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NDAR provides a single access to de-identified autism research data. For permission to download data, you will need an NDAR account with approved access to NDAR or a connected repository (AGRE, IAN, or the ATP). For NDAR access, you need to be a research investigator sponsored by an NIH recognized institution with federal wide assurance. See Request Access for more information.

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The filters you have selected from various query interfaces will be stored here, in the 'Filter Cart'. The database will be queried using filters added to your 'Filter Cart', when multiple filters are defined, each will be executed using 'AND' logic, so with each filter that is applied the result set gets smaller.

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1 Numbers reported are subjects by age
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Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

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Shared

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

General

Title, investigators, and Collection Description may be edited along with the Collection Phase. For Collection Phase, the options Pre-enrollment, Enrollment, and Completed can be chosen allowing the Collection Owner to indicate the stage of data collection.

Funding Source

The ability to associate the funding source for the project is provided. For NIH funded grants, linkage to Project Reporter information (e.g. R01MH123456) is supported. Projects funded by others, including the URL of the project, are listed. Non NIH funded projects will become available here to link that data with the appropriate funding agency.

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Any documents related to the project may be uploaded clarifying the data or acquisition methods used may be uploaded and made available here. The default is to share these documents to the general public. An option to share only to qualified Researchers is also an option.

Clinical Trials

For clinical trials, the option to link to the clinical trial in clinicaltrials.gov is optionally provided.

Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Longitudinal MRI Study of Infants at Risk for Autism
Joe Piven 
Research data for the IBIS Autism project. Autism Centers of Excellence (ACE) Network is a collaborative effort by investigators at four clinical sites: University of North Carolina (UNC), University of Washington (UW), Washington University (WU), and Yale University; and one data coordinating center (DCC) at the Montreal Neurological Institute (MNI) to conduct a longitudinal MRI/DTI and behavioral study of infants at high risk for autism (i.e., siblings of autistic individuals) at 6, 12 and 24 months (m) of age.
NDAR
Closed
Shared
$16,026,783.00
1,027
664
526

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NIH - Extramural None


R01HD055741-01 A Longitudinal MRI Study of Infants at Risk for Autism 07/01/2007 06/30/2012 664 526 UNIV OF NORTH CAROLINA CHAPEL HILL $16,026,783.00

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Experiments

To create a new Omics, eye tracking, fMRI, or EEG experiment, press the "+ New Experiment" button. Once an experiment is created, then raw files for these types of experiments should be provided, associating the experiment – through Experiment_ID – with the metadata defined in the experiments interface.

IDNameCreated DateStatusType
370Longitudinal MRI Study of Infants at Risk for Autism08/11/2015ApprovedfMRI

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Shared Data

Data structures with the number of subjects submitted and shared are provided.

Autism Diagnostic Interview, Revised (ADI-R) Clinical Assessments 377
Autism Observation Scale for Infants Clinical Assessments 403
CHARGE Medical History Clinical Assessments 435
CHARGE Physical Exam Clinical Assessments 378
CSBS DP Behavior Sample Clinical Assessments 73
Early Development Interview Clinical Assessments 403
First Year Inventory Clinical Assessments 64
Image Imaging 362
Infant Behavior Questionnaire Revised Clinical Assessments 371
M-CHAT Clinical Assessments 18
MacArthur-Bates CDI - Words and Gestures Form Clinical Assessments 103
Mullen Scales of Early Learning Clinical Assessments 541
Prefrontal task Clinical Assessments 73
Repetitive Behavior Scale - Revised (RBS-R) Clinical Assessments 418
Research Subject Clinical Assessments 941
Sensory Experiences Questionnaire Clinical Assessments 102
Social Communication Questionnaire (SCQ) - Current Form Clinical Assessments 142
Social Communication Questionnaire (SCQ) - Lifetime Clinical Assessments 293
Vineland-II - Survey Form (2005) Clinical Assessments 846

