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NDAR provides a single access to de-identified autism research data. For permission to download data, you will need an NDAR account with approved access to NDAR or a connected repository (AGRE, IAN, or the ATP). For NDAR access, you need to be a research investigator sponsored by an NIH recognized institution with federal wide assurance. See Request Access for more information.

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Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

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Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Dysfunction of Sensory Inhibition in Autism
Richard Edden 
Autism Spectrum Disorder (ASD) is a group of developmental disorders which affects approximately 1%of children, a prevalence rate that is increasing annually. The molecular basis of ASD is likely to becomplex and heterogeneous, but given the central role of the inhibitory neurotransmitter GABA incognitive control, development and plasticity and a growing body of evidence linking GABAergicdysfunction to autism and autistic phenotypes, GABA system is a strong potential area for ASD research.Recently, it has become possible to measure GABA concentration non-invasively in the brain usingmagnetic resonance spectroscopy (MRS), and in an extremely novel set of experiments we have shownthat differences in regional GABA concentration among healthy subjects have measurable behavioralcorrelates. For example, GABA concentration in sensorimotor cortex correlates with performance at asomotosensory discrimination task (see paper attached and below); this may have particular relevancefor autism, as atypical response to tactile stimuli is a common (and diagnostic) feature of autism and onethat can substantially impair behavioral functionThis proposal arises from a collaboration between Dr Richard Edden (PI) and Dr Stewart Mostofsky (Co-I)to apply the extremely novel pairing of MRS of GABA with somatosensory paradigms to investigatewhether there is a measurable GABA deficit in autism, and whether this correlates with autismassociateddifferences in somatosensory processing. The findings from examination of GABA MRS andits association with autistic behavior will provide a foundation for investigating novel treatmenttherapies, specifically use of medications that increase GABAergic activity. In Aim 1, we will measureGABA concentration in a group of 32 typically developing children (TDC) between the age of 8 and 12years to characterize the typical range. In Aim 2, we will compare twenty children with ASD to twentyTDC to investigate differences in GABAergic inhibition, and perform measures of tactile discrimination toinvestigate whether the abnormal tactile processing commonly observed in ASD arises from a GABAergicdeficit.
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NIH - Extramural None

R21MH098228-01 Dysfunction of Sensory Inhibition in Autism 07/01/2013 03/31/2015 108 7 JOHNS HOPKINS UNIVERSITY $460,279.00

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To create a new Omics, eye tracking, fMRI, or EEG experiment, press the "+ New Experiment" button. Once an experiment is created, then raw files for these types of experiments should be provided, associating the experiment – through Experiment_ID – with the metadata defined in the experiments interface.

IDNameCreated DateStatusType
No records found.

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Shared Data

Data structures with the number of subjects submitted and shared are provided.

Autism Diagnostic Interview, Revised (ADI-R) Clinical Assessments 24
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 3 Clinical Assessments 23
Spectroscopy Form Imaging 45
Vibrotactile Behavioral Battery Clinical Assessments 45

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:


Publications relevant to NDAR data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed IDStudyTitleJournalAuthorsDateStatus
28089657Create StudyAutism spectrum disorder in the scope of tactile processing.Developmental cognitive neuroscienceMikkelsen M, Wodka EL, Mostofsky SH, Puts NADecember 2016Not Relevant
28083565Create StudyThe Disrupted Connectivity Hypothesis of Autism Spectrum Disorders: Time for the Next Phase in Research.Biological psychiatry : cognitive neuroscience and neuroimagingVasa RA, Mostofsky SH, Ewen JBMay 2016Not Determined
27611990Create StudyReduced GABA and altered somatosensory function in children with autism spectrum disorder.Autism research : official journal of the International Society for Autism ResearchPuts NA, Wodka EL, Harris AD, Crocetti D, Tommerdahl M, Mostofsky SH, Edden RASeptember 2016Not Determined
27448580Create StudyThe Role of Attention in Somatosensory Processing: A Multi-trait, Multi-method Analysis.Journal of autism and developmental disordersWodka EL, Puts NA, Mahone EM, Edden RA, Tommerdahl M, Mostofsky SHJuly 2016Not Determined
27429731Create StudyAtypical lateralization of motor circuit functional connectivity in children with autism is associated with motor deficits.Molecular autismFloris DL, Barber AD, Nebel MB, Martinelli M, Lai MC, Crocetti D, Baron-Cohen S, Suckling J, Pekar JJ, Mostofsky SH2016Not Determined
27239903Create StudyProspective frequency correction for macromolecule-suppressed GABA editing at 3T.Journal of magnetic resonance imaging : JMRIEdden RA, Oeltzschner G, Harris AD, Puts NA, Chan KL, Boer VO, Schär M, Barker PBMay 30, 2016Not Relevant
26637451Create StudyLocal GABA Concentration Predicts Perceptual Improvements After Repetitive Sensory Stimulation in Humans.Cerebral cortex (New York, N.Y. : 1991)Heba S, Puts NA, Kalisch T, Glaubitz B, Haag LM, Lenz M, Dinse HR, Edden RA, Tegenthoff M, Schmidt-Wilcke TMarch 2016Not Determined
26041822Create StudyReduced GABAergic inhibition and abnormal sensory symptoms in children with Tourette syndrome.Journal of neurophysiologyPuts NA, Harris AD, Crocetti D, Nettles C, Singer HS, Tommerdahl M, Edden RA, Mostofsky SHAugust 2015Not Determined
25521836Create StudySpectral-editing measurements of GABA in the human brain with and without macromolecule suppression.Magnetic resonance in medicineHarris AD, Puts NA, Barker PB, Edden RADecember 2015Not Determined
25224339Create StudyReply to Dickinson and Milne.Journal of neurophysiologyPuts NA, Wodka EL, Tommerdahl M, Mostofsky SH, Edden RASeptember 15, 2014Not Determined
24523518Create StudyImpaired tactile processing in children with autism spectrum disorder.Journal of neurophysiologyPuts NA, Wodka EL, Tommerdahl M, Mostofsky SH, Edden RAMay 2014Not Determined

Relevant Publications
PubMed IDStudyTitleJournalAuthorsDate
No records found.
Data Expected
Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
ADOS info iconApproved
Vibrotactile Behavioral Battery info iconApproved
Spectroscopy info iconApproved
ADI-R info iconApproved
Structure not yet defined

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.