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Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
The CHARGE Study: Childhood Autism Risks From Genetics and the Environment
Irva Hertz-Picciotto 
Few rigorous epidemiologic studies have addressed the environmental causes and biologic underpinnings ofautism spectrum disorder (ASD). The CHARGE (CHildhood Autism Risks from Genetics and Environment)Study is a large, population-based case-control investigation of environmental risk factors, broadly defined, inrelation to ASD and developmental delay without ASD symptoms, with referents from the general population.Fieldwork began In 2003, and by now CHARGE has published widely on exposures such as air pollution,mercury, flame retardants, maternal nutritional status in the peri-conception, untreated fever during pregnancy,mitochondrial dysfunction, candidate genes, a wide array of functional immune markers in both the child andthe mother, and maternal metabolic conditions including obesity and diabetes. This last finding is notable,given the epidemic of obesity and type 2 diabetes that has occurred in parallel with the steady rise in ASD overthe last few decades. Moreover, an emerging literature implicates several endocrine disrupting chemicals ascontributing to obesity and metabolic dysregulation, including hyperinsulinemia, and to neurodevelopmentaldisorders as well. This project therefore builds upon these observations in several ways.First, obesity and type 2 or gestational diabetes will be examined in a larger sample, and glucose challengetest (GCT) results for the first time, to determine associations not only with development of ASD andintellectual impairment in the children, but also with specific speech and language delays, behavioralphenotypes such as attention deficits or hyperactivity, and gene expression. Second, these maternal metabolicconditions will be evaluated for associations with markers of both metabolic and immune dysregulation to bemeasured in neonatal bloodspots. Third, the predictive value of neonatal bloodspot markers for a laterdiagnosis of ASD or other child developmental and behavioral outcomes will be assessed. Fourth, the maternalmetabolic conditions will be analyzed for potential links with upstream exposures to phthalates and antibacterialcompounds, ubiquitous chemicals in common household products. Finally, this project will examinehow gene variants that play a role in biochemical pathways relevant to the processes under study mayinfluence susceptibility of the mother, the neonate or the child. To ensure adequate power for this analysis ofgene-environment interaction, the sample size will be increased to 2400 children. This project addressesseveral goals set by the NIH Interagency Autism Coordinating Committee: 1) to discover environmental factorscontributing to ASD, particularly in the prenatal period, 2) to understand biological mechanisms for ASD risk,including gene-by-environment interactions, and 3) to identify children at risk for ASD at earlier time points.Results of this detailed inquiry into early exposures, maternal pathophysiology and prognostic markers in thenewborn will set the stage for developing prevention strategies.
Loading Chart...
NIH - Extramural None

R01ES015359-01 The Charge Study: Childhood Autism Risks from Genetics and the Environment 02/08/2007 01/31/2012 11216 10304 UNIVERSITY OF CALIFORNIA AT DAVIS $6,938,839.00

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To create a new Omics, eye tracking, fMRI, or EEG experiment, press the "+ New Experiment" button. Once an experiment is created, then raw files for these types of experiments should be provided, associating the experiment – through Experiment_ID – with the metadata defined in the experiments interface.

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Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Shared Data

Data structures with the number of subjects submitted and shared are provided.

