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NDAR provides a single access to de-identified autism research data. For permission to download data, you will need an NDAR account with approved access to NDAR or a connected repository (AGRE, IAN, or the ATP). For NDAR access, you need to be a research investigator sponsored by an NIH recognized institution with federal wide assurance. See Request Access for more information.

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General

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Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Electrophysiologic Studies of Language Impairment in ASD (Years 1-5)
Timothy Roberts 
6-15 year old children recruited for MEG studies of auditory processing
NDAR
Closed
Shared
$1,960,285.00
235
180
136
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NIH - Extramural None


R01DC008871-01 Electrophysiological Signatures of Language Impairment in Autism Spectrum Disorde 07/01/2007 06/30/2012 180 136 CHILDRENS HOSP OF PHILADELPHIA $1,960,285.00

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Experiments

To create a new Omics, eye tracking, fMRI, or EEG experiment, press the "+ New Experiment" button. Once an experiment is created, then raw files for these types of experiments should be provided, associating the experiment – through Experiment_ID – with the metadata defined in the experiments interface.

IDNameCreated DateStatusType
No records found.

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Shared Data

Data structures with the number of subjects submitted and shared are provided.

Autism Diagnostic Observation Schedule (ADOS)- Module 3 Clinical Assessments 30
CELF-4 Clinical Eval of Lang Fundamentals, 4th ed Clinical Assessments 206
Magnetoencephalography (MEG) Imaging 166
Social Communication Questionnaire (SCQ) - Lifetime Clinical Assessments 219
Social Responsiveness Scale (SRS) Clinical Assessments 204
Wechsler Intelligence Scale for Children - IV [part 3] Clinical Assessments 52

