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NDAR provides a single access to de-identified autism research data. For permission to download data, you will need an NDAR account with approved access to NDAR or a connected repository (AGRE, IAN, or the ATP). For NDAR access, you need to be a research investigator sponsored by an NIH recognized institution with federal wide assurance. See Request Access for more information.

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1 Numbers reported are subjects by age
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Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

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General

Title, investigators, and Collection Description may be edited along with the Collection Phase. For Collection Phase, the options Pre-enrollment, Enrollment, and Completed can be chosen allowing the Collection Owner to indicate the stage of data collection.

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The ability to associate the funding source for the project is provided. For NIH funded grants, linkage to Project Reporter information (e.g. R01MH123456) is supported. Projects funded by others, including the URL of the project, are listed. Non NIH funded projects will become available here to link that data with the appropriate funding agency.

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For clinical trials, the option to link to the clinical trial in clinicaltrials.gov is optionally provided.

Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Biomarkers of Developmental Trajectories and Treatment in ASD
Susan Bookheimer 
This is a renewal for the UCLA Autism Center of Excellence. The primary focus of the UCLA ACE renewal is to understand the relationship between aberrant brain development and core deficits in autism by identifying mechanisms relating genes to brain structure/function and brain to behavior, and to develop effective interventions based on basic experimental and clinical research findings that will change outcomes in autism. In five interdependent projects and cores, our center builds on our expertise in autism genetics, multimodal brain imaging, early detection and analysis of core autism features, and experience in implementing randomized control trials of novel interventions that target these core symptoms. In this renewal application, projects focus on defining longitudinal trajectories of brain and behavioral development in infants with multiple risks for autism (Proj I); infants and toddlers with early signs of autism (Proj II), nonverbal school aged children with autism (Proj III), and higher functioning children/ adolescents (Proj IV),using a shared set of imaging, neurophysiological and neurobehavioral biomarkers, as well as genetic risk and expression analysis (Proj V) in longitudinal studies. This center is focused on understanding both early and later trajectories of emerging and developing functional connectivity and behavioral change in relation to variation in autism phenotypes, defining how genetic risks mediate both imaging and behavioral phenotypes, and altering trajectories through two separate treatments focused on core deficits in ASD, one targeted developing joint attention and social orientation in infants, and one focused on improving language nonverbal children with augmentative pharmacological intervention. Four cores support the scientific goals: an Administrative Core, facilitating scientific progress and providing data management/statistics support; a Diagnositc and Phenotyping Core; a Neuroimaging/Neurophysiology core, and a Research Education and Outreach core. The UCLA ACE benefits from our years of working together as a team. We present a highly integrated center with multiple collaborations across levels of analysis to further a strongly translational research strategy aimed at changing outcomes in children with autism spectrum disorders.
NDAR
Enrolling
Shared
$10,140,908.00
580
748
0

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NIH - Extramural None


P50HD055784-06 Biomarkers of Developmental Trajectories and Treatment in ASD 09/04/2012 05/31/2017 748 Not Reported UNIVERSITY OF CALIFORNIA LOS ANGELES $10,140,908.00

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Experiments

To create a new Omics, eye tracking, fMRI, or EEG experiment, press the "+ New Experiment" button. Once an experiment is created, then raw files for these types of experiments should be provided, associating the experiment – through Experiment_ID – with the metadata defined in the experiments interface.

IDNameCreated DateStatusType
131Jeste Lab UCLA ACEii: Charlie Brown and Sesame Street - Project 102/27/2014ApprovedEye Tracking
132Jeste Lab UCLA ACEii: Animacy - Project 102/27/2014ApprovedEye Tracking
133Jeste Lab UCLA ACEii: Mom Stranger - Project 202/27/2014ApprovedEye Tracking
134Jeste Lab UCLA ACEii: Face Emotion - Project 302/27/2014ApprovedEye Tracking
130Jeste Lab UCLA ACEii EEG02/24/2014ApprovedEEG
238P1_resting8min01/15/2015ApprovedfMRI
240P4_rewards01/15/2015ApprovedfMRI
241P4_resting6min01/15/2015ApprovedfMRI
242P4_faces01/15/2015ApprovedfMRI
320Geschwind 2015-9017 Omni2.5-806/10/2015ApprovedOmics
243P1_language01/15/2015ApprovedfMRI
239P1-nativelang01/15/2015ApprovedfMRI

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Shared Data

Data structures with the number of subjects submitted and shared are provided.

