Loading...

Reset Password

NDAR provides a single access to de-identified autism research data. For permission to download data, you will need an NDAR account with approved access to NDAR or a connected repository (AGRE, IAN, or the ATP). For NDAR access, you need to be a research investigator sponsored by an NIH recognized institution with federal wide assurance. See Request Access for more information.

Warning Notice

This is a U.S. Government computer system, which may be accessed and used only for authorized Government business by authorized personnel. Unauthorized access or use of this computer system may subject violators to criminal, civil, and/or administrative action.

All information on this computer system may be intercepted, recorded, read, copied, and disclosed by and to authorized personnel for official purposes, including criminal investigations. Such information includes sensitive data encrypted to comply with confidentiality and privacy requirements. Access or use of this computer system by any person, whether authorized or unauthorized, constitutes consent to these terms. There is no right of privacy in this system.

You have logged in with a temporary password. Please update your password. Passwords must contain 8 or more characters and must contain at least 3 of the following types of characters:

Subscribe to our mailing list

Mailing List(s)
Email Format

You are now leaving the National Database for Autism Research (NDAR) web site to go to:

Click on the address above if the page does not change within 10 seconds.

Disclaimer

NDAR is not responsible for the content of this external site and does not monitor other web sites for accuracy.

Selected Filters
No filters selected

The filters you have selected from various query interfaces will be stored here, in the 'Filter Cart'. The database will be queried using filters added to your 'Filter Cart', when multiple filters are defined, each will be executed using 'AND' logic, so with each filter that is applied the result set gets smaller.

From the 'Filter Cart' you can inspect each of the filters that have been defined, and you also have the option to remove filters. The 'Filter Cart' itself will display the number of filters applied along with the number of subjects that are identified by the combination of those filters. For example a GUID filter with two subjects, followed by a GUID filter for just one of those subjects would return only data for the subject that is in both GUID filters.

If you have a question about the filter cart, or underlying filters please contact the help desk at The NDA Help Desk

Description
Value Range
Notes
Data Structures with shared data
No filters have been selected

1 Numbers reported are subjects by age
New Trial
New Project

Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

Please select an experiment type below

New Documentation

Please enter the name of the data structure to search or if your definition does not exist, please upload that definition so that it can be appropriately defined for submission. Multiple data structures may be associated with a single Data Expected entry. Please add only one data structure per assessment.

Please provide a reason for the requested submission exemption and the
time-frame during which the exemption will be active.
Shared

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

General

Title, investigators, and Collection Description may be edited along with the Collection Phase. For Collection Phase, the options Pre-enrollment, Enrollment, and Completed can be chosen allowing the Collection Owner to indicate the stage of data collection.

Funding Source

The ability to associate the funding source for the project is provided. For NIH funded grants, linkage to Project Reporter information (e.g. R01MH123456) is supported. Projects funded by others, including the URL of the project, are listed. Non NIH funded projects will become available here to link that data with the appropriate funding agency.

Supporting Documentation

Any documents related to the project may be uploaded clarifying the data or acquisition methods used may be uploaded and made available here. The default is to share these documents to the general public. An option to share only to qualified Researchers is also an option.

Clinical Trials

For clinical trials, the option to link to the clinical trial in clinicaltrials.gov is optionally provided.

Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Autism Risk, Prenatal Environmental Exposures, and Pathophysiologic Markers
Irva Hertz-Picciotto 
An extension of the epidemiology project MARBLES (Markers of Autism Risk in Babies Learning Early Signs) to collect 1) extensive behavioral, medical, and exposure data, 2) biologic specimens from the mother and child, and 3) detailed psychometric assessments from birth to 3 years, Exposures of interest are 2 classes of compounds common in household products with known neuro- or neurodevelopmental toxicity: pyrethroid pesticides diphenyl ethers (flame retardants). We assessed associations of self-reported exposure, measurements of internal dose, and toxicologically-derived estimates of biologically effective dose with risk for ASD or other neurobehavioral development impairments. Second, we examined whether the exposure or dose estimates are associated with markers of aberrant immune responses or mitochondrial dysfunction and whether these markers predict clinically confirmed child developmental status at 3 years.
NDAR
Enrollment Completed
Shared
$9,025,412.00
258
1650
1310

Loading...

Loading...

