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NDAR provides a single access to de-identified autism research data. For permission to download data, you will need an NDAR account with approved access to NDAR or a connected repository (AGRE, IAN, or the ATP). For NDAR access, you need to be a research investigator sponsored by an NIH recognized institution with federal wide assurance. See Request Access for more information.

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General

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Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Epidemiological Research on Autism in Jamaica - Phase II
Mohammad Rahbar 
Autism Spectrum Disorders (ASDs) are complex lifelong neurodevelopmental and behavioraldisorders manifesting in infancy or early childhood, characterized by impairments in socialinteraction and communication, and by repetitive, stereotyped behavior. Although the causes ofASD are unknown, the evidence suggests that the origins are likely the result of geneenvironmentinteraction occurring in utero or very early in infancy. The long term goal of thisproject is to expand our capacity for conducting large scale population-based ASD studies inJamaica. During the past 2-3 years, with funding from NICHD/FIC (R21 HD057808; PI: Rahbar)our research team at the University of Texas Health Science Center at Houston (UTHealth) hascollaborated with Dr. Maureen Samms-Vaughan and her colleagues at the University of theWest Indies (UWI) in Jamaica to investigate the role of the glutathione-S-transferase (GST)genes and five heavy metals (lead, mercury, arsenic, cadmium, manganese) in relation to ASD.In the proposed project, we will assess the levels of polychlorinated biphenyls (PCBs) andorganochlorine (OC) pesticides in the cord-blood isolated from 144 newborns enrolled in the2011 Jamaican birth cohort to test the hypothesis that children in Jamaica are exposed in uteroto these chemicals and identify factors associated with such exposures. In addition, we willconduct an age- and sex-matched case-control study (240 matched pairs) to investigatewhether environmental exposures to PCBs and OC pesticides play a role in ASD. Furthermore,we will assess the role of select polymorphisms in GST genes (GSTM1, GSTT1, GSTP1), andtheir potential interactions with these OCs in relation to ASD. For both cases and controls wewill administer a questionnaire to assess the demographic and socioeconomic position,occupation, smoking and drinking status of the parents. In addition, information about familyhistory of developmental disorders, family size, birth order of the index child and whether thechild is taking any medications will be collected. Moreover, a dietary questionnaire aimed atcapturing possible exposure to environmental contaminants such as PCBs and OC pesticideswill be administered. At the end of interview, 1-2 mLs of saliva and about 4-5 mLs of serum willbe collected from the case and control children. The DNA isolation and analysis ofpolymorphisms will be conducted at the Center for Human Genetics at UT School of PublicHealth. Serum samples will be analyzed for 92 of the 209 PCBs congeners and 18 OCpesticides using capillary column gas chromatography by a CDC-certified lab at the Division ofChemistry and Toxicology at Michigan Department of Community Health in Lansing, Michigan.
NDAR
Enrolling
Shared
$2,288,601.00
344
1368
675
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NIH - Extramural None


R01ES022165-01 Epidemiological Research on Autism in Jamaica - Phase II 09/12/2013 04/30/2018 1368 675 UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON $2,288,601.00

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Experiments

To create a new Omics, eye tracking, fMRI, or EEG experiment, press the "+ New Experiment" button. Once an experiment is created, then raw files for these types of experiments should be provided, associating the experiment – through Experiment_ID – with the metadata defined in the experiments interface.

IDNameCreated DateStatusType
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Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Shared Data

Data structures with the number of subjects submitted and shared are provided.

