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NDAR provides a single access to de-identified autism research data. For permission to download data, you will need an NDAR account with approved access to NDAR or a connected repository (AGRE, IAN, or the ATP). For NDAR access, you need to be a research investigator sponsored by an NIH recognized institution with federal wide assurance. See Request Access for more information.

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Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

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General

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Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Autism Brain Imaging Data Exchange
Michael Milham, MD, Ph.D. 
Autism spectrum disorders (ASD) are characterized by qualitative impairment in reciprocal social communication, as well as by repetitive, restricted, and stereotyped behaviors. Previously considered rare, ASD are now recognized to occur in more than 1% of children, causing immense suffering to individuals and their families. The complexity and heterogeneity of ASD make it necessary to obtain large-scale samples which are difficult to attain in any individual lab. In response, the Autism Brain Imaging Data Exchange (ABIDE) hereby provides previously collected resting state functional magnetic resonance imaging (R-fMRI) datasets from 539 individuals with ASD and 573 typical controls for the purpose of data sharing in the broader scientific community. This grass-root initiative involved 16 international sites, sharing 20 samples yielding 1112 datasets composed of both MRI data and an extensive array of phenotypic information common across nearly all sites (see below). This unprecedented effort is expected to facilitate discovery science and comparisons across samples.In accordance with HIPAA guidelines and 1000 Functional Connectomes Project / INDI protocols, all datasets are anonymous, with no protected health information included.
NDAR
Closed
Shared
$801,614.00
1,112
0
0
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NIH - Extramural None
Leon Levy Foundation None
Joseph P. Healy None
Stavros Niarchos Foundation None


K23MH087770-01 Translational Developmental Neuroscience of Autism 01/01/2010 11/30/2013 Not Reported Not Reported NEW YORK UNIVERSITY SCHOOL OF MEDICINE $643,638.00
R03MH096321-01 Enhancement of the 1000 Functional Connectome Project 01/16/2012 11/30/2013 Not Reported Not Reported NATHAN S. KLINE INSTITUTE FOR PSYCH RES $157,976.00

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Experiments

To create a new Omics, eye tracking, fMRI, or EEG experiment, press the "+ New Experiment" button. Once an experiment is created, then raw files for these types of experiments should be provided, associating the experiment – through Experiment_ID – with the metadata defined in the experiments interface.

IDNameCreated DateStatusType
No records found.

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Shared Data

Data structures with the number of subjects submitted and shared are provided.

Advanced Normalization Tools (ANTs) Cortical Thickness Imaging 1102
Autism Diagnostic Interview, Revised (ADI-R) Clinical Assessments 379
Autism Diagnostic Observation Schedule (ADOS) - Module 2 (2007) Clinical Assessments 5
Autism Diagnostic Observation Schedule (ADOS) - Module 4 Clinical Assessments 174
Autism Diagnostic Observation Schedule (ADOS)- Module 2 Clinical Assessments 4
Autism Diagnostic Observation Schedule (ADOS)- Module 3 Clinical Assessments 233
Autism Diagnostic Observation Schedule (ADOS)- Module 3 (2007) Clinical Assessments 271
Autism Spectrum Quotient (AQ) Clinical Assessments 56
Edinburgh Handedness Inventory Clinical Assessments 370
Height and Weight Clinical Assessments 94
Ravens Coloured Progressive Matrices (CPM) Clinical Assessments 134
Social Communication Questionnaire (SCQ) - Lifetime Clinical Assessments 124
Social Responsiveness Scale (SRS) Clinical Assessments 184
Social Responsiveness Scale (SRS) - Adult/Self Version Clinical Assessments 46
Vineland-II - Parent and Caregiver Rating Form (2005) Clinical Assessments 112
Wechsler Abbreviated Scale of Intelligence (WASI) Clinical Assessments 554
Wechsler Adult Intelligence Scale III Clinical Assessments 66
Wechsler Intelligence Scale for Children III Clinical Assessments 49

