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NDAR provides a single access to de-identified autism research data. For permission to download data, you will need an NDAR account with approved access to NDAR or a connected repository (AGRE, IAN, or the ATP). For NDAR access, you need to be a research investigator sponsored by an NIH recognized institution with federal wide assurance. See Request Access for more information.

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Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

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Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Early Quantitative Characterization of Reciprocal Social Behavior
John Constantino 
This project is focused on the development, validation, and standardization of quantitative methods to measure core components of variation in the social development of young children.This is critical for understanding autism and will inform the development and evaluation of early interventions for children with autism and related conditions. The proposed application coversthe 18 to 48 month age range; i.e. the period when autism is actually first diagnosed. Currently, there exist few options for the tracking of autistic severity over time in this age range, few methods that allow severity trajectories to be reliably associated with candidate genetic and neurobiologic correlates of autistic impairment, and few established methods for making meaningful baseline measurements against which to quantify the impact of early intervention for young children with autism spectrum disorders (ASD). In this application, as we attempt toextend to early childhood a measurement system rooted in the ascertainment of quantitative autistic traits, we couple such measurements with laboratory assessment of visual socialengagement (VSE), a fundamental parameter of human social development, whose origins are traceable to earliest infancy and whose implications are wide-ranging with respect to all aspectsof early human social development. The specific aims are as follows: 1) To examine the general population distribution and longitudinal course of quantitative variation in reciprocal social behavior (and related indices of social behavioral development) in an ethnically diverse sampleof preschool age twins (n=420 pairs), assessed prospectively at key ages within the intervalfrom 18-48 months; 2) To examine stability and change in the same set of quantitative measures when implemented among children with ASD (n=90) first diagnosed at 18-24 months,and to clarify the relationship between these measures and traditional diagnostic assessmentsfor ASD; 3) To examine variation in visual social engagement (VSE) among preschool children (125 general populationtwin pairs and 75 clinical ASD subjects) representing the entire range of social variation that occurs in nature.
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NIH - Extramural None

R01HD068479-01 Early Quantitative Characterization of Reciprocal Social Behavior 08/01/2012 04/30/2018 4498 2636 WASHINGTON UNIVERSITY $2,727,277.00

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:


To create a new Omics, eye tracking, fMRI, or EEG experiment, press the "+ New Experiment" button. Once an experiment is created, then raw files for these types of experiments should be provided, associating the experiment – through Experiment_ID – with the metadata defined in the experiments interface.

IDNameCreated DateStatusType
No records found.

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Shared Data

Data structures with the number of subjects submitted and shared are provided.

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:


Publications relevant to NDAR data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed IDStudyTitleJournalAuthorsDateStatus
26497771Create StudyDiagnosis of autism spectrum disorder: reconciling the syndrome, its diverse origins, and variation in expression.The Lancet. NeurologyConstantino JN, Charman TMarch 2016Not Relevant
25677414Create StudyRapid video-referenced ratings of reciprocal social behavior in toddlers: a twin study.Journal of child psychology and psychiatry, and allied disciplinesMarrus N, Glowinski AL, Jacob T, Klin A, Jones W, Drain CE, Holzhauer KE, Hariprasad V, Fitzgerald RT, Mortenson EL, Sant SM, Cole L, Siegel SA, Zhang Y, Agrawal A, Heath AC, Constantino JNDecember 2015Not Determined
24019124Create StudyConfirmatory factor analytic structure and measurement invariance of quantitative autistic traits measured by the social responsiveness scale-2.Autism : the international journal of research and practiceFrazier TW, Ratliff KR, Gruber C, Zhang Y, Law PA, Constantino JNJanuary 2014Not Determined

Relevant Publications
PubMed IDStudyTitleJournalAuthorsDate
No records found.
Data Expected
Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
Video-Referenced Ratings of Reciprocal Social Behavior info iconApproved
Research Subject and Pedigree info iconApproved
M-CHAT info iconApproved
MacArthur Bates Communicative Development Inventory info iconApproved
Structure not yet defined

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.