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Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Intrinsic Brain Architecture of Young Children with Autism While Awake and Asleep
Adriana DiMartino 
Functional neuroimaging is increasingly enhancing our understanding of autism spectrum disorders (ASD) as disconnection syndromes, but because of its demands, most studies have focused on adults or older children. Conducting functional neuroimaging during natural sleep permits the study of young children and infants.Given the early onset of ASD, such studies may be crucial to the identification of biomarkers. However, the assumption that findings obtained during sleep can be generalized to wakefulness has not yet been systematically tested. This exploratory proposal represents a first step to fill this important gap by studying young children with ASD in two conditions - wakefulness and natural sleep - using resting-state functionalmagnetic resonance imaging (R-fMRI). By quantifying intrinsic functional connectivity (iFC) throughout the brain, R-fMRI provides a wealth of information about functional brain circuitry. While differences between asleep and awake R-fMRI in healthy adults have been described, to date, iFC measures in sleeping young children with ASD have not been systematically characterized, nor have they been contrasted with wakefulness. Accordingly, our overarching goal is to provide an initial systematic characterization of the stability (reliability) across states (awake and sleep) of whole-brain iFC in children with ASD. We propose to collect R-fMRI while awake and during natural sleep in at least 20 children with ASD between the ages of 66 to 90 months starting at the youngest ages at which children can be successfully scanned while awake. We willsurvey whole brain iFC employing structural and functional parcellation units commonly examined in the literature. We will also compute other whole-brain voxel-wise measures of intrinsic brain functional architecturepreviously reported to be abnormal in ASD and which capture specific properties not otherwise characterizedby traditional correlation analyses. These include Voxel Mirrored Homotopic Connectivity, RegionalHomogeneity, Fractional Amplitude of Low Frequency Fluctuations, Degree Centrality and Independent Component Analyses. Our hypothesis generating aims are (1) to test for significant differences between wakefulness and sleep across children with ASD, and (2) to systematically characterize the stability (reliability)of between-individual differences in R-fMRI measures across states (asleep, awake) as indexed by intraclass correlation coefficients. We will also address additional questions regarding the effects of different parcellation systems on measures of stability, the stability of brain-behavior relationships with ASD measures, and derive initial estimates of within-session test-retest reliability. Finally, to maximize the impact of this effort, we will make fully anonymized data available to the scientific community every six months as the data are collected. We expect such prospective data sharing to further enhance the scientific value of the proposed efforts. This will accelerate the pace at which the collected data can be used as a foundation for future efforts to study increasingly younger children so as to delineate the underlying pathophysiology of ASD.
Enrollment Completed
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NIH - Extramural None

R21MH102660-01 Intrinsic Brain Architecture of Young Children with Autism While Awake and Asleep 03/05/2014 02/29/2016 50 28 NEW YORK UNIVERSITY SCHOOL OF MEDICINE $466,125.00

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:


To create a new Omics, eye tracking, fMRI, or EEG experiment, press the "+ New Experiment" button. Once an experiment is created, then raw files for these types of experiments should be provided, associating the experiment – through Experiment_ID – with the metadata defined in the experiments interface.

IDNameCreated DateStatusType

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Shared Data

Data structures with the number of subjects submitted and shared are provided.

Aberrant Behavior Checklist (ABC) - Community Clinical Assessments 69
Autism Diagnostic Interview, Revised (ADI-R) Clinical Assessments 49
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 2 Clinical Assessments 6
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 3 Clinical Assessments 67
BRIEF-Parent Clinical Assessments 66
Child Behavior Checklist (CBCL) 1-5 Clinical Assessments 20
Child Behavior Checklist (CBCL) 6-18 Clinical Assessments 47
Child Information Sheet Clinical Assessments 75
Child's Sleep Habits Questionnaire (CSHQ) Clinical Assessments 60
Children's Communication Checklist - 2 Clinical Assessments 72
Comprehensive Assessment of Spoken Language Clinical Assessments 68
Conners Parent Rating Scales Revised (CPRS) 2002 Clinical Assessments 68
DAS-II: Differential Ability Scales 2nd Ed. School Age Clinical Assessments 38
DAS-II:Differential Ability Scales 2nd Ed. Early Years Clinical Assessments 36
Diagnosis Clinical Assessments 74
Edinburgh Handedness Inventory Clinical Assessments 56
Height and Weight Clinical Assessments 71
Image Imaging 51
Multidimensional Anxiety Scale for Children Parent and Self Clinical Assessments 4
Repetitive Behavior Scale - Revised (RBS-R) Clinical Assessments 63
Research Subject Clinical Assessments 76
Social Communication Questionnaire (SCQ) - Lifetime Clinical Assessments 69
Social Responsiveness Scale (SRS) Clinical Assessments 70
Vineland-II - Survey Form (2005) Clinical Assessments 73
Wechsler Abbreviated Scale of Intelligence (WASI) Clinical Assessments 2

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:


Publications relevant to NDAR data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed IDStudyTitleJournalAuthorsDateStatus
26888614Create StudyImaging the "At-Risk" Brain: Future Directions.Journal of the International Neuropsychological Society : JINSKoyama MS, Di Martino A, Castellanos FX, Ho EJ, Marcelle E, Leventhal B, Milham MPFebruary 2016Not Relevant
25233316Create StudyUnraveling the miswired connectome: a developmental perspective.NeuronDi Martino A, Fair DA, Kelly C, Satterthwaite TD, Castellanos FX, Thomason ME, Craddock RC, Luna B, Leventhal BL, Zuo XN, Milham MPSeptember 17, 2014Not Determined

Relevant Publications
PubMed IDStudyTitleJournalAuthorsDate
No records found.
Data Expected
Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
ABC Community info iconApproved
Imaging (Structural, fMRI, DTI, PET, microscopy) info iconApproved
Social Responsiveness Scale (SRS) info iconApproved
Wechsler Abbreviated Scale of Intelligence (WASI) info iconApproved
Social Communication Questionnaire (SCQ) info iconApproved
Demographics info iconApproved
Child Behavior Checklist (CBCL) info iconApproved
Childrens Communication Checklist-2 (CCC-2) info iconApproved
Childs Sleep Habits Questionnaire (CSHQ) info iconApproved
Repetitive Behavior Scale - Revised (RBS-R) info iconApproved
Multidimensional Anxiety Scale for Children (MASC) info iconApproved
ADOS info iconApproved
EEG info iconApproved
Comprehensive Assessment of Spoken Language (CASL) info iconApproved
Physical Exam info iconApproved
DAS-II: Differential Ability Scales info iconApproved
Diagnosis info iconApproved
ADI-R info iconApproved
Conners info iconApproved
Vineland (Parent and Caregiver) info iconApproved
Behavior Rating Inventory of Executive Function (BRIEF) info iconApproved
Research Subject and Pedigree info iconApproved
DSM IV Criteria info iconApproved
DSM-5 Checklist info iconApproved
Structure not yet defined

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.