No Data Shared

Loading...

Chart Expander
NIH - Extramural None


R01ES020392-01 Autism Risk, Prenatal Environmental Exposures, and Pathophysiologic Markers 08/24/2011 03/31/2016 1650 1310 UNIVERSITY OF CALIFORNIA AT DAVIS $9,025,412.00

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Experiments

To create a new Omics, eye tracking, fMRI, or EEG experiment, press the "+ New Experiment" button. Once an experiment is created, then raw files for these types of experiments should be provided, associating the experiment – through Experiment_ID – with the metadata defined in the experiments interface.

IDNameCreated DateStatusType
No records found.

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Shared Data

Data structures with the number of subjects submitted and shared are provided.

Autism Diagnostic Interview, Revised (ADI-R) Clinical Assessments 30
Autism Diagnostic Observation Schedule (ADOS) - Module 1 (2007) Clinical Assessments 63
Autism Diagnostic Observation Schedule (ADOS) - Module 2 (2007) Clinical Assessments 20
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 1 Clinical Assessments 17
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 2 Clinical Assessments 51
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 3 Clinical Assessments 1
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Toddler Module Clinical Assessments 17
Autism Observation Scale for Infants Clinical Assessments 125
CSBS DP Infant-Toddler Checklist Clinical Assessments 212
Early Development Questionnaire Clinical Assessments 101
Genomics Sample Genomics 30
M-CHAT Clinical Assessments 132
Mullen Scales of Early Learning Clinical Assessments 218
Parent Concerns Questionaire Clinical Assessments 227
Social Communication Questionnaire (SCQ) - Current Form Clinical Assessments 100
Vineland-II - Parent and Caregiver Rating Form (2005) Clinical Assessments 111
Vineland-II - Survey Form (2005) Clinical Assessments 3

