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NDAR provides a single access to de-identified autism research data. For permission to download data, you will need an NDAR account with approved access to NDAR or a connected repository (AGRE, IAN, or the ATP). For NDAR access, you need to be a research investigator sponsored by an NIH recognized institution with federal wide assurance. See Request Access for more information.

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Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

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Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Silvio O. Conte Center for Oxytocin and Social Cognition
Larry Young 
The oxytocin (OT) system is arguably the most viable target for pharmacologically enhancing social cognitionin psychiatric disorders with compromised social cognition, including autism spectrum disorder (ASD).Central OT enhances key aspects of social behavior in animals, and intranasal (IN) OT modulates socialcognition in humans. The mechanisms by which OT affects social cognition are not understood. We willlaunch a coordinated, interdisciplinary research program involving an outstanding team of investigators totest the hypothesis that OT enhances social cognition by increasing the salience and reinforcing value ofsocial stimuli by modulating activity and functional connectivity of the amygdala and brain regions involved inreward. Project scientists will use cutting edge techniques to assess functional connectivity between brainregions during social interactions, responses of individual neurons in the amygdala to social stimuli, or socialcognition in animals and humans. Projects 1 and 2 will use in vivo electrophysiology to examine the impactof OT on the neural representation of social stimuli in rodents and rhesus macaques. Project 3 will usecognitive tests to examine the impact of OT on social perception and social attunement in the primate.Project 4 will use cognitive testing and fMRI to examine the impact of OT on social cognition and neuralactivity in healthy and autistic humans. A Neurochemistry Core will provide vital services for the researchprojects and develop new tools for characterizing OT receptor expression in the brain. An AdministrativeCore will coordinate all Center related activities (seminar series, organizing meetings), will provide statisticalconsultation and coordinate outreach and training activities of Center personnel by strengthening existingrelationships and forging new relationships with numerous organizations in the Atlanta area. As a result, theCenter will create vibrant collaborative research, training and outreach environment that will have a nationalimpact on mental health research. The data collected by Center faculty will have important transiationaimplications that will directly impact novel strategies for pharmacologically treating social deficits inpsychiatric disorders.
NDAR
Enrolling
Shared
$7,863,998.00
31
496
160
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NIH - Extramural None


P50MH100023-01 Silvio O. Conte Center for Oxytocin and Social Cognition 07/01/2013 03/31/2018 496 160 EMORY UNIVERSITY $7,863,998.00

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Experiments

To create a new Omics, eye tracking, fMRI, or EEG experiment, press the "+ New Experiment" button. Once an experiment is created, then raw files for these types of experiments should be provided, associating the experiment – through Experiment_ID – with the metadata defined in the experiments interface.

IDNameCreated DateStatusType
No records found.

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Shared Data

Data structures with the number of subjects submitted and shared are provided.

Autism Diagnostic Interview, Revised (ADI-R) Clinical Assessments 20
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 4 Clinical Assessments 12
WASI-2 Clinical Assessments 22

