Loading...

Reset Password

NDAR provides a single access to de-identified autism research data. For permission to download data, you will need an NDAR account with approved access to NDAR or a connected repository (AGRE, IAN, or the ATP). For NDAR access, you need to be a research investigator sponsored by an NIH recognized institution with federal wide assurance. See Request Access for more information.

Warning Notice

This is a U.S. Government computer system, which may be accessed and used only for authorized Government business by authorized personnel. Unauthorized access or use of this computer system may subject violators to criminal, civil, and/or administrative action.

All information on this computer system may be intercepted, recorded, read, copied, and disclosed by and to authorized personnel for official purposes, including criminal investigations. Such information includes sensitive data encrypted to comply with confidentiality and privacy requirements. Access or use of this computer system by any person, whether authorized or unauthorized, constitutes consent to these terms. There is no right of privacy in this system.

You have logged in with a temporary password. Please update your password. Passwords must contain 8 or more characters and must contain at least 3 of the following types of characters:

Subscribe to our mailing list

Mailing List(s)
Email Format

You are now leaving the National Database for Autism Research (NDAR) web site to go to:

Click on the address above if the page does not change within 10 seconds.

Disclaimer

NDAR is not responsible for the content of this external site and does not monitor other web sites for accuracy.

Selected Filters
No filters selected

The filters you have selected from various query interfaces will be stored here, in the 'Filter Cart'. The database will be queried using filters added to your 'Filter Cart', when multiple filters are defined, each will be executed using 'AND' logic, so with each filter that is applied the result set gets smaller.

From the 'Filter Cart' you can inspect each of the filters that have been defined, and you also have the option to remove filters. The 'Filter Cart' itself will display the number of filters applied along with the number of subjects that are identified by the combination of those filters. For example a GUID filter with two subjects, followed by a GUID filter for just one of those subjects would return only data for the subject that is in both GUID filters.

If you have a question about the filter cart, or underlying filters please contact the help desk at The NDA Help Desk

Description
Value Range
Notes
Data Structures with shared data
No filters have been selected

1 Numbers reported are subjects by age
New Trial
New Project

Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

Please select an experiment type below

New Documentation

Please enter the name of the data structure to search or if your definition does not exist, please upload that definition so that it can be appropriately defined for submission. Multiple data structures may be associated with a single Data Expected entry. Please add only one data structure per assessment.

Please provide a reason for the requested submission exemption and the
time-frame during which the exemption will be active.
Shared

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

General

Title, investigators, and Collection Description may be edited along with the Collection Phase. For Collection Phase, the options Pre-enrollment, Enrollment, and Completed can be chosen allowing the Collection Owner to indicate the stage of data collection.

Funding Source

The ability to associate the funding source for the project is provided. For NIH funded grants, linkage to Project Reporter information (e.g. R01MH123456) is supported. Projects funded by others, including the URL of the project, are listed. Non NIH funded projects will become available here to link that data with the appropriate funding agency.

Supporting Documentation

Any documents related to the project may be uploaded clarifying the data or acquisition methods used may be uploaded and made available here. The default is to share these documents to the general public. An option to share only to qualified Researchers is also an option.

Clinical Trials

For clinical trials, the option to link to the clinical trial in clinicaltrials.gov is optionally provided.

Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
A Longitudinal MRI Study of Infants at Risk for Autism (ACE 2)
Joseph Piven 
This application is a competing continuation of an Autism Center of Excellence (ACE) Network grant. The initial grant supported a prospective, longitudinal examination of brain and behavior at 6, 12 and 24 months in infants at high familial risk (HR) for autism. By the completion of this initial study 400 HR and 150 low risk infants will have entered this study. Results reveal that HR infants who go on to have autism at 24 months have impairments in visual orienting and motor behavior at 6 months of age, which may lay the foundation for the emergence of the defining features of autism (social deficits, repetitive behaviors) observed in these same infants by 12 months of age. Aberrant white matter tract development is detectable by 6 months of age in infants classified as autistic at 24 months (1), with further widespread abnormalities in white matter tract development and an increased rate of brain volume growth observed over the 6-24 month period. Thus, our research establishes, for the first time, that such brain changes occur concurrently with the emergence of behavioral abnormalities in ASD. Taken together, these findings point to brain and behavior changes during the 1st year (and as early as 6 months of age) as being critically important in the onset and development of autistic behavior. In this application we propose to follow up these findings by conducting earlier (3 months), more frequent (3, 6, 9, 12, 15, 24 months) and more in depth examination of the trajectories of brain and behavior development in 200 HR and 60 LR infants, to more fully understand brain-behavior relationships during this critically important period preceding and coinciding with the emergence of the defining features of autism. We also propose to conduct follow up behavioral/diagnostic evaluations of our original sample of 400 HR subjects at 36 to 60 months of age, a time when the diagnosis of autism is considered to be more stable. This will allow us to map the trajectories of brain and behavior development and test the association between clinical ASD diagnosis and variation in developmental trajectories. Finally we propose to conduct an analysis of child and family level characteristics relevant to elucidating an early prediction model of later autism in the joint cohort of 600 HR subjects. The delineation of brain and behavior trajectories in early development and the ability to predict autism diagnosis from preclinical risk markers during infancy, prior to clinical diagnosis and during a period of substantial post-natal brain plasticity, when children may benefit maximally from early detection and intervention, has the potential to significantly improve the lives of affected individuals.
NDAR
Enrolling
Shared
$12,842,583.00
491
520
388

Loading...