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDAR data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed IDStudyTitleJournalAuthorsDateStatus
27335370Create StudyWarburg effect linked to cognitive-executive deficits in FMR1 premutation.FASEB journal : official publication of the Federation of American Societies for Experimental BiologyNapoli E, Song G, Schneider A, Hagerman R, Eldeeb MA, Azarang A, Tassone F, Giulivi COctober 2016Not Relevant
27089882Create StudyAltered Bioenergetics in Primary Dermal Fibroblasts from Adult Carriers of the FMR1 Premutation Before the Onset of the Neurodegenerative Disease Fragile X-Associated Tremor/Ataxia Syndrome.Cerebellum (London, England)Napoli E, Song G, Wong S, Hagerman R, Giulivi CApril 18, 2016Not Determined
27071785Create StudyAutism, Mitochondria and Polybrominated Diphenyl Ether Exposure.CNS & neurological disorders drug targetsWong S, Giulivi CJanuary 2016Not Determined
25929801Create StudyExposure to select phthalates and phenols through use of personal care products among Californian adults and their children.Environmental researchPhilippat C, Bennett D, Calafat AM, Picciotto IHJuly 2015Not Determined
25884939Create StudyPolybrominated diphenyl ether serum concentrations in a Californian population of children, their parents, and older adults: an exposure assessment study.Environmental health : a global access science sourceWu XM, Bennett DH, Moran RE, Sjödin A, Jones RS, Tancredi DJ, Tulve NS, Clifton MS, Colón M, Weathers W, Hertz-Picciotto I2015Not Determined
25583085Create StudyRapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks formed by hippocampal neurons in culture.Molecular pharmacologyCao Z, Zou X, Cui Y, Hulsizer S, Lein PJ, Wulff H, Pessah INApril 2015Not Determined
25249546Create StudyMaternal intake of supplemental iron and risk of autism spectrum disorder.American journal of epidemiologySchmidt RJ, Tancredi DJ, Krakowiak P, Hansen RL, Ozonoff SNovember 1, 2014Not Determined
25136376Create StudyMouse models of the fragile X premutation and fragile X-associated tremor/ataxia syndrome.Journal of neurodevelopmental disordersBerman RF, Buijsen RA, Usdin K, Pintado E, Kooy F, Pretto D, Pessah IN, Nelson DL, Zalewski Z, Charlet-Bergeurand N, Willemsen R, Hukema RK2014Not Determined
25072037Create StudyPotential therapeutic use of the ketogenic diet in autism spectrum disorders.Frontiers in pediatricsNapoli E, Dueñas N, Giulivi C2014Not Determined
24753527Create StudyDeficits in bioenergetics and impaired immune response in granulocytes from children with autism.PediatricsNapoli E, Wong S, Hertz-Picciotto I, Giulivi CMay 2014Not Determined
24518932Create StudyMaternal lifestyle and environmental risk factors for autism spectrum disorders.International journal of epidemiologyLyall K, Schmidt RJ, Hertz-Picciotto IApril 2014Not Determined
24482397Create StudyNanomolar bifenthrin alters synchronous Ca2+ oscillations and cortical neuron development independent of sodium channel activity.Molecular pharmacologyCao Z, Cui Y, Nguyen HM, Jenkins DP, Wulff H, Pessah INApril 2014Not Determined
24174710Create StudyGestational exposure to a viral mimetic poly(i:C) results in long-lasting changes in mitochondrial function by leucocytes in the adult offspring.Mediators of inflammationGiulivi C, Napoli E, Schwartzer J, Careaga M, Ashwood P2013Not Determined
24118221Create StudyDetermining source strength of semivolatile organic compounds using measured concentrations in indoor dust.Indoor airShin HM, Mckone TE, Nishioka MG, Fallin MD, Croen LA, Hertz-Picciotto I, Newschaffer CJ, Bennett DHJune 2014Not Relevant
23962276Create StudyTemporal variation of residential pesticide use and comparison of two survey platforms: a longitudinal study among households with young children in Northern California.Environmental health : a global access science sourceWu XM, Bennett DH, Ritz B, Tancredi DJ, Hertz-Picciotto IAugust 2013Not Relevant
23708622Create StudySimultaneous determination of polybrominated diphenyl ethers and polychlorinated biphenyls by gas chromatography-tandem mass spectrometry in human serum and plasma.TalantaLin YP, Pessah IN, Puschner BSeptember 15, 2013Not Determined
23623455Create StudyTrophoblast inclusions are significantly increased in the placentas of children in families at risk for autism.Biological psychiatryWalker CK, Anderson KW, Milano KM, Ye S, Tancredi DJ, Pessah IN, Hertz-Picciotto I, Kliman HJAugust 1, 2013Not Determined
23288049Create StudyToxicity of the flame-retardant BDE-49 on brain mitochondria and neuronal progenitor striatal cells enhanced by a PTEN-deficient background.Toxicological sciences : an official journal of the Society of ToxicologyNapoli E, Hung C, Wong S, Giulivi CMarch 2013Not Determined
23086694Create StudyToxicokinetic modeling of persistent organic pollutant levels in blood from birth to 45 months of age in longitudinal birth cohort studies.Environmental health perspectivesVerner MA, Sonneborn D, Lancz K, Muckle G, Ayotte P, Dewailly É, Kocan A, Palkovicová L, Trnovec T, Haddad S, Hertz-Picciotto I, Eggesbø MJanuary 2013Not Determined
22900024Create StudyMitochondrial dysfunction in Pten haplo-insufficient mice with social deficits and repetitive behavior: interplay between Pten and p53.PloS oneNapoli E, Ross-Inta C, Wong S, Hung C, Fujisawa Y, Sakaguchi D, Angelastro J, Omanska-Klusek A, Schoenfeld R, Giulivi C2012Not Determined
22719983Create StudyLack of evidence for neonatal misoprostol neurodevelopmental toxicity in C57BL6/J mice.PloS oneKoenig CM, Walker CK, Qi L, Pessah IN, Berman RF2012Not Determined
22492772Create StudyMaternal metabolic conditions and risk for autism and other neurodevelopmental disorders.PediatricsKrakowiak P, Walker CK, Bremer AA, Baker AS, Ozonoff S, Hansen RL, Hertz-Picciotto IMay 2012Not Determined

This tab provides a general status on the data expected to be shared. There are two types of data expected.

  1. By Relevant publications — Those publications that reported for the collection's grant and have a status of "relevant" for sharing are listed first. The grantee is expected to share the data specific to those publications using the NDA Study feature. If a publication is erroneously marked relevant, the PI should simply change the status. When sharing a study, only the outcome measures for the subjects/time-points are shared. Other data that have not met the share date, defined below, will remain embargoed. To initiate study creation, simply login, mark your publication as relevant and click on the link listed to begin.

