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NDAR provides a single access to de-identified autism research data. For permission to download data, you will need an NDAR account with approved access to NDAR or a connected repository (AGRE, IAN, or the ATP). For NDAR access, you need to be a research investigator sponsored by an NIH recognized institution with federal wide assurance. See Request Access for more information.

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1 Numbers reported are subjects by age
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Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

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SelectExperiment IdExperiment NameExperiment Type
  • Select One
  • EEG
  • EGG
  • Eye Tracking
  • Omics
  • fMRI
Created On
911Resting StatefMRI04/20/2018
910Modified Monetary Incentive Delay fMRI04/20/2018
908Resting State Pre-Stress Visit 1fMRI04/20/2018
907Montreal Imaging Stress Task Visit 1fMRI04/18/2018
9062-back Post-Stress Visit 1fMRI04/18/2018
9051-back Post-Stress Visit 1fMRI04/18/2018
9040-back Post-Stress Visit 1fMRI04/18/2018
9032-back Pre-Stress Visit 1fMRI04/18/2018
9021-back Pre-Stress Visit 1fMRI04/18/2018
9010-back Pre-Stress Visit 1fMRI04/18/2018
900DTIfMRI04/11/2018
899Investigating a Neurobehavioral Mechanism of Paranoia - Resting State ScansfMRI04/06/2018
898FAST-POMAfMRI04/03/2018
897parvizi_eeg_109EEG03/19/2018
896parvizi_eeg_107EEG03/19/2018
895parvizi_eeg_106EEG03/19/2018
894Dot ProbeEye Tracking03/07/2018
893Startle Habituation and Shock Sensitivity EvaluationEEG03/03/2018
892NPU EEG Task EEG03/03/2018
891Duke ACE ETEye Tracking03/02/2018
888Emotion 1.1 Determining context effects during potential threatfMRI02/26/2018
886RestfMRI02/14/2018
885SARTfMRI02/14/2018
884Plasma metabolic profileOmics02/05/2018
878Social Challenge AssessmentEye Tracking01/26/2018
877PRV-005-EEGEEG01/22/2018
876Mixed Anti and Pro (vgs) saccade mixed blocked (EyeTracking)Eye Tracking01/22/2018
875Attention modulation taskEye Tracking01/17/2018
874ruthldopa resting 17 and 18fMRI01/16/2018
873ruthldopa resting 15 and 16fMRI01/16/2018
872ruthldopa resting 13 and 14fMRI01/16/2018
871ruthldopa resting 11 and 12fMRI01/16/2018
870Resting State fMRIfMRI01/12/2018
869cyberballfMRI01/12/2018
868MDD_PilotfMRI01/12/2018
867Velten Mood Induction State-ItemfMRI01/12/2018
866Emotional Hemifield Task (EHT)EEG01/12/2018
865Genome EditingOmics01/12/2018
864parvizi_eeg_118EEG01/12/2018
863parvizi_eeg_117EEG01/12/2018
862parvizi_eeg_116EEG01/12/2018
861parvizi_eeg_115EEG01/12/2018
860parvizi_eeg_114EEG01/12/2018
859parvizi_eeg_113EEG01/12/2018
858PRV-003-EEGEEG01/12/2018
857PRV-004-EEGEEG01/12/2018
856PRV-007-EEGEEG01/12/2018
855Regulating Emotional Responses to Visual Images Across the Affective Instability SpectrumfMRI01/12/2018
854PRV-002-EEGEEG01/12/2018
853R61 Ezogabine Resting State FMRIfMRI01/11/2018
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Shared

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Clinical Trials

For clinical trials, the option to link to the clinical trial in clinicaltrials.gov is optionally provided.

Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Toward Outcome Measurement of Anxiety in Youth with Autism Spectrum Disorders
Lawrence D. Scahill 
This four-year multisite project will advance outcome measurement of anxiety in future clinical trials in youth with autism spectrum disorders (ASDs). Program announcement (PAR-11-045) declares that the dearth of outcome measures in developmentally disabled populations is a major impediment for drug research in developmentally disabled populations. Impairing anxiety is common in youth with ASDs and a plausible treatment target, but poorly studied (White et al., 2009; van Steensel et al., 2011; King et al., 2009). There are well-accepted outcome measures for anxiety in typically developing youth (RUPP Anxiety Group, 2001; Walkup et al., 2008). Given the language and cognitive deficits in ASDs, these measures are not suitable for youth with ASDs without modification. The need for outcome measures for anxiety in youth with ASDs has also been noted by consumer groups (www.autismspeaks.org). We have assembled an outstanding team of investigators and consultants to develop a parent-rated and a clinician-rated instrument for measuring anxiety in youth with ASDs who participate in clinical trials. We propose a mixed method approach in line with the FDA monograph: Patient-Reported Outcome Measures: Use in Medical Product Development to Support Labeling Claims (www.Fda.Gov/Cder/Guidance). In Yr 1, focus groups with parents will explore the manifestations of anxiety in children with ASDs. This information will be used to refine the CASI Anxiety scale (DSM-IV-based parent-rating) and modify the clinician-rated Pediatric Anxiety Rating Scale (PARS). Yr 2 will collect data on the revised CASI Anx scale (20-25 items) in 900 children with ASD ages 5 to 17 years on a secure web site. We will examine the distribution, internal consistency, factor structure and item analysis of this parent-rated scale. Test-retest reliability of the scale will be evaluated in a subsample of online respondents and a sample of subjects assessed in person. Validity of the CASI Anx scale will be evaluated by contrasting the correlations with another parent-rated measure of anxiety (convergent validity) and with measures of repetitive behavior, social disability and irritability (divergent validity). The revised PARS will be collected via in person assessments of 90 subjects to evaluate reliability (inter-rater, internal consistency) and validity in Yr 3. In Yrs 3-4, a high anxiety subgroup (above threshold on the CASI Anx scale) will be compared to controls (ASD with low anxiety) on physiological measures of heart rate [HR], heart rate variability [HRV] and electrodermal activity [EDA]). HR, HRV and EDA will be measured at rest and under mildly anxiety provoking conditions. Results from this exploratory investigation may identify read outs for early testing of compounds for anxiety in ASDs. The project has four deliverables: focus group results (Yr 2); a reliable and valid parent-rated anxiety outcome measure (Yr 3); a reliable and valid clinician-rated anxiety measure (Yr 4); preliminary HRV and EDA findings (soon after the grant period).
NDAR
Funding Completed
Shared
$2,652,375.00
140
0
1
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NIH - Extramural None


R01MH099021-01 Toward Outcome Measurement of Anxiety in Youth with Autism Spectrum Disorders 09/15/2012 05/31/2016 0 1 EMORY UNIVERSITY $2,652,375.00

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Experiments

To create a new Omics, eye tracking, fMRI, or EEG experiment, press the "+ New Experiment" button. Once an experiment is created, then raw files for these types of experiments should be provided, associating the experiment – through Experiment_ID – with the metadata defined in the experiments interface.

IDNameCreated DateStatusType
No records found.

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Shared Data

Data structures with the number of subjects submitted and shared are provided.

ACE Family Medical History Clinical Assessments 115
ACE Subject Medical History Clinical Assessments 118
Aberrant Behavior Checklist (ABC) - Community Clinical Assessments 136
Anxiety Disorders Interview Schedule Parent (ADIS IV P) Clinical Assessments 107
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 1 Clinical Assessments 7
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 2 Clinical Assessments 6
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 3 Clinical Assessments 92
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 4 Clinical Assessments 5
Caregiver Strain Questionnaire Clinical Assessments 123
Clinical Global Impression (CGI) Clinical Assessments 118
Demographics Clinical Assessments 139
Height and Weight Clinical Assessments 124
Repetitive Behavior Scale - Revised (RBS-R) Clinical Assessments 125
Research Subject Clinical Assessments 138
Screen for Child Anxiety Related Disorders (SCARED), Parent/Child Clinical Assessments 123
Social Communication Questionnaire (SCQ) - Lifetime Clinical Assessments 136
Stanford-Binet Intelligence Scales, Fifth Edition (SB5) Clinical Assessments 117
Vineland-II - Parent and Caregiver Rating Form (2005) Clinical Assessments 80
Vineland-II - Survey Form (2005) Clinical Assessments 20

