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NDAR provides a single access to de-identified autism research data. For permission to download data, you will need an NDAR account with approved access to NDAR or a connected repository (AGRE, IAN, or the ATP). For NDAR access, you need to be a research investigator sponsored by an NIH recognized institution with federal wide assurance. See Request Access for more information.

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Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Networked Cortical Responses to Movement Associated with ASD
Michael Murias 
This project examines three different networks (mu, beta, gamma) of brain activity that respond when people view scenes involving motion. We measure these network activities by recording electroencephalographic (EEG) responses to motion, and analyze their temporal, spectral, and spatial properties. In this proposal, we comprehensively characterize the brain response of fifty typically developing adults while they view and execute simple hand motions. The viewing of biological motion generates larger brain responses that non-biological motion, and there is evidence of altered brain response to biological motion in autism spectrum disorder (ASD). Results across studies have however been inconsistent. Likely causes of these inconsistencies are methodological differences in studies, and the heterogeneity of ASD. In this project we compare the brain response of fifty adults with ASD to age and IQ matched control participants while they view and execute the same simple hand motions. We will comprehensively assess the phenotypical behaviors characterizing the fifty individuals with autism, and correlate them with the brain network measurements. Based on previous literature, we expect to associate individuals with autism with atypical responses in one of the three brain networks. The novelty of this project is the comprehensive association of ASD phenotypes with two additional brain networks, which have not been previously studied in ASD populations. By examining a comprehensive network of brain networks associated with motion processing, we seek to establish phenotypical characteristics of individuals who exhibit specific atypical brain responses to biological motion. A goal of this research program is to identify biological markers for early diagnosis of ASD. To that end we propose to test thirty five year old children (half with ASD), and compare their brain responses to the same viewing and execution of simple hand motions. This will guide our understanding of the development of brain responses to motion, and assess their utility in the early diagnosis and treatment of ASD.
NDAR
Closed
Shared
$1,206,892.00
0
130
0
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NIH - Extramural None


R01MH094366-01 Networked Cortical Responses to Movement Associated with ASD 05/01/2012 04/30/2016 130 Not Reported DUKE UNIVERSITY $1,206,892.00

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IDNameCreated DateStatusType
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PubMed IDStudyTitleJournalAuthorsDateStatus
23733096Create StudyLocalized high gamma motor oscillations respond to perceived biologic motion.Journal of clinical neurophysiology : official publication of the American Electroencephalographic SocietyDarvas F, Rao RP, Murias MJune 2013Not Determined
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Relevant Publications
PubMed IDStudyTitleJournalAuthorsDate
No records found.
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Data Expected
Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
ADOS info iconApproved
Wechsler Abbreviated Scale of Intelligence (WASI) info iconApproved
Social Responsiveness Scale (SRS) info iconApproved
Social Communication Questionnaire (SCQ) info iconApproved
Physical Exam info iconApproved
Beery-Buktenica Developmental Test of Visual-Motor Integration info iconApproved
Research Subject and Pedigree info iconApproved
Communication Checklist - Adult info iconApproved
Childrens Communication Checklist-2 (CCC-2) info iconApproved
Peabody Picture Vocabulary Test, Fourth Edition info iconApproved
EEG info iconApproved
ADI-R info iconApproved
Vineland (Parent and Caregiver) info iconApproved
Expressive Vocabulary Test II (EVT II) info iconApproved
Structure not yet defined

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Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

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