ACE Family Medical History Clinical Assessments 144
ACE Subject Medical History Clinical Assessments 157
ACE Subject Physical Exam Clinical Assessments 70
Aberrant Behavior Checklist (ABC) - Community Clinical Assessments 24
Abnormal Involuntary Movement Scale Clinical Assessments 24
Autism Diagnostic Interview, Revised (ADI-R) Clinical Assessments 49
Autism Diagnostic Observation Schedule (ADOS)- Module 3 Clinical Assessments 22
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 1 Clinical Assessments 22
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 2 Clinical Assessments 7
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 3 Clinical Assessments 7
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Toddler Module Clinical Assessments 100
Autism Observation Scale for Infants Clinical Assessments 52
BRIEF-Parent Clinical Assessments 77
Child Behavior Checklist (CBCL) 6-18 Clinical Assessments 76
Child Symptom Inventory Parent/Teacher Checklist Clinical Assessments 77
Children's Yale-Brown Obsessive Compulsive Scale Clinical Assessments 13
Clinical Global Impression (CGI) Clinical Assessments 23
Clinical Lab Tests Clinical Assessments 19
Concomitant Medications Clinical Assessments 18
Eye Tracking Subject-Experiment Imaging 163
Genomics Genetic Test Genomics 53
Image Imaging 155
Infant Medical History Questionnaire Clinical Assessments 74
Interpersonal Competence Scale Clinical Assessments 78
Interpersonal Reactivity Index (IRI) Clinical Assessments 73
Leiter International Performance Scale-Revised (Leiter-R), Visualization and Reasoning Battery Clinical Assessments 24
M-CHAT Clinical Assessments 15
MacArthur-Bates CDI - Words and Gestures Form Clinical Assessments 58
Mullen Scales of Early Learning Clinical Assessments 142
Parent Concerns Questionaire Clinical Assessments 83
Peabody Picture Vocabulary Test, Fourth Edition-Form A Clinical Assessments 22
Preschool Language Scales Fifth edition (PLS-5) Clinical Assessments 23
Repetitive Behavior Scale - Revised (RBS-R) Clinical Assessments 102
Research Subject Clinical Assessments 439
SRS-2. Adult, Preschool and School Age Clinical Assessments 227
Sensory Profile Short Clinical Assessments 76
Side Effects Clinical Assessments 24
Simpson-Angus Extrapyramidal Side Effects Scale Clinical Assessments 24
Social Communication Questionnaire (SCQ) - Current Form Clinical Assessments 55
Social Communication Questionnaire (SCQ) - Lifetime Clinical Assessments 32
Social Responsiveness Scale (SRS) Clinical Assessments 78
Vineland-II - Parent and Caregiver Rating Form (2005) Clinical Assessments 42
Vineland-II - Survey Form (2005) Clinical Assessments 58
Vital Signs Clinical Assessments 24
WASI-2 Clinical Assessments 25
Wechsler Abbreviated Scale of Intelligence (WASI) Clinical Assessments 30
Wechsler Intelligence Scale for Children - IV [part 1] Clinical Assessments 15
Wechsler Intelligence Scale for Children - IV [part 2] Clinical Assessments 15

