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NDAR provides a single access to de-identified autism research data. For permission to download data, you will need an NDAR account with approved access to NDAR or a connected repository (AGRE, IAN, or the ATP). For NDAR access, you need to be a research investigator sponsored by an NIH recognized institution with federal wide assurance. See Request Access for more information.

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The filters you have selected from various query interfaces will be stored here, in the 'Filter Cart'. The database will be queried using filters added to your 'Filter Cart', when multiple filters are defined, each will be executed using 'AND' logic, so with each filter that is applied the result set gets smaller.

From the 'Filter Cart' you can inspect each of the filters that have been defined, and you also have the option to remove filters. The 'Filter Cart' itself will display the number of filters applied along with the number of subjects that are identified by the combination of those filters. For example a GUID filter with two subjects, followed by a GUID filter for just one of those subjects would return only data for the subject that is in both GUID filters.

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1 Numbers reported are subjects by age
New Trial
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Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

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Shared

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

General

Title, investigators, and Collection Description may be edited along with the Collection Phase. For Collection Phase, the options Pre-enrollment, Enrollment, and Completed can be chosen allowing the Collection Owner to indicate the stage of data collection.

Funding Source

The ability to associate the funding source for the project is provided. For NIH funded grants, linkage to Project Reporter information (e.g. R01MH123456) is supported. Projects funded by others, including the URL of the project, are listed. Non NIH funded projects will become available here to link that data with the appropriate funding agency.

Supporting Documentation

Any documents related to the project may be uploaded clarifying the data or acquisition methods used may be uploaded and made available here. The default is to share these documents to the general public. An option to share only to qualified Researchers is also an option.

Clinical Trials

For clinical trials, the option to link to the clinical trial in clinicaltrials.gov is optionally provided.

Collection Summary Collection Charts
Collection Title Collection Investigators Collection Description
Neural Phenotypes of Females with Autism Spectrum Disorder
Christine Wu Nordahl 
Autism spectrum disorder (ASD) affects 1 in 88 children in the United States, but the disorder is much morecommon in boys than in girls. The prevalence of ASD in boys is 5 times higher than in girls, with a rate of 1 in54 for boys and 1 in 252 for girls. Although this disparate sex ratio is among the most highly replicated findingsin studies of ASD, sex differences in ASD remain poorly understood. The neuropathology of ASD in females isunderstudied because ASD samples recruited for research studies typically reflect the strong male bias of thedisorder. The goal of this study is to evaluate a large, sex-balanced cohort of preschool-aged children withASD in order to elucidate the neural phenotypes of females with ASD and to identify sex-differences in theneuropathology of ASD. Children will be enrolled at the time of diagnosis (2-3 years of age) and followedlongitudinally for two years. Imaging will be carried out at study enrolment and then at two additional annualtime points and behavioral testing will be conducted twice, in conjunction with the first and third MRI time points.Imaging will include structural, diffusion-weighted and resting state functional connectivity in order toaccomplish the following aims: 1) to evaluate sex differences in the neural systems that underlie core deficits inASD 2) to investigate sex differences in brain growth trajectories in these neural systems and 3) to identifyassociations between distinct neural phenotypic subgroups and etiologic factors or behavioral outcomes.A comprehensive understanding of the female phenotype of ASD is a pressing and timely topic, as indicatedby national efforts to direct research towards this topic. This program of research responds to the InteragencyAutism Coordinating Committee (IACC) strategic plan to evaluate females with ASD as well as the mission ofthe NIH Office of Research on Womens Health to strengthen and enhance research related to diseases,disorders and conditions that affect females.
NDAR
Enrolling
Shared
$2,834,078.00
47
120
61
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NIH - Extramural None


R01MH104438-01 Neural Phenotypes of Females with Autism Spectrum Disorder 07/10/2014 04/30/2019 120 61 UNIVERSITY OF CALIFORNIA AT DAVIS $2,834,078.00

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Experiments

To create a new Omics, eye tracking, fMRI, or EEG experiment, press the "+ New Experiment" button. Once an experiment is created, then raw files for these types of experiments should be provided, associating the experiment – through Experiment_ID – with the metadata defined in the experiments interface.

IDNameCreated DateStatusType
No records found.

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Shared Data

Data structures with the number of subjects submitted and shared are provided.