Aberrant Behavior Checklist (ABC) - Community Clinical Assessments 326
Autism Diagnostic Interview, Revised (ADI-R) Clinical Assessments 201
Autism Diagnostic Observation Schedule (ADOS) - Module 1 (2007) Clinical Assessments 60
Autism Diagnostic Observation Schedule (ADOS) - Module 2 (2007) Clinical Assessments 38
Autism Diagnostic Observation Schedule (ADOS)- Module 3 (2007) Clinical Assessments 5
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 1 Clinical Assessments 58
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 2 Clinical Assessments 37
Demographics Clinical Assessments 329
Gastrointestinal History Clinical Assessments 326
Mullen Scales of Early Learning Clinical Assessments 328
Sleep History Clinical Assessments 326
Social Communication Questionnaire (SCQ) - Lifetime Clinical Assessments 132
Vineland I Clinical Assessments 329

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:


Publications relevant to NDAR data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed IDStudyTitleJournalAuthorsDateStatus
27639855Create StudySociodemographic Disparities in Intervention Service Utilization in Families of Children with Autism Spectrum Disorder.Journal of autism and developmental disordersNguyen CT, Krakowiak P, Hansen R, Hertz-Picciotto I, Angkustsiri KSeptember 2016Not Determined
27312731Create StudyAutism-specific maternal anti-fetal brain autoantibodies are associated with metabolic conditions.Autism research : official journal of the International Society for Autism ResearchKrakowiak P, Walker CK, Tancredi D, Hertz-Picciotto I, Van De Water JJune 17, 2016Not Determined
27071785Create StudyAutism, Mitochondria and Polybrominated Diphenyl Ether Exposure.CNS & neurological disorders drug targetsWong S, Giulivi CJanuary 2016Not Relevant
26725748Create StudyRisk factors in autism: Thinking outside the brain.Journal of autoimmunityMatelski L, Van De Water JFebruary 2016Not Relevant
26392128Create StudyNeonatal Cytokine Profiles Associated with Autism Spectrum Disorder.Biological psychiatryKrakowiak P, Goines PE, Tancredi DJ, Ashwood P, Hansen RL, Hertz-Picciotto I, Van de Water JAugust 14, 2015Not Determined
26298322Create StudyIncreased production of IL-17 in children with autism spectrum disorders and co-morbid asthma.Journal of neuroimmunologyAkintunde ME, Rose M, Krakowiak P, Heuer L, Ashwood P, Hansen R, Hertz-Picciotto I, Van de Water JSeptember 15, 2015Not Determined
26198445Create StudyPrenatal mercury exposure, autism, and developmental delay, using pharmacokinetic combination of newborn blood concentrations and questionnaire data: a case control study.Environmental health : a global access science sourceMcKean SJ, Bartell SM, Hansen RL, Barfod GH, Green PG, Hertz-Picciotto I2015Not Determined
26108271Create StudyPhthalate concentrations in house dust in relation to autism spectrum disorder and developmental delay in the CHildhood Autism Risks from Genetics and the Environment (CHARGE) study.Environmental health : a global access science sourcePhilippat C, Bennett DH, Krakowiak P, Rose M, Hwang HM, Hertz-Picciotto I2015Not Determined
26073892Create StudySelected vitamin D metabolic gene variants and risk for autism spectrum disorder in the CHARGE Study.Early human developmentSchmidt RJ, Hansen RL, Hartiala J, Allayee H, Sconberg JL, Schmidt LC, Volk HE, Tassone FAugust 2015Not Determined
26030513Create StudyPreeclampsia, placental insufficiency, autism, and antiphospholipid antibodies-reply.JAMA pediatricsWalker CK, Ashwood P, Hertz-Picciotto IJune 2015Not Relevant
25722050Create StudyAsthma and Allergies in Children With Autism Spectrum Disorders: Results From the CHARGE Study.Autism research : official journal of the International Society for Autism ResearchLyall K, Van de Water J, Ashwood P, Hertz-Picciotto IOctober 2015Not Determined
25656730Create StudyMaternal Recall Versus Medical Records of Metabolic Conditions from the Prenatal Period: A Validation Study.Maternal and child health journalKrakowiak P, Walker CK, Tancredi DJ, Hertz-Picciotto ISeptember 2015Not Determined
25485869Create StudyPreeclampsia, placental insufficiency, and autism spectrum disorder or developmental delay.JAMA pediatricsWalker CK, Krakowiak P, Baker A, Hansen RL, Ozonoff S, Hertz-Picciotto IFebruary 2015Not Determined