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDAR data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed IDStudyTitleJournalAuthorsDateStatus
28132692Create StudyA Recurrent De Novo Variant in NACC1 Causes a Syndrome Characterized by Infantile Epilepsy, Cataracts, and Profound Developmental Delay.American journal of human geneticsSchoch K, Meng L, Szelinger S, Bearden DR, Stray-Pedersen A, Busk OL, Stong N, Liston E, Cohn RD, Scaglia F, Rosenfeld JA, Tarpinian J, Skraban CM, Deardorff MA, Friedman JN, Akdemir ZC, Walley N, Mikati MA, Kranz PG, Jasien J, Mcconkie-Rosell A, Mcdonald M, Wechsler SB, Freemark M, Kansagra S, et al.February 2017Not Determined
27896947Create StudyReduced modulation of thalamocortical connectivity during exposure to sensory stimuli in ASD.Autism research : official journal of the International Society for Autism ResearchGreen SA, Hernandez L, Bookheimer SY, Dapretto MNovember 2016Not Determined
27601973Create StudyNoise Reduction in Arterial Spin Labeling Based Functional Connectivity Using Nuisance Variables.Frontiers in neuroscienceJann K, Smith RX, Rios Piedra EA, Dapretto M, Wang DJJanuary 2016Not Determined
27358719Create StudyCommentary: sex difference differences? A reply to Constantino.Molecular autismMessinger DS, Young GS, Webb SJ, Ozonoff S, Bryson SE, Carter A, Carver L, Charman T, Chawarska K, Curtin S, Dobkins K, Hertz-Picciotto I, Hutman T, Iverson JM, Landa R, Nelson CA, Stone WL, Tager-Flusberg H, Zwaigenbaum L2016Not Relevant
27343889Create StudySalience Network Connectivity in Autism Is Related to Brain and Behavioral Markers of Sensory Overresponsivity.Journal of the American Academy of Child and Adolescent PsychiatryGreen SA, Hernandez L, Bookheimer SY, Dapretto MJuly 2016Not Determined
27158270Create StudyIdentification of a distinct developmental and behavioral profile in children with Dup15q syndrome.Journal of neurodevelopmental disordersDistefano C, Gulsrud A, Huberty S, Kasari C, Cook E, Reiter LT, Thibert R, Jeste SSJanuary 2016Not Relevant
26881074Create StudyTheory of Mind Indexes the Broader Autism Phenotype in Siblings of Children with Autism at School Age.Autism research and treatmentTsang T, Gillespie-Lynch K, Hutman TJanuary 2016Not Determined
26797940Create StudyIncreasing Responsive Parent-Child Interactions and Joint Engagement: Comparing the Influence of Parent-Mediated Intervention and Parent Psychoeducation.Journal of autism and developmental disordersShire SY, Gulsrud A, Kasari CMay 2016Not Determined
26687839Create StudyCytoplasmic Rbfox1 Regulates the Expression of Synaptic and Autism-Related Genes.NeuronLee JA, Damianov A, Lin CH, Fontes M, Parikshak NN, Anderson ES, Geschwind DH, Black DL, Martin KCJanuary 6, 2016Not Relevant
26627310Create StudyJAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse.NeuronBerg JM, Lee C, Chen L, Galvan L, Cepeda C, Chen JY, Peñagarikano O, Stein JL, Li A, Oguro-Ando A, Miller JA, Vashisht AA, Starks ME, Kite EP, Tam E, Gdalyahu A, Al-Sharif NB, Burkett ZD, White SA, Fears SC, Levine MS, Wohlschlegel JA, Geschwind DHDecember 16, 2015Not Determined
26527311Create StudyJoint engagement modulates object discrimination in toddlers: a pilot electrophysiological investigation.Social neuroscienceHutman T, Harrop C, Baker E, Elder L, Abood K, Soares A, Jeste SSNovember 25, 2015Not Determined
26525461Create StudyIsolating active ingredients in a parent-mediated social communication intervention for toddlers with autism spectrum disorder.Journal of child psychology and psychiatry, and allied disciplinesGulsrud AC, Hellemann G, Shire S, Kasari CMay 2016Not Determined
26509118Create StudyNeural mechanisms of response inhibition and impulsivity in 22q11.2 deletion carriers and idiopathic attention deficit hyperactivity disorder.NeuroImage. ClinicalMontojo CA, Congdon E, Hwang L, Jalbrzikowski M, Kushan L, Vesagas TK, Jonas RK, Ventura J, Bilder RM, Bearden CE2015Not Determined
26451968Create StudySchool-age outcomes of infants at risk for autism spectrum disorder.Autism research : official journal of the International Society for Autism ResearchMiller M, Iosif AM, Young GS, Hill M, Phelps Hanzel E, Hutman T, Johnson S, Ozonoff SOctober 9, 2015Not Determined
26445698Create StudyAltered resting perfusion and functional connectivity of default mode network in youth with autism spectrum disorder.Brain and behaviorJann K, Hernandez LM, Beck-Pancer D, McCarron R, Smith RX, Dapretto M, Wang DJSeptember 2015Not Determined
26374786Create StudyAutism Spectrum Disorder and Epilepsy: Two Sides of the Same Coin?Journal of child neurologyJeste SS, Tuchman RDecember 2015Not Determined
26201030Create StudyTranscriptome Profiling of Peripheral Blood in 22q11.2 Deletion Syndrome Reveals Functional Pathways Related to Psychosis and Autism Spectrum Disorder.PloS oneJalbrzikowski M, Lazaro MT, Gao F, Huang A, Chow C, Geschwind DH, Coppola G, Bearden CE2015Not Relevant
26164418Create StudyInfants' behavioral styles in joint attention situations and parents' socio-economic status.Infant behavior & developmentAbels M, Hutman TAugust 2015Not Determined
26106930Create StudyCharacterizing Resting-State Brain Function Using Arterial Spin Labeling.Brain connectivityChen JJ, Jann K, Wang DJNovember 2015Not Relevant
26096080Create StudyWavelet-based regularity analysis reveals recurrent spatiotemporal behavior in resting-state fMRI.Human brain mappingSmith RX, Jann K, Ances B, Wang DJSeptember 2015Not Determined
26061819Create StudyNeurobiology of Sensory Overresponsivity in Youth With Autism Spectrum Disorders.JAMA psychiatryGreen SA, Hernandez L, Tottenham N, Krasileva K, Bookheimer SY, Dapretto MAugust 2015Not Determined
