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NDAR provides a single access to de-identified autism research data. For permission to download data, you will need an NDAR account with approved access to NDAR or a connected repository (AGRE, IAN, or the ATP). For NDAR access, you need to be a research investigator sponsored by an NIH recognized institution with federal wide assurance. See Request Access for more information.

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1 Numbers reported are subjects by age
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Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

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SelectExperiment IdExperiment NameExperiment Type
  • Select One
  • EEG
  • EGG
  • Eye Tracking
  • Omics
  • fMRI
Created On
909Resting State Post-Stress Visit 1fMRI04/20/2018
908Resting State Pre-Stress Visit 1fMRI04/20/2018
907Montreal Imaging Stress Task Visit 1fMRI04/18/2018
9062-back Post-Stress Visit 1fMRI04/18/2018
9051-back Post-Stress Visit 1fMRI04/18/2018
9040-back Post-Stress Visit 1fMRI04/18/2018
9032-back Pre-Stress Visit 1fMRI04/18/2018
9021-back Pre-Stress Visit 1fMRI04/18/2018
9010-back Pre-Stress Visit 1fMRI04/18/2018
900DTIfMRI04/11/2018
899Investigating a Neurobehavioral Mechanism of Paranoia - Resting State ScansfMRI04/06/2018
898FAST-POMAfMRI04/03/2018
897parvizi_eeg_109EEG03/19/2018
896parvizi_eeg_107EEG03/19/2018
895parvizi_eeg_106EEG03/19/2018
894Dot ProbeEye Tracking03/07/2018
893Startle Habituation and Shock Sensitivity EvaluationEEG03/03/2018
892NPU EEG Task EEG03/03/2018
891Duke ACE ETEye Tracking03/02/2018
888Emotion 1.1 Determining context effects during potential threatfMRI02/26/2018
886RestfMRI02/14/2018
885SARTfMRI02/14/2018
884Plasma metabolic profileOmics02/05/2018
878Social Challenge AssessmentEye Tracking01/26/2018
877PRV-005-EEGEEG01/22/2018
876Mixed Anti and Pro (vgs) saccade mixed blocked (EyeTracking)Eye Tracking01/22/2018
875Attention modulation taskEye Tracking01/17/2018
874ruthldopa resting 17 and 18fMRI01/16/2018
873ruthldopa resting 15 and 16fMRI01/16/2018
872ruthldopa resting 13 and 14fMRI01/16/2018
871ruthldopa resting 11 and 12fMRI01/16/2018
870Resting State fMRIfMRI01/12/2018
869cyberballfMRI01/12/2018
868MDD_PilotfMRI01/12/2018
867Velten Mood Induction State-ItemfMRI01/12/2018
866Emotional Hemifield Task (EHT)EEG01/12/2018
865Genome EditingOmics01/12/2018
864parvizi_eeg_118EEG01/12/2018
863parvizi_eeg_117EEG01/12/2018
862parvizi_eeg_116EEG01/12/2018
861parvizi_eeg_115EEG01/12/2018
860parvizi_eeg_114EEG01/12/2018
859parvizi_eeg_113EEG01/12/2018
858PRV-003-EEGEEG01/12/2018
857PRV-004-EEGEEG01/12/2018
856PRV-007-EEGEEG01/12/2018
855Regulating Emotional Responses to Visual Images Across the Affective Instability SpectrumfMRI01/12/2018
854PRV-002-EEGEEG01/12/2018
853R61 Ezogabine Resting State FMRIfMRI01/11/2018
852Paired AssociatesfMRI01/11/2018
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Shared

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For clinical trials, the option to link to the clinical trial in clinicaltrials.gov is optionally provided.

Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Methylomic and genomic impacts of organic pollutants in Dup15q syndrome
Janine LaSalle 
This study is designed to test a novel paradigm that the human genome dynamically interacts with the environment and that epigenetic mechanisms are at the interface of genome environment interactions. This study is designed to experimentally determine if PCB-95 and/or BDE-47 play a causal or compounding role in structural rearrangements of 15q using combined genomic and epigenomic approaches. In addition, this study will directly investigate the effect of combined genomic and environmental insults on the integrity of the methylome and transcriptome in human brain samples. The first aim seeks to experimentally model chromosome 15 duplication in a novel human cell line system to examine effects of PCB-95 or BDE-47 exposures on genomic stability (DNA-seq) and DNA methylation (MethylC-seq) using next generation sequencing technology. In the second aim, the effect of genetic and epigenetic changes on long-range chromatin loop structure within 15q11-q13 will be examined by chromatin conformation capture sequencing (4C-seq) and correlated to specific transcriptional alterations. The third aim seeks to directly investigate specific 15q gene targets for epigenetic and transcriptional changes in human brain samples with and without chromosome 15 duplication and high PCB-95 levels. The results of these studies are expected to formally test the hypothesis that DNA methylation levels reduced by specific environmental pollutants may result in genomic rearrangements and alterations in long-range chromatin,leading to transcriptional changes. In addition, epigenetic alterations of autism candidate genes involved in synaptogenesis in human brain samples are expected to be uncovered by this approach. Finally, the results of these studies are expected to be broadly relevant to understanding the relationship between the genome, environmental exposures, and the epigenome in human health and disease.
NDAR
Funding Completed
Shared
$1,840,993.00
0
0
0
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NIH - Extramural None


R01ES021707-01 Methylomic and genomic impacts of organic pollutants in Dup15q syndrome 06/12/2012 09/29/2017 Not Reported Not Reported UNIVERSITY OF CALIFORNIA AT DAVIS $1,840,993.00

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Experiments

To create a new Omics, eye tracking, fMRI, or EEG experiment, press the "+ New Experiment" button. Once an experiment is created, then raw files for these types of experiments should be provided, associating the experiment – through Experiment_ID – with the metadata defined in the experiments interface.

IDNameCreated DateStatusType
362MARBLES placenta MethylC-seq07/28/2015ApprovedOmics

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Shared Data

Data structures with the number of subjects submitted and shared are provided.