25249546Create StudyMaternal intake of supplemental iron and risk of autism spectrum disorder.American journal of epidemiologySchmidt RJ, Tancredi DJ, Krakowiak P, Hansen RL, Ozonoff SNovember 1, 2014Not Determined
24954055Create StudyNeurodevelopmental disorders and prenatal residential proximity to agricultural pesticides: the CHARGE study.Environmental health perspectivesShelton JF, Geraghty EM, Tancredi DJ, Delwiche LD, Schmidt RJ, Ritz B, Hansen RL, Hertz-Picciotto IOctober 2014Not Determined
24753527Create StudyDeficits in bioenergetics and impaired immune response in granulocytes from children with autism.PediatricsNapoli E, Wong S, Hertz-Picciotto I, Giulivi CMay 2014Not Determined
24733881Create StudyPrenatal SSRI use and offspring with autism spectrum disorder or developmental delay.PediatricsHarrington RA, Lee LC, Crum RM, Zimmerman AW, Hertz-Picciotto IMay 2014Not Determined
24613242Create StudyEmbryonic intraventricular exposure to autism-specific maternal autoantibodies produces alterations in autistic-like stereotypical behaviors in offspring mice.Behavioural brain researchCamacho J, Jones K, Miller E, Ariza J, Noctor S, Van de Water J, Martínez-Cerdeño VJune 1, 2014Not Determined
24518932Create StudyMaternal lifestyle and environmental risk factors for autism spectrum disorders.International journal of epidemiologyLyall K, Schmidt RJ, Hertz-Picciotto IApril 2014Not Determined
24456651Create StudyAutism spectrum disorder, flea and tick medication, and adjustments for exposure misclassification: the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study.Environmental health : a global access science sourceKeil AP, Daniels JL, Hertz-Picciotto I2014Not Determined
24399100Create StudyUtilization patterns of conventional and complementary/alternative treatments in children with autism spectrum disorders and developmental disabilities in a population-based study.Journal of developmental and behavioral pediatrics : JDBPAkins RS, Krakowiak P, Angkustsiri K, Hertz-Picciotto I, Hansen RLJanuary 2014Not Determined
24389156Create StudyAnti-brain antibodies are associated with more severe cognitive and behavioral profiles in Italian children with Autism Spectrum Disorder.Brain, behavior, and immunityPiras IS, Haapanen L, Napolioni V, Sacco R, Van de Water J, Persico AMMay 2014Not Determined
24337796Create StudyMaternal immune-mediated conditions, autism spectrum disorders, and developmental delay.Journal of autism and developmental disordersLyall K, Ashwood P, Van de Water J, Hertz-Picciotto IJuly 2014Not Determined
24332449Create StudyReduced excitatory amino acid transporter 1 and metabotropic glutamate receptor 5 expression in the cerebellum of fragile X mental retardation gene 1 premutation carriers with fragile X-associated tremor/ataxia syndrome.Neurobiology of agingPretto DI, Kumar M, Cao Z, Cunningham CL, Durbin-Johnson B, Qi L, Berman R, Noctor SC, Hagerman RJ, Pessah IN, Tassone FMay 2014Not Determined
24240654Create StudyAutism spectrum disorder: interaction of air pollution with the MET receptor tyrosine kinase gene.Epidemiology (Cambridge, Mass.)Volk HE, Kerin T, Lurmann F, Hertz-Picciotto I, McConnell R, Campbell DBJanuary 2014Not Determined
24193577Create StudyGastrointestinal problems in children with autism, developmental delays or typical development.Journal of autism and developmental disordersChaidez V, Hansen RL, Hertz-Picciotto IMay 2014Not Determined
24174712Create StudyIncreased anti-phospholipid antibodies in autism spectrum disorders.Mediators of inflammationCareaga M, Hansen RL, Hertz-Piccotto I, Van de Water J, Ashwood P2013Not Determined
24174710Create StudyGestational exposure to a viral mimetic poly(i:C) results in long-lasting changes in mitochondrial function by leucocytes in the adult offspring.Mediators of inflammationGiulivi C, Napoli E, Schwartzer J, Careaga M, Ashwood P2013Not Determined
23965925Create StudyInfertility and its treatments in association with autism spectrum disorders: a review and results from the CHARGE study.International journal of environmental research and public healthLyall K, Baker A, Hertz-Picciotto I, Walker CKAugust 2013Not Determined
23838888Create StudyAutism-specific maternal autoantibodies recognize critical proteins in developing brain.Translational psychiatryBraunschweig D, Krakowiak P, Duncanson P, Boyce R, Hansen RL, Ashwood P, Hertz-Picciotto I, Pessah IN, Van de Water J2013Not Determined
