National Database for Autism Research - Data

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Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

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Influence of Attention and Arousal on Sensory Abnormalities in ASD #2001 State:Shared

General
Experiments (1)
Shared Data
Publications (2)
Data Expected (9)
Associated Studies (0)

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General

Title, investigators, and Collection Description may be edited along with the Collection Phase. For Collection Phase, the options Pre-enrollment, Enrollment, and Completed can be chosen allowing the Collection Owner to indicate the stage of data collection.

Funding Source

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Supporting Documentation

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Clinical Trials

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Collection Title	Collection Investigators	Collection Description
Collection Title:	Influence of Attention and Arousal on Sensory Abnormalities in ASD
Investigators:	Jeanne Townsend
Collection Description:	Based upon our own work and existing evidence, we suggest a model in which basic sensory function is intact in ASD and abnormalities in sensory behavior result instead from the influence of poorly modulated arousal and attention on sensory responsiveness. We propose to address this important issue using electroencephalography (EEG) and physiological measures of arousal (skin conductance and heart rate) in young adults and children with ASD. We will assess auditory and visual sensory functions including levels of sensory response, habituation and neural response recovery, and will examine the influence of arousal and attention on sensory responsiveness. A wide variety of therapeutic interventions target sensory function, but there is scant evidence for the efficacy of these treatments. Understanding the nature of sensory abnormalities and the processing level at which sensory behavior is perturbed will guide the development of more effective therapeutic interventions and/or specific pharmacological treatments. Because abnormal sensory behavior is among the most troublesome of ASD symptoms, providing a scientific basis for treatment of these symptoms would have a significant impact on the field.
Data Source:	NDAR
Collection Phase:	Closed
Collection State:	Shared
Total Funded Amount:	$418,500.00
Subjects in the NDA:	58
Total Planned Enrollment:	80
Total Enrollment:	12

{"values":[]}

{"values":[["Autism Spectrum Affected",64],["Not Defined",18],["Typical Control",40],["Autism Spectrum Severely Affected",6]]}

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Funding Sources:

Funding Source Name	Funding Source URL
NIH - Extramural	None

Supporting Documentation:

Grant Information:

Project Number	Project Title	Start Date	End Date	Planned Enrollment	Actual Enrollment	Organization	Funds Obligated
R21MH096582-01	Influence of Attention and Arousal on Sensory Abnormalities in ASD	07/15/2012	05/31/2014	80	12	UNIVERSITY OF CALIFORNIA SAN DIEGO	$418,500.00

Clinical Trials:

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Experiments

To create a new Omics, eye tracking, fMRI, or EEG experiment, press the "+ New Experiment" button. Once an experiment is created, then raw files for these types of experiments should be provided, associating the experiment – through Experiment_ID – with the metadata defined in the experiments interface.

ID	Name	Created Date	Status	Type
293	Attention-Intensity	04/07/2015	Approved	EEG

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Shared Data

Data structures with the number of subjects submitted and shared are provided.

Shared Data:

Title	Type	Number of Subjects
Autism Diagnostic Interview, Revised (ADI-R)	Clinical Assessments	12
Autism Diagnostic Observation Schedule (ADOS) - Module 4	Clinical Assessments	6
Autism Diagnostic Observation Schedule (ADOS)- Module 3	Clinical Assessments	7
Beery VMI	Clinical Assessments	43
EEG Subject Files	Imaging	40
Research Subject	Clinical Assessments	40
Sensory Profile Adult	Clinical Assessments	39
Social Communication Questionnaire (SCQ) - Lifetime	Clinical Assessments	8
Social Responsiveness Scale (SRS)	Clinical Assessments	24
Social Responsiveness Scale (SRS) - Adult/Self Version	Clinical Assessments	30
Wechsler Abbreviated Scale of Intelligence (WASI)	Clinical Assessments	43

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Publications

Publications relevant to NDAR data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed ID	Study	Title	Journal	Authors	Date	Status
24488156	Create Study	Tracking the sensory environment: an ERP study of probability and context updating in ASD.	Journal of autism and developmental disorders	Westerfield MA, Zinni M, Vo K, Townsend J	February 2015	Not Determined
23975145	Create Study	Guidelines and best practices for electrophysiological data collection, analysis and reporting in autism.	Journal of autism and developmental disorders	Webb, Sara Jane; Bernier, Raphael; Henderson, Heather A; Johnson, Mark H; Jones, Emily J H; Lerner, Matthew D; McPartland, James C; Nelson, Charles A; Rojas, Donald C; Townsend, Jeanne; Westerfield, Marissa	February 2015	Not Relevant

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Relevant Publications

PubMed ID	Study	Title	Journal	Authors	Date
No records found.

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Data Expected

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
Social Communication Questionnaire (SCQ)						Approved
Social Responsiveness Scale (SRS)						Approved
Wechsler Abbreviated Scale of Intelligence (WASI)						Approved
Beery-Buktenica Developmental Test of Visual-Motor Integration						Approved
ADOS						Approved
Sensory Profile						Approved
Research Subject and Pedigree						Approved
ADI-R						Approved
EEG						Approved

Structure not yet defined

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Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

No studies are associated with this collection.

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