Autism Diagnostic Interview, Revised (ADI-R) Clinical Assessments 18
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 1 Clinical Assessments 14
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 2 Clinical Assessments 4
CHARGE Medical History Clinical Assessments 24
CHARGE Physical Exam Clinical Assessments 27
Child Behavior Checklist (CBCL) 1-5 Clinical Assessments 24
Child's Sleep Habits Questionnaire (CSHQ) Clinical Assessments 23
Children's Behavior Questionnaire Parent Clinical Assessments 23
Children's Behavior Questionnaire Short Form Clinical Assessments 24
Demographics Clinical Assessments 24
Early Development Questionnaire Clinical Assessments 24
Expressive One-Word Picture Vocabulary Test (2000) Clinical Assessments 21
Mullen Scales of Early Learning Clinical Assessments 25
Peabody Picture Vocabulary Test, Fourth Edition-Form A Clinical Assessments 20
Repetitive Behavior Scale - Revised (RBS-R) Clinical Assessments 23
Sensory Profile Short 2 Clinical Assessments 22
Social Communication Questionnaire (SCQ) - Lifetime Clinical Assessments 22
Social Responsiveness Scale (SRS) Clinical Assessments 22
Vineland-II - Parent and Caregiver Rating Form (2005) Clinical Assessments 23

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDAR data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed IDStudyTitleJournalAuthorsDateStatus
27747263Create StudySocio-Emotional and Cognitive Resilience in Children with Reading Disabilities.Current opinion in behavioral sciencesHaft SL, Myers CA, Hoeft FAugust 2016Not Relevant
27623194Create StudyIntergenerational Neuroimaging of Human Brain Circuitry.Trends in neurosciencesHo TC, Sanders SJ, Gotlib IH, Hoeft FOctober 2016Not Relevant
27458603Create StudyIntegrating MRI brain imaging studies of pre-reading children with current theories of developmental dyslexia: A review and quantitative meta-analysis.Current opinion in behavioral sciencesVandermosten M, Hoeft F, Norton ESAugust 2016Not Relevant
27273931Create StudyPersistence of megalencephaly in a subgroup of young boys with autism spectrum disorder.Autism research : official journal of the International Society for Autism ResearchLibero LE, Nordahl CW, Li DD, Ferrer E, Rogers SJ, Amaral DGNovember 2016Not Determined
27158271Create StudyMethods for acquiring MRI data in children with autism spectrum disorder and intellectual impairment without the use of sedation.Journal of neurodevelopmental disordersNordahl CW, Mello M, Shen AM, Shen MD, Vismara LA, Li D, Harrington K, Tanase C, Goodlin-Jones B, Rogers S, Abbeduto L, Amaral DG2016Not Determined
26818513Create StudyFemale-Specific Intergenerational Transmission Patterns of the Human Corticolimbic Circuitry.The Journal of neuroscience : the official journal of the Society for NeuroscienceYamagata B, Murayama K, Black JM, Hancock R, Mimura M, Yang TT, Reiss AL, Hoeft FJanuary 27, 2016Not Determined
26679527Create StudyNeuroanatomical anomalies of dyslexia: Disambiguating the effects of disorder, performance, and maturation.NeuropsychologiaXia Z, Hoeft F, Zhang L, Shu HJanuary 29, 2016Not Determined
26279309Create StudyAssessing hippocampal development and language in early childhood: Evidence from a new application of the Automatic Segmentation Adapter Tool.Human brain mappingLee JK, Nordahl CW, Amaral DG, Lee A, Solomon M, Ghetti SNovember 2015Not Determined
help.tab.dataexpected

Relevant Publications
PubMed IDStudyTitleJournalAuthorsDate
No records found.
help.tab.dataexpected.addnew
Data Expected
Data ExpectedTargeted EnrollmentInitial SubmissionSubjects SharedStatus
Research Subject and Pedigree info iconApproved
ADI-R info iconApproved
Imaging (Structural, fMRI, DTI, PET, microscopy) info iconApproved
Childs Sleep Habits Questionnaire (CSHQ) info iconApproved
Vineland (Parent and Caregiver) info iconApproved
Social Responsiveness Scale (SRS) info iconApproved
ADOS info iconApproved
Child Behavior Checklist (CBCL) info iconApproved
Childrens Behavior Questionnaire (CBQ) info iconApproved
Early Development Questionnaire info iconApproved
Mullen Scales of Early Learning info iconApproved
Repetitive Behavior Scale - Revised (RBS-R) info iconApproved
Sensory Profile info iconApproved
Social Communication Questionnaire (SCQ) info iconApproved
Expressive One-Word Picture Vocabulary Test (2000) info iconApproved
Demographics info iconApproved
Physical Exam info iconApproved
Medical History info iconApproved
Peabody Picture Vocabulary Test, Fourth Edition info iconApproved
Structure not yet defined

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

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