No Data Shared

Loading...

No Data Shared

Loading...

Chart Expander
NIH - Extramural None


R01HD055741-06 A Longitudinal MRI Study of Infants at Risk for Autism 09/04/2012 05/31/2017 520 388 UNIV OF NORTH CAROLINA CHAPEL HILL $12,842,583.00

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Experiments

To create a new Omics, eye tracking, fMRI, or EEG experiment, press the "+ New Experiment" button. Once an experiment is created, then raw files for these types of experiments should be provided, associating the experiment – through Experiment_ID – with the metadata defined in the experiments interface.

IDNameCreated DateStatusType
308A Longitudinal MRI Study of Infants at Risk for Autism (ACE 2)06/03/2015ApprovedfMRI

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Shared Data

Data structures with the number of subjects submitted and shared are provided.

Autism Diagnostic Interview, Revised (ADI-R) Clinical Assessments 11
Autism Observation Scale for Infants Clinical Assessments 6
CHARGE Medical History Clinical Assessments 424
CHARGE Physical Exam Clinical Assessments 26
CSBS DP Behavior Sample Clinical Assessments 1
Image Imaging 24
Infant Behavior Questionnaire Revised Clinical Assessments 1
M-CHAT Clinical Assessments 1
MacArthur-Bates CDI - Words and Gestures Form Clinical Assessments 2
Repetitive Behavior Scale - Revised (RBS-R) Clinical Assessments 2
Research Subject Clinical Assessments 50
Social Communication Questionnaire (SCQ) - Current Form Clinical Assessments 2
Social Communication Questionnaire (SCQ) - Lifetime Clinical Assessments 14
Vineland-II - Survey Form (2005) Clinical Assessments 28