26045943Create StudyEarly sex differences are not autism-specific: A Baby Siblings Research Consortium (BSRC) study.Molecular autismMessinger DS, Young GS, Webb SJ, Ozonoff S, Bryson SE, Carter A, Carver L, Charman T, Chawarska K, Curtin S, Dobkins K, Hertz-Picciotto I, Hutman T, Iverson JM, Landa R, Nelson CA, Stone WL, Tager-Flusberg H, Zwaigenbaum L2015Not Determined
26018425Create StudyVoICE: A semi-automated pipeline for standardizing vocal analysis across models.Scientific reportsBurkett ZD, Day NF, Peñagarikano O, Geschwind DH, White SA2015Not Determined
25973164Create StudyRecurrence rates provide evidence for sex-differential, familial genetic liability for autism spectrum disorders in multiplex families and twins.Molecular autismWerling DM, Geschwind DH2015Not Determined
25948600Create StudyCharacterizing caregiver responses to restricted and repetitive behaviors in toddlers with autism spectrum disorder.Autism : the international journal of research and practiceHarrop C, Gulsrud A, Shih W, Hovsepyan L, Kasari CApril 2016Not Determined
25891009Create StudyGene hunting in autism spectrum disorder: on the path to precision medicine.The Lancet. NeurologyGeschwind DH, State MWNovember 2015Not Determined
25891007Create StudyNeuroimaging in autism spectrum disorder: brain structure and function across the lifespan.The Lancet. NeurologyEcker C, Bookheimer SY, Murphy DGNovember 2015Not Determined
25822242Create StudyRandomized comparative efficacy study of parent-mediated interventions for toddlers with autism.Journal of consulting and clinical psychologyKasari C, Gulsrud A, Paparella T, Hellemann G, Berry KJune 2015Not Determined
25727539Create StudySocial responsiveness, an autism endophenotype: genomewide significant linkage to two regions on chromosome 8.The American journal of psychiatryLowe JK, Werling DM, Constantino JN, Cantor RM, Geschwind DHMarch 1, 2015Not Determined
25715178Create StudyCognitive decline preceding the onset of psychosis in patients with 22q11.2 deletion syndrome.JAMA psychiatryVorstman JA, Breetvelt EJ, Duijff SN, Eliez S, Schneider M, Jalbrzikowski M, Armando M, Vicari S, Shashi V, Hooper SR, Chow EW, Fung WL, Butcher NJ, Young DA, McDonald-McGinn DM, Vogels A, van Amelsvoort T, Gothelf D, Weinberger R, Weizman A, Klaassen PW, Koops S, Kates WR, Antshel KM, Simon TJ, et al.April 2015Not Determined
25695138Create StudyDevelopmental disorders.Current opinion in neurologyJeste, Shafali S; Geschwind, Daniel HApril 2015Not Relevant
25609168Create StudyExogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism.Science translational medicinePeñagarikano O, Lázaro MT, Lu XH, Gordon A, Dong H, Lam HA, Peles E, Maidment NT, Murphy NP, Yang XW, Golshani P, Geschwind DHJanuary 21, 2015Not Determined
25463468Create StudyFunctional connectivity in BOLD and CBF data: similarity and reliability of resting brain networks.NeuroImageJann K, Gee DG, Kilroy E, Schwab S, Smith RX, Cannon TD, Wang DJFebruary 1, 2015Not Determined
25457930Create Study18-month predictors of later outcomes in younger siblings of children with autism spectrum disorder: a baby siblings research consortium study.Journal of the American Academy of Child and Adolescent PsychiatryChawarska K, Shic F, Macari S, Campbell DJ, Brian J, Landa R, Hutman T, Nelson CA, Ozonoff S, Tager-Flusberg H, Young GS, Zwaigenbaum L, Cohen IL, Charman T, Messinger DS, Klin A, Johnson S, Bryson SDecember 2014Not Determined
25418720Create StudyMaternal inflammation contributes to brain overgrowth and autism-associated behaviors through altered redox signaling in stem and progenitor cells.Stem cell reportsLe Belle JE, Sperry J, Ngo A, Ghochani Y, Laks DR, López-Aranda M, Silva AJ, Kornblum HINovember 11, 2014Not Determined
25409314Create StudyProtein interaction networks reveal novel autism risk genes within GWAS statistical noise.PloS oneCorreia C, Oliveira G, Vicente AM2014Not Determined
25315782Create StudyEarly pragmatic language difficulties in siblings of children with autism: implications for DSM-5 social communication disorder?Journal of child psychology and psychiatry, and allied disciplinesMiller M, Young GS, Hutman T, Johnson S, Schwichtenberg AJ, Ozonoff SJuly 2015Not Determined
25245349Create StudyEarly head growth in infants at risk of autism: a baby siblings research consortium study.Journal of the American Academy of Child and Adolescent PsychiatryZwaigenbaum L, Young GS, Stone WL, Dobkins K, Ozonoff S, Brian J, Bryson SE, Carver LJ, Hutman T, Iverson JM, Landa RJ, Messinger DOctober 2014Not Determined
25078724Create StudyTime reproduction performance is associated with age and working memory in high-functioning youth with autism spectrum disorder.Autism research : official journal of the International Society for Autism ResearchBrenner LA, Shih VH, Colich NL, Sugar CA, Bearden CE, Dapretto MFebruary 2015Not Determined
25038753Create StudyMost genetic risk for autism resides with common variation.Nature geneticsGaugler T, Klei L, Sanders SJ, Bodea CA, Goldberg AP, Lee AB, Mahajan M, Manaa D, Pawitan Y, Reichert J, Ripke S, Sandin S, Sklar P, Svantesson O, Reichenberg A, Hultman CM, Devlin B, Roeder K, Buxbaum JDAugust 2014Not Determined
25011468Create StudyNeural signatures of autism spectrum disorders: insights into brain network dynamics.Neuropsychopharmacology : official publication of the American College of NeuropsychopharmacologyHernandez LM, Rudie JD, Green SA, Bookheimer S, Dapretto MJanuary 2015Not Determined
24577245Create StudyPsychiatric disorders from childhood to adulthood in 22q11.2 deletion syndrome: results from the International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome.The American journal of psychiatrySchneider M, Debbané M, Bassett AS, Chow EW, Fung WL, van den Bree M, Owen M, Murphy KC, Niarchou M, Kates WR, Antshel KM, Fremont W, McDonald-McGinn DM, Gur RE, Zackai EH, Vorstman J, Duijff SN, Klaassen PW, Swillen A, Gothelf D, Green T, Weizman A, Van Amelsvoort T, Evers L, Boot E, et al.June 2014Not Determined
