet defined

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Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study NameAbstractCollection/Study SubjectsData UsageState
Unravelling the Collective Diagnostic Power Behind the Features in the Autism Diagnostic Observation ScheduleBackground: Autism is a group of heterogeneous disorders defined by deficits in social interaction and communication. Typically, diagnosis depends on the results of a behavioural examination called the Autism Diagnostic Observation Schedule (ADOS). Unfortunately, administration of the ADOS exam is time-consuming and requires a significant amount of expert intervention, leading to delays in diagnosis and access to early intervention programs. The diagnostic power of each feature in the ADOS exam is currently unknown. Our hypothesis is that certain features could be removed from the exam without a significant reduction in diagnostic accuracy, sensitivity or specificity. Objective: Determine the smallest subset of predictive features in ADOS module-1 (an exam variant for patients with minimal verbal skills). Methodology: ADOS module-1 datasets were acquired from the Autism Genetic Resource Exchange and the National Database for Autism Research. The datasets contained 2572 samples with the following labels: autism (1763), autism spectrum (513), and non-autism (296). The datasets were used as input to 4 different cost-sensitive classifiers in Weka (functional trees, LADTree, logistic model trees, and PART). For each classifier, a 10-fold cross validation was preformed and the number of predictive features, accuracy, sensitivity, and specificity was recorded. Results & Conclusion: Each classifier resulted in a reduction of the number of ADOS features required for autism diagnosis. The LADtree classifier was able to obtain the largest reduction, utilizing only 10 of 29 ADOS module-1 features (96.8% accuracy, 96.9% sensitivity, and 95.9% specificity). Overall, these results are a step towards a more efficient behavioural exam for autism diagnosis. 5/2172Secondary AnalysisShared
Atypical pupillary light reflex and heart rate variability in children with autism spectrum disorderWe investigated pupillary light reflex (PLR) in 152 children with ASD, 116 typically developing (TD) children, and 36 children with non-ASD neurodevelopmental disorders (NDDs). Heart rate variability (HRV) was measured simultaneously to study potential impairments in the autonomic nervous system (ANS) associated with ASD. The results showed that the ASD group had significantly longer PLR latency, reduced relative constriction amplitude, and shorter constriction/redilation time than those of the TD group. Similar atypical PLR parameters were observed in the NDD group. A significant age effect on PLR latency was observed in children younger than 9 years in the TD group, but not in the ASD and NDD groups. Atypical HRV parameters were observed in the ASD and NDD groups. A significant negative correlation existed between the PLR constriction amplitude and average heart rate in children with an ASD, but not in children with typical development.287/287Primary AnalysisShared
Association between pupillary light reflex and sensory behaviors in children with autism spectrum disorders.Atypical pupillary light reflexes (PLR) has been observed in children with autism spectrum disorders (ASD), which suggests potential autonomic nervous system (ANS) dysfunction in ASD. ANS is also involved in modulating sensory processing and sensory dysfunction has been widely reported in children with ASD. However, the potential association between physiological measurements of PLR and behavioral observations (e.g. sensory behaviors) has not been examined extensively in literature. In this study, we investigated the potential correlation between PLR and frequently observed sensory behaviors in children with ASD. We found a significant association between PLR constriction amplitude and a set of sensory behaviors in the ASD group but not in typically developing children. Children with ASD who showed more atypical sensory behaviors also had smaller PLR constriction amplitudes. A smaller PLR constriction amplitude suggests lower parasympathetic modulation. This observation implies that some atypical sensory behaviors in children with ASD could be associated with decreased parasympathetic modulation.256/256Primary AnalysisShared
Acetaminophen Use for Fever in Children Associated with Autism Spectrum DisorderAutism Spectrum Disorder (ASD) is characterized by persistent deficits in social communication and restrictive behavior, interests, and activities. Our previous case-control study showed that use of acetaminophen at age 12-18 months is associated with increased likelihood for ASD (OR 8.37, 95% CI 2.08-33.7). In this study, we again show that acetaminophen use is associated with ASD (p = 0.013). Because these children are older than in our first study, the association is reversed; fewer children with ASD vs. non-ASD children use acetaminophen as a “first choice” compared to “never use” (OR 0.165, 95% CI 0.045, 0.599). We found significantly more children with ASD vs. non- ASD children change to the use of ibuprofen when acetaminophen is not effective at reducing fever (p = 0.033) and theorize this change in use is due to endocannabinoid system dysfunction. We also found that children with ASD vs. non-ASD children are significantly more likely to show an increase in sociability when they have a fever (p = 0.037) and theorize that this increase is due to anandamide activation of the endocannabinoid system in ASD children with low endocannabinoid tone from early acetaminophen use. In light of this we recommend that acetaminophen use be reviewed for safety in children.197/197Secondary AnalysisShared
* Data not on individual level
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