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDAR data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed IDStudyTitleJournalAuthorsDateStatus
27791287Create StudyDiffusion tensor spectroscopic imaging of the human brain in children and adults.Magnetic resonance in medicineFotso K, Dager SR, Landow A, Ackley E, Myers O, Dixon M, Shaw D, Corrigan NM, Posse SOctober 2016Not Determined
27497283Create StudyA touchscreen based global motion perception task for mice.Vision researchStirman JN, Townsend LB, Smith SLOctober 2016Not Relevant
27150231Create StudyDevelopment of cortical shape in the human brain from 6 to 24months of age via a novel measure of shape complexity.NeuroImageKim SH, Lyu I, Fonov VS, Vachet C, Hazlett HC, Smith RG, Piven J, Dager SR, Mckinstry RC, Pruett JR, Evans AC, Collins DL, Botteron KN, Schultz RT, Gerig G, Styner MA, July 15, 2016Not Determined
27065227Create StudyAutotract: Automatic cleaning and tracking of fibers.Proceedings of SPIE--the International Society for Optical EngineeringPrieto JC, Yang JY, Budin F, Styner MFebruary 27, 2016Not Relevant
26731103Create StudyThe Macaque Social Responsiveness Scale (mSRS): A Rapid Screening Tool for Assessing Variability in the Social Responsiveness of Rhesus Monkeys (Macaca mulatta).PloS oneFeczko EJ, Bliss-Moreau E, Walum H, Pruett JR, Parr LA2016Not Relevant
26612964Create StudyEarly Postnatal Myelin Content Estimate of White Matter via T1w/T2w Ratio.Proceedings of SPIE--the International Society for Optical EngineeringLee K, Cherel M, Budin F, Gilmore J, Consing KZ, Rasmussen J, Wadhwa PD, Entringer S, Glasser MF, Van Essen DC, Buss C, Styner M2015Relevant
26490257Create StudySplenium development and early spoken language in human infants.Developmental scienceSwanson MR, Wolff JJ, Elison JT, Gu H, Hazlett HC, Botteron K, Styner M, Paterson S, Gerig G, Constantino J, Dager S, Estes A, Vachet C, Piven J, IBIS NetworkOctober 21, 2015Not Determined
26203305Create StudyBehavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life.Journal of neurodevelopmental disordersEstes A, Zwaigenbaum L, Gu H, St John T, Paterson S, Elison JT, Hazlett H, Botteron K, Dager SR, Schultz RT, Kostopoulos P, Evans A, Dawson G, Eliason J, Alvarez S, Piven J, 2015Relevant
26089584Create StudyAutomatic Tissue Segmentation of Neonate Brain MR Images with Subject-specific Atlases.Proceedings of SPIE--the International Society for Optical EngineeringCherel M, Budin F, Prastawa M, Gerig G, Lee K, Buss C, Lyall A, Consing KZ, Styner MFebruary 21, 2015Not Determined
26088663Create StudyLong-Term Outcomes of Early Intervention in 6-Year-Old Children With Autism Spectrum Disorder.Journal of the American Academy of Child and Adolescent PsychiatryEstes A, Munson J, Rogers SJ, Greenson J, Winter J, Dawson GJuly 2015Not Determined
26028804Create StudySkeletal shape correspondence via entropy minimization.Proceedings of SPIE--the International Society for Optical EngineeringTu L, Styner M, Vicory J, Paniagua B, Prieto JC, Yang D, Pizer SM2015Not Determined
26028803Create StudyShape index distribution based local surface complexity applied to the human cortex.Proceedings of SPIE--the International Society for Optical EngineeringKim SH, Fonov V, Collins DL, Gerig G, IBIS Network, Styner MA2015Not Determined
26028801Create StudyAutomatic Sulcal Curve Extraction on the Human Cortical Surface.Proceedings of SPIE--the International Society for Optical EngineeringLyu I, Kim SH, Styner M2015Not Determined
25937563Create StudyAltered corpus callosum morphology associated with autism over the first 2 years of life.Brain : a journal of neurologyWolff JJ, Gerig G, Lewis JD, Soda T, Styner MA, Vachet C, Botteron KN, Elison JT, Dager SR, Estes AM, Hazlett HC, Schultz RT, Zwaigenbaum L, Piven J, July 2015Relevant
25704288Create StudyAccurate age classification of 6 and 12 month-old infants based on resting-state functional connectivity magnetic resonance imaging data.Developmental cognitive neurosciencePruett JR, Kandala S, Hoertel S, Snyder AZ, Elison JT, Nishino T, Feczko E, Dosenbach NU, Nardos B, Power JD, Adeyemo B, Botteron KN, McKinstry RC, Evans AC, Hazlett HC, Dager SR, Paterson S, Schultz RT, Collins DL, Fonov VS, Styner M, Gerig G, Das S, Kostopoulos P, Constantino JN, et al.April 2015Not Determined
25664349Create StudyGeodesic image regression with a sparse parameterization of diffeomorphisms.Geometric science of information : first international conference, GSI 2013, Paris, France, August 28-30, 2013 : proceedings / Frank Nielsen, Frederic Barbaresco (eds.). Geometric Science of Information (1st : 2013 : Paris, France)Fishbaugh J, Prastawa M, Gerig G, Durrleman S2013Not Determined
25538672Create StudySubject-Motion Correction in HARDI Acquisitions: Choices and Consequences.Frontiers in neurologyElhabian S, Gur Y, Vachet C, Piven J, Styner M, Leppert IR, Pike GB, Gerig G2014Not Determined
25506622Create StudyMixed-Effects Shape Models for Estimating Longitudinal Changes in Anatomy.Spatio-temporal image analysis for longitudinal and time-series image data : Second International Workshop, STIA 2012, held in conjunction with MICCAI 2012, Nice, France, October 1, 2012, proceedings / Stanley Durrleman, Tom Flecher, Gu...Datar M, Muralidharan P, Kumar A, Gouttard S, Piven J, for the IBIS Network, Gerig G, Whitaker R, Fletcher PTOctober 2012Not Determined
