NIMH Data Archive - Data

Genomics

Neuroimaging

Phenotype¹

New Trial
Clinical Trial

¹ Numbers reported are subjects by age

New Project
Grant/Project Number

Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

Collection - Use Existing Experiment

To associate an experiment to the current collection, just select an axperiment from the table below then click the associate experiment button to persist your changes (saving the collection is not required). Note that once an experiment has been associated to two or more collections, the experiment will not longer be editable.

The table search feature is case insensitive and targets the experiment id, experiment name and experiment type columns. The experiment id is searched only when the search term entered is a number, and filtered using a startsWith comparison. When the search term is not numeric the experiment name is used to filter the results.

Select	Experiment Id	Experiment Name	Experiment Type	Created On

24	HI-NGS_R1	Omics	02/16/2011
475	MB1-10 (CHOP)	Omics	06/07/2016
490	Illumina Infinium PsychArray BeadChip Assay	Omics	07/07/2016
501	PharmacoBOLD Resting State	fMRI	07/27/2016
506	PVPREF	Omics	08/05/2016
509	ABC-CT Resting v2	EEG	08/18/2016
13	Comparison of FI expression in Autistic and Neurotypical Homo Sapiens	Omics	12/28/2010
18	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	01/06/2011
22	Stitching PCR Sequencing	Omics	02/14/2011
26	ASD_Methylation	Omics	03/01/2011
29	Microarray family 03 (father, mother, sibling)	Omics	03/24/2011
37	Standard paired-end sequencing of BCRs	Omics	04/19/2011
38	Illumina Mate-Pair BCR sequencing	Omics	04/19/2011
39	Custom Jumping Libraries	Omics	04/19/2011
40	Custom CapBP	Omics	04/19/2011
41	Immunofluorescence	Omics	05/11/2011
43	Autism brain sample genotyping, Illumina	Omics	05/16/2011
47	ARRA Autism Sequencing Collaboration at Baylor. SOLiD 4 System	Omics	08/01/2011
53	AGRE Omni1-quad	Omics	10/11/2011
59	AGP genotyping	Omics	04/03/2012
60	Ultradeep 454 sequencing of synaptic genes from postmortem cerebella of individuals with ASD and neurotypical controls	Omics	06/23/2012
63	Microemulsion PCR and Targeted Resequencing for Variant Detection in ASD	Omics	07/20/2012
76	Whole Genome Sequencing in Autism Families	Omics	01/03/2013
519	Resting	fMRI	11/08/2016
90	Genotyped IAN Samples	Omics	07/09/2013
91	NJLAGS Axiom Genotyping Array	Omics	07/16/2013
93	AGP genotyping (CNV)	Omics	09/06/2013
106	Longitudinal Sleep Study. H20 200. Channel set 2	EEG	11/07/2013
107	Longitudinal Sleep Study. H20 200. Channel set 3	EEG	11/07/2013
108	Longitudinal Sleep Study. AURA 200	EEG	11/07/2013
105	Longitudinal Sleep Study. H20 200. Channel set 1	EEG	11/07/2013
109	Longitudinal Sleep Study. AURA 400	EEG	11/07/2013
116	Gene Expression Analysis WG-6	Omics	01/07/2014
131	Jeste Lab UCLA ACEii: Charlie Brown and Sesame Street - Project 1	Eye Tracking	02/27/2014
132	Jeste Lab UCLA ACEii: Animacy - Project 1	Eye Tracking	02/27/2014
133	Jeste Lab UCLA ACEii: Mom Stranger - Project 2	Eye Tracking	02/27/2014
134	Jeste Lab UCLA ACEii: Face Emotion - Project 3	Eye Tracking	02/27/2014
145	AGRE/FMR1_Illumina.JHU	Omics	04/14/2014
146	AGRE/MECP2_Sanger.JHU	Omics	04/14/2014
147	AGRE/MECP2_Junior.JHU	Omics	04/14/2014
151	Candidate Gene Identification in familial Autism	Omics	06/09/2014
152	NJLAGS Whole Genome Sequencing	Omics	07/01/2014
154	Math Autism Study - Vinod Menon	fMRI	07/15/2014
155	Resting	fMRI	07/25/2014
156	Speech	fMRI	07/25/2014
159	Emotion	fMRI	07/25/2014
160	syllable contrast	EEG	07/29/2014
167	School-age naturalistic stimuli	Eye Tracking	09/19/2014
44	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	06/27/2011
45	Exome Sequencing of 20 Sporadic Cases of Autism Spectrum Disorder	Omics	07/15/2011

Collection - Add Experiment

Add Supporting Documentation

Funding Source:
URL:

To add an existing Data Structure, enter its title in the search bar. If you need to request changes, select the indicator "No, it requires changes to meet research needs" after selecting the Structure, and upload the file with the request changes specific to the selected Data Structure. Your file should follow the Request Changes Procedure. If the Data Structure does not exist, select "Request New Data Structure" and upload the appropriate zip file.

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Please confirm that you will not be enrolling any more subjects and that all raw data has been collected and submitted.