Anthropometric Information Clinical Assessments 225
Autism Diagnostic Interview, Revised (ADI-R) Clinical Assessments 139
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 1 Clinical Assessments 94
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 2 Clinical Assessments 34
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 3 Clinical Assessments 7
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Toddler Module Clinical Assessments 5
Child Information Clinical Assessments 225
Enviromental Exposure Clinical Assessments 225
Family History Clinical Assessments 225
Parent Chemical or Substance Exposure Clinical Assessments 225
Pregnancy History Clinical Assessments 225
Research Subject Clinical Assessments 225
Social Communication Questionnaire (SCQ) - Current Form Clinical Assessments 50
Social Communication Questionnaire (SCQ) - Lifetime Clinical Assessments 34
Sociodemographics Clinical Assessments 225

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDAR data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed IDStudyTitleJournalAuthorsDateStatus
27834815Create StudyRole of Metabolic Genes in Blood Aluminum Concentrations of Jamaican Children with and without Autism Spectrum Disorder.International journal of environmental research and public healthRahbar MH, Samms-Vaughan M, Pitcher MR, Bressler J, Hessabi M, Loveland KA, Christian MA, Grove ML, Shakespeare-Pellington S, Beecher C, Mclaughlin W, Boerwinkle ENovember 2016Relevant
27775677Create StudyConcentrations of Polychlorinated Biphenyls and Organochlorine Pesticides in Umbilical Cord Blood Serum of Newborns in Kingston, Jamaica.International journal of environmental research and public healthRahbar MH, Samms-Vaughan M, Hessabi M, Dickerson AS, Lee M, Bressler J, Tomechko SE, Moreno EK, Loveland KA, Desai CC, Shakespeare-Pellington S, Reece JA, Morgan R, Geiger MJ, O'Keefe ME, Grove ML, Boerwinkle EOctober 2016Relevant
26309447Create StudySynergic effect of GSTP1 and blood manganese concentrations in Autism Spectrum Disorder.Research in autism spectrum disordersRahbar MH, Samms-Vaughan M, Ma J, Bressler J, Dickerson AS, Hessabi M, Loveland KA, Grove ML, Shakespeare-Pellington S, Beecher C, McLaughlin W, Boerwinkle EOctober 1, 2015Relevant
25915835Create StudyConcentration of lead, mercury, cadmium, aluminum, arsenic and manganese in umbilical cord blood of jamaican newborns.International journal of environmental research and public healthRahbar MH, Samms-Vaughan M, Dickerson AS, Hessabi M, Bressler J, Desai CC, Shakespeare-Pellington S, Reece JA, Morgan R, Loveland KA, Grove ML, Boerwinkle EMay 2015Relevant
25837555Create StudyFactors associated with blood lead concentrations of children in Jamaica.Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineeringRahbar MH, Samms-Vaughan M, Dickerson AS, Loveland KA, Ardjomand-Hessabi M, Bressler J, Shakespeare-Pellington S, Grove ML, Boerwinkle E2015Relevant