23623455Create StudyTrophoblast inclusions are significantly increased in the placentas of children in families at risk for autism.Biological psychiatryWalker CK, Anderson KW, Milano KM, Ye S, Tancredi DJ, Pessah IN, Hertz-Picciotto I, Kliman HJAugust 1, 2013Not Determined
23535821Create StudyGlobal increases in both common and rare copy number load associated with autism.Human molecular geneticsGirirajan S, Johnson RL, Tassone F, Balciuniene J, Katiyar N, Fox K, Baker C, Srikanth A, Yeoh KH, Khoo SJ, Nauth TB, Hansen R, Ritchie M, Hertz-Picciotto I, Eichler EE, Pessah IN, Selleck SBJuly 15, 2013Not Determined
23404082Create StudyTraffic-related air pollution, particulate matter, and autism.JAMA psychiatryVolk HE, Lurmann F, Penfold B, Hertz-Picciotto I, McConnell RJanuary 2013Not Determined
23347615Create StudyEvidence of reactive oxygen species-mediated damage to mitochondrial DNA in children with typical autism.Molecular autismNapoli E, Wong S, Giulivi CJanuary 2013Not Determined
23086694Create StudyToxicokinetic modeling of persistent organic pollutant levels in blood from birth to 45 months of age in longitudinal birth cohort studies.Environmental health perspectivesVerner MA, Sonneborn D, Lancz K, Muckle G, Ayotte P, Dewailly É, Kocan A, Palkovicová L, Trnovec T, Haddad S, Hertz-Picciotto I, Eggesbø MJanuary 2013Not Determined
22854260Create StudyDecreased levels of total immunoglobulin in children with autism are not a result of B cell dysfunction.Journal of neuroimmunologyHeuer LS, Rose M, Ashwood P, Van de Water JOctober 15, 2012Not Determined
22833194Create StudyAssociation of a MET genetic variant with autism-associated maternal autoantibodies to fetal brain proteins and cytokine expression.Translational psychiatryHeuer L, Braunschweig D, Ashwood P, Van de Water J, Campbell DB2011Not Determined
22767137Create StudyIdentification of expanded alleles of the FMR1 Gene in the CHildhood Autism Risks from Genes and Environment (CHARGE) study.Journal of autism and developmental disordersTassone F, Choudhary NS, Tassone F, Durbin-Johnson B, Hansen R, Hertz-Picciotto I, Pessah IMarch 2013Not Determined
22689191Create StudyMaternal autoantibodies in autism.Archives of neurologyBraunschweig D, Van de Water JJune 2012Not Determined
22648721Create StudyMaternal periconceptional folic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study.The American journal of clinical nutritionSchmidt RJ, Tancredi DJ, Ozonoff S, Hansen RL, Hartiala J, Allayee H, Schmidt LC, Tassone F, Hertz-Picciotto IJuly 2012Not Determined
22562209Create StudyIs maternal influenza or fever during pregnancy associated with autism or developmental delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) study.Journal of autism and developmental disordersZerbo O, Iosif AM, Walker C, Ozonoff S, Hansen RL, Hertz-Picciotto IJanuary 2013Not Determined
22534084Create StudyTipping the balance of autism risk: potential mechanisms linking pesticides and autism.Environmental health perspectivesShelton JF, Hertz-Picciotto I, Pessah INJuly 2012Not Determined
22492772Create StudyMaternal metabolic conditions and risk for autism and other neurodevelopmental disorders.PediatricsKrakowiak P, Walker CK, Bremer AA, Baker AS, Ozonoff S, Hansen RL, Hertz-Picciotto IMay 2012Not Determined
22399446Create StudyAutism spectrum disorders in Hispanics and non-Hispanics.Autism : the international journal of research and practiceChaidez V, Hansen RL, Hertz-Picciotto IJuly 2012Not Determined
22399411Create StudyParental occupational exposures and autism spectrum disorder.Journal of autism and developmental disordersMcCanlies EC, Fekedulegn D, Mnatsakanova A, Burchfiel CM, Sanderson WT, Charles LE, Hertz-Picciotto INovember 2012Not Determined
22275729Create StudyPre- and postnatal polychlorinated biphenyl concentrations and longitudinal measures of thymus volume in infants.Environmental health perspectivesJusko TA, Sonneborn D, Palkovicova L, Kocan A, Drobna B, Trnovec T, Hertz-Picciotto IApril 2012Not Determined
21610500Create StudyPrenatal vitamins, one-carbon metabolism gene variants, and risk for autism.Epidemiology (Cambridge, Mass.)Schmidt RJ, Hansen RL, Hartiala J, Allayee H, Schmidt LC, Tancredi DJ, Tassone F, Hertz-Picciotto IJuly 2011Not Determined