Collection Updated

Your Collection is now in Data Analysis phase and exempt from biannual submissions. Analyzed data is still expected prior to publication or no later than the project end date.

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Silvio O. Conte Center for Oxytocin and Social Cognition #2055

General
Experiments (0)
Shared Data
Publications (133)
Data Expected (6)
Associated Studies (1)

Collection Title	Collection Investigators	Collection Description
Collection Title:	Silvio O. Conte Center for Oxytocin and Social Cognition
Collection Investigators:	Larry Young
Collection Description:	The oxytocin (OT) system is arguably the most viable target for pharmacologically enhancing social cognition in psychiatric disorders with compromised social cognition, including autism spectrum disorder (ASD). Central OT enhances key aspects of social behavior in animals, and intranasal (IN) OT modulates social cognition in humans. The mechanisms by which OT affects social cognition are not understood. We will launch a coordinated, interdisciplinary research program involving an outstanding team of investigators to test the hypothesis that OT enhances social cognition by increasing the salience and reinforcing value of social stimuli by modulating activity and functional connectivity of the amygdala and brain regions involved in reward. Project scientists will use cutting edge techniques to assess functional connectivity between brain regions during social interactions, responses of individual neurons in the amygdala to social stimuli, or social cognition in animals and humans. Projects 1 and 2 will use in vivo electrophysiology to examine the impact of OT on the neural representation of social stimuli in rodents and rhesus macaques. Project 3 will use cognitive tests to examine the impact of OT on social perception and social attunement in the primate.Project 4 will use cognitive testing and fMRI to examine the impact of OT on social cognition and neuralactivity in healthy and autistic humans. A Neurochemistry Core will provide vital services for the research projects and develop new tools for characterizing OT receptor expression in the brain. An Administrative Core will coordinate all Center related activities (seminar series, organizing meetings), will provide statistical consultation and coordinate outreach and training activities of Center personnel by strengthening existing relationships and forging new relationships with numerous organizations in the Atlanta area. As a result, the Center will create vibrant collaborative research, training and outreach environment that will have a national impact on mental health research. The data collected by Center faculty will have important transiationaimplications that will directly impact novel strategies for pharmacologically treating social deficits in psychiatric disorders.
Data Repository:	NIMH Data Archive
Permission Group:
Collection Creation Date:	10/03/2013
Collection Phase:	Funding Completed
Collection Sub-Phase:	Close Out
Blinded Clinical Trial:	No
Total Funded Amount:	$5,908,165.00
Subjects Shared:	38

{"values":[]}

{"values":[["Not Defined",1],["Autism Spectrum Affected",15]]}

Loading Chart...

Funding Sources:

Funding Source Name	Funding Source URL
NIH - Extramural	None

Supporting Documentation:

Grant Information:

Project Number	Project Title	Start Date	End Date	Planned Enrollment	Actual Enrollment	Organization	Funds Obligated
P50MH100023-01	Silvio O. Conte Center for Oxytocin and Social Cognition	07/01/2013	06/30/2018	496	350	EMORY UNIVERSITY	$5,908,165.00

Clinical Trials:

helpcenter.collection.general-tab

Collection - General Tab

Fields available for edit on the top portion of the page include:

Collection Title
Investigators
Collection Description
Collection Phase
Funding Source
Clinical Trials

Collection Phase: The current status of a research project submitting data to an NDA Collection, based on the timing of the award and/or the data that have been submitted.

Pre-Enrollment: The default entry made when the NDA Collection is created.
Enrolling: Data have been submitted to the NDA Collection or the NDA Data Expected initial submission date has been reached for at least one data structure category in the NDA Collection.
Data Analysis: Subject level data collection for the research project is completed and has been submitted to the NDA Collection. The NDA Collection owner or the NDA Help Desk may set this phase when they’ve confirmed data submission is complete and submitted subject counts match at least 90% of the target enrollment numbers in the NDA Data Expected. Data submission reminders will be turned off for the NDA Collection.
Funding Completed: The NIH grant award (or awards) associated with the NDA Collection has reached its end date. NDA Collections in Funding Completed phase are assigned a subphase to indicate the status of data submission.
- The Data Expected Subphase indicates that NDA expects more data will be submitted
- The Closeout Subphase indicates the data submission is complete.
- The Sharing Not Met Subphase indicates that data submission was not completed as expected.

Blinded Clinical Trial Status:

This status is set by a Collection Owner and indicates the research project is a double blinded clinical trial. When selected, the public view of Data Expected will show the Data Expected items and the Submission Dates, but the targeted enrollment and subjects submitted counts will not be displayed.
Targeted enrollment and subjects submitted counts are visible only to NDA Administrators and to the NDA Collection or as the NDA Collection Owner.
When an NDA Collection that is flagged Blinded Clinical Trial reaches the maximum data sharing date for that Data Repository (see https://nda.nih.gov/nda/sharing-regimen.html), the embargo on Data Expected information is released.

Funding Source

The organization(s) responsible for providing the funding is listed here.