24497750Create StudyAtypical Neural Processing of Ironic and Sincere Remarks in Children and Adolescents with Autism Spectrum Disorders.Metaphor and symbolColich NL, Wang AT, Rudie JD, Hernandez LM, Bookheimer SY, Dapretto M2012Not Determined
24353275Create StudyIs early joint attention associated with school-age pragmatic language?Autism : the international journal of research and practiceGillespie-Lynch K, Khalulyan A, Del Rosario M, McCarthy B, Gomez L, Sigman M, Hutman TFebruary 2015Not Determined
24183016Create StudyCortical evolution: judge the brain by its cover.NeuronGeschwind DH, Rakic POctober 30, 2013Not Determined
24179761Create StudyAltered functional and structural brain network organization in autism.NeuroImage. ClinicalRudie JD, Brown JA, Beck-Pancer D, Hernandez LM, Dennis EL, Thompson PM, Bookheimer SY, Dapretto MJanuary 2012Not Determined
24177988Create StudyNeural substrates of inhibitory control deficits in 22q11.2 deletion syndrome.Cerebral cortex (New York, N.Y. : 1991)Montojo CA, Jalbrzikowski M, Congdon E, Domicoli S, Chow C, Dawson C, Karlsgodt KH, Bilder RM, Bearden CEApril 2015Not Relevant
24157390Create StudyOverreactive brain responses to sensory stimuli in youth with autism spectrum disorders.Journal of the American Academy of Child and Adolescent PsychiatryGreen SA, Rudie JD, Colich NL, Wood JJ, Shirinyan D, Hernandez L, Tottenham N, Dapretto M, Bookheimer SYNovember 2013Not Determined
24104518Create StudyThe association between parental interaction style and children's joint engagement in families with toddlers with autism.Autism : the international journal of research and practicePatterson SY, Elder L, Gulsrud A, Kasari CJuly 2014Not Determined
24099842Create StudyDynamic and static contributions of the cerebrovasculature to the resting-state BOLD signal.NeuroImageTak S, Wang DJ, Polimeni JR, Yan L, Chen JJJanuary 1, 2014Not Determined
24078018Create StudyUnderconnectivity of the superior temporal sulcus predicts emotion recognition deficits in autism.Social cognitive and affective neuroscienceAlaerts K, Woolley DG, Steyaert J, Di Martino A, Swinnen SP, Wenderoth NOctober 2014Not Determined
23992925Create StudyThe 22q11.2 deletion syndrome as a window into complex neuropsychiatric disorders over the lifespan.Biological psychiatryJonas RK, Montojo CA, Bearden CEMarch 1, 2014Not Determined
23912681Create StudyDefault mode network connectivity and reciprocal social behavior in 22q11.2 deletion syndrome.Social cognitive and affective neuroscienceSchreiner MJ, Karlsgodt KH, Uddin LQ, Chow C, Congdon E, Jalbrzikowski M, Bearden CESeptember 2014Not Determined
23820765Create StudyParent-reported temperament trajectories among infant siblings of children with autism.Journal of autism and developmental disordersDel Rosario M, Gillespie-Lynch K, Johnson S, Sigman M, Hutman TFebruary 2014Not Determined
23774715Create StudyThe autism brain imaging data exchange: towards a large-scale evaluation of the intrinsic brain architecture in autism.Molecular psychiatryDi Martino A, Yan CG, Li Q, Denio E, Castellanos FX, Alaerts K, Anderson JS, Assaf M, Bookheimer SY, Dapretto M, Deen B, Delmonte S, Dinstein I, Ertl-Wagner B, Fair DA, Gallagher L, Kennedy DP, Keown CL, Keysers C, Lainhart JE, Lord C, Luna B, Menon V, Minshew NJ, Monk CS, et al.June 2014Not Determined
23619947Create StudyAtypical gaze following in autism: a comparison of three potential mechanisms.Journal of autism and developmental disordersGillespie-Lynch K, Elias R, Escudero P, Hutman T, Johnson SPDecember 2013Not Determined
23452686Create StudyBeyond autism: a baby siblings research consortium study of high-risk children at three years of age.Journal of the American Academy of Child and Adolescent PsychiatryMessinger D, Young GS, Ozonoff S, Dobkins K, Carter A, Zwaigenbaum L, Landa RJ, Charman T, Stone WL, Constantino JN, Hutman T, Carver LJ, Bryson S, Iverson JM, Strauss MS, Rogers SJ, Sigman MMarch 2013Not Determined
23352155Create StudyRare inherited variation in autism: beginning to see the forest and a few trees.NeuronStein JL, Parikshak NN, Geschwind DHJanuary 23, 2013Not Determined
23298182Create StudyDecreased reelin expression and organophosphate pesticide exposure alters mouse behaviour and brain morphology.ASN neuroMullen BR, Khialeeva E, Hoffman DB, Ghiani CA, Carpenter EM2013Not Determined
23284270Create StudyEye-tracking as a Measure of Responsiveness to Joint Attention in Infants at Risk for Autism.Infancy : the official journal of the International Society on Infant StudiesJuly 1, 2012Not Determined
23139906Create StudyAltered integration of speech and gesture in children with autism spectrum disorders.Brain and behaviorHubbard AL, Mcnealy K, Scott-Van Zeeland AA, Callan DE, Bookheimer SY, Dapretto MSeptember 2012Not Determined
22965298Create StudyPreschool based JASPER intervention in minimally verbal children with autism: pilot RCT.Journal of autism and developmental disordersGoods KS, Ishijima E, Chang YC, Kasari CMay 2013Not Determined
22962003Create StudyDeficits in mental state attributions in individuals with 22q11.2 deletion syndrome (velo-cardio-facial syndrome).Autism research : official journal of the International Society for Autism ResearchHo JS, Radoeva PD, Jalbrzikowski M, Chow C, Hopkins J, Tran WC, Mehta A, Enrique N, Gilbert C, Antshel KM, Fremont W, Kates WR, Bearden CEDecember 2012Not Determined
22958829Create StudyAutism-associated promoter variant in MET impacts functional and structural brain networks.NeuronRudie JD, Hernandez LM, Brown JA, Beck-Pancer D, Colich NL, Gorrindo P, Thompson PM, Geschwind DH, Bookheimer SY, Levitt P, Dapretto MSeptember 6, 2012Not Determined