21610186Create StudyMinor physical anomalies in children with autism spectrum disorders.Autism : the international journal of research and practiceAngkustsiri K, Krakowiak P, Moghaddam B, Wardinsky T, Gardner J, Kalamkarian N, Hertz-Picciotto I, Hansen RLNovember 2011Not Determined
21543984Create StudyMonth of conception and risk of autism.Epidemiology (Cambridge, Mass.)Zerbo O, Iosif AM, Delwiche L, Walker C, Hertz-Picciotto IJuly 2011Not Determined
21538940Create StudyMAOA, DBH, and SLC6A4 variants in CHARGE: a case-control study of autism spectrum disorders.Autism research : official journal of the International Society for Autism ResearchTassone F, Qi L, Zhang W, Hansen RL, Pessah IN, Hertz-Picciotto IAugust 2011Not Determined
21205326Create StudyPolybrominated diphenyl ethers in relation to autism and developmental delay: a case-control study.Environmental health : a global access science sourceHertz-Picciotto I, Bergman A, Fängström B, Rose M, Krakowiak P, Pessah I, Hansen R, Bennett DH2011Not Determined
21156395Create StudyResidential proximity to freeways and autism in the CHARGE study.Environmental health perspectivesVolk HE, Hertz-Picciotto I, Delwiche L, Lurmann F, McConnell RJune 2011Not Determined
21134442Create StudyAutoantibodies to cerebellum in children with autism associate with behavior.Brain, behavior, and immunityGoines P, Haapanen L, Boyce R, Duncanson P, Braunschweig D, Delwiche L, Hansen R, Hertz-Picciotto I, Ashwood P, Van de Water JMarch 2011Not Determined
21119085Create StudyMitochondrial dysfunction in autism.JAMAGiulivi C, Zhang YF, Omanska-Klusek A, Ross-Inta C, Wong S, Hertz-Picciotto I, Tassone F, Pessah INDecember 1, 2010Not Determined
21095018Create StudyAssociations of impaired behaviors with elevated plasma chemokines in autism spectrum disorders.Journal of neuroimmunologyAshwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah IN, Van de Water JMarch 2011Not Determined
20833247Create StudyAltered T cell responses in children with autism.Brain, behavior, and immunityAshwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah IN, Van de Water JJuly 2011Not Determined
20806403Create StudyA comparison of multiple imputation and fully augmented weighted estimators for Cox regression with missing covariates.Statistics in medicineQi L, Wang YF, He YNovember 10, 2010Not Determined
20731829Create StudyNeurodevelopmental toxicity of prenatal polychlorinated biphenyls (PCBs) by chemical structure and activity: a birth cohort study.Environmental health : a global access science sourcePark HY, Hertz-Picciotto I, Sovcikova E, Kocan A, Drobna B, Trnovec T2010Not Determined
20705131Create StudyElevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome.Brain, behavior, and immunityAshwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah I, Van de Water JJanuary 2011Not Determined
20466021Create StudyEarly onset of neurological symptoms in fragile X premutation carriers exposed to neurotoxins.NeurotoxicologyPaul R, Pessah IN, Gane L, Ono M, Hagerman PJ, Brunberg JA, Tassone F, Bourgeois JA, Adams PE, Nguyen DV, Hagerman RAugust 2010Not Determined
20196589Create StudyPBDEs in 2-5 year-old children from California and associations with diet and indoor environment.Environmental science & technologyRose M, Bennett DH, Bergman A, Fängström B, Pessah IN, Hertz-Picciotto IApril 1, 2010Not Determined
20160651Create StudyThe immune system's role in the biology of autism.Current opinion in neurologyGoines P, Van de Water JApril 2010Not Determined
20143326Create StudyIndependent and dependent contributions of advanced maternal and paternal ages to autism risk.Autism research : official journal of the International Society for Autism ResearchShelton JF, Tancredi DJ, Hertz-Picciotto IFebruary 2010Not Determined
20056569Create StudyBlood mercury concentrations in CHARGE Study children with and without autism.Environmental health perspectivesHertz-Picciotto I, Green PG, Delwiche L, Hansen R, Walker C, Pessah INJanuary 2010Not Determined
20049980Create StudyGeographic distribution of autism in California: a retrospective birth cohort analysis.Autism research : official journal of the International Society for Autism ResearchVan Meter KC, Christiansen LE, Delwiche LD, Azari R, Carpenter TE, Hertz-Picciotto IFebruary 2010Not Determined