25440311Create StudyRepetitive behavior in 12-month-olds later classified with autism spectrum disorder.Journal of the American Academy of Child and Adolescent PsychiatryElison JT, Wolff JJ, Reznick JS, Botteron KN, Estes AM, Gu H, Hazlett HC, Meadows AJ, Paterson SJ, Zwaigenbaum L, Piven J, Infant Brain Imaging Study (IBIS) NetworkNovember 2014Not Determined
25356196Create StudyA JOINT FRAMEWORK FOR 4D SEGMENTATION AND ESTIMATION OF SMOOTH TEMPORAL APPEARANCE CHANGES.Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical ImagingGao Y, Prastawa M, Styner M, Piven J, Gerig G2014-AprNot Relevant
25356195Create StudyA PRELIMINARY STUDY ON THE EFFECT OF MOTION CORRECTION ON HARDI RECONSTRUCTION.Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical ImagingElhabian S, Gur Y, Vachet C, Piven J, Styner M, Leppert I, Pike GB, Gerig G2014-AprNot Determined
25356194Create StudyPARAMETRIC REGRESSION SCHEME FOR DISTRIBUTIONS: ANALYSIS OF DTI FIBER TRACT DIFFUSION CHANGES IN EARLY BRAIN DEVELOPMENT.Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical ImagingSharma A, Fletcher PT, Gilmore JH, Escolar ML, Gupta A, Styner M, Gerig G2014-AprRelevant
25356192Create StudyGEODESIC REGRESSION OF IMAGE AND SHAPE DATA FOR IMPROVED MODELING OF 4D TRAJECTORIES.Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical ImagingFishbaugh J, Prastawa M, Gerig G, Durrleman S2014-AprNot Determined
25320779Create StudySubject-specific prediction using nonlinear population modeling: application to early brain maturation from DTI.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted InterventionSadeghi N, Fletcher PT, Prastawa M, Gilmore JH, Gerig G2014Not Determined
25312279Create StudyBrief Report: Chimpanzee Social Responsiveness Scale (CSRS) Detects Individual Variation in Social Responsiveness for Captive Chimpanzees.Journal of autism and developmental disordersFaughn C, Marrus N, Shuman J, Ross SR, Constantino JN, Pruett JR, Povinelli DJMay 2015Not Determined
25309699Create StudyCharacterizing growth patterns in longitudinal MRI using image contrast.Proceedings of SPIE--the International Society for Optical EngineeringVardhan A, Prastawa M, Vachet C, Piven J, Gerig GMarch 21, 2014Relevant
25103541Create StudyStriatal development in autism: repetitive behaviors and the reward circuitry.Biological psychiatryKohls G, Yerys BE, Schultz RTSeptember 1, 2014Not Determined
24802306Create StudyNetwork inefficiencies in autism spectrum disorder at 24 months.Translational psychiatryLewis JD, Evans AC, Pruett JR, Botteron K, Zwaigenbaum L, Estes A, Gerig G, Collins L, Kostopoulos P, McKinstry R, Dager S, Paterson S, Schultz RT, Styner M, Hazlett H, Piven J2014Not Determined
24684012Create StudyGeodesic shape regression in the framework of currents.Information processing in medical imaging : proceedings of the ... conferenceFishbaugh J, Prastawa M, Gerig G, Durrleman S2013Not Determined
24655647Create StudyBAP: not-quite-autism in infants.Journal of the American Academy of Child and Adolescent PsychiatryPruett JRApril 2014Not Determined
24567717Create StudyMulti-atlas segmentation of subcortical brain structures via the AutoSeg software pipeline.Frontiers in neuroinformaticsWang J, Vachet C, Rumple A, Gouttard S, Ouziel C, Perrot E, Du G, Huang X, Gerig G, Styner M2014Relevant
24552513Create StudyLongitudinal patterns of repetitive behavior in toddlers with autism.Journal of child psychology and psychiatry, and allied disciplinesWolff JJ, Botteron KN, Dager SR, Elison JT, Estes AM, Gu H, Hazlett HC, Pandey J, Paterson SJ, Schultz RT, Zwaigenbaum L, Piven J, IBIS NetworkAugust 2014Not Determined
24523693Create StudyDTIPrep: quality control of diffusion-weighted images.Frontiers in neuroinformaticsOguz I, Farzinfar M, Matsui J, Budin F, Liu Z, Gerig G, Johnson HJ, Styner M2014Not Determined
24443698Create StudyMODELING LONGITUDINAL MRI CHANGES IN POPULATIONS USING A LOCALIZED, INFORMATION-THEORETIC MEASURE OF CONTRAST.Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical ImagingVardhan A, Prastawa M, Sharma A, Piven J, Gerig GDecember 31, 2013Relevant
24443688Create StudySPATIOTEMPORAL MODELING OF DISCRETE-TIME DISTRIBUTION-VALUED DATA APPLIED TO DTI TRACT EVOLUTION IN INFANT NEURODEVELOPMENT.Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical ImagingSharma A, Fletcher PT, Gilmore JH, Escolar ML, Gupta A, Styner M, Gerig GDecember 31, 2013Relevant
24443681Create StudyLONGITUDINAL GROWTH MODELING OF DISCRETE-TIME FUNCTIONS WITH APPLICATION TO DTI TRACT EVOLUTION IN EARLY NEURODEVELOPMENT.Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical ImagingSharma A, Durrleman S, Gilmore JH, Gerig GDecember 31, 2013Not Relevant
24409141Create StudyUNC-Utah NA-MIC framework for DTI fiber tract analysis.Frontiers in neuroinformaticsVerde AR, Budin F, Berger JB, Gupta A, Farzinfar M, Kaiser A, Ahn M, Johnson H, Matsui J, Hazlett HC, Sharma A, Goodlett C, Shi Y, Gouttard S, Vachet C, Piven J, Zhu H, Gerig G, Styner M2014Not Determined
24392201Create StudyA framework for longitudinal data analysis via shape regression.Proceedings of SPIE--the International Society for Optical EngineeringFishbaugh J, Durrleman S, Piven J, Gerig GFebruary 23, 2012Not Determined