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDAR data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed IDStudyTitleJournalAuthorsDateStatus
27791287Create StudyDiffusion tensor spectroscopic imaging of the human brain in children and adults.Magnetic resonance in medicineFotso K, Dager SR, Landow A, Ackley E, Myers O, Dixon M, Shaw D, Corrigan NM, Posse SOctober 2016Not Determined
27497283Create StudyA touchscreen based global motion perception task for mice.Vision researchStirman JN, Townsend LB, Smith SLOctober 2016Not Relevant
27150231Create StudyDevelopment of cortical shape in the human brain from 6 to 24months of age via a novel measure of shape complexity.NeuroImageKim SH, Lyu I, Fonov VS, Vachet C, Hazlett HC, Smith RG, Piven J, Dager SR, Mckinstry RC, Pruett JR, Evans AC, Collins DL, Botteron KN, Schultz RT, Gerig G, Styner MA, July 15, 2016Not Determined
27065227Create StudyAutotract: Automatic cleaning and tracking of fibers.Proceedings of SPIE--the International Society for Optical EngineeringPrieto JC, Yang JY, Budin F, Styner MFebruary 27, 2016Not Relevant
26731103Create StudyThe Macaque Social Responsiveness Scale (mSRS): A Rapid Screening Tool for Assessing Variability in the Social Responsiveness of Rhesus Monkeys (Macaca mulatta).PloS oneFeczko EJ, Bliss-Moreau E, Walum H, Pruett JR, Parr LA2016Not Relevant
26612964Create StudyEarly Postnatal Myelin Content Estimate of White Matter via T1w/T2w Ratio.Proceedings of SPIE--the International Society for Optical EngineeringLee K, Cherel M, Budin F, Gilmore J, Consing KZ, Rasmussen J, Wadhwa PD, Entringer S, Glasser MF, Van Essen DC, Buss C, Styner M2015Not Determined
26490257Create StudySplenium development and early spoken language in human infants.Developmental scienceSwanson MR, Wolff JJ, Elison JT, Gu H, Hazlett HC, Botteron K, Styner M, Paterson S, Gerig G, Constantino J, Dager S, Estes A, Vachet C, Piven J, IBIS NetworkOctober 21, 2015Not Determined
26203305Create StudyBehavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life.Journal of neurodevelopmental disordersEstes A, Zwaigenbaum L, Gu H, St John T, Paterson S, Elison JT, Hazlett H, Botteron K, Dager SR, Schultz RT, Kostopoulos P, Evans A, Dawson G, Eliason J, Alvarez S, Piven J, 2015Not Determined
26089584Create StudyAutomatic Tissue Segmentation of Neonate Brain MR Images with Subject-specific Atlases.Proceedings of SPIE--the International Society for Optical EngineeringCherel M, Budin F, Prastawa M, Gerig G, Lee K, Buss C, Lyall A, Consing KZ, Styner MFebruary 21, 2015Not Determined
26088663Create StudyLong-Term Outcomes of Early Intervention in 6-Year-Old Children With Autism Spectrum Disorder.Journal of the American Academy of Child and Adolescent PsychiatryEstes, Annette; Munson, Jeffrey; Rogers, Sally J; Greenson, Jessica; Winter, Jamie; Dawson, GeraldineJuly 2015Not Relevant
26028804Create StudySkeletal shape correspondence via entropy minimization.Proceedings of SPIE--the International Society for Optical EngineeringTu, Liyun; Styner, Martin; Vicory, Jared; Paniagua, Beatriz; Prieto, Juan Carlos; Yang, Dan; Pizer, Stephen M2015Not Relevant
26028803Create StudyShape index distribution based local surface complexity applied to the human cortex.Proceedings of SPIE--the International Society for Optical EngineeringKim, Sun Hyung; Fonov, Vladimir; Collins, D Louis; Gerig, Guido; IBIS Network; Styner, Martin A2015Not Relevant
26028801Create StudyAutomatic Sulcal Curve Extraction on the Human Cortical Surface.Proceedings of SPIE--the International Society for Optical EngineeringLyu, Ilwoo; Kim, Sun Hyung; Styner, Martin2015Not Relevant
25937563Create StudyAltered corpus callosum morphology associated with autism over the first 2 years of life.Brain : a journal of neurologyWolff JJ, Gerig G, Lewis JD, Soda T, Styner MA, Vachet C, Botteron KN, Elison JT, Dager SR, Estes AM, Hazlett HC, Schultz RT, Zwaigenbaum L, Piven J, July 2015Not Determined