19937285Create StudyCorrelations between gene expression and mercury levels in blood of boys with and without autism.Neurotoxicity researchStamova B, Green PG, Tian Y, Hertz-Picciotto I, Pessah IN, Hansen R, Yang X, Teng J, Gregg JP, Ashwood P, Van de Water J, Sharp FRJanuary 2011Not Determined
19921347Create StudyCorrelations of gene expression with blood lead levels in children with autism compared to typically developing controls.Neurotoxicity researchTian Y, Green PG, Stamova B, Hertz-Picciotto I, Pessah IN, Hansen R, Yang X, Gregg JP, Ashwood P, Jickling G, Van de Water J, Sharp FRJanuary 2011Not Determined
19800697Create StudyDecreased cellular IL-23 but not IL-17 production in children with autism spectrum disorders.Journal of neuroimmunologyOnore C, Enstrom A, Krakowiak P, Hertz-Picciotto I, Hansen R, Van de Water J, Ashwood PNovember 30, 2009Not Determined
19737792Create StudyCommentary: Diagnostic change and the increased prevalence of autism.International journal of epidemiologyHertz-Picciotto IOctober 2009Not Determined
19666104Create StudyDifferential monocyte responses to TLR ligands in children with autism spectrum disorders.Brain, behavior, and immunityEnstrom AM, Onore CE, Van de Water JA, Ashwood PJanuary 2010Not Determined
19647017Create StudyWITHDRAWN: Neurodevelopmental toxicity of prenatal polychlorinated biphenyls (PCBs) by chemical structure and activity in a birth cohort.NeurotoxicologyPark HY, Hertz-Picciotto I, Sovcikova E, Kocan A, Trnovec TJuly 30, 2009Not Determined
19360687Create StudyThe onset of autism: patterns of symptom emergence in the first years of life.Autism research : official journal of the International Society for Autism ResearchOzonoff S, Heung K, Byrd R, Hansen R, Hertz-Picciotto IDecember 2008Not Determined
19343198Create StudyReduced levels of immunoglobulin in children with autism correlates with behavioral symptoms.Autism research : official journal of the International Society for Autism ResearchHeuer L, Ashwood P, Schauer J, Goines P, Krakowiak P, Hertz-Picciotto I, Hansen R, Croen LA, Pessah IN, Van de Water JOctober 2008Not Determined
19307110Create StudyPlasma fatty acid profiles in autism: a case-control study.Prostaglandins, leukotrienes, and essential fatty acidsWiest MM, German JB, Harvey DJ, Watkins SM, Hertz-Picciotto IApril 2009Not Determined
19234401Create StudyThe rise in autism and the role of age at diagnosis.Epidemiology (Cambridge, Mass.)Hertz-Picciotto I, Delwiche LJanuary 2009Not Determined
19211157Create StudyPreliminary evidence of the in vitro effects of BDE-47 on innate immune responses in children with autism spectrum disorders.Journal of neuroimmunologyAshwood P, Schauer J, Pessah IN, Van de Water JMarch 31, 2009Not Determined
19136055Create StudyIncreased IgG4 levels in children with autism disorder.Brain, behavior, and immunityEnstrom A, Krakowiak P, Onore C, Pessah IN, Hertz-Picciotto I, Hansen RL, Van de Water JA, Ashwood PMarch 2009Not Determined
19132145Create StudyMECP2 promoter methylation and X chromosome inactivation in autism.Autism research : official journal of the International Society for Autism ResearchNagarajan RP, Patzel KA, Martin M, Yasui DH, Swanberg SE, Hertz-Picciotto I, Hansen RL, Van de Water J, Pessah IN, Jiang R, Robinson WP, LaSalle JMJune 2008Not Determined
18762342Create StudyDecreased transforming growth factor beta1 in autism: a potential link between immune dysregulation and impairment in clinical behavioral outcomes.Journal of neuroimmunologyAshwood P, Enstrom A, Krakowiak P, Hertz-Picciotto I, Hansen RL, Croen LA, Ozonoff S, Pessah IN, Van de Water JNovember 15, 2008Not Determined
18762240Create StudyAltered gene expression and function of peripheral blood natural killer cells in children with autism.Brain, behavior, and immunityEnstrom AM, Lit L, Onore CE, Gregg JP, Hansen RL, Pessah IN, Hertz-Picciotto I, Van de Water JA, Sharp FR, Ashwood PJanuary 2009Not Determined
18627595Create StudyA cohort study of in utero polychlorinated biphenyl (PCB) exposures in relation to secondary sex ratio.Environmental health : a global access science sourceHertz-Picciotto I, Jusko TA, Willman EJ, Baker RJ, Keller JA, Teplin SW, Charles MJ2008Not Determined
18507863Create StudyA procedure to characterize geographic distributions of rare disorders in cohorts.International journal of health geographicsVan Meter KC, Christiansen LE, Hertz-Picciotto I, Azari R, Carpenter TE2008Not Determined
