National Database for Autism Research - Data

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Select	Experiment Id	Experiment Name	Experiment Type Select One EEG EGG Eye Tracking Omics fMRI	Created On

955	Food Choice Task	fMRI	06/21/2018
954	Taste_fMRI	fMRI	06/20/2018
953	Shallow Episodic	fMRI	06/20/2018
952	Semantic Encoding	fMRI	06/20/2018
951	Resting State	fMRI	06/20/2018
950	NBACK	fMRI	06/20/2018
949	Resting State	fMRI	06/18/2018
943	Emotional Face Task	fMRI	06/13/2018
941	Meridians localizer	fMRI	06/07/2018
940	V1 localizer movingDots	fMRI	06/07/2018
939	movingDots	fMRI	06/07/2018
938	MT localizer dots movingDots	fMRI	06/07/2018
937	MT localizer gratings movingDots	fMRI	06/07/2018
936	V1 localizer periphery	fMRI	06/07/2018
935	Contrast periphery	fMRI	06/07/2018
934	MT localizer periphery	fMRI	06/07/2018
933	Pilot01: Posner Cueing with st-tACS	Eye Tracking	06/06/2018
932	Social- Theory of Mind Localizer Task	fMRI	06/01/2018
931	Faces Task	fMRI	05/31/2018
930	Go_Nogo	fMRI	05/30/2018
929	Moral Rating	fMRI	05/30/2018
928	Pain Detection	fMRI	05/30/2018
927	Reward Task	fMRI	05/30/2018
926	Go no Go Task	fMRI	05/30/2018
924	EARLI Placenta WGBS	Omics	05/24/2018
923	Anxiety-CBT fMRI (pre-post) - Version 4 Block	fMRI	05/15/2018
922	Anxiety-CBT fMRI (pre-post) - Version 3 Block	fMRI	05/15/2018
921	Anxiety-CBT fMRI (pre-post) - Version 2 Block	fMRI	05/15/2018
920	Anxiety-CBT fMRI (pre-post) - Version 1 Block	fMRI	05/15/2018
919	Neural overlap in item representations across episodes impairs context memory	fMRI	05/11/2018
918	ReferenceTissue: U01MH106892_Brain_Amplicon_Seq	Omics	05/08/2018
917	Virginia_single_cell_HiSeq3000	Omics	05/03/2018
916	Virginia_single_cell_HiSeq2500	Omics	05/03/2018
915	Virginia_single_cell_MiSeq	Omics	05/03/2018
914	PFC analysis in blood	Omics	04/27/2018
913	Task and emotional content driven visual competition	fMRI	04/27/2018
912	Task and emotional content driven visual competition	EEG	04/23/2018
911	Resting State	fMRI	04/20/2018
910	Modified Monetary Incentive Delay	fMRI	04/20/2018
908	Resting State Pre-Stress Visit 1	fMRI	04/20/2018
907	Montreal Imaging Stress Task Visit 1	fMRI	04/18/2018
906	2-back Post-Stress Visit 1	fMRI	04/18/2018
905	1-back Post-Stress Visit 1	fMRI	04/18/2018
904	0-back Post-Stress Visit 1	fMRI	04/18/2018
903	2-back Pre-Stress Visit 1	fMRI	04/18/2018
902	1-back Pre-Stress Visit 1	fMRI	04/18/2018
901	0-back Pre-Stress Visit 1	fMRI	04/18/2018
900	DTI	fMRI	04/11/2018
899	Investigating a Neurobehavioral Mechanism of Paranoia - Resting State Scans	fMRI	04/06/2018
898	FAST-POMA	fMRI	04/03/2018

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Neural and Behavioral Outcomes of Social Skills Groups in Children with ASD #1501 State:Shared

General
Experiments (0)
Shared Data
Publications (1)
Data Expected (9)
Associated Studies (4)