25704288Create StudyAccurate age classification of 6 and 12 month-old infants based on resting-state functional connectivity magnetic resonance imaging data.Developmental cognitive neurosciencePruett Jr, John R; Kandala, Sridhar; Hoertel, Sarah; Snyder, Abraham Z; Elison, Jed T; Nishino, Tomoyuki; Feczko, Eric; Dosenbach, Nico U F; Nardos, Binyam; Power, Jonathan D; Adeyemo, Babatunde; Botteron, Kelly N; McKinstry, Robert C; Evans, Alan C; Hazlett, Heather C; Dager, Stephen R; Paterson, Sarah; Schultz, Robert T; Collins, D Louis; Fonov, Vladimir S; Styner, Martin; Gerig, Guido; Das, Samir; Kostopoulos, Penelope; Constantino, John N; Estes, Annette M; IBIS Network; Petersen, Steven E; Schlaggar, Bradley L; Piven, JosephApril 2015Not Relevant
25664349Create StudyGeodesic image regression with a sparse parameterization of diffeomorphisms.Geometric science of information : first international conference, GSI 2013, Paris, France, August 28-30, 2013 : proceedings / Frank Nielsen, Frederic Barbaresco (eds.). Geometric Science of Information (1st : 2013 : Paris, France)Fishbaugh J, Prastawa M, Gerig G, Durrleman S2013Not Determined
25538672Create StudySubject-Motion Correction in HARDI Acquisitions: Choices and Consequences.Frontiers in neurologyElhabian S, Gur Y, Vachet C, Piven J, Styner M, Leppert IR, Pike GB, Gerig G2014Not Determined
25506622Create StudyMixed-Effects Shape Models for Estimating Longitudinal Changes in Anatomy.Spatio-temporal image analysis for longitudinal and time-series image data : Second International Workshop, STIA 2012, held in conjunction with MICCAI 2012, Nice, France, October 1, 2012, proceedings / Stanley Durrleman, Tom Flecher, Gu...Datar M, Muralidharan P, Kumar A, Gouttard S, Piven J, for the IBIS Network, Gerig G, Whitaker R, Fletcher PTOctober 2012Not Determined
25440311Create StudyRepetitive behavior in 12-month-olds later classified with autism spectrum disorder.Journal of the American Academy of Child and Adolescent PsychiatryElison JT, Wolff JJ, Reznick JS, Botteron KN, Estes AM, Gu H, Hazlett HC, Meadows AJ, Paterson SJ, Zwaigenbaum L, Piven J, Infant Brain Imaging Study (IBIS) NetworkNovember 2014Not Determined
25356196Create StudyA JOINT FRAMEWORK FOR 4D SEGMENTATION AND ESTIMATION OF SMOOTH TEMPORAL APPEARANCE CHANGES.Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical ImagingGao Y, Prastawa M, Styner M, Piven J, Gerig G2014-AprNot Relevant
25356195Create StudyA PRELIMINARY STUDY ON THE EFFECT OF MOTION CORRECTION ON HARDI RECONSTRUCTION.Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical ImagingElhabian S, Gur Y, Vachet C, Piven J, Styner M, Leppert I, Pike GB, Gerig G2014-AprNot Determined
25356194Create StudyPARAMETRIC REGRESSION SCHEME FOR DISTRIBUTIONS: ANALYSIS OF DTI FIBER TRACT DIFFUSION CHANGES IN EARLY BRAIN DEVELOPMENT.Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical ImagingSharma A, Fletcher PT, Gilmore JH, Escolar ML, Gupta A, Styner M, Gerig G2014-AprNot Determined
25356192Create StudyGEODESIC REGRESSION OF IMAGE AND SHAPE DATA FOR IMPROVED MODELING OF 4D TRAJECTORIES.Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical ImagingFishbaugh J, Prastawa M, Gerig G, Durrleman S2014-AprNot Determined
25320779Create StudySubject-specific prediction using nonlinear population modeling: application to early brain maturation from DTI.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted InterventionSadeghi N, Fletcher PT, Prastawa M, Gilmore JH, Gerig G2014Not Determined
25312279Create StudyBrief Report: Chimpanzee Social Responsiveness Scale (CSRS) Detects Individual Variation in Social Responsiveness for Captive Chimpanzees.Journal of autism and developmental disordersFaughn, Carley; Marrus, Natasha; Shuman, Jeremy; Ross, Stephen R; Constantino, John N; Pruett Jr, John R; Povinelli, Daniel JMay 2015Not Relevant
25309699Create StudyCharacterizing growth patterns in longitudinal MRI using image contrast.Proceedings of SPIE--the International Society for Optical EngineeringVardhan A, Prastawa M, Vachet C, Piven J, Gerig GMarch 21, 2014Not Determined
25103541Create StudyStriatal development in autism: repetitive behaviors and the reward circuitry.Biological psychiatryKohls G, Yerys BE, Schultz RTSeptember 1, 2014Not Determined
24802306Create StudyNetwork inefficiencies in autism spectrum disorder at 24 months.Translational psychiatryLewis JD, Evans AC, Pruett JR, Botteron K, Zwaigenbaum L, Estes A, Gerig G, Collins L, Kostopoulos P, McKinstry R, Dager S, Paterson S, Schultz RT, Styner M, Hazlett H, Piven J2014Not Determined