24386543Create StudyUNC-Utah NA-MIC DTI framework: Atlas Based Fiber Tract Analysis with Application to a Study of Nicotine Smoking Addiction.Proceedings of SPIE--the International Society for Optical EngineeringVerde AR, Berger JB, Gupta A, Farzinfar M, Kaiser A, Chanon VW, Boettiger C, Goodlett C, Shi Y, Zhu H, Gerig G, Gouttard S, Vachet C, Styner MMarch 13, 2013Not Determined
24353382Create StudyAutomatic corpus callosum segmentation using a deformable active Fourier contour model.Proceedings of SPIE--the International Society for Optical EngineeringVachet C, Yvernault B, Bhatt K, Smith RG, Gerig G, Hazlett HC, Styner MMarch 23, 2012Not Determined
24353381Create StudyMeasures for Validation of DTI Tractography.Proceedings of SPIE--the International Society for Optical EngineeringGouttard S, Goodlett CB, Kubicki M, Gerig GFebruary 23, 2012Not Determined
24353379Create StudyQuality Control of Diffusion Weighted Images.Proceedings of SPIE--the International Society for Optical EngineeringLiu Z, Wang Y, Gerig G, Gouttard S, Tao R, Fletcher T, Styner MMarch 11, 2010Not Determined
24353378Create StudyChanges of MR and DTI appearance in early human brain development.Proceedings of SPIE--the International Society for Optical EngineeringMarc C, Vachet C, Gerig G, Blocher J, Gilmore J, Styner MMarch 12, 2010Not Determined
24353377Create StudyEvaluation of DTI Property Maps as Basis of DTI Atlas Building.Proceedings of SPIE--the International Society for Optical EngineeringLiu Z, Goodlett C, Gerig G, Styner MMarch 12, 2010Not Determined
24353376Create StudyTowards Analysis of Growth Trajectory through Multi-modal Longitudinal MR Imaging.Proceedings of SPIE--the International Society for Optical EngineeringSadeghi N, Prastawa M, Gilmore JH, Lin W, Gerig GMarch 12, 2010Relevant
24069234Create StudyAge-specific average head template for typically developing 6-month-old infants.PloS oneAkiyama LF, Richards TR, Imada T, Dager SR, Wroblewski L, Kuhl PK2013Not Determined
23959506Create StudyMULTIVARIATE MODELING OF LONGITUDINAL MRI IN EARLY BRAIN DEVELOPMENT WITH CONFIDENCE MEASURES.Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical ImagingSadeghi N, Prastawa M, Fletcher PT, Vachet C, Wang B, Gilmore J, Gerig G2013Not Relevant
23959442Create StudyA NEW FRAMEWORK FOR ANALYZING WHITE MATTER MATURATION IN EARLY BRAIN DEVELOPMENT.Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical ImagingPrastawa M, Sadeghi N, Gilmore JH, Lin W, Gerig G2010Not Relevant
23958630Create StudyQUANTIFYING REGIONAL GROWTH PATTERNS THROUGH LONGITUDINAL ANALYSIS OF DISTANCES BETWEEN MULTIMODAL MR INTENSITY DISTRIBUTIONS.Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical ImagingVardhan A, Prastawa M, Gouttard S, Piven J, Gerig G2012Not Relevant
23956495Create StudyToward a comprehensive framework for the spatiotemporal statistical analysis of longitudinal shape data.International journal of computer visionDurrleman S, Pennec X, Trouvé A, Braga J, Gerig G, Ayache NMay 2013Not Determined
23846465Create StudyLongitudinal image registration with temporally-dependent image similarity measure.IEEE transactions on medical imagingCsapo I, Davis B, Shi Y, Sanchez M, Styner M, Niethammer MOctober 2013Not Determined
23833547Create StudyDTI Quality Control Assessment via Error Estimation From Monte Carlo Simulations.Proceedings of SPIE--the International Society for Optical EngineeringFarzinfar M, Li Y, Verde AR, Oguz I, Gerig G, Styner MAMarch 13, 2013Not Relevant
23684874Create StudyDiffusion imaging quality control via entropy of principal direction distribution.NeuroImageFarzinfar M, Oguz I, Smith RG, Verde AR, Dietrich C, Gupta A, Escolar ML, Piven J, Pujol S, Vachet C, Gouttard S, Gerig G, Dager S, McKinstry RC, Paterson S, Evans AC, IBIS network, Styner MANovember 15, 2013Relevant
23595508Create StudyENTROPY BASED DTI QUALITY CONTROL VIA REGIONAL ORIENTATION DISTRIBUTION.Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical ImagingFarzinfar M, Dietrich C, Smith R, Li Y, Gupta A, Liu Z, Styner M2012Not Determined
23568185Create StudyBuilding Spatiotemporal Anatomical Models using Joint 4-D Segmentation, Registration, and Subject-Specific Atlas Estimation.Proceedings / sponsored by IEEE Computer Society Technical Committee on Pattern Analysis and Machine Intelligence. Workshop on Mathematical Methods in Biomedical Image AnalysisPrastawa M, Awate SP, Gerig G2012Not Determined
23511344Create StudyWhite matter microstructure and atypical visual orienting in 7-month-olds at risk for autism.The American journal of psychiatryElison JT, Paterson SJ, Wolff JJ, Reznick JS, Sasson NJ, Gu H, Botteron KN, Dager SR, Estes AM, Evans AC, Gerig G, Hazlett HC, Schultz RT, Styner M, Zwaigenbaum L, Piven J, IBIS NetworkAugust 2013Not Determined
23432829Create StudyFrontolimbic neural circuitry at 6 months predicts individual differences in joint attention at 9 months.Developmental scienceElison JT, Wolff JJ, Heimer DC, Paterson SJ, Gu H, Hazlett HC, Styner M, Gerig G, Piven J, March 2013Not Determined