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDAR data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed IDStudyTitleJournalAuthorsDateStatus
27696740Create StudyExploring the relationship between cortical GABA concentrations, auditory gamma-band responses and development in ASD: Evidence for an altered maturational trajectory in ASD.Autism research : official journal of the International Society for Autism ResearchPort RG, Gaetz W, Bloy L, Wang DJ, Blaskey L, Kuschner ES, Levy SE, Brodkin ES, Roberts TPOctober 2016Not Determined
27158589Create StudyMaturation of auditory neural processes in autism spectrum disorder - A longitudinal MEG study.NeuroImage. ClinicalPort RG, Edgar JC, Ku M, Bloy L, Murray R, Blaskey L, Levy SE, Roberts TPJanuary 1, 2016Not Determined
26869473Create StudyRelationship between M100 Auditory Evoked Response and Auditory Radiation Microstructure in 16p11.2 Deletion and Duplication Carriers.AJNR. American journal of neuroradiologyBerman JI, Chudnovskaya D, Blaskey L, Kuschner E, Mukherjee P, Buckner R, Nagarajan S, Chung WK, Sherr EH, Roberts TPFebruary 11, 2016Not Determined
26730806Create StudyTranslating Adult Electrophysiology Findings to Younger Patient Populations: Difficulty Measuring 40-Hz Auditory Steady-State Responses in Typically Developing Children and Children with Autism Spectrum Disorder.Developmental neuroscienceEdgar JC, Fisk CL, Liu S, Pandey J, Herrington JD, Schultz RT, Roberts TP2016Not Determined
25745372Create StudyProspective MEG biomarkers in ASD: pre-clinical evidence and clinical promise of electrophysiological signatures.The Yale journal of biology and medicinePort, Russell G; Anwar, Ayesha R; Ku, Matthew; Carlson, Gregory C; Siegel, Steven J; Roberts, Timothy P LMarch 2015Not Relevant
25231288Create StudyResting-state alpha in autism spectrum disorder and alpha associations with thalamic volume.Journal of autism and developmental disordersEdgar, J Christopher; Heiken, Kory; Chen, Yu-Han; Herrington, John D; Chow, Vivian; Liu, Song; Bloy, Luke; Huang, Mingxiong; Pandey, Juhi; Cannon, Katelyn M; Qasmieh, Saba; Levy, Susan E; Schultz, Robert T; Roberts, Timothy P LMarch 2015Not Determined
25109843Create StudyAlpha-to-gamma phase-amplitude coupling methods and application to autism spectrum disorder.Brain connectivityBerman JI, Liu S, Bloy L, Blaskey L, Roberts TP, Edgar JCMarch 2015Not Determined
24983132Create StudyCreating multimodal predictors using missing data: classifying and subtyping autism spectrum disorder.Journal of neuroscience methodsIngalhalikar M, Parker WA, Bloy L, Roberts TP, Verma RSeptember 30, 2014Not Determined
24769280Create StudySpectro-temporal correlates of lexical access during auditory lexical decision.Brain and languageBrennan J, Lignos C, Embick D, Roberts TPJune 2014Not Determined
24335547Create StudyLeft hemisphere diffusivity of the arcuate fasciculus: influences of autism spectrum disorder and language impairment.AJNR. American journal of neuroradiologyRoberts TP, Heiken K, Zarnow D, Dell J, Nagae L, Blaskey L, Solot C, Levy SE, Berman JI, Edgar JCMarch 2014Not Determined
24055954Create StudyMaturational differences in thalamocortical white matter microstructure and auditory evoked response latencies in autism spectrum disorders.Brain researchRoberts TP, Lanza MR, Dell J, Qasmieh S, Hines K, Blaskey L, Zarnow DM, Levy SE, Edgar JC, Berman JINovember 6, 2013Not Determined
23963593Create StudyJoint analysis of band-specific functional connectivity and signal complexity in autism.Journal of autism and developmental disordersGhanbari, Yasser; Bloy, Luke; Christopher Edgar, J; Blaskey, Lisa; Verma, Ragini; Roberts, Timothy P LFebruary 2015Not Determined
23963591Create StudyNeuromagnetic oscillations predict evoked-response latency delays and core language deficits in autism spectrum disorders.Journal of autism and developmental disordersEdgar JC, Khan SY, Blaskey L, Chow VY, Rey M, Gaetz W, Cannon KM, Monroe JF, Cornew L, Qasmieh S, Liu S, Welsh JP, Levy SE, Roberts TPFebruary 2015Not Determined
23707581Create StudyGABA estimation in the brains of children on the autism spectrum: measurement precision and regional cortical variation.NeuroImageGaetz W, Bloy L, Wang DJ, Port RG, Blaskey L, Levy SE, Roberts TPFebruary 1, 2014Not Determined
23493892Create StudyHigh angular resolution diffusion imaging probabilistic tractography of the auditory radiation.AJNR. American journal of neuroradiologyBerman JI, Lanza MR, Blaskey L, Edgar JC, Roberts TPAugust 2013Not Determined
23454050Create StudyEvidence for a motor gamma-band network governing response interference.NeuroImageGaetz W, Liu C, Zhu H, Bloy L, Roberts TPJuly 1, 2013Not Determined
23286164Create StudyUsing multiparametric data with missing features for learning patterns of pathology.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted InterventionIngalhalikar M, Parker WA, Bloy L, Roberts TP, Verma R2012Not Determined
23286135Create StudyDominant component analysis of electrophysiological connectivity networks.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted InterventionGhanbari Y, Bloy L, Batmanghelich K, Roberts TP, Verma R2012Not Determined
23286056Create StudyIdentifying sub-populations via unsupervised cluster analysis on multi-edge similarity graphs.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted InterventionIngalhalikar M, Smith AR, Bloy L, Gur R, Roberts TP, Verma R2012Not Determined
22771812Create StudyNMDA antagonist MK801 recreates auditory electrophysiology disruption present in autism and other neurodevelopmental disorders.Behavioural brain researchSaunders JA, Gandal MJ, Roberts TP, Siegel SJOctober 1, 2012Not Determined
22726567Create StudyMice with reduced NMDA receptor expression: more consistent with autism than schizophrenia?Genes, brain, and behaviorGandal MJ, Anderson RL, Billingslea EN, Carlson GC, Roberts TP, Siegel SJAugust 2012Not Determined
22577870Create StudyVariable bandwidth filtering for improved sensitivity of cross-frequency coupling metrics.Brain connectivityBerman JI, McDaniel J, Liu S, Cornew L, Gaetz W, Roberts TP, Edgar JC2012Not Determined
22551948Create StudyDelayed magnetic mismatch negativity field, but not auditory M100 response, in specific language impairment.NeuroreportRoberts TP, Heiken K, Kahn SY, Qasmieh S, Blaskey L, Solot C, Parker WA, Verma R, Edgar JCMay 30, 2012Not Determined
22500705Create StudyAn integrated framework for high angular resolution diffusion imaging-based investigation of structural connectivity.Brain connectivityBloy L, Ingalhalikar M, Batmanghelich NK, Schultz RT, Roberts TP, Verma R2012Not Determined
22492573Create StudyElevated mean diffusivity in the left hemisphere superior longitudinal fasciculus in autism spectrum disorders increases with more profound language impairment.AJNR. American journal of neuroradiologyNagae LM, Zarnow DM, Blaskey L, Dell J, Khan SY, Qasmieh S, Levy SE, Roberts TPOctober 2012Not Determined
22207057Create StudyResting-state oscillatory activity in autism spectrum disorders.Journal of autism and developmental disordersCornew L, Roberts TP, Blaskey L, Edgar JCSeptember 2012Not Determined
21968323Create StudyWord repetition priming-induced oscillations in auditory cortex: a magnetoencephalography study.NeuroreportTavabi K, Embick D, Roberts TPDecember 7, 2011Not Determined
21893205Create StudyWhite matter atlas generation using HARDI based automated parcellation.NeuroImageBloy L, Ingalhalikar M, Eavani H, Schultz RT, Roberts TP, Verma RFebruary 15, 2012Not Determined
21769992Create StudyFunctional and structural correlates of the aging brain: relating visual cortex (V1) gamma band responses to age-related structural change.Human brain mappingGaetz W, Roberts TP, Singh KD, Muthukumaraswamy SDSeptember 2012Not Determined
21609768Create StudyDiffusion based abnormality markers of pathology: toward learned diagnostic prediction of ASD.NeuroImageIngalhalikar M, Parker D, Bloy L, Roberts TP, Verma RAugust 1, 2011Not Determined
21597392Create StudySpectral-temporal analysis of cortical oscillations during lexical processing.NeuroreportTavabi K, Embick D, Roberts TPJuly 13, 2011Not Determined
21392733Create StudyAuditory magnetic mismatch field latency: a biomarker for language impairment in autism.Biological psychiatryRoberts TP, Cannon KM, Tavabi K, Blaskey L, Khan SY, Monroe JF, Qasmieh S, Levy SE, Edgar JCAugust 1, 2011Not Determined
21215806Create StudyRelating MEG measured motor cortical oscillations to resting γ-aminobutyric acid (GABA) concentration.NeuroImageGaetz W, Edgar JC, Wang DJ, Roberts TPMarch 15, 2011Not Determined
21130222Create StudyValidating γ oscillations and delayed auditory responses as translational biomarkers of autism.Biological psychiatryGandal MJ, Edgar JC, Ehrlichman RS, Mehta M, Roberts TP, Siegel SJDecember 15, 2010Not Determined
20879275Create StudyDTI based diagnostic prediction of a disease via pattern classification.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted InterventionIngalhalikar M, Kanterakis S, Gur R, Roberts TP, Verma R2010Not Determined
20063319Create StudyMEG detection of delayed auditory evoked responses in autism spectrum disorders: towards an imaging biomarker for autism.Autism research : official journal of the International Society for Autism ResearchRoberts TP, Khan SY, Rey M, Monroe JF, Cannon K, Blaskey L, Woldoff S, Qasmieh S, Gandal M, Schmidt GL, Zarnow DM, Levy SE, Edgar JCFebruary 2010Not Determined
19898261Create StudyDevelopmental correlation of diffusion anisotropy with auditory-evoked response.NeuroreportRoberts TP, Khan SY, Blaskey L, Dell J, Levy SE, Zarnow DM, Edgar JCDecember 9, 2009Not Determined
19819542Create StudyAutism.Lancet (London, England)Levy SE, Mandell DS, Schultz RTNovember 7, 2009Not Determined
19491710Create StudyAbsence of M100 source asymmetry in autism associated with language functioning.NeuroreportSchmidt GL, Rey MM, Oram Cardy JE, Roberts TPJuly 15, 2009Not Determined
18336941Create StudyElectrophysiological signatures: magnetoencephalographic studies of the neural correlates of language impairment in autism spectrum disorders.International journal of psychophysiology : official journal of the International Organization of PsychophysiologyRoberts TP, Schmidt GL, Egeth M, Blaskey L, Rey MM, Edgar JC, Levy SEMay 2008Not Determined
help.tab.dataexpected