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Publications

Publications relevant to NDAR data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed IDStudyTitleJournalAuthorsDateStatus
29016856Create StudyNeuronal overexpression of Ube3a isoform 2 causes behavioral impairments and neuroanatomical pathology relevant to 15q11.2-q13.3 duplication syndrome.Human molecular geneticsCopping NA, Christian SGB, Ritter DJ, Islam MS, Buscher N, Zolkowska D, Pride MC, Berg EL, Lasalle JM, Ellegood J, Lerch JP, Reiter LT, Silverman JL, Dindot SVOctober 2017Not Determined
28925810Create StudyUBE3A-mediated regulation of imprinted genes and epigenome-wide marks in human neurons.EpigeneticsLopez SJ, Dunaway K, Islam MS, Mordaunt C, Vogel Ciernia A, Meguro-Horike M, Horike SI, Segal DJ, Lasalle JMSeptember 2017Not Determined
28781890Create StudySelf-reported pregnancy exposures and placental DNA methylation in the MARBLES prospective autism sibling study.Environmental epigeneticsSchmidt RJ, Schroeder DI, Crary-Dooley FK, Barkoski JM, Tancredi DJ, Walker CK, Ozonoff S, Hertz-Picciotto I, Lasalle JMDecember 2016Not Relevant
28362264Create StudySmall-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group.Environmental health perspectivesBreton CV, Marsit CJ, Faustman E, Nadeau K, Goodrich JM, Dolinoy DC, Herbstman J, Holland N, Lasalle JM, Schmidt R, Yousefi P, Perera F, Joubert BR, Wiemels J, Taylor M, Yang IV, Chen R, Hew KM, Freeland DM, Miller R, Murphy SKApril 2017Not Relevan
28032673Create StudyDental Pulp Stem Cells Model Early Life and Imprinted DNA Methylation Patterns.Stem cells (Dayton, Ohio)Dunaway K, Goorha S, Matelski L, Urraca N, Lein PJ, Korf I, Reiter LT, Lasalle JMDecember 2016Not Relevant
28018572Create StudyPlacental methylome analysis from a prospective autism study.Molecular autismSchroeder DI, Schmidt RJ, Crary-Dooley FK, Walker CK, Ozonoff S, Tancredi DJ, Hertz-Picciotto I, Lasalle JMJanuary 2016Not Determined
27974215Create StudyCumulative Impact of Polychlorinated Biphenyl and Large Chromosomal Duplications on DNA Methylation, Chromatin, and Expression of Autism Candidate Genes.Cell reportsDunaway KW, Islam MS, Coulson RL, Lopez SJ, Vogel Ciernia A, Chu RG, Yasui DH, Pessah IN, Lott P, Mordaunt C, Meguro-Horike M, Horike SI, Korf I, Lasalle JMDecember 2016Not Determined
27611852Create StudyWilson Disease: Epigenetic effects of choline supplementation on phenotype and clinical course in a mouse model.EpigeneticsMedici V, Kieffer DA, Shibata NM, Chima H, Kim K, Canovas A, Medrano JF, Islas-Trejo AD, Kharbanda KK, Olson K, Su RJ, Islam MS, Syed R, Keen CL, Miller AY, Rutledge JC, Halsted CH, Lasalle JMNovember 2016Not Relevant
27150399Create StudyThe landscape of DNA methylation amid a perfect storm of autism aetiologies.Nature reviews. NeuroscienceCiernia AV, Lasalle JJuly 2016Not Relevant
26830258Create StudyAutism and Cancer Share Risk Genes, Pathways, and Drug Targets.Trends in genetics : TIGCrawley JN, Heyer WD, LaSalle JMMarch 2016Not Relevant
26585570Create StudyEpigenetic regulation of UBE3A and roles in human neurodevelopmental disorders.EpigenomicsLaSalle JM, Reiter LT, Chamberlain SJOctober 2015Not Determined
26241857Create StudyEarly Developmental and Evolutionary Origins of Gene Body DNA Methylation Patterns in Mammalian Placentas.PLoS geneticsSchroeder DI, Jayashankar K, Douglas KC, Thirkill TL, York D, Dickinson PJ, Williams LE, Samollow PB, Ross PJ, Bannasch DL, Douglas GC, LaSalle JMAugust 2015Not Determined
26105183Create StudyEpigenetic mechanisms in diurnal cycles of metabolism and neurodevelopment.Human molecular geneticsPowell WT, Lasalle JMOctober 15, 2015Not Relevant
24810691Create StudyCharacterization of timed changes in hepatic copper concentrations, methionine metabolism, gene expression, and global DNA methylation in the Jackson toxic milk mouse model of Wilson disease.International journal of molecular sciencesLe A, Shibata NM, French SW, Kim K, Kharbanda KK, Islam MS, Lasalle JM, Halsted CH, Keen CL, Medici V2014Not Relevant
24734033Create StudyGenome-wide analysis of DNA methylation, copy number variation, and gene expression in monozygotic twins discordant for primary biliary cirrhosis.Frontiers in immunologySelmi C, Cavaciocchi F, Lleo A, Cheroni C, De Francesco R, Lombardi SA, De Santis M, Meda F, Raimondo MG, Crotti C, Folci M, Zammataro L, Mayo MJ, Bach N, Shimoda S, Gordon SC, Miozzo M, Invernizzi P, Podda M, Scavelli R, Martin MR, Seldin MF, Lasalle JM, Gershwin ME2014Not Relevant