23285617Create StudyAnalysis of longitudinal shape variability via subject specific growth modeling.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted InterventionFishbaugh J, Prastawa M, Durrleman S, Piven J, Gerig G, IBIS Network2012Not Determined
23235270Create StudyRegional characterization of longitudinal DT-MRI to study white matter maturation of the early developing brain.NeuroImageSadeghi N, Prastawa M, Fletcher PT, Wolff J, Gilmore JH, Gerig GMarch 2013Relevant
23223157Create StudySPATIAL INTENSITY PRIOR CORRECTION FOR TISSUE SEGMENTATION IN THE DEVELOPING HUMAN BRAIN.Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical ImagingKim SH, Fonov V, Piven J, Gilmore J, Vachet C, Gerig G, Collins DL, Styner M, The IBIS Network2011Relevant
22684595Create StudyBrain volume findings in 6-month-old infants at high familial risk for autism.The American journal of psychiatryHazlett HC, Gu H, McKinstry RC, Shaw DW, Botteron KN, Dager SR, Styner M, Vachet C, Gerig G, Paterson SJ, Schultz RT, Estes AM, Evans AC, Piven J, IBIS NetworkJune 2012Not Determined
22370873Create StudyConsensus paper: pathological role of the cerebellum in autism.Cerebellum (London, England)Fatemi SH, Aldinger KA, Ashwood P, Bauman ML, Blaha CD, Blatt GJ, Chauhan A, Chauhan V, Dager SR, Dickson PE, Estes AM, Goldowitz D, Heck DH, Kemper TL, King BH, Martin LA, Millen KJ, Mittleman G, Mosconi MW, Persico AM, Sweeney JA, Webb SJ, Welsh JPSeptember 2012Not Determined
21995056Create StudyIterative refinement of point correspondences for 3D statistical shape models.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted InterventionSeshamani S, Chintalapani G, Taylor R2011Not Determined
21995054Create StudyEstimation of smooth growth trajectories with controlled acceleration from time series shape data.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted InterventionFishbaugh J, Durrleman S, Gerig G2011Not Determined
21761651Create StudyOptimal data-driven sparse parameterization of diffeomorphisms for population analysis.Information processing in medical imaging : proceedings of the ... conferenceDurrleman S, Prastawa M, Gerig G, Joshi SJanuary 2011Not Relevant
21438139Create StudyMutations in the TSGA14 gene in families with autism spectrum disorders.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric GeneticsKorvatska O, Estes A, Munson J, Dawson G, Bekris LM, Kohen R, Yu CE, Schellenberg GD, Raskind WHApril 2011Not Determined
21256236Create StudyDTI registration in atlas based fiber analysis of infantile Krabbe disease.NeuroImageWang Y, Gupta A, Liu Z, Zhang H, Escolar ML, Gilmore JH, Gouttard S, Fillard P, Maltbie E, Gerig G, Styner MApril 2011Not Determined
21244423Create StudyPoor fine-motor and visuospatial skills predict persistence of pediatric-onset obsessive-compulsive disorder into adulthood.Journal of child psychology and psychiatry, and allied disciplinesBloch MH, Sukhodolsky DG, Dombrowski PA, Panza KE, Craiglow BG, Landeros-Weisenberger A, Leckman JF, Peterson BS, Schultz RTSeptember 2011Not Determined
21042871Create StudyDiscrepancies between academic achievement and intellectual ability in higher-functioning school-aged children with autism spectrum disorder.Journal of autism and developmental disordersEstes A, Rivera V, Bryan M, Cali P, Dawson GAugust 2011Not Determined
21041620Create StudyLaterobasal amygdalar enlargement in 6- to 7-year-old children with autism spectrum disorder.Archives of general psychiatryKim JE, Lyoo IK, Estes AM, Renshaw PF, Shaw DW, Friedman SD, Kim DJ, Yoon SJ, Hwang J, Dager SRNovember 2010Not Determined
20426000Create StudySpatiotemporal atlas estimation for developmental delay detection in longitudinal datasets.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted InterventionDurrleman S, Pennec X, Trouvé A, Gerig G, Ayache N2009Not Determined
19819542Create StudyAutism.Lancet (London, England)Levy SE, Mandell DS, Schultz RTNovember 7, 2009Not Determined
19243924Create StudyCerebellar vermal volumes and behavioral correlates in children with autism spectrum disorder.Psychiatry researchWebb SJ, Sparks BF, Friedman SD, Shaw DW, Giedd J, Dawson G, Dager SRApril 30, 2009Not Determined
18982614Create StudyAssessment of reliability of multi-site neuroimaging via traveling phantom study.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted InterventionGouttard S, Styner M, Prastawa M, Piven J, Gerig G2008Not Determined
18606031Create StudyEarly behavioral intervention, brain plasticity, and the prevention of autism spectrum disorder.Development and psychopathologyDawson G2008Not Determined
18058011Create StudyHead circumference as an early predictor of autism symptoms in younger siblings of children with autism spectrum disorder.Journal of autism and developmental disordersElder LM, Dawson G, Toth K, Fein D, Munson JJuly 2008Not Determined
17975722Create StudyCharacteristics associated with presence of depressive symptoms in adults with autism spectrum disorder.Journal of autism and developmental disordersSterling L, Dawson G, Estes A, Greenson JJuly 2008Not Determined
17963435Create StudyLevel of intellectual functioning predicts patterns of associated symptoms in school-age children with autism spectrum disorder.American journal of mental retardation : AJMREstes AM, Dawson G, Sterling L, Munson JNovember 2007Not Determined