Relevant Publications
PubMed IDStudyTitleJournalAuthorsDate
No records found.
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Data Expected
Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
Clinical Evaluation of Language Fundamentals (CELF) info iconApproved
Research Subject and Pedigree info iconApproved
Wechsler Intelligence Scale for Children info iconApproved
Magnetoencephalography (MEG) info iconApproved
Imaging (Structural, fMRI, DTI, PET, microscopy) info iconApproved
Structure not yet defined

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study Name Description Number of Subjects
Collection / Total
Data Use State
The Sensitivity and Specificity of the Social Communication Questionnaire for Autism Spectrum Disorder with Respect to Age Scientific Abstract The Social Communication Questionnaire (SCQ) assesses communication skills and social functioning in screening for symptoms of autism-spectrum disorder (ASD). The SCQ is recommended for individuals between 4 to 40 years with a cutoff score of 15 for referral. Mixed findings have been reported regarding the recommended cutoff score’s ability to accurately classify an individual as at-risk for ASD (sensitivity) versus an individual as not at-risk for ASD (specificity). Based on a sample from the National Database for Autism Research (n=344; age: 1.58 to 25.92 years old), the present study examined the SCQ’s sensitivity versus specificity across a range of ages. We recommend that the cutoff scores for the SCQ be re-evaluated with age as a consideration. Lay Abstract The age neutrality of the Social Communication Questionnaire (SCQ) was examined as a common screener for ASD. Mixed findings have been reported regarding the recommended cutoff score’s ability to accurately classify an individual as at-risk for ASD (sensitivity) versus accurately classifying an individual as not at-risk for ASD (specificity). With a sample from the National Database for Autism Research, the present study examined the SCQ’s sensitivity versus specificity. Analyses indicated that the actual sensitivity and specificity scores were lower than initially reported by the creators of the SCQ. 27 / 339 Secondary Analysis Shared
* Data not on individual level
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