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General

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Funding Source

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Clinical Trials

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Collection Title	Collection Investigators	Collection Description
Collection Title:	Neural and Behavioral Outcomes of Social Skills Groups in Children with ASD
Investigators:	A. Ting Wang, Latha V. Soorya
Collection Description:	Neuroimaging and phenotypic measures of school-age children undergoing social skills group interventions. The purpose of this investigation is to examine the acute and sustained effects of a CBT-based social skills treatment on social cognition and the neural architecture that supports it. High-functioning children with ASD (8-11 years old) will be randomly assigned to a 12-week cognitive behavioral social skills group or a social play comparison group to control for non-specific therapeutic effects. Functional MRI scans as well as behavioral assessments of social cognition, adaptive functioning, and symptom severity will be acquired at baseline, immediately following treatment, and at a 3- month follow-up. We hypothesize that children in the CBT group will show greater improvement in social functioning and increased activation of key brain regions, relative to children in the social play comparison group, both post-treatment and at follow-up. This study aims to address some of the earlier methodological limitations to provide much needed information about the short-term efficacy and durability of a CBT approach to social skills treatment, as well as the neural events that accompany and/or predict response to treatment.
Data Source:	NDAR
Collection Phase:	Funding Completed
Collection State:	Shared
Total Funded Amount:	$578,049.00
Subjects in the NDA:	37
Total Planned Enrollment:	50
Total Enrollment:	2

{"values":[]}

{"values":[["Not Defined",80],["Autism Spectrum Mildly Affected",5],["Autism Spectrum Severely Affected",3],["Typical Control",3],["Autism Spectrum Affected",6]]}

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Funding Sources:

Funding Source Name	Funding Source URL
NIH - Extramural	None

Supporting Documentation:

Grant Information:

Project Number	Project Title	Start Date	End Date	Planned Enrollment	Actual Enrollment	Organization	Funds Obligated
R21MH089236-01	Neural and Behavioral Outcomes of Social Skills Groups in Children with ASD	09/30/2009	08/31/2012	50	2	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	$578,049.00

Clinical Trials:

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Experiments

To create a new Omics, eye tracking, fMRI, or EEG experiment, press the "+ New Experiment" button. Once an experiment is created, then raw files for these types of experiments should be provided, associating the experiment – through Experiment_ID – with the metadata defined in the experiments interface.

ID	Name	Created Date	Status	Type
No records found.

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Shared Data

Data structures with the number of subjects submitted and shared are provided.

Shared Data:

Title	Type	Number of Subjects
Autism Diagnostic Interview, Revised (ADI-R)	Clinical Assessments	36
Autism Diagnostic Observation Schedule (ADOS)- Module 3	Clinical Assessments	36
Image	Imaging	36
Reading the Mind in the Eyes Task (RMET)	Clinical Assessments	34
Social Responsiveness Scale (SRS)	Clinical Assessments	32
Vineland-II - Parent and Caregiver Rating Form (2005)	Clinical Assessments	10
Vineland-II - Survey Form (2005)	Clinical Assessments	37
Wechsler Intelligence Scale for Children - IV [part 1]	Clinical Assessments	10
Wechsler Intelligence Scale for Children - IV [part 2]	Clinical Assessments	35

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Publications

Publications relevant to NDAR data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed ID	Study	Title	Journal	Authors	Date	Status
25721186	Create Study	Randomized comparative trial of a social cognitive skills group for children with autism spectrum disorder.	Journal of the American Academy of Child and Adolescent Psychiatry	Soorya LV, Siper PM, Beck T, Soffes S, Halpern D, Gorenstein M, Kolevzon A, Buxbaum J, Wang AT	March 2015	Not Determined