18482108Create StudySleep problems in children with autism spectrum disorders, developmental delays, and typical development: a population-based study.Journal of sleep researchKrakowiak P, Goodlin-Jones B, Hertz-Picciotto I, Croen LA, Hansen RLJune 2008Not Determined
18426515Create StudyPrenatal polychlorinated biphenyl exposures in eastern Slovakia modify effects of social factors on birthweight.Paediatric and perinatal epidemiologySonneborn D, Park HY, Petrik J, Kocan A, Palkovicova L, Trnovec T, Nguyen D, Hertz-Picciotto IMay 2008Not Determined
18285840Create StudySerum PCB concentrations in relation to locally produced food items in eastern Slovakia.Journal of exposure science & environmental epidemiologySonneborn D, Park HY, Babinska K, Palkovicova L, Trnovec T, Kocan A, Nguyen DV, Hertz-Picciotto INovember 2008Not Determined
18191778Create StudyRegression in autism: prevalence and associated factors in the CHARGE Study.Ambulatory pediatrics : the official journal of the Ambulatory Pediatric AssociationHansen RL, Ozonoff S, Krakowiak P, Angkustsiri K, Jones C, Deprey LJ, Le DN, Croen LA, Hertz-Picciotto I2008 Jan-FebNot Determined
18078998Create StudyAutism: maternally derived antibodies specific for fetal brain proteins.NeurotoxicologyBraunschweig D, Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Croen LA, Pessah IN, Van de Water JMarch 2008Not Determined
18006270Create StudyGene expression changes in children with autism.GenomicsGregg JP, Lit L, Baron CA, Hertz-Picciotto I, Walker W, Davis RA, Croen LA, Ozonoff S, Hansen R, Pessah IN, Sharp FRJanuary 2008Not Determined
17347881Create StudyBrief report: plasma leptin levels are elevated in autism: association with early onset phenotype?Journal of autism and developmental disordersAshwood P, Kwong C, Hansen R, Hertz-Picciotto I, Croen L, Krakowiak P, Walker W, Pessah IN, Van de Water JJanuary 2008Not Determined
16835068Create StudyThe CHARGE study: an epidemiologic investigation of genetic and environmental factors contributing to autism.Environmental health perspectivesHertz-Picciotto I, Croen LA, Hansen R, Jones CR, van de Water J, Pessah INJuly 2006Not Determined

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Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study Name Description Number of Subjects
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Data Use State
Rare Inherited and De Novo CNVs Reveal Complex Contributions to ASD Risk in Multiplex families NOTE: NOT ALL DATA HAS BEEN UPLOADED FOR THIS STUDY. Rare mutations, including copy-number variants (CNVs), contribute significantly to autism spectrum disorder (ASD) risk. Although their importance has been established in families with only one affected child (simplex families), the contribution of both de novo and inherited CNVs to ASD in families with multiple affected individuals (multiplex families) is less well understood. We analyzed 1,532 families from the Autism Genetic Resource Exchange (AGRE) to assess the impact of de novo and rare CNVs on ASD risk in multiplex families. We observed a higher burden of large, rare CNVs, including inherited events, in individuals with ASD than in their unaffected siblings (odds ratio [OR] = 1.7), but the rate of de novo events was significantly lower than in simplex families. In previously characterized ASD risk loci, we identified 49 CNVs, comprising 24 inherited events, 19 de novo events, and 6 events of unknown inheritance, a significant enrichment in affected versus control individuals (OR = 3.3). In 21 of the 30 families (71%) in whom at least one affected sibling harbored an established ASD major risk CNV, including five families harboring inherited CNVs, the CNV was not shared by all affected siblings, indicating that other risk factors are contributing. We also identified a rare risk locus for ASD and language delay at chromosomal region 2q24 (implicating NR4A2) and another lower-penetrance locus involving inherited deletions and duplications of WWOX. The genetic architecture in multiplex families differs from that in simplex families and is complex, warranting more complete genetic characterization of larger multiplex ASD cohorts. 1 / 5288 Primary Analysis Shared
* Data not on individual level