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDAR data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed IDStudyTitleJournalAuthorsDateStatus
26693400Create StudyPeriventricular white matter abnormalities and restricted repetitive behavior in autism spectrum disorder.NeuroImage. ClinicalBlackmon K, Ben-Avi E, Wang X, Pardoe HR, Di Martino A, Halgren E, Devinsky O, Thesen T, Kuzniecky RJanuary 2016Not Determined
26365788Create StudyShort-term test-retest reliability of resting state fMRI metrics in children with and without attention-deficit/hyperactivity disorder.Developmental cognitive neuroscienceSomandepalli K, Kelly C, Reiss PT, Zuo XN, Craddock RC, Yan CG, Petkova E, Castellanos FX, Milham MP, Di Martino AOctober 2015Not Determined
26058882Create StudyLocal brain connectivity across development in autism spectrum disorder: A cross-sectional investigation.Autism research : official journal of the International Society for Autism ResearchDajani DR, Uddin LQJanuary 2016Not Determined
25951196Create StudyVariation in functional connectivity along anterior-to-posterior intraparietal sulcus, and relationship with age across late childhood and adolescence.Developmental cognitive neuroscienceVinette SA, Bray SJune 2015Not Determined
25809403Create StudyAge-related changes in intrinsic function of the superior temporal sulcus in autism spectrum disorders.Social cognitive and affective neuroscienceAlaerts K, Nayar K, Kelly C, Raithel J, Milham MP, Di Martino AOctober 2015Not Determined
25727858Create StudyMulticenter mapping of structural network alterations in autism.Human brain mappingValk SL, Di Martino A, Milham MP, Bernhardt BCJune 2015Not Determined
24583255Create StudyA multivariate distance-based analytic framework for connectome-wide association studies.NeuroImageShehzad Z, Kelly C, Reiss PT, Cameron Craddock R, Emerson JW, McMahon K, Copland DA, Castellanos FX, Milham MPJune 2014Not Determined
24565362Create StudyAbnormal amygdala functional connectivity associated with emotional lability in children with attention-deficit/hyperactivity disorder.Journal of the American Academy of Child and Adolescent PsychiatryHulvershorn LA, Mennes M, Castellanos FX, Di Martino A, Milham MP, Hummer TA, Roy AKMarch 2014Not Determined
24560717Create StudyCommon intrinsic connectivity states among posteromedial cortex subdivisions: Insights from analysis of temporal dynamics.NeuroImageYang Z, Craddock RC, Margulies DS, Yan CG, Milham MPJune 2014Not Determined
24078018Create StudyUnderconnectivity of the superior temporal sulcus predicts emotion recognition deficits in autism.Social cognitive and affective neuroscienceAlaerts K, Woolley DG, Steyaert J, Di Martino A, Swinnen SP, Wenderoth NOctober 2014Not Determined
23774715Create StudyThe autism brain imaging data exchange: towards a large-scale evaluation of the intrinsic brain architecture in autism.Molecular psychiatryDi Martino A, Yan CG, Li Q, Denio E, Castellanos FX, Alaerts K, Anderson JS, Assaf M, Bookheimer SY, Dapretto M, Deen B, Delmonte S, Dinstein I, Ertl-Wagner B, Fair DA, Gallagher L, Kennedy DP, Keown CL, Keysers C, Lainhart JE, Lord C, Luna B, Menon V, Minshew NJ, Monk CS, et al.June 2014Not Determined
23722212Create StudyImaging human connectomes at the macroscale.Nature methodsCraddock RC, Jbabdi S, Yan CG, Vogelstein JT, Castellanos FX, Di Martino A, Kelly C, Heberlein K, Colcombe S, Milham MPJune 2013Not Determined
23716135Create StudyResponse time intra-subject variability: commonalities between children with autism spectrum disorders and children with ADHD.European child & adolescent psychiatryAdamo N, Huo L, Adelsberg S, Petkova E, Castellanos FX, Di Martino AFebruary 2014Not Determined
23631991Create StudyClinical applications of the functional connectome.NeuroImageCastellanos FX, Di Martino A, Craddock RC, Mehta AD, Milham MPOctober 15, 2013Not Determined
23631983Create StudyStandardizing the intrinsic brain: towards robust measurement of inter-individual variation in 1000 functional connectomes.NeuroImageYan CG, Craddock RC, Zuo XN, Zang YF, Milham MPOctober 15, 2013Not Determined
23541632Create StudyShared and distinct intrinsic functional network centrality in autism and attention-deficit/hyperactivity disorder.Biological psychiatryDi Martino A, Zuo XN, Kelly C, Grzadzinski R, Mennes M, Schvarcz A, Rodman J, Lord C, Castellanos FX, Milham MPOctober 2013Not Determined
23499792Create StudyA comprehensive assessment of regional variation in the impact of head micromovements on functional connectomics.NeuroImageYan CG, Cheung B, Kelly C, Colcombe S, Craddock RC, Di Martino A, Li Q, Zuo XN, Castellanos FX, Milham MPAugust 2013Not Determined
23123682Create StudyMaking data sharing work: the FCP/INDI experience.NeuroImageMennes M, Biswal BB, Castellanos FX, Milham MPNovember 15, 2013Not Determined
22508759Create StudyIncreased response-time variability across different cognitive tasks in children with ADHD.Journal of attention disordersAdamo N, Di Martino A, Esu L, Petkova E, Johnson K, Kelly S, Castellanos FX, Zuddas AJuly 2014Not Determined
22440648Create StudyA convergent functional architecture of the insula emerges across imaging modalities.NeuroImageKelly C, Toro R, Di Martino A, Cox CL, Bellec P, Castellanos FX, Milham MPJuly 2012Not Determined
21974788Create StudyDimensional brain-behavior relationships in children with attention-deficit/hyperactivity disorder.Biological psychiatryChabernaud C, Mennes M, Kelly C, Nooner K, Di Martino A, Castellanos FX, Milham MPMarch 2012Not Determined
21896497Create StudyThe balance between feeling and knowing: affective and cognitive empathy are reflected in the brain's intrinsic functional dynamics.Social cognitive and affective neuroscienceCox CL, Uddin LQ, Di Martino A, Castellanos FX, Milham MP, Kelly CAugust 2012Not Determined
21653865Create StudyResting-state functional connectivity indexes reading competence in children and adults.The Journal of neuroscience : the official journal of the Society for NeuroscienceKoyama MS, Di Martino A, Zuo XN, Kelly C, Mennes M, Jutagir DR, Castellanos FX, Milham MPJune 2011Not Determined
21296165Create StudyExtracting information from functional connectivity maps via function-on-scalar regression.NeuroImageReiss PT, Mennes M, Petkova E, Huang L, Hoptman MJ, Biswal BB, Colcombe SJ, Zuo XN, Milham MPMay 2011Not Determined
21195388Create StudyAberrant striatal functional connectivity in children with autism.Biological psychiatryDi Martino A, Kelly C, Grzadzinski R, Zuo XN, Mennes M, Mairena MA, Lord C, Castellanos FX, Milham MPMay 2011Not Determined
21108041Create StudyExamining autistic traits in children with ADHD: does the autism spectrum extend to ADHD?Journal of autism and developmental disordersGrzadzinski R, Di Martino A, Brady E, Mairena MA, O'Neale M, Petkova E, Lord C, Castellanos FXSeptember 2011Not Determined
20974260Create StudyLinking inter-individual differences in neural activation and behavior to intrinsic brain dynamics.NeuroImageMennes M, Zuo XN, Kelly C, Di Martino A, Zang YF, Biswal B, Castellanos FX, Milham MPFebruary 2011Not Determined
help.tab.dataexpected

