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Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Characterizing mechanistic heterogeneity across ADHD and Autism
Fair, Damien A 
Progress in establishing the etiology of psychiatric illness is limited by the absence of objective biological measures able to detect and discriminate between disorders. This problem is particularly important in developmental disorders, where early identification could eventually assist in prevention of life long impairments. The two earliest onset, most common, and costly developmental disorders in child psychiatry are attention deficit hyperactivity disorder (ADHD) and Autism spectrum disorders (ASD). A recent 2011 study, surveying the years 1997-2008, has now verified that 1 in 6 children have a developmental disability, a 17% increase over the past decade driven largely by increases in ASD and ADHD. These developments highlight the need for innovative approaches to address the underlying cause of these disorders. It is likely that the clinical heterogeneity and the imprecise nature of their nosological distinctions represent fundamentally confounding factors limiting a better understanding of their etiology, prevention, and treatment. Interestingly, an emerging observation regarding brain imaging in ASD and ADHD is that they often have the same atypical functional brain signatures. However, because these two syndromes are almost exclusively studied separately, it is difficult to determine atypical brain function that is common, compared to what is distinct for each disorder. If we are to improve our understanding regarding the underlying etiology of these disorders, it will be necessary to study these populations simultaneously. With that said, simply comparing groups of children based on their DSM diagnosis is unlikely to suffice. The behavioral and biological heterogeneity within each syndrome further complicates the meaning of any given group difference found in brain imaging. Thus, progress in our understanding requires not only examining these disorders in the same studies, but also identifying how brain signatures relate to distinct behavioral components (i.e., endophenotypes) that span the syndromes. Under this context, and consistent with NIMHs new strategic plan, Strategy 1.4 (also see RDoC), the current proposal aims to use resting state functional connectivity MRI (rsfcMRI) and structural connectivity (DTI) to identify brain signatures that correspond to fundamental behavioral components (executive, facial recognition, and affect recognition) found in ADHD and, or ASD. We also aim to develop integrated, multimodal sub-classifications (i.e. neurotypes) or biosignatures of these disorders with computational tools that include Graph Theory and support vector machine (SVM) based pattern classification. The potential impact of the proposed mechanistic categorization on future functional, genetic, treatment, and other translational studies of ADHD and ASD are substantial.
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NIH - Extramural None

R01MH096773-01 Characterizing mechanistic heterogeneity across ADHD and Autism 08/06/2012 05/31/2018 323 259 OREGON HEALTH & SCIENCE UNIVERSITY $3,045,389.00

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To create a new Omics, eye tracking, fMRI, or EEG experiment, press the "+ New Experiment" button. Once an experiment is created, then raw files for these types of experiments should be provided, associating the experiment – through Experiment_ID – with the metadata defined in the experiments interface.

IDNameCreated DateStatusType
No records found.

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Shared Data

Data structures with the number of subjects submitted and shared are provided.

ADHD Rating Scale Clinical Assessments 234
Autism Diagnostic Interview, Revised (ADI-R) Clinical Assessments 73
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 3 Clinical Assessments 72
BASC Parent Rating Scale Adolescent Clinical Assessments 76
BASC Parent Rating Scale Child Clinical Assessments 125
Children's Communication Checklist - 2 Clinical Assessments 278
Conners 3 - Parent Short Clinical Assessments 231
Demographics Short Form Clinical Assessments 293
Research Subject Clinical Assessments 41
Social Communication Questionnaire (SCQ) - Current Form Clinical Assessments 138
Strengths and Difficulties Questionnaire Clinical Assessments 222

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:


Publications relevant to NDAR data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed IDStudyTitleJournalAuthorsDateStatus
27477019Create StudyThe Rhesus Monkey Connectome Predicts Disrupted Functional Networks Resulting from Pharmacogenetic Inactivation of the Amygdala.NeuronGrayson DS, Bliss-Moreau E, Machado CJ, Bennett J, Shen K, Grant KA, Fair DA, Amaral DGJuly 2016Not Relevant
27050322Create StudyPrenatal domoic acid exposure disrupts mouse pro-social behavior and functional connectivity MRI.Behavioural brain researchMills BD, Pearce HL, Khan O, Jarrett BR, Fair DA, Lahvis GPJuly 15, 2016Not Relevant
26499255Create StudyImplications of newborn amygdala connectivity for fear and cognitive development at 6-months-of-age.Developmental cognitive neuroscienceGraham AM, Buss C, Rasmussen JM, Rudolph MD, Demeter DV, Gilmore JH, Styner M, Entringer S, Wadhwa PD, Fair DAOctober 3, 2015Not Determined
25809052Create StudyEarly life stress is associated with default system integrity and emotionality during infancy.Journal of child psychology and psychiatry, and allied disciplinesGraham AM, Pfeifer JH, Fisher PA, Carpenter S, Fair DANovember 2015Not Determined
25714740Create StudyCommentary: Developmental connectomics to advance our understanding of typical and atypical brain development--a commentary on Vértes and Bullmore (2015).Journal of child psychology and psychiatry, and allied disciplinesGraham, Alice M; Fair, Damien AMarch 2015Not Relevant
25660033Create StudyCharacterizing heterogeneity in children with and without ADHD based on reward system connectivity.Developmental cognitive neuroscienceCosta Dias TG, Iyer SP, Carpenter SD, Cary RP, Wilson VB, Mitchell SH, Nigg JT, Fair DAFebruary 2015Not Determined
25512496Create StudyLarge-scale topology and the default mode network in the mouse connectome.Proceedings of the National Academy of Sciences of the United States of AmericaStafford JM, Jarrett BR, Miranda-Dominguez O, Mills BD, Cain N, Mihalas S, Lahvis GP, Lattal KM, Mitchell SH, David SV, Fryer JD, Nigg JT, Fair DADecember 30, 2014Not Determined
25459874Create StudyThe potential of infant fMRI research and the study of early life stress as a promising exemplar.Developmental cognitive neuroscienceGraham, Alice M; Pfeifer, Jennifer H; Fisher, Philip A; Lin, Weili; Gao, Wei; Fair, Damien AApril 2015Not Relevant
25386919Create StudyConnectotyping: model based fingerprinting of the functional connectome.PloS oneMiranda-Dominguez O, Mills BD, Carpenter SD, Grant KA, Kroenke CD, Nigg JT, Fair DA2014Not Determined
25312831Create StudySex differences in the neural substrates of spatial working memory during adolescence are not mediated by endogenous testosterone.Brain researchAlarcón G, Cservenka A, Fair DA, Nagel BJDecember 17, 2014Not Determined
25307115Create StudyResearch review: Functional brain connectivity and child psychopathology--overview and methodological considerations for investigators new to the field.Journal of child psychology and psychiatry, and allied disciplinesMatthews, Marguerite; Fair, Damien AApril 2015Not Relevant
25233316Create StudyUnraveling the miswired connectome: a developmental perspective.NeuronDi Martino A, Fair DA, Kelly C, Satterthwaite TD, Castellanos FX, Thomason ME, Craddock RC, Luna B, Leventhal BL, Zuo XN, Milham MPSeptember 17, 2014Not Determined
25212412Create StudyDietary intervention rescues maternal obesity induced behavior deficits and neuroinflammation in offspring.Journal of neuroinflammationKang SS, Kurti A, Fair DA, Fryer JD2014Not Determined
25116862Create StudyStructural and functional connectivity of the human brain in autism spectrum disorders and attention-deficit/hyperactivity disorder: A rich club-organization study.Human brain mappingRay S, Miller M, Karalunas S, Robertson C, Grayson DS, Cary RP, Hawkey E, Painter JG, Kriz D, Fombonne E, Nigg JT, Fair DADecember 2014Not Determined
