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NDAR provides a single access to de-identified autism research data. For permission to download data, you will need an NDAR account with approved access to NDAR or a connected repository (AGRE, IAN, or the ATP). For NDAR access, you need to be a research investigator sponsored by an NIH recognized institution with federal wide assurance. See Request Access for more information.

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Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Autism Spectrum Disorder - Inflammatory Subtype: Molecular Characterization
Harumi Jyonouchi 
Previously, we have reported that some of those 'poor responders' are characterized by fluctuating behavioral symptoms following immune insults (typically microbial infection), and persistent gastrointestinal (GI) symptoms. We have also found that peripheral blood (PB) monocytes (Mo) from those children have altered innate immune responses, as compared to normal/ASD case controls. This study categorized those subjects as the ASD-inflammatory subtype (ASD-IS). ASD-IS children, with the above described distinct clinical features and laboratory findings, are expected to be Ideal for detecting specific factors that are not identified by current epigenetic approaches, employing the general ASD population. Moreover, ASD-IS children are in critical need for other therapeutic options, since respond so poorly to first line conventional treatments. Our previous results have also revealed a discrepancy between protein and transcript expression in PB Mo from ASD-IS children. This finding indicates a possible role of post-transcriptional regulations that are often exerted by microRNA (miRNA).On the basis or those findings, we hypothesized:3)The above-described clinical phenotype of ASD-IS children is associated with aberrant innate Immune responses, which are reflected in changes in functions, and miRNA profiles of the PB Mo obtained from ASD-IS children.4)Those changes are reproducible and positively correlate with changes of behavioral symptoms in ASD-IS children.Our long-term objective is to identify easily accessible biomarkers that will allow for the early detection of ASD-IS children and improve the disease outcome by applying other treatment options such as immunomodulating agents. Two specific alms are proposed.Specific Alm#1 To test the sub-hypothesis 11mt miRNA profiles and functions or purified PB monocytes are altered in the ASD-IS children, by studying functions and miRNA profiles of purified PB Mo in 40 ASO-IS children in comparison with ASD children with or without non-lgE mediated food allergy (NFA) as case controls. Typically developing children and NFA children without ASD will also serve as case controls. PB Mo function will be assessed by measuring the production of both pro inflammatory and counter-regulatory cytokines and chemoklnes by purified PB Mo. miRNA profiles will be assessed by deep sequencing. Inclusion of NFA children with or without ASD will allow for us to determine If the changes or innate immune abnormalities observed in ASD-IS children are associated with NFA or not. This is important because our previous study showed that ASD-IS children exhibit features of NFA at a young age, along with persistent GI symptoms. In the disease specific miRNA is identified, plasma levels of such miRNA will be measured.Specific Aim#2 To test the sub-hypothesis that certain markers of PB monocytes are reproducible and positively correlate with changes in behavioral symptoms in ASD-IS children by studying the PB Mo functions on 3 occasions (at the time of enrollment, 4-6 mo later, and during 'flare ups' following immune insults) in ASD-IS children. Changes in PB Mo functions will be evaluated in association with changes in behavioral symptoms of cognitive activity by ABC, VABS, and CHQS (for behavioral symptoms) and JWlll or BDI (for cognitive activity). Pain and discomfort associated with medical conditions (such as GI symptoms) will also be assessed by using NCCPC-R at the time of sample obtainment. Those measures will also be done in case controls described In Aim #1 at the time of enrollment and 4-6 mo later.
NDAR
Enrolling
Shared
$400,000.00
107
200
0
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NJ Governor’s Council for Medical Research None



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Experiments

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IDNameCreated DateStatusType
497miRNA Sequencing07/15/2016ApprovedOmics

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Shared Data

Data structures with the number of subjects submitted and shared are provided.

ACE Family Medical History Clinical Assessments 106
ACE Subject Medical History Clinical Assessments 107
ACE Subject Physical Exam Clinical Assessments 106
Aberrant Behavior Checklist (ABC) - Community Clinical Assessments 83
Child's Sleep Habits Questionnaire (CSHQ) Clinical Assessments 78
Genomics Subject Genomics 67
Non Communicating Children's Pain Checklist - Revised Clinical Assessments 56
Vineland-II - Parent and Caregiver Rating Form (2005) Clinical Assessments 44
Woodcock Johnson Tests of Cognitive Abilities and Tests of Achievement Clinical Assessments 36

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDAR data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed IDStudyTitleJournalAuthorsDateStatus
No records found.
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Relevant Publications
PubMed IDStudyTitleJournalAuthorsDate
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Data Expected
Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
ABC Community info iconApproved
Childs Sleep Habits Questionnaire (CSHQ) info iconApproved
genomics/omics info iconApproved
Research Subject and Pedigree info iconApproved
Vineland (Parent and Caregiver) info iconApproved
Woodcock-Johnson Tests of Cognitive Abilities and Achievement info iconApproved
Genetic Test info iconApproved
Medical History info iconApproved
Physical Exam info iconApproved
Non-Communicating Childrens Pain Checklist - Revised (NCCPC-R) info iconApproved
Structure not yet defined

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Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

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