Relevant Publications
PubMed IDStudyTitleJournalAuthorsDate
No records found.
help.tab.dataexpected.addnew
Data Expected
Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
Wechsler Abbreviated Scale of Intelligence (WASI) info iconApproved
ADOS info iconApproved
Autistic Spectrum Quotient info iconApproved
Ravens Coloured Progressive Matrices (CPM) info iconApproved
Social Communication Questionnaire (SCQ) info iconApproved
Research Subject and Pedigree info iconApproved
Wechsler Adult Intelligence Scale info iconApproved
Vineland (Parent and Caregiver) info iconApproved
Wechsler Intelligence Scale for Children info iconApproved
ADI-R info iconApproved
Evaluated Data info iconApproved
Physical Exam info iconApproved
Social Responsiveness Scale (SRS) info iconApproved
Structure not yet defined

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study Name Description Number of Subjects
Collection / Total
Data Use State
Derivation of Brain Structure Volumes from MRI Neuroimages hosted by NDAR using C-PAC pipeline and ANTs An automated pipeline was developed to reference Neuroimages hosted by the National Database for Autism Research (NDAR) and derive volumes for distinct brain structures using Advanced Normalization Tools (ANTs) and the Configurable-Pipeline for the Analysis of Connectomes (C-PAC) platform. This pipeline utilized the ANTs cortical thickness methodology discuessed in "Large-Scale Evaluation of ANTs and Freesurfer Cortical Tchickness Measurements" [http://www.ncbi.nlm.nih.gov/pubmed/24879923] to extract a cortical thickness volume from T1-weighted anatomical MRI data gathered from the NDAR database. This volume was then registered to an stereotaxic-space anatomical template (OASIS-30 Atropos Template) which was acquired from the Mindboggle Project webpage [http://mindboggle.info/data.html]. After registration, the mean cortical thickness was calculated at 31 ROIs on each hemisphere of the cortex and using the Desikan-Killiany-Tourville (DKT-31) cortical labelling protocol [http://mindboggle.info/faq/labels.html] over the OASIS-30 template. **NOTE: This study is ongoing; additional data my be available in the future.** As a result, each subject that was processed has a cortical thickness volume image and a text file with the mean thickness ROIs (in mm) stored in Amazon Web Services (AWS) Simple Storage Service (S3). Additionally, these results were tabulated in an AWS-hosted database (through NDAR) to enable simple, efficient querying and data access. All of the code used to perform this analysis is publicly available on Github [https://github.com/FCP-INDI/ndar-dev]. Additionally, as a computing platform, we developed an Amazon Machine Image (AMI) that comes fully equipped to run this pipeline on any dataset. Using AWS Elastic Cloud Computing (EC2), users can launch our publicly available AMI ("C-PAC with benchmark", AMI ID: "ami-fee34296", N. Virginia region) and run the ANTs cortical thickness pipeline. The AMI is fully compatible with Sun Grid Engine as well; this enables users to perform many pipeline runs in parallel over a cluster-computing framework. 1102 / 1540 Secondary Analysis Shared
* Data not on individual level
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