This tab provides a general status on the data expected to be shared. There are two types of data expected.

  1. By Relevant publications — Those publications that reported for the collection's grant and have a status of "relevant" for sharing are listed first. The grantee is expected to share the data specific to those publications using the NDA Study feature. If a publication is erroneously marked relevant, the PI should simply change the status. When sharing a study, only the outcome measures for the subjects/time-points are shared. Other data that have not met the share date, defined below, will remain embargoed. To initiate study creation, simply login, mark your publication as relevant and click on the link listed to begin.

  2. By Data Structure — The number of subjects expected, received and shared is provided. Investigators are expected to update the data that they are collecting, the initial submission date and initial share dates. The NIMH Data Archive shares data when those dates are met.

  3. Submission Exemption — Those with Administrative or Submission Access to the Collection may request an exemption for submission for a defined period by stating the reason and timeframe. Note that the program officer on the grant may review this request.


Relevant Publications
PubMed IDStudyTitleJournalAuthorsDate
26612964Create StudyEarly Postnatal Myelin Content Estimate of White Matter via T1w/T2w Ratio.Proceedings of SPIE--the International Society for Optical EngineeringLee K, Cherel M, Budin F, Gilmore J, Consing KZ, Rasmussen J, Wadhwa PD, Entringer S, Glasser MF, Van Essen DC, Buss C, Styner M2015
26203305Create StudyBehavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life.Journal of neurodevelopmental disordersEstes A, Zwaigenbaum L, Gu H, St John T, Paterson S, Elison JT, Hazlett H, Botteron K, Dager SR, Schultz RT, Kostopoulos P, Evans A, Dawson G, Eliason J, Alvarez S, Piven J, 2015
25937563Create StudyAltered corpus callosum morphology associated with autism over the first 2 years of life.Brain : a journal of neurologyWolff JJ, Gerig G, Lewis JD, Soda T, Styner MA, Vachet C, Botteron KN, Elison JT, Dager SR, Estes AM, Hazlett HC, Schultz RT, Zwaigenbaum L, Piven J, July 2015
25356194Create StudyPARAMETRIC REGRESSION SCHEME FOR DISTRIBUTIONS: ANALYSIS OF DTI FIBER TRACT DIFFUSION CHANGES IN EARLY BRAIN DEVELOPMENT.Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical ImagingSharma A, Fletcher PT, Gilmore JH, Escolar ML, Gupta A, Styner M, Gerig G2014-Apr
25309699Create StudyCharacterizing growth patterns in longitudinal MRI using image contrast.Proceedings of SPIE--the International Society for Optical EngineeringVardhan A, Prastawa M, Vachet C, Piven J, Gerig GMarch 21, 2014
24567717Create StudyMulti-atlas segmentation of subcortical brain structures via the AutoSeg software pipeline.Frontiers in neuroinformaticsWang J, Vachet C, Rumple A, Gouttard S, Ouziel C, Perrot E, Du G, Huang X, Gerig G, Styner M2014
24443698Create StudyMODELING LONGITUDINAL MRI CHANGES IN POPULATIONS USING A LOCALIZED, INFORMATION-THEORETIC MEASURE OF CONTRAST.Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical ImagingVardhan A, Prastawa M, Sharma A, Piven J, Gerig GDecember 31, 2013
24443688Create StudySPATIOTEMPORAL MODELING OF DISCRETE-TIME DISTRIBUTION-VALUED DATA APPLIED TO DTI TRACT EVOLUTION IN INFANT NEURODEVELOPMENT.Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical ImagingSharma A, Fletcher PT, Gilmore JH, Escolar ML, Gupta A, Styner M, Gerig GDecember 31, 2013
24353376Create StudyTowards Analysis of Growth Trajectory through Multi-modal Longitudinal MR Imaging.Proceedings of SPIE--the International Society for Optical EngineeringSadeghi N, Prastawa M, Gilmore JH, Lin W, Gerig GMarch 12, 2010
23684874Create StudyDiffusion imaging quality control via entropy of principal direction distribution.NeuroImageFarzinfar M, Oguz I, Smith RG, Verde AR, Dietrich C, Gupta A, Escolar ML, Piven J, Pujol S, Vachet C, Gouttard S, Gerig G, Dager S, McKinstry RC, Paterson S, Evans AC, IBIS network, Styner MANovember 15, 2013
23235270Create StudyRegional characterization of longitudinal DT-MRI to study white matter maturation of the early developing brain.NeuroImageSadeghi N, Prastawa M, Fletcher PT, Wolff J, Gilmore JH, Gerig GMarch 2013
23223157Create StudySPATIAL INTENSITY PRIOR CORRECTION FOR TISSUE SEGMENTATION IN THE DEVELOPING HUMAN BRAIN.Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical ImagingKim SH, Fonov V, Piven J, Gilmore J, Vachet C, Gerig G, Collins DL, Styner M, The IBIS Network2011

For those with privileges to edit the collection, it is possible to upload your data definitions using this interface. NDA support staff will then follow up with a harmonized data definition for you to use in providing additional data.

Data Expected
Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
Research Subject and Pedigree info iconApproved
Early Development Inventory (EDI) info iconApproved
Imaging (Structural, fMRI, DTI, PET, microscopy) info iconApproved
ADOS info iconApproved
Social Responsiveness Scale (SRS) info iconApproved
Social Communication Questionnaire (SCQ) info iconApproved
Repetitive Behavior Scale - Revised (RBS-R) info iconApproved
Physical Exam info iconApproved
Vineland (Parent and Caregiver) info iconApproved
ADI-R info iconApproved
M-CHAT info iconApproved
MacArthur Bates Communicative Development Inventory info iconApproved
LENA - Frequency of Speech info iconApproved
Intervention History info iconApproved
Autism Observation Scale for Infants (AOSI) info iconApproved
Communication and Symbolic Behavior Scales (CSBS) info iconApproved
Early Childhood Behavioral Questionnaire (ECBQ) info iconApproved
Family Environment Scale info iconApproved
Infant Behavior Questionnaire (IBQ) info iconApproved
Medical History info iconApproved
EEG info iconApproved
Visual Habituation Task info iconApproved
Eye Tracking info iconApproved
Joint Attention / Social and Nonsocial Orienting Task info iconApproved
Mullen Scales of Early Learning info iconApproved
Alberta Infant Motor Scale (AIMS) info iconApproved
Structure not yet defined