25685181Create StudyInteraction between GSTT1 and GSTP1 allele variants as a risk modulating-factor for autism spectrum disorders.Research in autism spectrum disordersRahbar MH, Samms-Vaughan M, Ma J, Bressler J, Loveland KA, Hessabi M, Dickerson AS, Grove ML, Shakespeare-Pellington S, Beecher C, McLaughlin W, Boerwinkle EApril 1, 2015Relevant
25546274Create StudyBlood lead concentrations in Jamaican children with and without autism spectrum disorder.International journal of environmental research and public healthRahbar MH, Samms-Vaughan M, Dickerson AS, Loveland KA, Ardjomand-Hessabi M, Bressler J, Shakespeare-Pellington S, Grove ML, Pearson DA, Boerwinkle EJanuary 2015Relevant
25149876Create StudyBlood manganese concentrations in Jamaican children with and without autism spectrum disorders.Environmental health : a global access science sourceRahbar MH, Samms-Vaughan M, Dickerson AS, Loveland KA, Ardjomand-Hessabi M, Bressler J, Shakespeare-Pellington S, Grove ML, Pearson DA, Boerwinkle E2014Relevant
25101770Create StudyRole of metabolic genes in blood arsenic concentrations of Jamaican children with and without autism spectrum disorder.International journal of environmental research and public healthRahbar MH, Samms-Vaughan M, Ma J, Bressler J, Loveland KA, Ardjomand-Hessabi M, Dickerson AS, Grove ML, Shakespeare-Pellington S, Beecher C, McLaughlin W, Boerwinkle EAugust 2014Relevant
25089152Create StudyRole of fruits, grains, and seafood consumption in blood cadmium concentrations of Jamaican children with and without Autism Spectrum Disorder.Research in autism spectrum disordersRahbar MH, Samms-Vaughan M, Dickerson AS, Loveland KA, Ardjomand-Hessabi M, Bressler J, Lee M, Shakespeare-Pellington S, Grove ML, Pearson DA, Boerwinkle ESeptember 1, 2014Relevant
22819887Create StudyThe role of drinking water sources, consumption of vegetables and seafood in relation to blood arsenic concentrations of Jamaican children with and without Autism Spectrum Disorders.The Science of the total environmentRahbar MH, Samms-Vaughan M, Ardjomand-Hessabi M, Loveland KA, Dickerson AS, Chen Z, Bressler J, Shakespeare-Pellington S, Grove ML, Bloom K, Wirth J, Pearson DA, Boerwinkle ESeptember 1, 2012Relevant
22488160Create StudySeafood consumption and blood mercury concentrations in Jamaican children with and without autism spectrum disorders.Neurotoxicity researchRahbar MH, Samms-Vaughan M, Loveland KA, Ardjomand-Hessabi M, Chen Z, Bressler J, Shakespeare-Pellington S, Grove ML, Bloom K, Pearson DA, Lalor GC, Boerwinkle EJanuary 2013Relevant
22230961Create StudyMaternal and paternal age are jointly associated with childhood autism in Jamaica.Journal of autism and developmental disordersRahbar MH, Samms-Vaughan M, Loveland KA, Pearson DA, Bressler J, Chen Z, Ardjomand-Hessabi M, Shakespeare-Pellington S, Grove ML, Beecher C, Bloom K, Boerwinkle ESeptember 2012Relevant
help.tab.dataexpected