24684012Create StudyGeodesic shape regression in the framework of currents.Information processing in medical imaging : proceedings of the ... conferenceFishbaugh J, Prastawa M, Gerig G, Durrleman S2013Not Determined
24655647Create StudyBAP: not-quite-autism in infants.Journal of the American Academy of Child and Adolescent PsychiatryPruett JRApril 2014Not Determined
24567717Create StudyMulti-atlas segmentation of subcortical brain structures via the AutoSeg software pipeline.Frontiers in neuroinformaticsWang J, Vachet C, Rumple A, Gouttard S, Ouziel C, Perrot E, Du G, Huang X, Gerig G, Styner M2014Not Determined
24552513Create StudyLongitudinal patterns of repetitive behavior in toddlers with autism.Journal of child psychology and psychiatry, and allied disciplinesWolff JJ, Botteron KN, Dager SR, Elison JT, Estes AM, Gu H, Hazlett HC, Pandey J, Paterson SJ, Schultz RT, Zwaigenbaum L, Piven J, IBIS NetworkAugust 2014Not Determined
24523693Create StudyDTIPrep: quality control of diffusion-weighted images.Frontiers in neuroinformaticsOguz I, Farzinfar M, Matsui J, Budin F, Liu Z, Gerig G, Johnson HJ, Styner M2014Not Determined
24443698Create StudyMODELING LONGITUDINAL MRI CHANGES IN POPULATIONS USING A LOCALIZED, INFORMATION-THEORETIC MEASURE OF CONTRAST.Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical ImagingVardhan A, Prastawa M, Sharma A, Piven J, Gerig GDecember 31, 2013Not Determined
24443688Create StudySPATIOTEMPORAL MODELING OF DISCRETE-TIME DISTRIBUTION-VALUED DATA APPLIED TO DTI TRACT EVOLUTION IN INFANT NEURODEVELOPMENT.Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical ImagingSharma A, Fletcher PT, Gilmore JH, Escolar ML, Gupta A, Styner M, Gerig GDecember 31, 2013Not Determined
24443681Create StudyLONGITUDINAL GROWTH MODELING OF DISCRETE-TIME FUNCTIONS WITH APPLICATION TO DTI TRACT EVOLUTION IN EARLY NEURODEVELOPMENT.Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical ImagingSharma A, Durrleman S, Gilmore JH, Gerig GDecember 31, 2013Not Relevant
24409141Create StudyUNC-Utah NA-MIC framework for DTI fiber tract analysis.Frontiers in neuroinformaticsVerde AR, Budin F, Berger JB, Gupta A, Farzinfar M, Kaiser A, Ahn M, Johnson H, Matsui J, Hazlett HC, Sharma A, Goodlett C, Shi Y, Gouttard S, Vachet C, Piven J, Zhu H, Gerig G, Styner M2014Not Determined
24392201Create StudyA framework for longitudinal data analysis via shape regression.Proceedings of SPIE--the International Society for Optical EngineeringFishbaugh J, Durrleman S, Piven J, Gerig GFebruary 23, 2012Not Determined
24386543Create StudyUNC-Utah NA-MIC DTI framework: Atlas Based Fiber Tract Analysis with Application to a Study of Nicotine Smoking Addiction.Proceedings of SPIE--the International Society for Optical EngineeringVerde AR, Berger JB, Gupta A, Farzinfar M, Kaiser A, Chanon VW, Boettiger C, Goodlett C, Shi Y, Zhu H, Gerig G, Gouttard S, Vachet C, Styner MMarch 13, 2013Not Determined
24353382Create StudyAutomatic corpus callosum segmentation using a deformable active Fourier contour model.Proceedings of SPIE--the International Society for Optical EngineeringVachet C, Yvernault B, Bhatt K, Smith RG, Gerig G, Hazlett HC, Styner MMarch 23, 2012Not Determined
24353381Create StudyMeasures for Validation of DTI Tractography.Proceedings of SPIE--the International Society for Optical EngineeringGouttard S, Goodlett CB, Kubicki M, Gerig GFebruary 23, 2012Not Determined
24353379Create StudyQuality Control of Diffusion Weighted Images.Proceedings of SPIE--the International Society for Optical EngineeringLiu Z, Wang Y, Gerig G, Gouttard S, Tao R, Fletcher T, Styner MMarch 11, 2010Not Determined
24353378Create StudyChanges of MR and DTI appearance in early human brain development.Proceedings of SPIE--the International Society for Optical EngineeringMarc C, Vachet C, Gerig G, Blocher J, Gilmore J, Styner MMarch 12, 2010Not Determined
24353377Create StudyEvaluation of DTI Property Maps as Basis of DTI Atlas Building.Proceedings of SPIE--the International Society for Optical EngineeringLiu Z, Goodlett C, Gerig G, Styner MMarch 12, 2010Not Determined
24353376Create StudyTowards Analysis of Growth Trajectory through Multi-modal Longitudinal MR Imaging.Proceedings of SPIE--the International Society for Optical EngineeringSadeghi N, Prastawa M, Gilmore JH, Lin W, Gerig GMarch 12, 2010Not Determined