22912605Create StudyInsights into multimodal imaging classification of ADHD.Frontiers in systems neuroscienceColby JB, Rudie JD, Brown JA, Douglas PK, Cohen MS, Shehzad ZJanuary 2012Not Determined
22849751Create StudyAutism genetics: searching for specificity and convergence.Genome biologyBerg JM, Geschwind DH2012Not Determined
22843504Create StudyIndividual common variants exert weak effects on the risk for autism spectrum disorderspi.Human molecular geneticsAnney R, Klei L, Pinto D, Almeida J, Bacchelli E, Baird G, Bolshakova N, Bölte S, Bolton PF, Bourgeron T, Brennan S, Brian J, Casey J, Conroy J, Correia C, Corsello C, Crawford EL, de Jonge M, Delorme R, Duketis E, Duque F, Estes A, Farrar P, Fernandez BA, Folstein SE, et al.November 1, 2012Not Determined
22760337Create StudyNeural and behavioral responses during self-evaluative processes differ in youth with and without autism.Journal of autism and developmental disordersPfeifer JH, Merchant JS, Colich NL, Hernandez LM, Rudie JD, Dapretto MFebruary 2013Not Determined
22728336Create StudyInfants' pre-empathic behaviors are associated with language skills.Infant behavior & developmentHutman T, Rozga A, DeLaurentis A, Sigman M, Dapretto MJune 2012Not Determined
22525955Create StudyLongitudinal follow-up of children with autism receiving targeted interventions on joint attention and play.Journal of the American Academy of Child and Adolescent PsychiatryKasari C, Gulsrud A, Freeman S, Paparella T, Hellemann GMay 2012Not Determined
22365836Create StudyWhat does CNTNAP2 reveal about autism spectrum disorder?Trends in molecular medicinePeñagarikano O, Geschwind DHMarch 2012Not Determined
22318914Create StudyAn fMRI investigation of responses to peer rejection in adolescents with autism spectrum disorders.Developmental cognitive neuroscienceMasten CL, Colich NL, Rudie JD, Bookheimer SY, Eisenberger NI, Dapretto MJuly 2011Not Determined
22187107Create StudyBrief report: longitudinal improvements in the quality of joint attention in preschool children with autism.Journal of autism and developmental disordersLawton K, Kasari CFebruary 2012Not Determined
21996756Create StudyA novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder.Human geneticsCasey JP, Magalhaes T, Conroy JM, Regan R, Shah N, Anney R, Shields DC, Abrahams BS, Almeida J, Bacchelli E, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Bolton PF, Bourgeron T, Brennan S, Cali P, Correia C, Corsello C, Coutanche M, Dawson G, de Jonge M, Delorme R, et al.April 2012Not Determined
21962519Create StudyAbsence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits.CellPeñagarikano O, Abrahams BS, Herman EI, Winden KD, Gdalyahu A, Dong H, Sonnenblick LI, Gruver R, Almajano J, Bragin A, Golshani P, Trachtenberg JT, Peles E, Geschwind DHSeptember 30, 2011Not Determined
21855394Create StudyGenetics of autism spectrum disorders.Trends in cognitive sciencesGeschwind DHSeptember 2011Not Determined
21784971Create StudyReduced functional integration and segregation of distributed neural systems underlying social and emotional information processing in autism spectrum disorders.Cerebral cortex (New York, N.Y. : 1991)Rudie JD, Shehzad Z, Hernandez LM, Colich NL, Bookheimer SY, Iacoboni M, Dapretto MMay 2012Not Determined
21522181Create StudyGene-ontology enrichment analysis in two independent family-based samples highlights biologically plausible processes for autism spectrum disorders.European journal of human genetics : EJHGAnney RJ, Kenny EM, O'Dushlaine C, Yaspan BL, Parkhomenka E, Buxbaum JD, Sutcliffe J, Gill M, Gallagher L, Autism Genome Project, Buxbaum JD, Sutcliffe J, Gill M, Gallagher LOctober 2011Not Determined
21519953Create StudySelective visual attention at twelve months: signs of autism in early social interactions.Journal of autism and developmental disordersHutman T, Chela MK, Gillespie-Lynch K, Sigman MApril 2012Not Determined
21484201Create StudyNovel method for combined linkage and genome-wide association analysis finds evidence of distinct genetic architecture for two subtypes of autism.Journal of neurodevelopmental disordersVieland VJ, Hallmayer J, Huang Y, Pagnamenta AT, Pinto D, Khan H, Monaco AP, Paterson AD, Scherer SW, Sutcliffe JS, Szatmari P, June 2011Not Determined
21358544Create StudyNeurodevelopmental disorders: hope for a new beginning.Current opinion in neurologyGeschwind DHApril 2011Not Determined
21334443Create StudyAtypical neural networks for social orienting in autism spectrum disorders.NeuroImageGreene DJ, Colich N, Iacoboni M, Zaidel E, Bookheimer SY, Dapretto MMay 1, 2011Not Determined
21211782Create StudyProliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner.Cell stem cellLe Belle JE, Orozco NM, Paucar AA, Saxe JP, Mottahedeh J, Pyle AD, Wu H, Kornblum HIJanuary 7, 2011Not Determined
21048216Create StudyAltered functional connectivity in frontal lobe circuits is associated with variation in the autism risk gene CNTNAP2.Science translational medicineScott-Van Zeeland AA, Abrahams BS, Alvarez-Retuerto AI, Sonnenblick LI, Rudie JD, Ghahremani D, Mumford JA, Poldrack RA, Dapretto M, Geschwind DH, Bookheimer SYNovember 3, 2010Not Determined
20663923Create StudyA genome-wide scan for common alleles affecting risk for autism.Human molecular geneticsAnney R, Klei L, Pinto D, Regan R, Conroy J, Magalhaes TR, Correia C, Abrahams BS, Sykes N, Pagnamenta AT, Almeida J, Bacchelli E, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Bölte S, Bolton PF, Bourgeron T, Brennan S, Brian J, Carson AR, Casallo G, Casey J, et al.October 15, 2010Not Determined
20552678Create StudyAccuracy of phenotyping of autistic children based on Internet implemented parent report.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric GeneticsLee H, Marvin AR, Watson T, Piggot J, Law JK, Law PA, Constantino JN, Nelson SFSeptember 2010Not Determined