Supporting Documentation

Users with Submission privileges, as well as Collection Owners, Program Officers, and those with Administrator privileges, may upload and attach supporting documentation. By default, supporting documentation is shared to the general public, however, the option is also available to limit this information to qualified researchers only.

Grant Information

Identifiable details are displayed about the Project of which the Collection was derived from. You may click in the Project Number to view a full report of the Project captured by the NIH.

Clinical Trials

Any data that is collected to support or further the research of clinical studies will be available here. Collection Owners and those with Administrator privileges may add new clinical trials.

Frequently Asked Questions

How does the NIMH Data Archive (NDA) determine which Permission Group data are submitted into?

During Collection creation, NDA staff determine the appropriate Permission Group based on the type of data to be submitted, the type of access that will be available to data access users, and the information provided by the Program Officer during grant award.
How do I know when a NDA Collection has been created?

When a Collection is created by NDA staff, an email notification will automatically be sent to the PI(s) of the grant(s) associated with the Collection to notify them.
Is a single grant number ever associated with more than one Collection?

The NDA system does not allow for a single grant to be associated with more than one Collection; therefore, a single grant will not be listed in the Grant Information section of a Collection for more than one Collection.
Why is there sometimes more than one grant included in a Collection?

In general, each Collection is associated with only one grant; however, multiple grants may be associated if the grant has multiple competing segments for the same grant number or if multiple different grants are all working on the same project and it makes sense to hold the data in one Collection (e.g., Cooperative Agreements).

Glossary

Administrator Privilege

A privilege provided to a user associated with an NDA Collection or NDA Study whereby that user can perform a full range of actions including providing privileges to other users.
Collection Owner

Generally, the Collection Owner is the contact PI listed on a grant. Only one NDA user is listed as the Collection owner. Most automated emails are primarily sent to the Collection Owner.
Collection Phase
The Collection Phase provides information on data submission as opposed to grant/project completion so while the Collection phase and grant/project phase may be closely related they are often different. Collection users with Administrative Privileges are encouraged to edit the Collection Phase. The Program Officer as listed in eRA (for NIH funded grants) may also edit this field. Changes must be saved by clicking the Save button at the bottom of the page. This field is sortable alphabetically in ascending or descending order. Collection Phase options include:
- Pre-Enrollment: A grant/project has started, but has not yet enrolled subjects.
- Enrolling: A grant/project has begun enrolling subjects. Data submission is likely ongoing at this point.
- Data Analysis: A grant/project has completed enrolling subjects and has completed all data submissions.
- Funding Completed: A grant/project has reached the project end date.
Collection Title

An editable field with the title of the Collection, which is often the title of the grant associated with the Collection.
Grant

Provides the grant number(s) for the grant(s) associated with the Collection. The field is a hyperlink so clicking on the Grant number will direct the user to the grant information in the NIH Research Portfolio Online Reporting Tools (RePORT) page.
Supporting Documentation

Various documents and materials to enable efficient use of the data by investigators unfamiliar with the project and may include the research protocol, questionnaires, and study manuals.
NIH Research Initiative

NDA Collections may be organized by scientific similarity into NIH Research Initiatives, to facilitate query tool user experience. NIH Research Initiatives map to one or multiple Funding Opportunity Announcements.
Permission Group

Access to shared record-level data in NDA is provisioned at the level of a Permission Group. NDA Permission Groups consist of one or multiple NDA Collections that contain data with the same subject consents.
Planned Enrollment

Number of human subject participants to be enrolled in an NIH-funded clinical research study. The data is provided in competing applications and annual progress reports.
Actual Enrollment

Number of human subjects enrolled in an NIH-funded clinical research study. The data is provided in annual progress reports.
NDA Collection

A virtual container and organization structure for data and associated documentation from one grant or one large project/consortium. It contains tools for tracking data submission and allows investigators to define a wide array of other elements that provide context for the data, including all general information regarding the data and source project, experimental parameters used to collect any event-based data contained in the Collection, methods, and other supporting documentation. They also allow investigators to link underlying data to an NDA Study, defining populations and subpopulations specific to research aims.
Data Use Limitations

Data Use Limitations (DULs) describe the appropriate secondary use of a dataset and are based on the original informed consent of a research participant. NDA only accepts consent-based data use limitations defined by the NIH Office of Science Policy.
Total Subjects Shared

The total number of unique subjects for whom data have been shared and are available for users with permission to access data.

Contact NDA Help Desk

ID	Name	Created Date	Status	Type
No records found.

helpcenter.collection.experiments-tab

Collection - Experiments

The number of Experiments included is displayed in parentheses next to the tab name. You may download all experiments associated with the Collection via the Download button. You may view individual experiments by clicking the Experiment Name and add them to the Filter Cart via the Add to Cart button.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may create or edit an Experiment.

Please note: The creation of an NDA Experiment does not necessarily mean that data collected, according to the defined Experiment, has been submitted or shared.