24069234Create StudyAge-specific average head template for typically developing 6-month-old infants.PloS oneAkiyama LF, Richards TR, Imada T, Dager SR, Wroblewski L, Kuhl PK2013Not Determined
23959506Create StudyMULTIVARIATE MODELING OF LONGITUDINAL MRI IN EARLY BRAIN DEVELOPMENT WITH CONFIDENCE MEASURES.Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical ImagingSadeghi N, Prastawa M, Fletcher PT, Vachet C, Wang B, Gilmore J, Gerig G2013Not Relevant
23959442Create StudyA NEW FRAMEWORK FOR ANALYZING WHITE MATTER MATURATION IN EARLY BRAIN DEVELOPMENT.Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical ImagingPrastawa M, Sadeghi N, Gilmore JH, Lin W, Gerig G2010Not Relevant
23958630Create StudyQUANTIFYING REGIONAL GROWTH PATTERNS THROUGH LONGITUDINAL ANALYSIS OF DISTANCES BETWEEN MULTIMODAL MR INTENSITY DISTRIBUTIONS.Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical ImagingVardhan A, Prastawa M, Gouttard S, Piven J, Gerig G2012Not Relevant
23956495Create StudyToward a comprehensive framework for the spatiotemporal statistical analysis of longitudinal shape data.International journal of computer visionDurrleman S, Pennec X, Trouvé A, Braga J, Gerig G, Ayache NMay 2013Not Determined
23846465Create StudyLongitudinal image registration with temporally-dependent image similarity measure.IEEE transactions on medical imagingCsapo I, Davis B, Shi Y, Sanchez M, Styner M, Niethammer MOctober 2013Not Determined
23833547Create StudyDTI Quality Control Assessment via Error Estimation From Monte Carlo Simulations.Proceedings of SPIE--the International Society for Optical EngineeringFarzinfar M, Li Y, Verde AR, Oguz I, Gerig G, Styner MAMarch 13, 2013Not Relevant
23684874Create StudyDiffusion imaging quality control via entropy of principal direction distribution.NeuroImageFarzinfar M, Oguz I, Smith RG, Verde AR, Dietrich C, Gupta A, Escolar ML, Piven J, Pujol S, Vachet C, Gouttard S, Gerig G, Dager S, McKinstry RC, Paterson S, Evans AC, IBIS network, Styner MANovember 15, 2013Not Determined
23595508Create StudyENTROPY BASED DTI QUALITY CONTROL VIA REGIONAL ORIENTATION DISTRIBUTION.Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical ImagingFarzinfar M, Dietrich C, Smith R, Li Y, Gupta A, Liu Z, Styner M2012Not Determined
23568185Create StudyBuilding Spatiotemporal Anatomical Models using Joint 4-D Segmentation, Registration, and Subject-Specific Atlas Estimation.Proceedings / sponsored by IEEE Computer Society Technical Committee on Pattern Analysis and Machine Intelligence. Workshop on Mathematical Methods in Biomedical Image AnalysisPrastawa M, Awate SP, Gerig G2012Not Determined
23511344Create StudyWhite matter microstructure and atypical visual orienting in 7-month-olds at risk for autism.The American journal of psychiatryElison JT, Paterson SJ, Wolff JJ, Reznick JS, Sasson NJ, Gu H, Botteron KN, Dager SR, Estes AM, Evans AC, Gerig G, Hazlett HC, Schultz RT, Styner M, Zwaigenbaum L, Piven J, IBIS NetworkAugust 2013Not Determined
23432829Create StudyFrontolimbic neural circuitry at 6 months predicts individual differences in joint attention at 9 months.Developmental scienceElison JT, Wolff JJ, Heimer DC, Paterson SJ, Gu H, Hazlett HC, Styner M, Gerig G, Piven J, March 2013Not Determined
23285617Create StudyAnalysis of longitudinal shape variability via subject specific growth modeling.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted InterventionFishbaugh J, Prastawa M, Durrleman S, Piven J, Gerig G, IBIS Network2012Not Determined
23235270Create StudyRegional characterization of longitudinal DT-MRI to study white matter maturation of the early developing brain.NeuroImageSadeghi N, Prastawa M, Fletcher PT, Wolff J, Gilmore JH, Gerig GMarch 2013Not Determined
23223157Create StudySPATIAL INTENSITY PRIOR CORRECTION FOR TISSUE SEGMENTATION IN THE DEVELOPING HUMAN BRAIN.Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical ImagingKim SH, Fonov V, Piven J, Gilmore J, Vachet C, Gerig G, Collins DL, Styner M, The IBIS Network2011Not Determined
22684595Create StudyBrain volume findings in 6-month-old infants at high familial risk for autism.The American journal of psychiatryHazlett HC, Gu H, McKinstry RC, Shaw DW, Botteron KN, Dager SR, Styner M, Vachet C, Gerig G, Paterson SJ, Schultz RT, Estes AM, Evans AC, Piven J, IBIS NetworkJune 2012Not Determined
