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NDAR provides a single access to de-identified autism research data. For permission to download data, you will need an NDAR account with approved access to NDAR or a connected repository (AGRE, IAN, or the ATP). For NDAR access, you need to be a research investigator sponsored by an NIH recognized institution with federal wide assurance. See Request Access for more information.

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1 Numbers reported are subjects by age
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Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

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SelectExperiment IdExperiment NameExperiment Type
  • Select One
  • EEG
  • EGG
  • Eye Tracking
  • Omics
  • fMRI
Created On
886RestfMRI02/14/2018
885SARTfMRI02/14/2018
884Plasma metabolic profileOmics02/05/2018
878Social Challenge AssessmentEye Tracking01/26/2018
877PRV-005-EEGEEG01/22/2018
876Mixed Anti and Pro (vgs) saccade mixed blocked eye trackingEye Tracking01/22/2018
875Attention modulation taskEye Tracking01/17/2018
874ruthldopa resting 17 and 18fMRI01/16/2018
873ruthldopa resting 15 and 16fMRI01/16/2018
872ruthldopa resting 13 and 14fMRI01/16/2018
871ruthldopa resting 11 and 12fMRI01/16/2018
870Resting State fMRIfMRI01/12/2018
869cyberballfMRI01/12/2018
868MDD_PilotfMRI01/12/2018
867Velten Mood Induction State-ItemfMRI01/12/2018
866Emotional Hemifield Task (EHT)EEG01/12/2018
865Genome EditingOmics01/12/2018
864parvizi_eeg_118EEG01/12/2018
863parvizi_eeg_117EEG01/12/2018
862parvizi_eeg_116EEG01/12/2018
861parvizi_eeg_115EEG01/12/2018
860parvizi_eeg_114EEG01/12/2018
859parvizi_eeg_113EEG01/12/2018
858PRV-003-EEGEEG01/12/2018
857PRV-004-EEGEEG01/12/2018
856PRV-007-EEGEEG01/12/2018
855Regulating Emotional Responses to Visual Images Across the Affective Instability SpectrumfMRI01/12/2018
854PRV-002-EEGEEG01/12/2018
853R61 Ezogabine Resting State FMRIfMRI01/11/2018
852Paired AssociatesfMRI01/11/2018
851PRV-001-EEGEEG01/11/2018
850Reward ProcessingfMRI01/11/2018
849Resting EEG (1024 samples/s)EEG01/11/2018
845Fast face -1 runfMRI01/10/2018
844MIST_MAST_fMRIfMRI01/10/2018
843RTT AHA-1Omics01/09/2018
84230 words (simultaneous fMRI and EEG acquisition)EEG01/08/2018
841Neural Correlates of Episodic Retrieval fMRI01/08/2018
84030 words (simultaneous fMRI and EEG acquisition)fMRI01/08/2018
838Memory Guided Saccade Encode and Maintenance v3fMRI01/05/2018
837Memory Guided Saccade Encode and Maintenance v2fMRI01/05/2018
836Food ExposurefMRI01/03/2018
835Model ExposurefMRI01/02/2018
834BlankingEye Tracking12/28/2017
833DoubleStepEye Tracking12/26/2017
832Memory Guided Saccade Encode and Maintenance v1 fMRI12/21/2017
831Mixed Anti and Pro (vgs) saccade mixed blocked taskfMRI12/21/2017
830T1 AlternativefMRI12/19/2017
829fMRI Movie Trailer Video 2fMRI12/18/2017
828fMRI Movie Trailer Video 1fMRI12/18/2017
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Shared

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

General

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Clinical Trials

For clinical trials, the option to link to the clinical trial in clinicaltrials.gov is optionally provided.

Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
A Family-Genetic Study of Autism and Fragile X Syndrome
Molly C. Losh 
Fragile X syndrome (FXS) is associated with an increased risk of autism, with prevalence rates ranging from 25-50%. This translates to an approximate relative risk of over 100, indicating that FMR1 (the gene causing FXS) confers considerable vulnerability to autism. While efforts to uncover the causal mechanisms in autism are often confounded by multiple unknown etiologies, genetically defined syndromes such as FXS provide the rare opportunity to examine gene-brain-behavior associations in an etiologically homogeneous condition. This project is an attempt to inform the role of FMR1 in autism symptomatology through the study of 1st degree relatives who are at increased genetic liability - relatives of individuals with autism and relatives of individuals with FXS, who are carriers of the FMR1 premutation. This project builds on our prior studies of autism and the broad autism phenotype (BAP), to examine key developmental, clinical, language, and social cognitive phenotypes shown to cosegregate with autism and the BAP. We propose to examine these phenotypes among FXS carriers in comparison to data collected from 1st degree relatives of individuals with autism, to identify potentially overlapping profiles across groups, which may be linked to FMR1. These analyses capitalize on an unprecedented opportunity -- the availability of archival childhood language and cognitive testing records from a large cohort of families of individuals with FXS and autism. Using these highly valuable data, we will characterize longitudinally the language and cognitive development of autism and FXS relatives over the early school-age years, and examine downstream outcomes across clinical, language, and social cognitive domains. Phenotypes will be examined in relation to FMR1 variation and expression of FMRP, the fragile X-mental retardation protein that is deficient in FXS and is believed to cause the cognitive and behavioral impairments in FXS. The proposed project will help to refine current understanding of the role of FMR1 in autism symptomatology, and further characterize the phenotype of the fragile X premutation.
NDAR
Enrolling
Shared
$3,838,034.00
250
440
121
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NIH - Extramural None


R01MH091131-01 A Family-Genetic Study of Autism and Fragile X Syndrome 05/01/2012 03/31/2018 440 121 NORTHWESTERN UNIVERSITY $3,838,034.00

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Experiments

To create a new Omics, eye tracking, fMRI, or EEG experiment, press the "+ New Experiment" button. Once an experiment is created, then raw files for these types of experiments should be provided, associating the experiment – through Experiment_ID – with the metadata defined in the experiments interface.