Frequently Asked Questions

Can an Experiment be associated with more than one Collection?
Yes -see the “Copy” button in the bottom left when viewing an experiment. There are two actions that can be performed via this button:
1. Copy the experiment with intent for modifications.
2. Associate the experiment to the collection. No modifications can be made to the experiment.

Glossary

Experiment Status

An Experiment must be Approved before data using the associated Experiment_ID may be uploaded.
Experiment ID

The ID number automatically generated by NDA which must be included in the appropriate file when uploading data to link the Experiment Definition to the subject record.

Contact NDA Help Desk

Shared Data:

Title	Type	Number of Subjects
Autism Diagnostic Interview, Revised (ADI-R)	Clinical Assessments	20
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 4	Clinical Assessments	12
WASI-2	Clinical Assessments	38
Wechsler Memory Scale, Third Edition (WMS-III)	Clinical Assessments	21

helpcenter.collection.shared-data-tab

Collection - Shared Data

This tab provides a quick overview of the Data Structure title, Data Type, and Number of Subjects that are currently Shared for the Collection. The information presented in this tab is automatically generated by NDA and cannot be edited. If no information is visible on this tab, this would indicate the Collection does not have shared data or the data is private.

The shared data is available to other researchers who have permission to access data in the Collection's designated Permission Group(s). Use the Download button to get all shared data from the Collection to the Filter Cart.

Frequently Asked Questions

How will I know if another researcher uses data that I shared through the NIMH Data Archive (NDA)?

To see what data your project have submitted are being used by a study, simply go the Associated Studies tab of your collection. Alternatively, you may review an NDA Study Attribution Report available on the General tab.
Can I get a supplement to share data from a completed research project?

Often it becomes more difficult to organize and format data electronically after the project has been completed and the information needed to create a GUID may not be available; however, you may still contact a program staff member at the appropriate funding institution for more information.
Can I get a supplement to share data from a research project that is still ongoing?

Unlike completed projects where researchers may not have the information needed to create a GUID and/or where the effort needed to organize and format data becomes prohibitive, ongoing projects have more of an opportunity to overcome these challenges. Please contact a program staff member at the appropriate funding institution for more information.

Glossary

Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Type

A grouping of data by similar characteristics such as Clinical Assessments, Omics, or Neurosignal data.
Shared