25006969Create StudySubtyping attention-deficit/hyperactivity disorder using temperament dimensions: toward biologically based nosologic criteria.JAMA psychiatryKaralunas SL, Fair D, Musser ED, Aykes K, Iyer SP, Nigg JTSeptember 2014Not Determined
24890898Create StudyEmotional processing and brain activity in youth at high risk for alcoholism.Alcoholism, clinical and experimental researchCservenka A, Fair DA, Nagel BJJuly 2014Not Determined
24741045Create StudyBridging the gap between the human and macaque connectome: a quantitative comparison of global interspecies structure-function relationships and network topology.The Journal of neuroscience : the official journal of the Society for NeuroscienceMiranda-Dominguez O, Mills BD, Grayson D, Woodall A, Grant KA, Kroenke CD, Fair DAApril 16, 2014Not Determined
24642753Create StudyOrganizing heterogeneous samples using community detection of GIMME-derived resting state functional networks.PloS oneGates KM, Molenaar PC, Iyer SP, Nigg JT, Fair DA2014Not Determined
24505468Create StudyStructural and functional rich club organization of the brain in children and adults.PloS oneGrayson DS, Ray S, Carpenter S, Iyer S, Dias TG, Stevens C, Nigg JT, Fair DA2014Not Determined
24501348Create StudyDietary omega-3 fatty acids modulate large-scale systems organization in the rhesus macaque brain.The Journal of neuroscience : the official journal of the Society for NeuroscienceGrayson DS, Kroenke CD, Neuringer M, Fair DAFebruary 5, 2014Not Determined
24440571Create StudyResting state functional connectivity of the nucleus accumbens in youth with a family history of alcoholism.Psychiatry researchCservenka A, Casimo K, Fair DA, Nagel BJMarch 30, 2014Not Determined
24214656Create StudyAttention deficit hyperactivity disorder.Current topics in behavioral neurosciencesMatthews M, Nigg JT, Fair DA2014Not Determined
24078018Create StudyUnderconnectivity of the superior temporal sulcus predicts emotion recognition deficits in autism.Social cognitive and affective neuroscienceAlaerts K, Woolley DG, Steyaert J, Di Martino A, Swinnen SP, Wenderoth NOctober 2014Not Determined
23774715Create StudyThe autism brain imaging data exchange: towards a large-scale evaluation of the intrinsic brain architecture in autism.Molecular psychiatryDi Martino A, Yan CG, Li Q, Denio E, Castellanos FX, Alaerts K, Anderson JS, Assaf M, Bookheimer SY, Dapretto M, Deen B, Delmonte S, Dinstein I, Ertl-Wagner B, Fair DA, Gallagher L, Kennedy DP, Keown CL, Keysers C, Lainhart JE, Lord C, Luna B, Menon V, Minshew NJ, Monk CS, et al.June 2014Not Determined
23501054Create StudyInferring functional connectivity in MRI using Bayesian network structure learning with a modified PC algorithm.NeuroImageIyer SP, Shafran I, Grayson D, Gates K, Nigg JT, Fair DAJuly 15, 2013Not Determined
23206930Create StudyReward circuit connectivity relates to delay discounting in children with attention-deficit/hyperactivity disorder.European neuropsychopharmacology : the journal of the European College of NeuropsychopharmacologyCosta Dias TG, Wilson VB, Bathula DR, Iyer SP, Mills KL, Thurlow BL, Stevens CA, Musser ED, Carpenter SD, Grayson DS, Mitchell SH, Nigg JT, Fair DAJanuary 2013Not Determined

Relevant Publications
PubMed IDStudyTitleJournalAuthorsDate
No records found.
Data Expected
Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
ADHD Rating Scale info iconApproved
Research Subject and Pedigree info iconApproved
Demographics info iconApproved
Childrens Communication Checklist-2 (CCC-2) info iconApproved
Behavior Assessment System for Children (BASC) info iconApproved
Broad Psychopathology Form info iconApproved
ADI-R info iconApproved
Conners info iconApproved
Kiddie-Sads (K-SADS) info iconApproved
Social Communication Questionnaire (SCQ) info iconApproved
Imaging (Structural, fMRI, DTI, PET, microscopy) info iconApproved
ADOS info iconApproved
Structure not yet defined

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.