24730561Create StudyMethylation and gene expression responses to ethanol feeding and betaine supplementation in the cystathionine beta synthase-deficient mouse.Alcoholism, clinical and experimental researchMedici V, Schroeder DI, Woods R, LaSalle JM, Geng Y, Shibata NM, Peerson J, Hodzic E, Dayal S, Tsukamoto H, Kharbanda KK, Tillman B, French SW, Halsted CHJune 2014Not Relevant
24502430Create StudyA survey of seizures and current treatments in 15q duplication syndrome.EpilepsiaConant KD, Finucane B, Cleary N, Martin A, Muss C, Delany M, Murphy EK, Rabe O, Luchsinger K, Spence SJ, Schanen C, Devinsky O, Cook EH, Lasalle J, Reiter LT, Thibert RLMarch 2014Not Determined
24404383Create StudyAutism genes keep turning up chromatin.OA autismLasalle JMJune 19, 2013Not Determined
24283879Create StudyHow has the study of the human placenta aided our understanding of partially methylated genes?EpigenomicsSchroeder DI, LaSalle JMDecember 2013Not Determined
24220304Create StudyMaternal choline modifies fetal liver copper, gene expression, DNA methylation, and neonatal growth in the tx-j mouse model of Wilson disease.EpigeneticsMedici V, Shibata NM, Kharbanda KK, Islam MS, Keen CL, Kim K, Tillman B, French SW, Halsted CH, LaSalle JMFebruary 2014Not Determined
23731492Create StudyEpigenetic layers and players underlying neurodevelopment.Trends in neurosciencesLaSalle JM, Powell WT, Yasui DHAugust 2013Not Determined
23677056Create StudyEpigenomic strategies at the interface of genetic and environmental risk factors for autism.Journal of human geneticsLaSalle JMJuly 2013Not Determined
23530188Create StudyThe human placenta methylome.Proceedings of the National Academy of Sciences of the United States of AmericaSchroeder DI, Blair JD, Lott P, Yu HO, Hong D, Crary F, Ashwood P, Walker C, Korf I, Robinson WP, LaSalle JMApril 9, 2013Not Determined
22945834Create StudyWilson's disease: changes in methionine metabolism and inflammation affect global DNA methylation in early liver disease.Hepatology (Baltimore, Md.)Medici V, Shibata NM, Kharbanda KK, LaSalle JM, Woods R, Liu S, Engelberg JA, Devaraj S, Török NJ, Jiang JX, Havel PJ, Lönnerdal B, Kim K, Halsted CHFebruary 2013Not Determined
22930557Create StudyLevels of select PCB and PBDE congeners in human postmortem brain reveal possible environmental involvement in 15q11-q13 duplication autism spectrum disorder.Environmental and molecular mutagenesisMitchell MM, Woods R, Chi LH, Schmidt RJ, Pessah IN, Kostyniak PJ, LaSalle JMOctober 2012Not Determined
22861365Create StudyX chromosome gene methylation in peripheral lymphocytes from monozygotic twins discordant for scleroderma.Clinical and experimental immunologySelmi C, Feghali-Bostwick CA, Lleo A, Lombardi SA, De Santis M, Cavaciocchi F, Zammataro L, Mitchell MM, Lasalle JM, Medsger T, Gershwin MESeptember 2012Not Determined
22343140Create StudyLong-lived epigenetic interactions between perinatal PBDE exposure and Mecp2308 mutation.Human molecular geneticsWoods R, Vallero RO, Golub MS, Suarez JK, Ta TA, Yasui DH, Chi LH, Kostyniak PJ, Pessah IN, Berman RF, LaSalle JMJune 1, 2012Not Determined
22207353Create StudyRole of DNMT3B in the regulation of early neural and neural crest specifiers.EpigeneticsMartins-Taylor K, Schroeder DI, LaSalle JM, Lalande M, Xu RHJanuary 1, 2012Not Determined
22152151Create StudyIncreased copy number for methylated maternal 15q duplications leads to changes in gene and protein expression in human cortical samples.Molecular autismScoles HA, Urraca N, Chadwick SW, Reiter LT, Lasalle JM2011Not Determined
21725066Create StudyNeuron-specific impairment of inter-chromosomal pairing and transcription in a novel model of human 15q-duplication syndrome.Human molecular geneticsMeguro-Horike M, Yasui DH, Powell W, Schroeder DI, Oshimura M, Lasalle JM, Horike SOctober 1, 2011Not Determined
21617367Create StudyA genomic point-of-view on environmental factors influencing the human brain methylome.EpigeneticsLaSalle JMJuly 2011Not Determined
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Relevant Publications
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Data Expected
Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
Research Subject and Pedigree info iconApproved
genomics/omics info iconApproved
Structure not yet defined

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study NameAbstractCollection/Study SubjectsData UsageState
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