20546081Create StudyResponse to distress in infants at risk for autism: a prospective longitudinal study.Journal of child psychology and psychiatry, and allied disciplinesHutman T, Rozga A, DeLaurentis AD, Barnwell JM, Sugar CA, Sigman MSeptember 2010Not Determined
20531469Create StudyFunctional impact of global rare copy number variation in autism spectrum disorders.NaturePinto D, Pagnamenta AT, Klei L, Anney R, Merico D, Regan R, Conroy J, Magalhaes TR, Correia C, Abrahams BS, Almeida J, Bacchelli E, Bader GD, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Bölte S, Bolton PF, Bourgeron T, Brennan S, Brian J, Bryson SE, Carson AR, et al.July 15, 2010Not Determined
20437601Create StudyReward processing in autism.Autism research : official journal of the International Society for Autism ResearchScott-Van Zeeland AA, Dapretto M, Ghahremani DG, Poldrack RA, Bookheimer SYApril 2010Not Determined
20394055Create StudyLanguage-related Cntnap2 gene is differentially expressed in sexually dimorphic song nuclei essential for vocal learning in songbirds.The Journal of comparative neurologyPanaitof SC, Abrahams BS, Dong H, Geschwind DH, White SAJune 1, 2010Not Determined
20385903Create StudyConnecting genes to brain in the autism spectrum disorders.Archives of neurologyAbrahams BS, Geschwind DHApril 2010Not Determined
20303070Create StudyNo neural evidence of statistical learning during exposure to artificial languages in children with autism spectrum disorders.Biological psychiatryScott-Van Zeeland AA, McNealy K, Wang AT, Sigman M, Bookheimer SY, Dapretto MAugust 15, 2010Not Determined
20302390Create StudyFactors predicting language lateralization in patients with perisylvian vascular malformations. Clinical article.Journal of neurosurgeryLee DJ, Pouratian N, Bookheimer SY, Martin NAOctober 2010Not Determined
20121438Create StudyThe reliability of neuroanatomy as a predictor of eloquence: a review.Neurosurgical focusPouratian N, Bookheimer SYFebruary 2010Not Relevant
19874940Create StudyAutism: the ups and downs of neuroligin.Biological psychiatryGeschwind DHNovember 15, 2009Not Determined
19630577Create StudyAdvances in autism.Annual review of medicineGeschwind DH2009Not Determined
19557195Create StudyGenome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes.PLoS geneticsBucan M, Abrahams BS, Wang K, Glessner JT, Herman EI, Sonnenblick LI, Alvarez Retuerto AI, Imielinski M, Hadley D, Bradfield JP, Kim C, Gidaya NB, Lindquist I, Hutman T, Sigman M, Kustanovich V, Lajonchere CM, Singleton A, Kim J, Wassink TH, McMahon WM, Owley T, Sweeney JA, Coon H, Nurnberger JI, et al.June 2009Not Determined
19477629Create StudyGenetic advances in autism: heterogeneity and convergence on shared pathways.Current opinion in genetics & developmentBill BR, Geschwind DHJune 2009Not Determined
19404256Create StudyCommon genetic variants on 5p14.1 associate with autism spectrum disorders.NatureWang K, Zhang H, Ma D, Bucan M, Glessner JT, Abrahams BS, Salyakina D, Imielinski M, Bradfield JP, Sleiman PM, Kim CE, Hou C, Frackelton E, Chiavacci R, Takahashi N, Sakurai T, Rappaport E, Lajonchere CM, Munson J, Estes A, Korvatska O, Piven J, Sonnenblick LI, Alvarez Retuerto AI, Herman EI, et al.May 28, 2009Not Determined
19155745Create StudyYour brain on Google: patterns of cerebral activation during internet searching.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric PsychiatrySmall GW, Moody TD, Siddarth P, Bookheimer SYFebruary 2009Not Determined
19125863Create StudyMethyl-CpG-binding protein 2 polymorphisms and vulnerability to autism.Genes, brain, and behaviorLoat CS, Curran S, Lewis CM, Duvall J, Geschwind D, Bolton P, Craig IWOctober 2008Not Determined
18999331Create StudyModeling longitudinal change in the language abilities of children with autism: parent behaviors and child characteristics as predictors of change.Developmental psychologySiller M, Sigman MNovember 2008Not Determined
18987363Create StudyA functional genetic link between distinct developmental language disorders.The New England journal of medicineVernes SC, Newbury DF, Abrahams BS, Winchester L, Nicod J, Groszer M, Alarcón M, Oliver PL, Davies KE, Geschwind DH, Monaco AP, Fisher SENovember 27, 2008Not Determined
18984147Create StudyAutism: many genes, common pathways?CellGeschwind DHOctober 31, 2008Not Determined
18954473Create StudyFrontal contributions to face processing differences in autism: evidence from fMRI of inverted face processing.Journal of the International Neuropsychological Society : JINSBookheimer SY, Wang AT, Scott A, Sigman M, Dapretto MNovember 2008Not Determined
18704077Create StudyAutism: Family connections.NatureGeschwind DHAugust 14, 2008Not Determined
18414403Create StudyAdvances in autism genetics: on the threshold of a new neurobiology.Nature reviews. GeneticsAbrahams BS, Geschwind DHMay 2008Not Determined
17347882Create StudyOffering to share: how to put heads together in autism neuroimaging.Journal of autism and developmental disordersBelmonte MK, Mazziotta JC, Minshew NJ, Evans AC, Courchesne E, Dager SR, Bookheimer SY, Aylward EH, Amaral DG, Cantor RM, Chugani DC, Dale AM, Davatzikos C, Gerig G, Herbert MR, Lainhart JE, Murphy DG, Piven J, Reiss AL, Schultz RT, Zeffiro TA, Levi-Pearl S, Lajonchere C, Colamarino SAJanuary 2008Not Determined
17322880Create StudyMapping autism risk loci using genetic linkage and chromosomal rearrangements.Nature geneticsAutism Genome Project Consortium, Szatmari P, Paterson AD, Zwaigenbaum L, Roberts W, Brian J, Liu XQ, Vincent JB, Skaug JL, Thompson AP, Senman L, Feuk L, Qian C, Bryson SE, Jones MB, Marshall CR, Scherer SW, Vieland VJ, Bartlett C, Mangin LV, Goedken R, Segre A, Pericak-Vance MA, Cuccaro ML, Gilbert JR, et al.March 2007Not Determined