Relevant Publications
PubMed IDStudyTitleJournalAuthorsDate
27834815Create StudyRole of Metabolic Genes in Blood Aluminum Concentrations of Jamaican Children with and without Autism Spectrum Disorder.International journal of environmental research and public healthRahbar MH, Samms-Vaughan M, Pitcher MR, Bressler J, Hessabi M, Loveland KA, Christian MA, Grove ML, Shakespeare-Pellington S, Beecher C, Mclaughlin W, Boerwinkle ENovember 2016
27775677Create StudyConcentrations of Polychlorinated Biphenyls and Organochlorine Pesticides in Umbilical Cord Blood Serum of Newborns in Kingston, Jamaica.International journal of environmental research and public healthRahbar MH, Samms-Vaughan M, Hessabi M, Dickerson AS, Lee M, Bressler J, Tomechko SE, Moreno EK, Loveland KA, Desai CC, Shakespeare-Pellington S, Reece JA, Morgan R, Geiger MJ, O'Keefe ME, Grove ML, Boerwinkle EOctober 2016
26309447Create StudySynergic effect of GSTP1 and blood manganese concentrations in Autism Spectrum Disorder.Research in autism spectrum disordersRahbar MH, Samms-Vaughan M, Ma J, Bressler J, Dickerson AS, Hessabi M, Loveland KA, Grove ML, Shakespeare-Pellington S, Beecher C, McLaughlin W, Boerwinkle EOctober 1, 2015
25915835Create StudyConcentration of lead, mercury, cadmium, aluminum, arsenic and manganese in umbilical cord blood of jamaican newborns.International journal of environmental research and public healthRahbar MH, Samms-Vaughan M, Dickerson AS, Hessabi M, Bressler J, Desai CC, Shakespeare-Pellington S, Reece JA, Morgan R, Loveland KA, Grove ML, Boerwinkle EMay 2015
25837555Create StudyFactors associated with blood lead concentrations of children in Jamaica.Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineeringRahbar MH, Samms-Vaughan M, Dickerson AS, Loveland KA, Ardjomand-Hessabi M, Bressler J, Shakespeare-Pellington S, Grove ML, Boerwinkle E2015
25685181Create StudyInteraction between GSTT1 and GSTP1 allele variants as a risk modulating-factor for autism spectrum disorders.Research in autism spectrum disordersRahbar MH, Samms-Vaughan M, Ma J, Bressler J, Loveland KA, Hessabi M, Dickerson AS, Grove ML, Shakespeare-Pellington S, Beecher C, McLaughlin W, Boerwinkle EApril 1, 2015
25546274Create StudyBlood lead concentrations in Jamaican children with and without autism spectrum disorder.International journal of environmental research and public healthRahbar MH, Samms-Vaughan M, Dickerson AS, Loveland KA, Ardjomand-Hessabi M, Bressler J, Shakespeare-Pellington S, Grove ML, Pearson DA, Boerwinkle EJanuary 2015
25149876Create StudyBlood manganese concentrations in Jamaican children with and without autism spectrum disorders.Environmental health : a global access science sourceRahbar MH, Samms-Vaughan M, Dickerson AS, Loveland KA, Ardjomand-Hessabi M, Bressler J, Shakespeare-Pellington S, Grove ML, Pearson DA, Boerwinkle E2014
25101770Create StudyRole of metabolic genes in blood arsenic concentrations of Jamaican children with and without autism spectrum disorder.International journal of environmental research and public healthRahbar MH, Samms-Vaughan M, Ma J, Bressler J, Loveland KA, Ardjomand-Hessabi M, Dickerson AS, Grove ML, Shakespeare-Pellington S, Beecher C, McLaughlin W, Boerwinkle EAugust 2014
25089152Create StudyRole of fruits, grains, and seafood consumption in blood cadmium concentrations of Jamaican children with and without Autism Spectrum Disorder.Research in autism spectrum disordersRahbar MH, Samms-Vaughan M, Dickerson AS, Loveland KA, Ardjomand-Hessabi M, Bressler J, Lee M, Shakespeare-Pellington S, Grove ML, Pearson DA, Boerwinkle ESeptember 1, 2014
22819887Create StudyThe role of drinking water sources, consumption of vegetables and seafood in relation to blood arsenic concentrations of Jamaican children with and without Autism Spectrum Disorders.The Science of the total environmentRahbar MH, Samms-Vaughan M, Ardjomand-Hessabi M, Loveland KA, Dickerson AS, Chen Z, Bressler J, Shakespeare-Pellington S, Grove ML, Bloom K, Wirth J, Pearson DA, Boerwinkle ESeptember 1, 2012
22488160Create StudySeafood consumption and blood mercury concentrations in Jamaican children with and without autism spectrum disorders.Neurotoxicity researchRahbar MH, Samms-Vaughan M, Loveland KA, Ardjomand-Hessabi M, Chen Z, Bressler J, Shakespeare-Pellington S, Grove ML, Bloom K, Pearson DA, Lalor GC, Boerwinkle EJanuary 2013
22230961Create StudyMaternal and paternal age are jointly associated with childhood autism in Jamaica.Journal of autism and developmental disordersRahbar MH, Samms-Vaughan M, Loveland KA, Pearson DA, Bressler J, Chen Z, Ardjomand-Hessabi M, Shakespeare-Pellington S, Grove ML, Beecher C, Bloom K, Boerwinkle ESeptember 2012
help.tab.dataexpected.addnew
Data Expected
Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
ADOS info iconApproved
Medical History info iconApproved
ADI-R info iconApproved
Physical Exam info iconApproved
Social Communication Questionnaire (SCQ) info iconApproved
Demographics info iconApproved
Enviromental Evaluation info iconApproved
Research Subject and Pedigree info iconApproved
Diet/Food Diary/Log info iconApproved
Genetic Test info iconApproved
genomics/omics info iconApproved
Structure not yet defined

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

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