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDAR data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed IDStudyTitleJournalAuthorsDateStatus
28122239Create StudyFixations Gate Species-Specific Responses to Free Viewing of Faces in the Human and Macaque Amygdala.Cell reportsMinxha J, Mosher C, Morrow JK, Mamelak AN, Adolphs R, Gothard KM, Rutishauser UJanuary 2017Not Relevant
27922101Create StudySocial determinants of eyeblinks in adult male macaques.Scientific reportsBallesta S, Mosher CP, Szep J, Fischl KD, Gothard KMDecember 2016Not Relevant
27838170Create StudyAn evaluation of central penetration from a peripherally administered oxytocin receptor selective antagonist in nonhuman primates.Bioorganic & medicinal chemistrySmith AL, Walum H, Connor-Stroud F, Freeman SM, Inoue K, Parr LA, Goodman MM, Young LJJanuary 2017Not Relevant
27793769Create StudyOxytocin receptors modulate a social salience neural network in male prairie voles.Hormones and behaviorJohnson ZV, Walum H, Xiao Y, Riefkohl PC, Young LJJanuary 2017Not Relevant
27752543Create StudyTactile Stimulation of the Face and the Production of Facial Expressions Activate Neurons in the Primate Amygdala.eNeuroMosher CP, Zimmerman PE, Fuglevand AJ, Gothard KM2016 Sep-OctNot Relevant
27522019Create StudyA single prolonged stress paradigm produces enduring impairments in social bonding in monogamous prairie voles.Behavioural brain researchArai A, Hirota Y, Miyase N, Miyata S, Young LJ, Osako Y, Yuri K, Mitsui SDecember 2016Not Relevant
27453637Create StudyDistributions of oxytocin and vasopressin 1a receptors in the Taiwan vole and their role in social monogamy.Journal of zoology (London, England : 1987)Chappell AR, Freeman SM, Lin YK, Laprairie JL, Inoue K, Young LJ, Hayes LDJune 2016Not Relevant
27343726Create StudyOxytocin enhances gaze-following responses to videos of natural social behavior in adult male rhesus monkeys.PsychoneuroendocrinologyPutnam PT, Roman JM, Zimmerman PE, Gothard KMOctober 2016Not Relevant
27209233Create StudyInitial investigation of three selective and potent small molecule oxytocin receptor PET ligands in New World monkeys.Bioorganic & medicinal chemistry lettersSmith AL, Freeman SM, Barnhart TE, Abbott DH, Ahlers EO, Kukis DL, Bales KL, Goodman MM, Young LJJuly 15, 2016Not Relevant
26940141Create StudyComparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications.Journal of neuroendocrinologyFreeman SM, Young LJApril 2016Not Relevant
26893121Create StudyVariation in the Oxytocin Receptor Gene Predicts Brain Region-Specific Expression and Social Attachment.Biological psychiatryKing LB, Walum H, Inoue K, Eyrich NW, Young LJDecember 15, 2015Not Relevant
26798013Create StudyOxytocin-dependent consolation behavior in rodents.Science (New York, N.Y.)Burkett JP, Andari E, Johnson ZV, Curry DC, de Waal FB, Young LJJanuary 22, 2016Not Relevant
26731103Create StudyThe Macaque Social Responsiveness Scale (mSRS): A Rapid Screening Tool for Assessing Variability in the Social Responsiveness of Rhesus Monkeys (Macaca mulatta).PloS oneFeczko EJ, Bliss-Moreau E, Walum H, Pruett JR, Parr LA2016Not Relevant
26723109Create StudyThe Need for a Theoretical Framework of Social Functioning to Optimize Targeted Therapies in Psychiatric Disorders.Biological psychiatryAndari EFebruary 1, 2016Not Relevant
26723107Create StudyUnderstanding the Oxytocin System and Its Relevance to Psychiatry.Biological psychiatryShamay-Tsoory S, Young LJFebruary 1, 2016Not Relevant
26643557Create StudyCentral oxytocin receptors mediate mating-induced partner preferences and enhance correlated activation across forebrain nuclei in male prairie voles.Hormones and behaviorJohnson ZV, Walum H, Jamal YA, Xiao Y, Keebaugh AC, Inoue K, Young LJMarch 2016Not Relevant
26615473Create StudyOxytocin in the nucleus accumbens shell reverses CRFR2-evoked passive stress-coping after partner loss in monogamous male prairie voles.PsychoneuroendocrinologyBosch OJ, Dabrowska J, Modi ME, Johnson ZV, Keebaugh AC, Barrett CE, Ahern TH, Guo J, Grinevich V, Rainnie DG, Neumann ID, Young LJFebruary 2016Not Relevant
26392632Create StudyEstablishing the reliability of rhesus macaque social network assessment from video observations.Animal behaviourFeczko E, Mitchell TA, Walum H, Brooks JM, Heitz TR, Young LJ, Parr LASeptember 1, 2015Not Determined
26379517Create StudyEditorial: Oxytocin's routes in social behavior: into the 21st century.Frontiers in behavioral neuroscienceAndari E2015Not Relevant
26210057Create StudyStatistical and Methodological Considerations for the Interpretation of Intranasal Oxytocin Studies.Biological psychiatryWalum, Hasse; Waldman, Irwin D; Young, Larry JFebruary 1, 2016Not Relevant