This tab provides a general status on the data expected to be shared. There are two types of data expected.

  1. By Relevant publications — Those publications that reported for the collection's grant and have a status of "relevant" for sharing are listed first. The grantee is expected to share the data specific to those publications using the NDA Study feature. If a publication is erroneously marked relevant, the PI should simply change the status. When sharing a study, only the outcome measures for the subjects/time-points are shared. Other data that have not met the share date, defined below, will remain embargoed. To initiate study creation, simply login, mark your publication as relevant and click on the link listed to begin.

  2. By Data Structure — The number of subjects expected, received and shared is provided. Investigators are expected to update the data that they are collecting, the initial submission date and initial share dates. The NIMH Data Archive shares data when those dates are met.

  3. Submission Exemption — Those with Administrative or Submission Access to the Collection may request an exemption for submission for a defined period by stating the reason and timeframe. Note that the program officer on the grant may review this request.


Relevant Publications
PubMed IDStudyTitleJournalAuthorsDate
No records found.

For those with privileges to edit the collection, it is possible to upload your data definitions using this interface. NDA support staff will then follow up with a harmonized data definition for you to use in providing additional data.

Data Expected
Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
ADOS info iconApproved
Repetitive Behavior Scale - Revised (RBS-R) info iconApproved
Vital Signs Assessment info iconApproved
Wechsler Abbreviated Scale of Intelligence (WASI) info iconApproved
Social Responsiveness Scale (SRS) info iconApproved
Social Communication Questionnaire (SCQ) info iconApproved
Interpersonal Reactivity Index info iconApproved
Interpersonal Competence Scale (ICS) info iconApproved
ADI-R info iconApproved
Wechsler Intelligence Scale for Children info iconApproved
Genetic Test info iconApproved
Simpson-Angus Rating Scale (SAS) info iconApproved
Preschool Language Scale (PLS) info iconApproved
Physical Exam info iconApproved
Peabody Picture Vocabulary Test, Fourth Edition info iconApproved
ABC Community info iconApproved
Parent Concerns Questionaire info iconApproved
Mullen Scales of Early Learning info iconApproved
Medical History info iconApproved
Behavior Rating Inventory of Executive Function (BRIEF) info iconApproved
Vineland (Parent and Caregiver) info iconApproved
Imaging (Structural, fMRI, DTI, PET, microscopy) info iconApproved
Child Behavior Checklist (CBCL) info iconApproved
Child Symptom Inventory Parent Checklist info iconApproved
Childrens Yale-Brown OC Scale (CY-BOCS) info iconApproved
Sensory Profile info iconApproved
Leiter International Performance Scale-Revised (Leiter-R) info iconApproved
Eye Tracking info iconApproved
Side Effects info iconApproved
Clinical Global Impression (CGI) info iconApproved
Abnormal Involuntary Movement Scale (AIMS) info iconApproved
Autism Observation Scale for Infants (AOSI) info iconApproved
MacArthur Bates Communicative Development Inventory info iconApproved
Clinical Lab Tests info iconApproved
Research Subject and Pedigree info iconApproved
M-CHAT info iconApproved
Concomitant Medication info iconApproved
Receptive-Expressive Emergent Language Test-Third Edition info iconApproved
Pupillary Light Reflex with Heart Rate Variability  info iconApproved
Parenting Daily Hassles info iconApproved
Mean Length of Utterance (MLU) info iconApproved
Reynell Developmental Language Scales info iconApproved
Imitation and Praxis Battery info iconApproved
Early Social Communication Scales (ESCS) info iconApproved
Demographics info iconApproved
Caregiver Expectancies info iconApproved
Caregiver Child Interaction (CCX) Scale info iconApproved
Therapist-Child Interaction in Session (TCX) info iconApproved
Structured Play Assessment info iconApproved
EEG info iconApproved
Infant-Toddler Social-Emotional Assessment info iconApproved
Response to Distress info iconApproved
genomics/omics info iconApproved
Structure not yet defined

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study Name Description Number of Subjects
Collection / Total
Data Use State
Rare Inherited and De Novo CNVs Reveal Complex Contributions to ASD Risk in Multiplex families NOTE: NOT ALL DATA HAS BEEN UPLOADED FOR THIS STUDY. Rare mutations, including copy-number variants (CNVs), contribute significantly to autism spectrum disorder (ASD) risk. Although their importance has been established in families with only one affected child (simplex families), the contribution of both de novo and inherited CNVs to ASD in families with multiple affected individuals (multiplex families) is less well understood. We analyzed 1,532 families from the Autism Genetic Resource Exchange (AGRE) to assess the impact of de novo and rare CNVs on ASD risk in multiplex families. We observed a higher burden of large, rare CNVs, including inherited events, in individuals with ASD than in their unaffected siblings (odds ratio [OR] = 1.7), but the rate of de novo events was significantly lower than in simplex families. In previously characterized ASD risk loci, we identified 49 CNVs, comprising 24 inherited events, 19 de novo events, and 6 events of unknown inheritance, a significant enrichment in affected versus control individuals (OR = 3.3). In 21 of the 30 families (71%) in whom at least one affected sibling harbored an established ASD major risk CNV, including five families harboring inherited CNVs, the CNV was not shared by all affected siblings, indicating that other risk factors are contributing. We also identified a rare risk locus for ASD and language delay at chromosomal region 2q24 (implicating NR4A2) and another lower-penetrance locus involving inherited deletions and duplications of WWOX. The genetic architecture in multiplex families differs from that in simplex families and is complex, warranting more complete genetic characterization of larger multiplex ASD cohorts. 1 / 5288 Primary Analysis Shared
Derivation of Quality Measures for Time-Series Images by Neuroimaging Pipelines Using the National Database for Autism Research cloud platform, MRI data were analyzed using neuroimaging pipelines that included packages available as part of the Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC) Computational Environment to derive standardized measures of MR image quality. Time series QA was performed according to Friedman, et al. (http://www.ncbi.nlm.nih.gov/pubmed/16952468) providing values for Signal to Noise Ratio that can be compared to other subjects. 41 / 356 Secondary Analysis Shared
* Data not on individual level