The term 'Shared' generally means available to others; however, there are some slightly different meanings based on what is Shared. A Shared NDA Study is viewable and searchable publicly regardless of the user's role or whether the user has an NDA account. A Shared NDA Study does not necessarily mean that data used in the NDA Study have been shared as this is independently determined. Data are shared according the schedule defined in a Collection's Data Expected Tab and/or in accordance with data sharing expectations in the NDA Data Sharing Terms and Conditions. Additionally, Supporting Documentation uploaded to a Collection may be shared independent of whether data are shared.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDA data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed ID	Study	Title	Journal	Authors	Date	Status
38253222	Create Study	Melanocortin agonism in a social context selectively activates nucleus accumbens in an oxytocin-dependent manner.	Neuropharmacology	Ford, Charles L; McDonough, Anna A; Horie, Kengo; Young, Larry J	April 1, 2024	Not Determined
37961356	Create Study	Natural variation in oxytocin receptor signaling causes widespread changes in brain transcription: a link to the natural killer gene complex.	bioRxiv : the preprint server for biology	Boender, Arjen J; Johnson, Zachary V; Gruenhagen, George W; Horie, Kengo; Hegarty, Brianna E; Streelman, Jeffrey T; Walum, Hasse; Young, Larry J	October 27, 2023	Not Determined
37919790	Create Study	Increased proliferation and neuronal fate in prairie vole brain progenitor cells cultured in vitro: effects by social exposure and sexual dimorphism.	Biology of sex differences	Ávila-González, Daniela; Romero-Morales, Italo; Caro, Lizette; Martínez-Juárez, Alejandro; Young, Larry J; Camacho-Barrios, Francisco; Martínez-Alarcón, Omar; Castro, Analía E; Paredes, Raúl G; Díaz, Néstor F; Portillo, Wendy	November 2, 2023	Not Determined
37745495	Create Study	Instinct to insight: Neural correlates of ethological strategy learning.	bioRxiv : the preprint server for biology	Lu, Kai; Wong, Kelvin T; Zhou, Lin N; Shi, Yike T; Yang, Chengcheng J; Liu, Robert C	September 12, 2023	Not Determined
37372130	Create Study	The Neurobiology of Love and Pair Bonding from Human and Animal Perspectives.	Biology	Blumenthal, Sarah A; Young, Larry J	June 12, 2023	Not Determined
37256960	Create Study	An AAV-CRISPR/Cas9 strategy for gene editing across divergent rodent species: Targeting neural oxytocin receptors as a proof of concept.	Science advances	Boender, Arjen J; Boon, Marina; Albers, H Elliott; Eck, Samantha R; Fricker, Brandon A; Kelly, Aubrey M; LeDoux, Joseph E; Motta, Simone C; Shrestha, Prerana; Taylor, Jack H; Trainor, Brian C; Triana-Del Rio, Rodrigo; Young, Larry J	June 2, 2023	Not Determined
37188684	Create Study	Oxytocin receptor antagonism during early vocal learning reduces song preference and imitation in zebra finches.	Scientific reports	Pilgeram, Natalie R; Baran, Nicole M; Bhise, Aditya; Davis, Matthew T; Iverson, Erik N K; Kim, Emily; Lee, Sumin; Rodriguez-Saltos, Carlos A; Maney, Donna L	May 15, 2023	Not Determined
37113978	Create Study	Developmental pyrethroid exposure causes a neurodevelopmental disorder phenotype in mice.	PNAS nexus	Curtis, Melissa A; Dhamsania, Rohan K; Branco, Rachel C; Guo, Ji-Dong; Creeden, Justin; Neifer, Kari L; Black, Carlie A; Winokur, Emily J; Andari, Elissar; Dias, Brian G; Liu, Robert C; Gourley, Shannon L; Miller, Gary W; Burkett, James P	April 1, 2023	Not Determined
37023360	Create Study	Review of Major Social Determinants of Health in Schizophrenia-Spectrum Psychotic Disorders: III. Biology.	Schizophrenia bulletin	Jeste, Dilip V; Malaspina, Dolores; Bagot, Kara; Barch, Deanna M; Cole, Steve; Dickerson, Faith; Dilmore, Amanda; Ford, Charles L; Karcher, Nicole R; Luby, Joan; Rajji, Tarek; Pinto-Tomas, Adrián A; Young, Larry J	July 4, 2023	Not Determined
36762715	Create Study	Oxytocin antagonist does not disrupt rabbit maternal behavior despite binding to brain oxytocin receptors.	Journal of neuroendocrinology	Jiménez, Angeles; Jiménez, Pedro; Inoue, Kiyoshi; Young, Larry J; González-Mariscal, Gabriela	July 1, 2023	Not Determined
36736847	Create Study	How social information impacts action in rodents and humans: the role of the prefrontal cortex and its connections.	Neuroscience and biobehavioral reviews	Kietzman, Henry W; Gourley, Shannon L	April 1, 2023	Not Determined
36635470	Create Study	Song preferences predict the quality of vocal learning in zebra finches.	Scientific reports	Rodríguez-Saltos, Carlos Antonio; Bhise, Aditya; Karur, Prasanna; Khan, Ramsha Nabihah; Lee, Sumin; Ramsay, Gordon; Maney, Donna L	January 12, 2023	Not Determined
36271259	Create Study	Distribution of vasopressin 1a and oxytocin receptor protein and mRNA in the basal forebrain and midbrain of the spiny mouse (Acomys cahirinus).	Brain structure & function	Powell, Jeanne M; Inoue, Kiyoshi; Wallace, Kelly J; Seifert, Ashley W; Young, Larry J; Kelly, Aubrey M	March 1, 2023	Not Determined
