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NDAR provides a single access to de-identified autism research data. For permission to download data, you will need an NDAR account with approved access to NDAR or a connected repository (AGRE, IAN, or the ATP). For NDAR access, you need to be a research investigator sponsored by an NIH recognized institution with federal wide assurance. See Request Access for more information.

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Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

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Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Mapping Thalamocortical Networks Across Development in ASD
Carissa Cascio 
Autism spectrum disorders (ASD) are a group of pervasive developmental disorderscharacterized by deficits in social interaction and communication, and rigid or stereotypical behaviors. Thesecomplex behavioral problems arise, in part, from deficits in more basic sensory and motor systems. Thethalamus plays a central role in processing sensory information and modulating overall cortical activity.Consequently, dysfunction of the thalamus and its connections with the cortex may account for some of thesymptoms of ASD. Indeed, there is growing evidence that the structure and function of the thalamus isabnormal in ASD and contributes to ASD symptoms.Despite emerging evidence of thalamic abnormalities in ASD, several critical gaps in our knowledgeabout thalamic pathology in ASD remain. First, thalamocortical networks are organized topographically suchthat separate thalamic nuclei project to specific cortical areas raising the distinct possibility that thalamocorticalnetworks may selectively affected in ASD. Second, we know virtually nothing about the post-nataldevelopmental trajectories of thalamocortical networks in ASD. This is critical given mounting evidence thatthe developmental trajectories of the brain are altered in ASD. Moreover, the severity of ASD symptoms variesacross the lifespan. Consequently, a complete understanding of thalamic circuitry in ASD and the relationshipbetween thalamocortical network disturbances and ASD phenotypes will require systematic mapping ofthalamocortical networks across the lifespan.This proposal will begin to address these critical gaps. Using an innovative resting-state fMRI method,we will determine if thalamocortical networks are altered in ASD (Aim 1); examine the developmentaltrajectories of thalamocortical networks in ASD (Aim 2); and establish the functional relevance ofthalamocortical networks to the expression of ASD symptoms (Aim 3). The proposed work will contribute toour understanding of brain-basis of ASD.
Enrollment Completed
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NIH - Extramural None

R21MH101321-01 Mapping Thalamocortical Networks Across Development in ASD 03/07/2014 02/29/2016 92 19 VANDERBILT UNIVERSITY $432,034.00

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:


To create a new Omics, eye tracking, fMRI, or EEG experiment, press the "+ New Experiment" button. Once an experiment is created, then raw files for these types of experiments should be provided, associating the experiment – through Experiment_ID – with the metadata defined in the experiments interface.

IDNameCreated DateStatusType
361fMRI Cascio TNAD07/28/2015ApprovedfMRI

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Shared Data

Data structures with the number of subjects submitted and shared are provided.

Autism Diagnostic Interview, Revised (ADI-R) Clinical Assessments 8
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 2 Clinical Assessments 2
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 3 Clinical Assessments 32
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 4 Clinical Assessments 20
Image Imaging 58
Social Communication Questionnaire (SCQ) - Current Form Clinical Assessments 16
WASI-2 Clinical Assessments 89

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:


Publications relevant to NDAR data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed IDStudyTitleJournalAuthorsDateStatus
27081401Create StudyA functional neuroimaging study of fusiform response to restricted interests in children and adolescents with autism spectrum disorder.Journal of neurodevelopmental disordersFoss-Feig JH, Mcgugin RW, Gauthier I, Mash LE, Ventola P, Cascio CJJanuary 2016Not Determined
26941174Create StudyBrain structure in autism: a voxel-based morphometry analysis of the Autism Brain Imaging Database Exchange (ABIDE).Brain imaging and behaviorRiddle K, Cascio CJ, Woodward NDMarch 3, 2016Not Determined
26061674Create StudyResting-State Functional Connectivity in Psychiatric Disorders.JAMA psychiatryWoodward ND, Cascio CJAugust 2015Not Determined

Relevant Publications
PubMed IDStudyTitleJournalAuthorsDate
No records found.
Data Expected
Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
Imaging (Structural, fMRI, DTI, PET, microscopy) info iconApproved
Wechsler Abbreviated Scale of Intelligence (WASI) info iconApproved
Social Communication Questionnaire (SCQ) info iconApproved
ADI-R info iconApproved
ADOS info iconApproved
Research Subject and Pedigree info iconApproved
Thermal Detection Ability info iconApproved
Sensory Profile info iconApproved
Bruininks-Oseretsky Test info iconApproved
Somatosensory Contact Ability info iconApproved
Repetitive Behavior Scale - Revised (RBS-R) info iconApproved
Structure not yet defined

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.