26196439Create StudyThe oxytocin system promotes resilience to the effects of neonatal isolation on adult social attachment in female prairie voles.Translational psychiatryBarrett CE, Arambula SE, Young LJ2015Not Relevant
26146650Create StudyNeurobiological mechanisms of social attachment and pair bonding.Current opinion in behavioral sciencesJohnson, Zachary V; Young, Larry JJune 2015Not Relevant
26062432Create StudyNeural mechanisms of mother-infant bonding and pair bonding: Similarities, differences, and broader implications.Hormones and behaviorNuman M, Young LJJanuary 2016Not Relevant
25874849Create StudyRNAi knockdown of oxytocin receptor in the nucleus accumbens inhibits social attachment and parental care in monogamous female prairie voles.Social neuroscienceKeebaugh AC, Barrett CE, Laprairie JL, Jenkins JJ, Young LJ2015Not Relevant
25874677Create StudySensory systems: The yin and yang of cortical oxytocin.NatureLiu, Robert CApril 23, 2015Not Relevant
25700501Create StudyNeuroscience. Can oxytocin treat autism?Science (New York, N.Y.)Young LJ, Barrett CEFebruary 20, 2015Not Relevant
25652247Create StudyMelanocortin Receptor Agonists Facilitate Oxytocin-Dependent Partner Preference Formation in the Prairie Vole.Neuropsychopharmacology : official publication of the American College of NeuropsychopharmacologyModi ME, Inoue K, Barrett CE, Kittelberger KA, Smith DG, Landgraf R, Young LJJuly 2015Not Relevant
25482173Create StudyOxytocin, social cognition and psychiatry.Neuropsychopharmacology : official publication of the American College of NeuropsychopharmacologyYoung LJJanuary 2015Not Relevant
25414633Create StudySocial relevance drives viewing behavior independent of low-level salience in rhesus macaques.Frontiers in neuroscienceSolyst JA, Buffalo EA2014Not Relevant
25283782Create StudyNeurons in the monkey amygdala detect eye contact during naturalistic social interactions.Current biology : CBMosher CP, Zimmerman PE, Gothard KMOctober 20, 2014Not Relevant
25124431Create StudyThe biology of mammalian parenting and its effect on offspring social development.Science (New York, N.Y.)Rilling JK, Young LJAugust 15, 2014Not Relevant
25072016Create StudyAutism Spectrum Disorder: Defining Dimensions and Subgroups.Current developmental disorders reportsOusley O, Cermak TMarch 1, 2014Not Relevant
24845184Create StudyThe neuroanatomical distribution of oxytocin receptor binding and mRNA in the male rhesus macaque (Macaca mulatta).PsychoneuroendocrinologyFreeman SM, Inoue K, Smith AL, Goodman MM, Young LJJuly 2014Not Relevant
24845176Create StudyAerosolized oxytocin increases cerebrospinal fluid oxytocin in rhesus macaques.PsychoneuroendocrinologyModi ME, Connor-Stroud F, Landgraf R, Young LJ, Parr LAJuly 2014Not Relevant
24814726Create StudyNeuroanatomical distribution of oxytocin and vasopressin 1a receptors in the socially monogamous coppery titi monkey (Callicebus cupreus).NeuroscienceFreeman SM, Walum H, Inoue K, Smith AL, Goodman MM, Bales KL, Young LJJuly 25, 2014Not Relevant
24509130Create StudyA nonparametric method for detecting fixations and saccades using cluster analysis: removing the need for arbitrary thresholds.Journal of neuroscience methodsKönig SD, Buffalo EAApril 30, 2014Not Relevant
24367110Create StudyCommon polymorphism in the oxytocin receptor gene (OXTR) is associated with human social recognition skills.Proceedings of the National Academy of Sciences of the United States of AmericaSkuse DH, Lori A, Cubells JF, Lee I, Conneely KN, Puura K, Lehtimäki T, Binder EB, Young LJFebruary 4, 2014Not Determined
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Relevant Publications
PubMed IDStudyTitleJournalAuthorsDate
No records found.
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Data Expected
Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
Ravens Coloured Progressive Matrices (CPM) info iconApproved
State-Trait Anxiety Inventory for Adults info iconApproved
Positive and Negative Affect Schedule info iconApproved
Wechsler Abbreviated Scale of Intelligence (WASI) info iconApproved
Autistic Spectrum Quotient info iconApproved
NEO Personality Inventory (NEO PI-R) info iconApproved
Vital Signs Assessment info iconApproved
ADOS info iconApproved
ADI-R info iconApproved
Peabody Picture Vocabulary Test, Fourth Edition info iconApproved
Research Subject and Pedigree info iconApproved
Bipolar Profile of Mood States (POMS) Questionnaire info iconApproved
EEG info iconApproved
Social Anxiety Scale info iconApproved
Beck Depression Inventory II info iconApproved
Imaging (Structural, fMRI, DTI, PET, microscopy) info iconApproved
Structure not yet defined

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

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