22370873Create StudyConsensus paper: pathological role of the cerebellum in autism.Cerebellum (London, England)Fatemi SH, Aldinger KA, Ashwood P, Bauman ML, Blaha CD, Blatt GJ, Chauhan A, Chauhan V, Dager SR, Dickson PE, Estes AM, Goldowitz D, Heck DH, Kemper TL, King BH, Martin LA, Millen KJ, Mittleman G, Mosconi MW, Persico AM, Sweeney JA, Webb SJ, Welsh JPSeptember 2012Not Determined
21995056Create StudyIterative refinement of point correspondences for 3D statistical shape models.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted InterventionSeshamani S, Chintalapani G, Taylor R2011Not Determined
21995054Create StudyEstimation of smooth growth trajectories with controlled acceleration from time series shape data.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted InterventionFishbaugh J, Durrleman S, Gerig G2011Not Determined
21761651Create StudyOptimal data-driven sparse parameterization of diffeomorphisms for population analysis.Information processing in medical imaging : proceedings of the ... conferenceDurrleman S, Prastawa M, Gerig G, Joshi SJanuary 2011Not Relevant
21438139Create StudyMutations in the TSGA14 gene in families with autism spectrum disorders.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric GeneticsKorvatska O, Estes A, Munson J, Dawson G, Bekris LM, Kohen R, Yu CE, Schellenberg GD, Raskind WHApril 2011Not Determined
21256236Create StudyDTI registration in atlas based fiber analysis of infantile Krabbe disease.NeuroImageWang Y, Gupta A, Liu Z, Zhang H, Escolar ML, Gilmore JH, Gouttard S, Fillard P, Maltbie E, Gerig G, Styner MApril 2011Not Determined
21244423Create StudyPoor fine-motor and visuospatial skills predict persistence of pediatric-onset obsessive-compulsive disorder into adulthood.Journal of child psychology and psychiatry, and allied disciplinesBloch MH, Sukhodolsky DG, Dombrowski PA, Panza KE, Craiglow BG, Landeros-Weisenberger A, Leckman JF, Peterson BS, Schultz RTSeptember 2011Not Determined
21042871Create StudyDiscrepancies between academic achievement and intellectual ability in higher-functioning school-aged children with autism spectrum disorder.Journal of autism and developmental disordersEstes A, Rivera V, Bryan M, Cali P, Dawson GAugust 2011Not Determined
21041620Create StudyLaterobasal amygdalar enlargement in 6- to 7-year-old children with autism spectrum disorder.Archives of general psychiatryKim JE, Lyoo IK, Estes AM, Renshaw PF, Shaw DW, Friedman SD, Kim DJ, Yoon SJ, Hwang J, Dager SRNovember 2010Not Determined
20426000Create StudySpatiotemporal atlas estimation for developmental delay detection in longitudinal datasets.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted InterventionDurrleman S, Pennec X, Trouvé A, Gerig G, Ayache N2009Not Determined
19819542Create StudyAutism.Lancet (London, England)Levy SE, Mandell DS, Schultz RTNovember 7, 2009Not Determined
19243924Create StudyCerebellar vermal volumes and behavioral correlates in children with autism spectrum disorder.Psychiatry researchWebb SJ, Sparks BF, Friedman SD, Shaw DW, Giedd J, Dawson G, Dager SRApril 30, 2009Not Determined
18982614Create StudyAssessment of reliability of multi-site neuroimaging via traveling phantom study.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted InterventionGouttard S, Styner M, Prastawa M, Piven J, Gerig G2008Not Determined
18606031Create StudyEarly behavioral intervention, brain plasticity, and the prevention of autism spectrum disorder.Development and psychopathologyDawson G2008Not Determined
18058011Create StudyHead circumference as an early predictor of autism symptoms in younger siblings of children with autism spectrum disorder.Journal of autism and developmental disordersElder LM, Dawson G, Toth K, Fein D, Munson JJuly 2008Not Determined
17975722Create StudyCharacteristics associated with presence of depressive symptoms in adults with autism spectrum disorder.Journal of autism and developmental disordersSterling L, Dawson G, Estes A, Greenson JJuly 2008Not Determined
17963435Create StudyLevel of intellectual functioning predicts patterns of associated symptoms in school-age children with autism spectrum disorder.American journal of mental retardation : AJMREstes AM, Dawson G, Sterling L, Munson JNovember 2007Not Determined