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Relevant Publications

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Data Expected

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
ADOS						Approved
Wechsler Intelligence Scale for Children						Approved
Vineland (Parent and Caregiver)						Approved
ADI-R						Approved
Research Subject and Pedigree						Approved
Social Responsiveness Scale (SRS)						Approved
Diagnostic Analysis of Nonverbal Accuracy-2 (DANVA2)						Approved
Reading the Mind in the Eyes						Approved
Imaging (Structural, fMRI, DTI, PET, microscopy)						Approved

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Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study Name	Abstract	Collection/Study Subjects	Data Usage	State
Derivation of Brain Structure Volumes from MRI Neuroimages hosted by NDAR using C-PAC pipeline and ANTs	An automated pipeline was developed to reference Neuroimages hosted by the National Database for Autism Research (NDAR) and derive volumes for distinct brain structures using Advanced Normalization Tools (ANTs) and the Configurable-Pipeline for the Analysis of Connectomes (C-PAC) platform. This pipeline utilized the ANTs cortical thickness methodology discuessed in "Large-Scale Evaluation of ANTs and Freesurfer Cortical Tchickness Measurements" [http://www.ncbi.nlm.nih.gov/pubmed/24879923] to extract a cortical thickness volume from T1-weighted anatomical MRI data gathered from the NDAR database. This volume was then registered to an stereotaxic-space anatomical template (OASIS-30 Atropos Template) which was acquired from the Mindboggle Project webpage [http://mindboggle.info/data.html]. After registration, the mean cortical thickness was calculated at 31 ROIs on each hemisphere of the cortex and using the Desikan-Killiany-Tourville (DKT-31) cortical labelling protocol [http://mindboggle.info/faq/labels.html] over the OASIS-30 template. NOTE: This study is ongoing; additional data my be available in the future. As a result, each subject that was processed has a cortical thickness volume image and a text file with the mean thickness ROIs (in mm) stored in Amazon Web Services (AWS) Simple Storage Service (S3). Additionally, these results were tabulated in an AWS-hosted database (through NDAR) to enable simple, efficient querying and data access. All of the code used to perform this analysis is publicly available on Github [https://github.com/FCP-INDI/ndar-dev]. Additionally, as a computing platform, we developed an Amazon Machine Image (AMI) that comes fully equipped to run this pipeline on any dataset. Using AWS Elastic Cloud Computing (EC2), users can launch our publicly available AMI ("C-PAC with benchmark", AMI ID: "ami-fee34296", N. Virginia region) and run the ANTs cortical thickness pipeline. The AMI is fully compatible with Sun Grid Engine as well; this enables users to perform many pipeline runs in parallel over a cluster-computing framework.	3/1540	Secondary Analysis	Shared
Derivation of Quality Measures for Structural Images by Neuroimaging Pipelines	Using the National Database for Autism Research cloud platform, MRI data were analyzed using neuroimaging pipelines that included packages available as part of the Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC) Computational Environment to derive standardized measures of MR image quality. Structural QA was performed according to Haselgrove, et al (http://journal.frontiersin.org/Journal/10.3389/fninf.2014.00052/abstract) to provide values for Signal to Noise (SNR) and Contrast to Noise (CNR) Ratios that can be compared between subjects within NDAR and between other public data releases.	3/425	Secondary Analysis	Shared
Derivation of Brain Structure Volumes from MRI Neuroimages hosted by NDAR using NITRC-CE	A draft publication is in progress. GitHub repository with code for working with NDAR Data is available here: https://github.com/chaselgrove/ndar Note this study is ongoing; additional may be added.	3/356	Secondary Analysis	Shared
Derivation of Quality Measures for Time-Series Images by Neuroimaging Pipelines	Using the National Database for Autism Research cloud platform, MRI data were analyzed using neuroimaging pipelines that included packages available as part of the Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC) Computational Environment to derive standardized measures of MR image quality. Time series QA was performed according to Friedman, et al. (http://www.ncbi.nlm.nih.gov/pubmed/16952468) providing values for Signal to Noise Ratio that can be compared to other subjects.	3/356	Secondary Analysis	Shared

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