36216140	Create Study	The neural basis of smile authenticity judgments and the potential modulatory role of the oxytocin receptor gene (OXTR).	Behavioural brain research	Lee, Minwoo; Lori, Adriana; Langford, Nicole A; Rilling, James K	February 2, 2023	Not Determined
36103822	Create Study	Medial orbitofrontal neurotrophin systems integrate hippocampal input into outcome-specific value representations.	Cell reports	Woon, Ellen P; Butkovich, Laura M; Peluso, Arianna A; Elbasheir, Aziz; Taylor, Kian; Gourley, Shannon L	September 13, 2022	Not Determined
35970891	Create Study	Social incentivization of instrumental choice in mice requires amygdala-prelimbic cortex-nucleus accumbens connectivity.	Nature communications	Kietzman, Henry W; Trinoskey-Rice, Gracy; Blumenthal, Sarah A; Guo, Jidong D; Gourley, Shannon L	August 15, 2022	Not Determined
35868206	Create Study	Enhanced endogenous oxytocin signaling in the brain modulates neural responses to social misalignment and promotes conformity in humans: A multi-locus genetic profile approach.	Psychoneuroendocrinology	Lee, Minwoo; Lori, Adriana; Langford, Nicole A; Rilling, James K	October 1, 2022	Not Determined
35863332	Create Study	Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities.	Endocrinology	Rigney, Nicole; de Vries, Geert J; Petrulis, Aras; Young, Larry J	September 1, 2022	Not Determined
35859012	Create Study	The promise of 3,4-methylenedioxymethamphetamine (MDMA) in combination with prolonged exposure therapy for posttraumatic stress disorder.	Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology	Rothbaum, Barbara O; Maples-Keller, Jessica L	January 1, 2023	Not Determined
35858094	Create Study	Sex-specific and social experience-dependent oxytocin-endocannabinoid interactions in the nucleus accumbens: implications for social behaviour.	Philosophical transactions of the Royal Society of London. Series B, Biological sciences	Borie, Amélie M; Young, Larry J; Liu, Robert C	August 29, 2022	Not Determined
35790399	Create Study	Age-Induced Changes in µ-Opioid Receptor Signaling in the Midbrain Periaqueductal Gray of Male and Female Rats.	The Journal of neuroscience : the official journal of the Society for Neuroscience	Fullerton, Evan F; Karom, Mary C; Streicher, John M; Young, Larry J; Murphy, Anne Z	August 10, 2022	Not Determined
35763609	Create Study	Oxytocin receptors are widely distributed in the prairie vole (Microtus ochrogaster) brain: Relation to social behavior, genetic polymorphisms, and the dopamine system.	The Journal of comparative neurology	Inoue, Kiyoshi; Ford, Charles L; Horie, Kengo; Young, Larry J	November 1, 2022	Not Determined
35447094	Create Study	Marmosets confirm that context is king.	Neuron	Gothard, Katalin M	April 20, 2022	Not Determined
35325840	Create Study	Cell adhesion presence during adolescence controls the architecture of projection-defined prefrontal cortical neurons and reward-related action strategies later in life.	Developmental cognitive neuroscience	Kietzman, Henry W; Shapiro, Lauren P; Trinoskey-Rice, Gracy; Gourley, Shannon L	April 1, 2022	Not Determined
35302856	Create Study	Saccade-related neural communication in the human medial temporal lobe is modulated by the social relevance of stimuli.	Science advances	Staudigl, Tobias; Minxha, Juri; Mamelak, Adam N; Gothard, Katalin M; Rutishauser, Ueli	March 18, 2022	Not Determined
35166140	Create Study	A randomized controlled trial of 3,4-methylenedioxymethamphetamine (MDMA) and fear extinction retention in healthy adults.	Journal of psychopharmacology (Oxford, England)	Maples-Keller, Jessica L; Norrholm, Seth D; Burton, Mark; Reiff, Collin; Coghlan, Callan; Jovanovic, Tanja; Yasinski, Carly; Jarboe, Kathleen; Rakofsky, Jeffrey; Rauch, Sheila; Dunlop, Boadie W; Rothbaum, Barbara O	March 1, 2022	Not Determined
35108521	Create Study	Social experience alters oxytocinergic modulation in the nucleus accumbens of female prairie voles.	Current biology : CB	Borie, Amélie M; Agezo, Sena; Lunsford, Parker; Boender, Arjen J; Guo, Ji-Dong; Zhu, Hong; Berman, Gordon J; Young, Larry J; Liu, Robert C	March 14, 2022	Not Determined
35087387	Create Study	Maturation of Social-Vocal Communication in Prairie Vole (Microtus ochrogaster) Pups.	Frontiers in behavioral neuroscience	Warren, Megan R; Campbell, Drayson; Borie, Amélie M; Ford 4th, Charles L; Dharani, Ammar M; Young, Larry J; Liu, Robert C	January 1, 2021	Not Determined
35044077	Create Study	Exploring gene-culture coevolution in humans by inferring neuroendophenotypes: A case study of the oxytocin receptor gene and cultural tightness.	Genes, brain, and behavior	Lee, Minwoo; Lindo, John; Rilling, James K	March 1, 2022	Not Determined
34880473	Create Study	Refining oxytocin therapy for autism: context is key.	Nature reviews. Neurology	Ford, Charles L; Young, Larry J	February 1, 2022	Not Determined