This tab provides a general status on the data expected to be shared. There are two types of data expected.

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Relevant Publications
PubMed IDStudyTitleJournalAuthorsDate
No records found.

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Data Expected
Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
Medical History info iconApproved
Vineland (Parent and Caregiver) info iconApproved
Prefrontal Task info iconApproved
Autism Observation Scale for Infants (AOSI) info iconApproved
Communication and Symbolic Behavior Scales (CSBS) info iconApproved
Imaging (Structural, fMRI, DTI, PET, microscopy) info iconApproved
ADOS info iconApproved
Physical Exam info iconApproved
Mullen Scales of Early Learning info iconApproved
MacArthur Bates Communicative Development Inventory info iconApproved
Research Subject and Pedigree info iconApproved
ADI-R info iconApproved
Repetitive Behavior Scale - Revised (RBS-R) info iconApproved
M-CHAT info iconApproved
Infant Behavior Questionnaire (IBQ) info iconApproved
First Year Inventory (FYI) info iconApproved
Sensory Experiences Questionnaire (SEQ) info iconApproved
Social Communication Questionnaire (SCQ) info iconApproved
Early Development Inventory (EDI) info iconApproved
Structure not yet defined

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study Name Description Number of Subjects
Collection / Total
Data Use State
Identification of Infants at High-Risk for Autism Spectrum Disorder Using Multiparameter Multiscale White Matter Connectivity Networks Autism spectrum disorder (ASD) is a wide range of disabilities that cause life-long cognitive impairment and social, communication, and behavioral challenges. Early diagnosis and medical intervention are important for improving the life quality of autistic patients. However, in the current practice, diagnosis often has to be delayed until the behavioral symptoms become evident during childhood. In this study, we demonstrate the feasibility of using machine learning techniques for identifying high-risk ASD infants at as early as six months after birth. This is based on the observation that ASD-induced abnormalities in white matter (WM) tracts and whole-brain connectivity have already started to appear within 24 months after birth. In particular, we propose a novel multikernel support vector machine classification framework by using the connectivity features gathered from WM connectivity networks, which are generated via multiscale regions of interest (ROIs) and multiple diffusion statistics such as fractional anisotropy, mean diffusivity, and average fiber length. Our proposed framework achieves an accuracy of 76% and an area of 0.80 under the receiver operating characteristic curve (AUC), in comparison to the accuracy of 70% and the AUC of 70% provided by the best singleparameter single-scale network. The improvement in accuracy is mainly due to the complementary information provided by multiparameter multiscale networks. In addition, our framework also provides the potential imaging connectomic markers and an objective means for early ASD diagnosis. 490 / 490 Secondary Analysis Shared
Psychometric Analysis of the Social Communication Questionnaire Using an Item-Response Theory Framework: Implications for the Use of the Lifetime and Current Forms The Social Communication Questionnaire (SCQ) was developed as a screener of Autism Spectrum Disorder (ASD). To date, the majority of the SCQ utility studies focused on its external validity (e.g., ROC curve analyses), but very few have addressed the internal validity issues. With samples consisting of 2,134 individuals available from the National Database for Autism Research (NDAR), the current study examined the factor structure, item-level characteristics, and measurement equivalence of the SCQ forms (i.e., Lifetime form and Current form) using both the classical true score theory and the item response theory (IRT). While our findings indicate sufficient psychometric properties of the SCQ Lifetime form, measurement issues emerged with respect to the SCQ Current form. These issues include lower internal consistencies, a weaker factor structure, lower item discriminations, significant pseudo-guessing effects, and subscale-level measurement bias. Thus, we caution researchers and clinicians about the use of the SCQ Current form. In particular, it seems inappropriate to use the Current form as an alternative to the Lifetime form among children younger than 5 years old or under other special situations (e.g., teacher-report data), although such practices were advised by the publisher of the SCQ. Instead, we recommend modifying the wording of the Lifetime form items rather than switching to the Current form where a 3-month timeframe is specified for responding to SCQ items. Future studies may consider investigating the association between the temporality of certain behaviors and the individual’s potential for being diagnosed with ASD, as well as the age neutrality of the SCQ. 240 / 2134 Secondary Analysis Shared
