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NDAR provides a single access to de-identified autism research data. For permission to download data, you will need an NDAR account with approved access to NDAR or a connected repository (AGRE, IAN, or the ATP). For NDAR access, you need to be a research investigator sponsored by an NIH recognized institution with federal wide assurance. See Request Access for more information.

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1 Numbers reported are subjects by age
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Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

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Shared

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General

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Funding Source

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Clinical Trials

For clinical trials, the option to link to the clinical trial in clinicaltrials.gov is optionally provided.

Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Autism: Social and Communication Predictors in Siblings (Landa) AND Effects of Active Motor and Social Training on Developmental Trajectories in Infants at High-risk for Autism Spectrum Disorders (Libertus)
Rebecca Landa, Klaus Libertus 
The purpose of the proposed study is to identify very early indicators of ASD, beginning in infancy. Specific aims are to: (1) define markers of disrupted neurobehavioral development that appear between 6 and 14 months of age, before clinical signs of ASD; (2) translate ASD clinical indicators identified in the second year of life into early ASD diagnostic criteria applicable to 1- and 2-year olds; and (3) define protective factors associated with outcomes in sibs-A to inform treatment approaches. These aims will be achieved through the use of a prospective, longitudinal research design where assessments occur at regular intervals between 6 and 36 months. Participants will include younger siblings of children with autism (sibs-A) who are at high genetic risk for ASD as well as language and social delays; preterm infants, who are at high risk for developmental delays but lower risk for ASD than sibs-A; and younger siblings of children with typical development who are deemed to be at low risk for developing ASD. At 36 months, children will receive confirmatory outcome classification into one of three groups: ASD; Non-ASD Delay; and No Delays. Measures administered at each age assess visual attention to social and non-social stimuli, motor and communication development, object exploration, understanding of others intended actions, and ASD symptoms. Statistical analyses will include ANOVA, Pearson's correlation, Classification and Regression Trees, regression models, and propensity score methods. High-impact findings are anticipated. Based on discoveries from this study about the nature of very early disruptions in development, new ASD screeners for infants and toddlers may be developed that are more sensitive and specific than existing tools. In addition, proposals for the content and instructional methods used in very early interventions will be made. Such interventions may prevent aspects of the ASD phenotype from emerging, or dampen the severity of expression of the disorder.
NDAR
Enrolling
Shared
$3,487,870.00
349
560
264
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NIH - Extramural None
Autism Science Foundation None


R01MH059630-11 Autism: Social And Communication Predictors in Siblings 09/01/2012 03/31/2018 560 264 HUGO W. MOSER RES INST KENNEDY KRIEGER $3,487,870.00

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Experiments

To create a new Omics, eye tracking, fMRI, or EEG experiment, press the "+ New Experiment" button. Once an experiment is created, then raw files for these types of experiments should be provided, associating the experiment – through Experiment_ID – with the metadata defined in the experiments interface.

IDNameCreated DateStatusType
No records found.

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Shared Data

Data structures with the number of subjects submitted and shared are provided.

Autism Diagnostic Interview, Revised (ADI-R) Clinical Assessments 1
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 1 Clinical Assessments 9
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 2 Clinical Assessments 78
DSM-IV Checklist (Early Steps; SOFAS) Clinical Assessments 87
Research Subject Clinical Assessments 1077
Structured Play Summary Clinical Assessments 84
Vineland-II - Survey Form (2005) Clinical Assessments 306