34784762	Create Study	The neural correlates of grandmaternal caregiving.	Proceedings. Biological sciences	Rilling, James K; Gonzalez, Amber; Lee, Minwoo	November 24, 2021	Not Determined
34605209	Create Study	Postnatal myelination of the immature rat cingulum is regulated by GABAB receptor activity.	Developmental neurobiology	Pudasaini, Samipa; Friedrich, Vivien; Bührer, Christoph; Endesfelder, Stefanie; Scheuer, Till; Schmitz, Thomas	January 1, 2022	Not Determined
34562056	Create Study	Expression of oxytocin receptors in the zebra finch brain during vocal development.	Developmental neurobiology	Davis, Matthew T; Grogan, Kathleen E; Fraccaroli, Isabel; Libecap, Timothy J; Pilgeram, Natalie R; Maney, Donna L	January 1, 2022	Not Determined
34536549	Create Study	Development of a triazolobenzodiazepine-based PET probe for subtype-selective vasopressin 1A receptor imaging.	Pharmacological research	Haider, Ahmed; Xiao, Zhiwei; Xia, Xiaotian; Chen, Jiahui; Van, Richard S; Kuang, Shi; Zhao, Chunyu; Rong, Jian; Shao, Tuo; Ramesh, Perla; Aravind, Appu; Shao, Yihan; Ran, Chongzhao; Young, Larry J; Liang, Steven H	November 1, 2021	Not Determined
34482474	Create Study	Distribution of brain oxytocin and vasopressin V1a receptors in chimpanzees (Pan troglodytes): comparison with humans and other primate species.	Brain structure & function	Rogers Flattery, Christina N; Coppeto, Daniel J; Inoue, Kiyoshi; Rilling, James K; Preuss, Todd M; Young, Larry J	June 1, 2022	Not Determined
34364786	Create Study	Harnessing the healing power of love.	Trends in molecular medicine	Ford, Charles L; Young, Larry J	September 1, 2021	Not Determined
34271138	Create Study	Prioritization of social information by the basolateral amygdala in rats.	Neurobiology of learning and memory	Song, Zhimin; Swarna, Sujith; Manns, Joseph R	October 1, 2021	Not Determined
34266588	Create Study	The promiscuity of the oxytocin-vasopressin systems and their involvement in autism spectrum disorder.	Handbook of clinical neurology	Borie, Amelie M; Theofanopoulou, Constantina; Andari, Elissar	January 1, 2021	Not Determined
34226275	Create Study	Paraventricular Nucleus Oxytocin Subsystems Promote Active Paternal Behaviors in Mandarin Voles.	The Journal of neuroscience : the official journal of the Society for Neuroscience	He, Zhixiong; Zhang, Lizi; Hou, Wenjuan; Zhang, Xin; Young, Larry J; Li, Laifu; Liu, Limin; Ma, Huan; Xun, Yufeng; Lv, Zijian; Li, Yitong; Jia, Rui; Li, Jingang; Tai, Fadao	August 4, 2021	Not Determined
34112579	Create Study	Persistent behavioral and neurobiological consequences of social isolation during adolescence.	Seminars in cell & developmental biology	Li, Dan C; Hinton, Elizabeth A; Gourley, Shannon L	October 1, 2021	Not Determined
34102266	Create Study	Distribution of Vasopressin and Oxytocin Neurons in the Basal Forebrain and Midbrain of Spiny Mice (Acomys cahirinus).	Neuroscience	Kelly, Aubrey M; Seifert, Ashley W	August 1, 2021	Not Determined
34058981	Create Study	Comparative neurotranscriptomics reveal widespread species differences associated with bonding.	BMC genomics	Tripp, Joel A; Berrio, Alejandro; McGraw, Lisa A; Matz, Mikhail V; Davis, Jamie K; Inoue, Kiyoshi; Thomas, James W; Young, Larry J; Phelps, Steven M	May 31, 2021	Not Determined
34058309	Create Study	Microglia react to partner loss in a sex- and brain site-specific manner in prairie voles.	Brain, behavior, and immunity	Pohl, Tobias T; Jung, Oona; Di Benedetto, Barbara; Young, Larry J; Bosch, Oliver J	August 1, 2021	Not Determined
33864008	Create Study	Incerto-thalamic modulation of fear via GABA and dopamine.	Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology	Venkataraman, Archana; Hunter, Sarah C; Dhinojwala, Maria; Ghebrezadik, Diana; Guo, JiDong; Inoue, Kiyoshi; Young, Larry J; Dias, Brian George	August 1, 2021	Not Determined
33823654	Create Study	Oxytocin, Neural Plasticity, and Social Behavior.	Annual review of neuroscience	Froemke, Robert C; Young, Larry J	July 8, 2021	Not Determined
33775781	Create Study	Raised without a father: monoparental care effects over development, sexual behavior, sexual reward, and pair bonding in prairie voles.	Behavioural brain research	Valera-Marín, Guillermo; Young, Larry J; Camacho, Francisco; Paredes, Raúl G; Rodríguez, Verónica M; Díaz, Néstor F; Portillo, Wendy	June 25, 2021	Not Determined
33764079	Create Study	The stressed orbitofrontal cortex.	Behavioral neuroscience	Sequeira, Michelle K; Gourley, Shannon L	April 1, 2021	Not Determined
33587397	Create Study	Effects of Oxytocin on Emotion Recognition in Schizophrenia: A Randomized Double-Blind Pilot Study.	Journal of clinical psychopharmacology	Andari, Elissar; Massa, Nicholas M; Fargotstein, Molly D; Taylor, Nicholas B; Halverson, David M; Owens, Andrew V; Currin, Danielle L; Bhattacharya, Arpita; Gitman, Dmitriy; Cuthbert, Bruce C; Young, Larry J; Duncan, Erica J	March 1, 2021	Not Determined