Revising the Social Communication Questionnaire scoring procedures for Autism Spectrum Disorder and potential Social Communication Disorder In analyzing data from the National Database for Autism Research, we examine revising the Social Communication Questionnaire (SCQ), a commonly used screening instrument for Autism Spectrum Disorder. A combination of Item Response Theory and Mokken scaling techniques were utilized to achieve this and abbreviated scoring of the SCQ is suggested. The psychometric sensitivity of this abbreviated SCQ was examined via bootstrapped Receiver Operator Characteristic (ROC) curve analyses. Additionally, we examined the sensitivity of the abbreviated and total scaled SCQ as it relates to a potential diagnosis of Social (Pragmatic) Communication Disorder (SCD). As SCD is a new disorder introduced with the fifth edition of the Diagnostic and Statistical Manual (DSM-5), we identified individuals with potential diagnosis of SCD among individuals with ASD via mixture modeling techniques using the same NDAR data. These analyses revealed two classes or clusters of individuals when considering the two core areas of impairment among individuals with ASD: social communication and restricted, repetitive patterns of behavior. 4 / 1021 Secondary Analysis Shared
The Sensitivity and Specificity of the Social Communication Questionnaire for Autism Spectrum Disorder with Respect to Age Scientific Abstract The Social Communication Questionnaire (SCQ) assesses communication skills and social functioning in screening for symptoms of autism-spectrum disorder (ASD). The SCQ is recommended for individuals between 4 to 40 years with a cutoff score of 15 for referral. Mixed findings have been reported regarding the recommended cutoff score’s ability to accurately classify an individual as at-risk for ASD (sensitivity) versus an individual as not at-risk for ASD (specificity). Based on a sample from the National Database for Autism Research (n=344; age: 1.58 to 25.92 years old), the present study examined the SCQ’s sensitivity versus specificity across a range of ages. We recommend that the cutoff scores for the SCQ be re-evaluated with age as a consideration. Lay Abstract The age neutrality of the Social Communication Questionnaire (SCQ) was examined as a common screener for ASD. Mixed findings have been reported regarding the recommended cutoff score’s ability to accurately classify an individual as at-risk for ASD (sensitivity) versus accurately classifying an individual as not at-risk for ASD (specificity). With a sample from the National Database for Autism Research, the present study examined the SCQ’s sensitivity versus specificity. Analyses indicated that the actual sensitivity and specificity scores were lower than initially reported by the creators of the SCQ. 5 / 339 Secondary Analysis Shared
Rare Inherited and De Novo CNVs Reveal Complex Contributions to ASD Risk in Multiplex families NOTE: NOT ALL DATA HAS BEEN UPLOADED FOR THIS STUDY. Rare mutations, including copy-number variants (CNVs), contribute significantly to autism spectrum disorder (ASD) risk. Although their importance has been established in families with only one affected child (simplex families), the contribution of both de novo and inherited CNVs to ASD in families with multiple affected individuals (multiplex families) is less well understood. We analyzed 1,532 families from the Autism Genetic Resource Exchange (AGRE) to assess the impact of de novo and rare CNVs on ASD risk in multiplex families. We observed a higher burden of large, rare CNVs, including inherited events, in individuals with ASD than in their unaffected siblings (odds ratio [OR] = 1.7), but the rate of de novo events was significantly lower than in simplex families. In previously characterized ASD risk loci, we identified 49 CNVs, comprising 24 inherited events, 19 de novo events, and 6 events of unknown inheritance, a significant enrichment in affected versus control individuals (OR = 3.3). In 21 of the 30 families (71%) in whom at least one affected sibling harbored an established ASD major risk CNV, including five families harboring inherited CNVs, the CNV was not shared by all affected siblings, indicating that other risk factors are contributing. We also identified a rare risk locus for ASD and language delay at chromosomal region 2q24 (implicating NR4A2) and another lower-penetrance locus involving inherited deletions and duplications of WWOX. The genetic architecture in multiplex families differs from that in simplex families and is complex, warranting more complete genetic characterization of larger multiplex ASD cohorts. 3 / 5288 Primary Analysis Shared
* Data not on individual level