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDAR data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed IDStudyTitleJournalAuthorsDateStatus
27358719Create StudyCommentary: sex difference differences? A reply to Constantino.Molecular autismMessinger DS, Young GS, Webb SJ, Ozonoff S, Bryson SE, Carter A, Carver L, Charman T, Chawarska K, Curtin S, Dobkins K, Hertz-Picciotto I, Hutman T, Iverson JM, Landa R, Nelson CA, Stone WL, Tager-Flusberg H, Zwaigenbaum L2016Not Relevant
27252667Create StudyReady, Set, Go! Low Anticipatory Response during a Dyadic Task in Infants at High Familial Risk for Autism.Frontiers in psychologyLanda RJ, Haworth JL, Nebel MBJanuary 2016Not Determined
26903251Create StudyProspective Longitudinal Studies of Infant Siblings of Children With Autism: Lessons Learned and Future Directions.Journal of the American Academy of Child and Adolescent PsychiatrySzatmari P, Chawarska K, Dawson G, Georgiades S, Landa R, Lord C, Messinger DS, Thurm A, Halladay AMarch 2016Not Determined
25921776Create StudyDiagnostic stability in young children at risk for autism spectrum disorder: a baby siblings research consortium study.Journal of child psychology and psychiatry, and allied disciplinesOzonoff S, Young GS, Landa RJ, Brian J, Bryson S, Charman T, Chawarska K, Macari SL, Messinger D, Stone WL, Zwaigenbaum L, Iosif AMSeptember 2015Not Determined
25457930Create Study18-month predictors of later outcomes in younger siblings of children with autism spectrum disorder: a baby siblings research consortium study.Journal of the American Academy of Child and Adolescent PsychiatryChawarska K, Shic F, Macari S, Campbell DJ, Brian J, Landa R, Hutman T, Nelson CA, Ozonoff S, Tager-Flusberg H, Young GS, Zwaigenbaum L, Cohen IL, Charman T, Messinger DS, Klin A, Johnson S, Bryson SDecember 2014Not Determined
25295021Create StudyScaffolded reaching experiences encourage grasping activity in infants at high risk for autism.Frontiers in psychologyLibertus K, Landa RJ2014Not Determined
25245349Create StudyEarly head growth in infants at risk of autism: a baby siblings research consortium study.Journal of the American Academy of Child and Adolescent PsychiatryZwaigenbaum L, Young GS, Stone WL, Dobkins K, Ozonoff S, Brian J, Bryson SE, Carver LJ, Hutman T, Iverson JM, Landa RJ, Messinger DOctober 2014Not Determined
24978128Create StudyLimited fine motor and grasping skills in 6-month-old infants at high risk for autism.Child developmentLibertus K, Sheperd KA, Ross SW, Landa RJ2014 Nov-DecNot Determined
24140841Create StudyThe Early Motor Questionnaire (EMQ): a parental report measure of early motor development.Infant behavior & developmentLibertus K, Landa RJDecember 2013Not Determined
23739542Create StudyAssociation between severity of behavioral phenotype and comorbid attention deficit hyperactivity disorder symptoms in children with autism spectrum disorders.Autism : the international journal of research and practiceRao PA, Landa RJApril 2014Not Determined
23452686Create StudyBeyond autism: a baby siblings research consortium study of high-risk children at three years of age.Journal of the American Academy of Child and Adolescent PsychiatryMessinger D, Young GS, Ozonoff S, Dobkins K, Carter A, Zwaigenbaum L, Landa RJ, Charman T, Stone WL, Constantino JN, Hutman T, Carver LJ, Bryson S, Iverson JM, Strauss MS, Rogers SJ, Sigman MMarch 2013Not Determined
23110514Create StudyDevelopmental trajectories in children with and without autism spectrum disorders: the first 3 years.Child developmentLanda RJ, Gross AL, Stuart EA, Faherty A2013 Mar-AprNot Determined
22982285Create StudyRelation between early motor delay and later communication delay in infants at risk for autism.Infant behavior & developmentBhat AN, Galloway JC, Landa RJDecember 2012Not Determined
22958474Create StudyInfant siblings and the investigation of autism risk factors.Journal of neurodevelopmental disordersNewschaffer CJ, Croen LA, Fallin MD, Hertz-Picciotto I, Nguyen DV, Lee NL, Berry CA, Farzadegan H, Hess HN, Landa RJ, Levy SE, Massolo ML, Meyerer SC, Mohammed SM, Oliver MC, Ozonoff S, Pandey J, Schroeder A, Shedd-Wise KM2012Not Determined
22917124Create StudyHead lag in infants at risk for autism: a preliminary study.The American journal of occupational therapy : official publication of the American Occupational Therapy AssociationFlanagan JE, Landa R, Bhat A, Bauman M2012 Sep-OctNot Determined
22574686Create StudyLatent class analysis of early developmental trajectory in baby siblings of children with autism.Journal of child psychology and psychiatry, and allied disciplinesLanda RJ, Gross AL, Stuart EA, Bauman MSeptember 2012Not Determined
21844053Create StudyRecurrence risk for autism spectrum disorders: a Baby Siblings Research Consortium study.PediatricsOzonoff S, Young GS, Carter A, Messinger D, Yirmiya N, Zwaigenbaum L, Bryson S, Carver LJ, Constantino JN, Dobkins K, Hutman T, Iverson JM, Landa R, Rogers SJ, Sigman M, Stone WLSeptember 2011Not Determined
21584850Create StudyPredictive and concurrent validity of parent concern about young children at risk for autism.Journal of autism and developmental disordersHess CR, Landa RJApril 2012Not Determined
20456532Create StudySocial and non-social visual attention patterns and associative learning in infants at risk for autism.Journal of child psychology and psychiatry, and allied disciplinesBhat AN, Galloway JC, Landa RJSeptember 2010Not Determined
20361243Create StudyOnset patterns prior to 36 months in autism spectrum disorders.Journal of autism and developmental disordersKalb LG, Law JK, Landa R, Law PANovember 2010Not Determined
18253102Create StudyDiagnosis of autism spectrum disorders in the first 3 years of life.Nature clinical practice. NeurologyLanda RJMarch 2008Not Determined
17606819Create StudySocial and communication development in toddlers with early and later diagnosis of autism spectrum disorders.Archives of general psychiatryLanda RJ, Holman KC, Garrett-Mayer EJuly 2007Not Determined
17216332Create StudyResponse to joint attention in toddlers at risk for autism spectrum disorder: a prospective study.Journal of autism and developmental disordersSullivan M, Finelli J, Marvin A, Garrett-Mayer E, Bauman M, Landa RJanuary 2007Not Determined
16712640Create StudyDevelopment in infants with autism spectrum disorders: a prospective study.Journal of child psychology and psychiatry, and allied disciplinesLanda R, Garrett-Mayer EJune 2006Not Determined
16161095Create StudyAssessment of social communication skills in preschoolers.Mental retardation and developmental disabilities research reviewsLanda, Rebecca J2005Not Determined
help.tab.dataexpected

Relevant Publications
PubMed IDStudyTitleJournalAuthorsDate
No records found.
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Data Expected
Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
Research Subject and Pedigree info iconApproved
Vineland (Parent and Caregiver) info iconApproved
ADOS info iconApproved
ADI-R info iconApproved
DSM IV Criteria info iconApproved
Structured Play Assessment info iconApproved
Self-Generated Engagement (Social and Object) info iconApproved
Understanding Others Intention info iconApproved
Object Contingency Imitation info iconApproved
Systematic Observation of Red Flags for ASD in Young Children (SORF) info iconApproved
Eye Tracking info iconApproved
Mullen Scales of Early Learning info iconApproved
Treatment History Measure info iconApproved
Communication and Symbolic Behavior Scales (CSBS) info iconApproved
Parent-Child Play Sample info iconApproved
Structure not yet defined

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

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