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study Name Description Number of Subjects
Collection / Total
Data Use State
Revising the Social Communication Questionnaire scoring procedures for Autism Spectrum Disorder and potential Social Communication Disorder In analyzing data from the National Database for Autism Research, we examine revising the Social Communication Questionnaire (SCQ), a commonly used screening instrument for Autism Spectrum Disorder. A combination of Item Response Theory and Mokken scaling techniques were utilized to achieve this and abbreviated scoring of the SCQ is suggested. The psychometric sensitivity of this abbreviated SCQ was examined via bootstrapped Receiver Operator Characteristic (ROC) curve analyses. Additionally, we examined the sensitivity of the abbreviated and total scaled SCQ as it relates to a potential diagnosis of Social (Pragmatic) Communication Disorder (SCD). As SCD is a new disorder introduced with the fifth edition of the Diagnostic and Statistical Manual (DSM-5), we identified individuals with potential diagnosis of SCD among individuals with ASD via mixture modeling techniques using the same NDAR data. These analyses revealed two classes or clusters of individuals when considering the two core areas of impairment among individuals with ASD: social communication and restricted, repetitive patterns of behavior. 1 / 1021 Secondary Analysis Shared
Derivation of Quality Measures for Time-Series Images by Neuroimaging Pipelines Using the National Database for Autism Research cloud platform, MRI data were analyzed using neuroimaging pipelines that included packages available as part of the Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC) Computational Environment to derive standardized measures of MR image quality. Time series QA was performed according to Friedman, et al. (http://www.ncbi.nlm.nih.gov/pubmed/16952468) providing values for Signal to Noise Ratio that can be compared to other subjects. 3 / 356 Secondary Analysis Shared
Derivation of Brain Structure Volumes from MRI Neuroimages hosted by NDAR using NITRC-CE A draft publication is in progress. GitHub repository with code for working with NDAR Data is available here: https://github.com/chaselgrove/ndar **Note this study is ongoing; additional may be added.** 3 / 356 Secondary Analysis Shared
Derivation of Quality Measures for Structural Images by Neuroimaging Pipelines Using the National Database for Autism Research cloud platform, MRI data were analyzed using neuroimaging pipelines that included packages available as part of the Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC) Computational Environment to derive standardized measures of MR image quality. Structural QA was performed according to Haselgrove, et al (http://journal.frontiersin.org/Journal/10.3389/fninf.2014.00052/abstract) to provide values for Signal to Noise (SNR) and Contrast to Noise (CNR) Ratios that can be compared between subjects within NDAR and between other public data releases. 3 / 425 Secondary Analysis Shared
Derivation of Brain Structure Volumes from MRI Neuroimages hosted by NDAR using C-PAC pipeline and ANTs An automated pipeline was developed to reference Neuroimages hosted by the National Database for Autism Research (NDAR) and derive volumes for distinct brain structures using Advanced Normalization Tools (ANTs) and the Configurable-Pipeline for the Analysis of Connectomes (C-PAC) platform. This pipeline utilized the ANTs cortical thickness methodology discuessed in "Large-Scale Evaluation of ANTs and Freesurfer Cortical Tchickness Measurements" [http://www.ncbi.nlm.nih.gov/pubmed/24879923] to extract a cortical thickness volume from T1-weighted anatomical MRI data gathered from the NDAR database. This volume was then registered to an stereotaxic-space anatomical template (OASIS-30 Atropos Template) which was acquired from the Mindboggle Project webpage [http://mindboggle.info/data.html]. After registration, the mean cortical thickness was calculated at 31 ROIs on each hemisphere of the cortex and using the Desikan-Killiany-Tourville (DKT-31) cortical labelling protocol [http://mindboggle.info/faq/labels.html] over the OASIS-30 template. **NOTE: This study is ongoing; additional data my be available in the future.** As a result, each subject that was processed has a cortical thickness volume image and a text file with the mean thickness ROIs (in mm) stored in Amazon Web Services (AWS) Simple Storage Service (S3). Additionally, these results were tabulated in an AWS-hosted database (through NDAR) to enable simple, efficient querying and data access. All of the code used to perform this analysis is publicly available on Github [https://github.com/FCP-INDI/ndar-dev]. Additionally, as a computing platform, we developed an Amazon Machine Image (AMI) that comes fully equipped to run this pipeline on any dataset. Using AWS Elastic Cloud Computing (EC2), users can launch our publicly available AMI ("C-PAC with benchmark", AMI ID: "ami-fee34296", N. Virginia region) and run the ANTs cortical thickness pipeline. The AMI is fully compatible with Sun Grid Engine as well; this enables users to perform many pipeline runs in parallel over a cluster-computing framework. 3 / 1540 Secondary Analysis Shared
* Data not on individual level