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NDAR provides a single access to de-identified autism research data. For permission to download data, you will need an NDAR account with approved access to NDAR or a connected repository (AGRE, IAN, or the ATP). For NDAR access, you need to be a research investigator sponsored by an NIH recognized institution with federal wide assurance. See Request Access for more information.

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Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Cellular Density and Morphology in the Autistic Temporal Human Cerebral Cortex
Veronica Martinez Cerdeno 
This project will analyze the temporal lobe of 21 autistic postmortem human brains (diagnosed as autistic, not as other autism spectrum disorders) and the temporal lobe of 18 control postmortem human brains. The data obtained from this project will also serve as the basis for future studies focusing on the neuropathology and the imbalance excitation / inhibition of the autistic brain.
NDAR
Closed
Shared
$1,794,150.00
61
0
0
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NIH - Extramural None

Experiments_details.docx Methods Detailed description of experiments Qualified Researchers

R01MH094681-01 Cellular Density and Morphology in the Autistic Temporal Human Cerebral Cortex 06/02/2011 04/30/2016 Not Reported Not Reported UNIVERSITY OF CALIFORNIA AT DAVIS $1,794,150.00

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To create a new Omics, eye tracking, fMRI, or EEG experiment, press the "+ New Experiment" button. Once an experiment is created, then raw files for these types of experiments should be provided, associating the experiment – through Experiment_ID – with the metadata defined in the experiments interface.

IDNameCreated DateStatusType
506PVPREF08/05/2016ApprovedOmics
505CRTEM08/05/2016ApprovedOmics
503PYRTEM08/04/2016ApprovedOmics

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Shared Data

Data structures with the number of subjects submitted and shared are provided.

Genomics Sample Genomics 38
Genomics Subject Genomics 60
Research Subject Clinical Assessments 44

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Publications

Publications relevant to NDAR data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed IDStudyTitleJournalAuthorsDateStatus
27562638Create StudyAbnormal white matter tracts resembling pencil fibers involving prefrontal cortex (Brodmann area 47) in autism: a case report.Journal of medical case reportsHashemi E, Ariza J, Lechpammer M, Noctor SC, Martínez-Cerdeño VAugust 2016Not Determined
27390186Create StudyDendrite and spine modifications in autism and related neurodevelopmental disorders in patients and animal models.Developmental neurobiologyMartínez-Cerdeño VJuly 8, 2016Not Relevant
27259564Create StudyCerebellar Mild Iron Accumulation in a Subset of FMR1 Premutation Carriers with FXTAS.Cerebellum (London, England)Rogers H, Ariza J, Monterrubio A, Hagerman P, Martínez-Cerdeño VJune 4, 2016Not Relevant
26922658Study (421)The Number of Parvalbumin-Expressing Interneurons Is Decreased in the Medial Prefrontal Cortex in Autism.Cerebral cortex (New York, N.Y. : 1991)Hashemi E, Ariza J, Rogers H, Noctor SC, Martínez-Cerdeño VFebruary 27, 2016Relevant
26439982Create StudyCortical evolution 2015: Discussion of neural progenitor cell nomenclature.The Journal of comparative neurologyMartínez-Cerdeño V, Noctor SCFebruary 15, 2016Not Relevant
26368352Create StudyFragile X-Associated Tremor/Ataxia Syndrome in a Man in His 30s.JAMA neurologyMartínez-Cerdeño V, Lechpammer M, Lott A, Schneider A, Hagerman RSeptember 2015Not Relevant
26365141Create StudyAdvances in the Understanding of the Gabaergic Neurobiology of FMR1 Expanded Alleles Leading to Targeted Treatments for Fragile X Spectrum Disorder.Current pharmaceutical designLozano R, Martinez-Cerdeno V, Hagerman RJ2015Not Relevant
26267763Create StudyEvolutionary origin of Tbr2-expressing precursor cells and the subventricular zone in the developing cortex.The Journal of comparative neurologyMartínez-Cerdeño V, Cunningham CL, Camacho J, Keiter JA, Ariza J, Lovern M, Noctor SCFebruary 15, 2016Not Relevant
25582788Study (420)Preliminary findings suggest the number and volume of supragranular and infragranular pyramidal neurons are similar in the anterior superior temporal area of control subjects and subjects with autism.Neuroscience lettersKim E, Camacho J, Combs Z, Ariza J, Lechpammer M, Noctor SC, Martínez-Cerdeño VMarch 4, 2015Relevant
25535268Create StudyPrenatal Exposure to Autism-Specific Maternal Autoantibodies Alters Proliferation of Cortical Neural Precursor Cells, Enlarges Brain, and Increases Neuronal Size in Adult Animals.Cerebral cortex (New York, N.Y. : 1991)Martínez-Cerdeño V, Camacho J, Fox E, Miller E, Ariza J, Kienzle D, Plank K, Noctor SC, Van De Water JJanuary 2016Not Relevant
25498860Create StudyDysregulated iron metabolism in the choroid plexus in fragile X-associated tremor/ataxia syndrome.Brain researchAriza J, Steward C, Rueckert F, Widdison M, Coffman R, Afjei A, Noctor SC, Hagerman R, Hagerman P, Martínez-Cerdeño VFebruary 19, 2015Not Relevant
25067827Create StudyRELN-expressing neuron density in layer I of the superior temporal lobe is similar in human brains with autism and in age-matched controls.Neuroscience lettersCamacho J, Ejaz E, Ariza J, Noctor SC, Martínez-Cerdeño VSeptember 5, 2014Not Relevant
24987337Create StudyCajal, Retzius, and Cajal-Retzius cells.Frontiers in neuroanatomyMartínez-Cerdeño V, Noctor SCJanuary 2014Not Relevant
24613242Create StudyEmbryonic intraventricular exposure to autism-specific maternal autoantibodies produces alterations in autistic-like stereotypical behaviors in offspring mice.Behavioural brain researchCamacho J, Jones K, Miller E, Ariza J, Noctor S, Van de Water J, Martínez-Cerdeño VJune 1, 2014Not Relevant
23724007Create StudyDiversity of neural precursor cell types in the prenatal macaque cerebral cortex exists largely within the astroglial cell lineage.PloS oneCunningham CL, Martínez-Cerdeño V, Noctor SC2013Not Relevant
23467340Create StudyMicroglia regulate the number of neural precursor cells in the developing cerebral cortex.The Journal of neuroscience : the official journal of the Society for NeuroscienceCunningham CL, Martínez-Cerdeño V, Noctor SCMarch 6, 2013Not Relevant
22272298Create StudyComparative analysis of the subventricular zone in rat, ferret and macaque: evidence for an outer subventricular zone in rodents.PloS oneMartínez-Cerdeño V, Cunningham CL, Camacho J, Antczak JL, Prakash AN, Cziep ME, Walker AI, Noctor SC2012Not Relevant
21521495Create StudyFurther characterization of autoantibodies to GABAergic neurons in the central nervous system produced by a subset of children with autism.Molecular autismWills S, Rossi CC, Bennett J, Martinez Cerdeño V, Ashwood P, Amaral DG, Van de Water J2011Not Relevant
20935171Create StudyPremutation CGG-repeat expansion of the Fmr1 gene impairs mouse neocortical development.Human molecular geneticsCunningham CL, Martínez Cerdeño V, Navarro Porras E, Prakash AN, Angelastro JM, Willemsen R, Hagerman PJ, Pessah IN, Berman RF, Noctor SCJanuary 1, 2011Not Relevant
help.tab.dataexpected