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDAR data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed IDStudyTitleJournalAuthorsDateStatus
29550689Create StudyRethinking avoidance: Toward a balanced approach to avoidance in treating anxiety disorders.Journal of anxiety disordersHofmann SG, Hay ACApril 2018Not Determined
29434552Create StudyWhy Cognitive Behavioral Therapy Is the Current Gold Standard of Psychotherapy.Frontiers in psychiatryDavid D, Cristea I, Hofmann SGJanuary 2018Not Determined
28440699Create StudyEffect of treatments for depression on quality of life: a meta-analysis.Cognitive behaviour therapyHofmann SG, Curtiss J, Carpenter JK, Kind SJune 2017Not Determined
28104735Create StudyInitial severity of depression and efficacy of cognitive-behavioural therapy: individual-participant data meta-analysis of pill-placebo-controlled trials.The British journal of psychiatry : the journal of mental scienceFurukawa TA, Weitz ES, Tanaka S, Hollon SD, Hofmann SG, Andersson G, Twisk J, Derubeis RJ, Dimidjian S, Hegerl U, Mergl R, Jarrett RB, Vittengl JR, Watanabe N, Cuijpers PMarch 2017Not Determined
27694457Create StudyA Complex Network Perspective on Clinical Science.Perspectives on psychological science : a journal of the Association for Psychological ScienceHofmann SG, Curtiss J, Mcnally RJSeptember 2016Not Determined
27315514Create StudyRANDOMIZED TRIAL OF D-CYCLOSERINE ENHANCEMENT OF COGNITIVE-BEHAVIORAL THERAPY FOR PANIC DISORDER.Depression and anxietyOtto MW, Pollack MH, Dowd SM, Hofmann SG, Pearlson G, Szuhany KL, Gueorguieva R, Krystal JH, Simon NM, Tolin DFAugust 2016Not Determined
27182094Create StudyInterpersonal Emotion Regulation Questionnaire (IERQ): Scale Development and Psychometric Characteristics.Cognitive therapy and researchHofmann SG, Carpenter JK, Curtiss JJune 2016Not Determined
27009055Create StudyPsychodynamic therapy: a poorly defined concept with questionable evidence.Evidence-based mental healthHofmann SGMay 2016Not Determined
26670323Create StudyFactor Structure of the Parent-Report Mood and Feelings Questionnaire (MFQ) in an Outpatient Mental Health Sample.Journal of abnormal child psychologyJeffreys M, Rozenman M, Gonzalez A, Warnick EM, Dauser C, Scahill L, Woolston J, Robin Weersing VAugust 2016Not Determined
26222127Create StudyAttention allocation in social anxiety during a speech.Cognition & emotionLin M, Hofmann SG, Qian M, Kind S, Yu HSeptember 2016Not Determined
26094200Create StudyEffect of intranasal oxytocin administration on psychiatric symptoms: A meta-analysis of placebo-controlled studies.Psychiatry researchHofmann SG, Fang A, Brager DNAugust 30, 2015Not Determined
25882391Create StudySensitivity of the modified Children's Yale-Brown Obsessive Compulsive Scale to detect change: Results from two multi-site trials.Autism : the international journal of research and practiceScahill L, Sukhodolsky DG, Anderberg E, Dimitropoulos A, Dziura J, Aman MG, Mccracken J, Tierney E, Hallett V, Katz K, Vitiello B, Mcdougle CFebruary 2016Not Determined
25827035Create StudyTreatments for social anxiety disorder: considerations regarding psychodynamic therapy findings.The American journal of psychiatryHofmann SG, Barlow DH, Clark DM, Hollon SD, Mayo-Wilson EApril 2015Not Relevant
25774643Create StudyPsychometric properties of an innovative self-report measure: The Social Anxiety Questionnaire for adults.Psychological assessmentCaballo VE, Arias B, Salazar IC, Irurtia MJ, Hofmann SG, September 2015Not Determined
25072016Create StudyAutism Spectrum Disorder: Defining Dimensions and Subgroups.Current developmental disorders reportsOusley O, Cermak TMarch 1, 2014Not Determined
24342389Create StudyChildren's Yale-Brown obsessive compulsive scale in autism spectrum disorder: component structure and correlates of symptom checklist.Journal of the American Academy of Child and Adolescent PsychiatryScahill L, Dimitropoulos A, McDougle CJ, Aman MG, Feurer ID, McCracken JT, Tierney E, Pu J, White S, Lecavalier L, Hallett V, Bearss K, King B, Arnold LE, Vitiello BJanuary 2014Not Determined
24158679Create StudyMeasuring anxiety as a treatment endpoint in youth with autism spectrum disorder.Journal of autism and developmental disordersLecavalier L, Wood JJ, Halladay AK, Jones NE, Aman MG, Cook EH, Handen BL, King BH, Pearson DA, Hallett V, Sullivan KA, Grondhuis S, Bishop SL, Horrigan JP, Dawson G, Scahill LMay 2014Not Determined
23800481Create StudyThe role of emotion regulation in autism spectrum disorder.Journal of the American Academy of Child and Adolescent PsychiatryMazefsky CA, Herrington J, Siegel M, Scarpa A, Maddox BB, Scahill L, White SWJuly 2013Not Determined
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Relevant Publications
PubMed IDStudyTitleJournalAuthorsDate
No records found.
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Data Expected
Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
Clinical Global Impression (CGI) info iconApproved
Preferences for Activities of Children info iconApproved
Clinical Global Impression of Severity info iconApproved
ABC Community info iconApproved
Vineland (Parent and Caregiver) info iconApproved
Medical History info iconApproved
Physical Exam info iconApproved
Research Subject and Pedigree info iconApproved
ADOS info iconApproved
Pediatric Anxiety Rating Scale (PARS) info iconApproved
Social Communication Questionnaire (SCQ) info iconApproved
Demographics info iconApproved
Caregiver Strain Questionnaire info iconApproved
Screen for Childhood Anxiety Related Emotional Disorders (SCARED) info iconApproved
Anxiety Disorders Interview Schedule info iconApproved
Stanford Binet info iconApproved
Repetitive Behavior Scale - Revised (RBS-R) info iconApproved
Childrens Yale-Brown OC Scale (CY-BOCS) info iconApproved
Structure not yet defined

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study NameAbstractCollection/Study SubjectsData UsageState
No records found.
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