  2. By Data Structure — The number of subjects expected, received and shared is provided. Investigators are expected to update the data that they are collecting, the initial submission date and initial share dates. The NIMH Data Archive shares data when those dates are met.

  3. Submission Exemption — Those with Administrative or Submission Access to the Collection may request an exemption for submission for a defined period by stating the reason and timeframe. Note that the program officer on the grant may review this request.


Relevant Publications
PubMed IDStudyTitleJournalAuthorsDate
No records found.

For those with privileges to edit the collection, it is possible to upload your data definitions using this interface. NDA support staff will then follow up with a harmonized data definition for you to use in providing additional data.

Data Expected
Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
Diary of Symptoms info iconApproved
Vineland (Parent and Caregiver) info iconApproved
Mullen Scales of Early Learning info iconApproved
Communication and Symbolic Behavior Scales (CSBS) info iconApproved
M-CHAT info iconApproved
Autism Observation Scale for Infants (AOSI) info iconApproved
Social Communication Questionnaire (SCQ) info iconApproved
Early Development Questionnaire info iconApproved
Child Behavior Checklist (CBCL) info iconApproved
Social Responsiveness Scale (SRS) info iconApproved
Parent Concerns Questionaire info iconApproved
genomics/omics info iconApproved
ADI-R info iconApproved
Enviromental Evaluation info iconApproved
ADOS info iconApproved
Research Subject and Pedigree info iconApproved
Structure not yet defined

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study Name Description Number of Subjects
Collection / Total
Data Use State
Revising the Social Communication Questionnaire scoring procedures for Autism Spectrum Disorder and potential Social Communication Disorder In analyzing data from the National Database for Autism Research, we examine revising the Social Communication Questionnaire (SCQ), a commonly used screening instrument for Autism Spectrum Disorder. A combination of Item Response Theory and Mokken scaling techniques were utilized to achieve this and abbreviated scoring of the SCQ is suggested. The psychometric sensitivity of this abbreviated SCQ was examined via bootstrapped Receiver Operator Characteristic (ROC) curve analyses. Additionally, we examined the sensitivity of the abbreviated and total scaled SCQ as it relates to a potential diagnosis of Social (Pragmatic) Communication Disorder (SCD). As SCD is a new disorder introduced with the fifth edition of the Diagnostic and Statistical Manual (DSM-5), we identified individuals with potential diagnosis of SCD among individuals with ASD via mixture modeling techniques using the same NDAR data. These analyses revealed two classes or clusters of individuals when considering the two core areas of impairment among individuals with ASD: social communication and restricted, repetitive patterns of behavior. 45 / 1021 Secondary Analysis Shared
Psychometric Analysis of the Social Communication Questionnaire Using an Item-Response Theory Framework: Implications for the Use of the Lifetime and Current Forms The Social Communication Questionnaire (SCQ) was developed as a screener of Autism Spectrum Disorder (ASD). To date, the majority of the SCQ utility studies focused on its external validity (e.g., ROC curve analyses), but very few have addressed the internal validity issues. With samples consisting of 2,134 individuals available from the National Database for Autism Research (NDAR), the current study examined the factor structure, item-level characteristics, and measurement equivalence of the SCQ forms (i.e., Lifetime form and Current form) using both the classical true score theory and the item response theory (IRT). While our findings indicate sufficient psychometric properties of the SCQ Lifetime form, measurement issues emerged with respect to the SCQ Current form. These issues include lower internal consistencies, a weaker factor structure, lower item discriminations, significant pseudo-guessing effects, and subscale-level measurement bias. Thus, we caution researchers and clinicians about the use of the SCQ Current form. In particular, it seems inappropriate to use the Current form as an alternative to the Lifetime form among children younger than 5 years old or under other special situations (e.g., teacher-report data), although such practices were advised by the publisher of the SCQ. Instead, we recommend modifying the wording of the Lifetime form items rather than switching to the Current form where a 3-month timeframe is specified for responding to SCQ items. Future studies may consider investigating the association between the temporality of certain behaviors and the individual’s potential for being diagnosed with ASD, as well as the age neutrality of the SCQ. 4 / 2134 Secondary Analysis Shared
* Data not on individual level