Relevant Publications
PubMed IDStudyTitleJournalAuthorsDate
No records found.
help.tab.dataexpected.addnew
Data Expected
Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
Research Subject and Pedigree info iconApproved
genomics/omics info iconApproved
Structure not yet defined

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study Name Description Number of Subjects
Collection / Total
Data Use State
Preliminary findings suggest the number and volume of supragranular and infragranular pyramidal neurons are similar in the anterior superior temporal area of control subjects and subjects with autism. We investigated the cytoarchitecture of the anterior superior temporal area (TA2) of the postmortem cerebral cortex in 9 subjects with autism and 9 age-matched typically developing subjects between the ages of 13 and 56 years. The superior temporal gyrus is involved in auditory processing and social cognition and its pathology has been correlated with autism. We quantified the number and soma volume of pyramidal neurons in the supragranular layers and pyramidal neurons in the infragranular layers in each subject. We did not find significant differences in the number or volume of supragranular or infragranular neurons in the cerebral cortex of subjects with autism compared to typically developing subjects. This report does not support an alteration of supragranular to infragranular neurons in autism. However, further stereological analysis of the number of cells and cell volumes in specific cortical areas is needed to better establish the cellular phenotype of the autistic cerebral cortex and to understand its clinical relevance in autism. 18 / 18 Primary Analysis Shared
The Number of Parvalbumin-Expressing Interneurons Is Decreased in the Medial Prefrontal Cortex in Autism. UNASSIGNED: The cognitive phenotype of autism has been correlated with an altered balance of excitation to inhibition in the cerebral cortex, which could result from a change in the number, function, or morphology of GABA-expressing interneurons. The number of GABAergic interneuron subtypes has not been quantified in the autistic cerebral cortex. We classified interneurons into 3 subpopulations based on expression of the calcium-binding proteins parvalbumin, calbindin, or calretinin. We quantified the number of each interneuron subtype in postmortem neocortical tissue from 11 autistic cases and 10 control cases. Prefrontal Brodmann Areas (BA) BA46, BA47, and BA9 in autism and age-matched controls were analyzed by blinded researchers. We show that the number of parvalbumin+ interneurons in these 3 cortical areas-BA46, BA47, and BA9-is significantly reduced in autism compared with controls. The number of calbindin+ and calretinin+ interneurons did not differ in the cortical areas examined. Parvalbumin+ interneurons are fast-spiking cells that synchronize the activity of pyramidal cells through perisomatic and axo-axonic inhibition. The reduced number of parvalbumin+ interneurons could disrupt the balance of excitation/inhibition and alter gamma wave oscillations in the cerebral cortex of autistic subjects. These data will allow development of novel treatments specifically targeting parvalbumin interneurons. 20 / 20 Primary Analysis Shared
* Data not on individual level
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