IDNameCreated DateStatusType
No records found.

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Shared Data

Data structures with the number of subjects submitted and shared are provided.

FXS Demographics Clinical Assessments 250
Genomics Genetic Test Genomics 151
Research Subject Clinical Assessments 242
Wechsler Abbreviated Scale of Intelligence (WASI) Clinical Assessments 113

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDAR data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed IDStudyTitleJournalAuthorsDateStatus
28654411Create StudyA Multi-Method Investigation of Pragmatic Development in Individuals With Down Syndrome.American journal on intellectual and developmental disabilitiesLee M, Bush L, Martin GE, Barstein J, Maltman N, Klusek J, Losh MJuly 2017Not Relevant
28161297Study (449)Signaling of noncomprehension in communication breakdowns in fragile X syndrome, Down syndrome, and autism spectrum disorder.Journal of communication disordersMartin GE, Barstein J, Hornickel J, Matherly S, Durante G, Losh MJanuary 2017Not Relevant
28095705Create StudyWhat's the story? A computational analysis of narrative competence in autism.Autism : the international journal of research and practiceLee M, Martin GE, Hogan A, Hano D, Gordon PC, Losh MJanuary 1, 2017Not Relevant
28070788Create StudyDevelopmental Markers of Genetic Liability to Autism in Parents: A Longitudinal, Multigenerational Study.Journal of autism and developmental disordersLosh M, Martin GE, Lee M, Klusek J, Sideris J, Barron S, Wassink TMarch 2017Not Relevant
28050218Create StudyA developmental, longitudinal investigation of autism phenotypic profiles in fragile X syndrome.Journal of neurodevelopmental disordersLee M, Martin GE, Berry-Kravis E, Losh MJanuary 2016Not Relevant
26212380Create StudyNeurological and endocrine phenotypes of fragile X carrier women.Clinical geneticsHall D, Todorova-Koteva K, Pandya S, Bernard B, Ouyang B, Walsh M, Pounardjian T, Deburghraeve C, Zhou L, Losh M, Leehey M, Berry-Kravis EJanuary 2016Not Relevant
25420222Create StudyCardiac autonomic regulation in autism and Fragile X syndrome: a review.Psychological bulletinKlusek, Jessica; Roberts, Jane E; Losh, MollyJanuary 2015Not Relevant
25097672Create StudyAssociated features in females with an FMR1 premutation.Journal of neurodevelopmental disordersWheeler AC, Bailey DB, Berry-Kravis E, Greenberg J, Losh M, Mailick M, Milà M, Olichney JM, Rodriguez-Revenga L, Sherman S, Smith L, Summers S, Yang JC, Hagerman RJanuary 2014Not Relevant
24686468Create StudyA comparison of pragmatic language in boys with autism and fragile X syndrome.Journal of speech, language, and hearing research : JSLHRKlusek J, Martin GE, Losh MOctober 2014Not Relevant
24528851Create StudyConsistency between research and clinical diagnoses of autism among boys and girls with fragile X syndrome.Journal of intellectual disability research : JIDRKlusek J, Martin GE, Losh MOctober 2014Not Relevant
24432860Create StudyPhysiological arousal in autism and fragile X syndrome: group comparisons and links with pragmatic language.American journal on intellectual and developmental disabilitiesKlusek J, Martin GE, Losh MNovember 2013Not Relevant
23889838Create StudyLongitudinal profiles of expressive vocabulary, syntax and pragmatic language in boys with fragile X syndrome or Down syndrome.International journal of language & communication disorders / Royal College of Speech & Language TherapistsMartin GE, Losh M, Estigarribia B, Sideris J, Roberts J2013 Jul-AugNot Relevant
23188882Create StudySex differences and within-family associations in the broad autism phenotype.Autism : the international journal of research and practiceKlusek J, Losh M, Martin GEFebruary 2014Not Relevant
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Relevant Publications
PubMed IDStudyTitleJournalAuthorsDate
No records found.
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Data Expected
Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
Pragmatic Protocol info iconApproved
Research Subject and Pedigree info iconApproved
Genetic Test info iconApproved
Wechsler Abbreviated Scale of Intelligence (WASI) info iconApproved
Demographics info iconApproved
genomics/omics info iconApproved
Wechsler Preschool Primary Scale Intelligence (WPPSI) info iconApproved
Trustworthiness of Faces info iconApproved
Movie Stills Task info iconApproved
Rapid Automatized Naming (RAN) info iconApproved
Mini-International Neuropsychiatric Interview (MINI) info iconApproved
Iowa Test of Basic Skills (ITBS) info iconApproved
Wechsler Intelligence Scale for Children info iconApproved
Physical Exam info iconApproved
Modified Personality Assessment Schedule-Revised (MPAS-R) info iconApproved
ADOS info iconApproved
ADI-R info iconApproved
Broad Autism Phenotype Questionnaire (BAPQ) info iconApproved
Social Responsiveness Scale (SRS) info iconApproved
Structure not yet defined

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

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