33582574	Create Study	The role of oxytocin signaling in depression and suicidality in returning war veterans.	Psychoneuroendocrinology	Warrener, Corinne D; Valentin, Edward M; Gallin, Camilla; Richey, Lynnet; Ross, Deanna B; Hood, Chelsea J; Lori, Adriana; Cubells, Joseph; Rauch, Sheila A M; Rilling, James K	April 1, 2021	Not Determined
33443015	Create Study	Brain functional networks associated with social bonding in monogamous voles.	eLife	López-Gutiérrez, M Fernanda; Gracia-Tabuenca, Zeus; Ortiz, Juan J; Camacho, Francisco J; Young, Larry J; Paredes, Raúl G; Díaz, Néstor F; Portillo, Wendy; Alcauter, Sarael	January 14, 2021	Not Determined
33260106	Create Study	Translational opportunities for circuit-based social neuroscience: advancing 21st century psychiatry.	Current opinion in neurobiology	Ford, Charles L; Young, Larry J	June 1, 2021	Not Determined
33125871	Create Study	Oxytocin Influences Male Sexual Activity via Non-synaptic Axonal Release in the Spinal Cord.	Current biology : CB	Oti, Takumi; Satoh, Keita; Uta, Daisuke; Nagafuchi, Junta; Tateishi, Sayaka; Ueda, Ryota; Takanami, Keiko; Young, Larry J; Galione, Antony; Morris, John F; Sakamoto, Tatsuya; Sakamoto, Hirotaka	January 11, 2021	Not Determined
33092784	Create Study	Investigation of Oxtr-expressing Neurons Projecting to Nucleus Accumbens using Oxtr-ires-Cre Knock-in prairie Voles (Microtus ochrogaster).	Neuroscience	Horie, Kengo; Inoue, Kiyoshi; Nishimori, Katsuhiko; Young, Larry J	November 10, 2020	Not Determined
32979349	Create Study	Methylation of OXT and OXTR genes, central oxytocin, and social behavior in female macaques.	Hormones and behavior	De Leon, Desirée; Nishitani, Shota; Walum, Hasse; McCormack, Kai M; Wilson, Mark E; Smith, Alicia K; Young, Larry J; Sanchez, Mar M	November 1, 2020	Not Determined
32912424	Create Study	Cumulative Stress Burden on Motivated Action Revealed.	Biological psychiatry	Kietzman, Henry W; Gourley, Shannon L	October 1, 2020	Not Determined
32884100	Create Study	Genetic and epigenetic modulation of the oxytocin receptor and implications for autism.	Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology	Andari, Elissar; Rilling, James K	January 2021	Not Determined
32876047	Create Study	Mesoscopic-scale functional networks in the primate amygdala.	eLife	Morrow, Jeremiah K; Cohen, Michael X; Gothard, Katalin M	September 2020	Not Determined
32839565	Create Study	Multidimensional processing in the amygdala.	Nature reviews. Neuroscience	Gothard, Katalin M	October 1, 2020	Not Determined
32683141	Create Study	Oxytocin and postpartum depression: A systematic review.	Psychoneuroendocrinology	Thul, Taylor A; Corwin, Elizabeth J; Carlson, Nicole S; Brennan, Patricia A; Young, Larry J	October 1, 2020	Not Determined
32556583	Create Study	Reward-related dynamical coupling between basolateral amygdala and nucleus accumbens.	Brain structure & function	Hsu, Chia-Chun; Madsen, Teresa E; O'Gorman, Elizabeth; Gourley, Shannon L; Rainnie, Donald G	July 2020	Not Determined
32544402	Create Study	Oxytocin, vasopressin and social behavior in the age of genome editing: A comparative perspective.	Hormones and behavior	Boender, Arjen J; Young, Larry J	August 1, 2020	Not Determined
32502487	Create Study	Becoming a better parent: Mice learn sounds that improve a stereotyped maternal behavior.	Hormones and behavior	Dunlap, Alexander G; Besosa, Cristina; Pascual, Leila M; Chong, Kelly K; Walum, Hasse; Kacsoh, Dorottya B; Tankeu, Brenda B; Lu, Kai; Liu, Robert C	August 1, 2020	Not Determined
32071244	Create Study	Sexually dimorphic role of oxytocin in medaka mate choice.	Proceedings of the National Academy of Sciences of the United States of America	Yokoi S, Naruse K, Kamei Y, Ansai S, Kinoshita M, Mito M, Iwasaki S, Inoue S, Okuyama T, Nakagawa S, Young LJ, Takeuchi H	March 2020	Not Determined
31935400	Create Study	Oxytocin receptor antagonist reverses the blunting effect of pair bonding on fear learning in monogamous prairie voles.	Hormones and behavior	Hirota, Yu; Arai, Aki; Young, Larry J; Osako, Yoji; Yuri, Kazunari; Mitsui, Shinichi	April 2020	Not Determined
31931508	Create Study	Epigenetic modification of the oxytocin receptor gene: implications for autism symptom severity and brain functional connectivity.	Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology	Andari, Elissar; Nishitani, Shota; Kaundinya, Gopinath; Caceres, Gabriella A; Morrier, Michael J; Ousley, Opal; Smith, Alicia K; Cubells, Joseph F; Young, Larry J	June 2020	Not Determined
31820488	Create Study	Involvement of the rodent prelimbic and medial orbitofrontal cortices in goal-directed action: A brief review.	Journal of neuroscience research	Woon, Ellen P; Sequeira, Michelle K; Barbee, Britton R; Gourley, Shannon L	June 2020	Not Determined
31560922	Create Study	Circuits for social learning: A unified model and application to Autism Spectrum Disorder.	Neuroscience and biobehavioral reviews	DeMayo, Marilena M; Young, Larry J; Hickie, Ian B; Song, Yun Ju C; Guastella, Adam J	December 2019	Not Determined
31533960	Create Study	Multidimensional Neural Selectivity in the Primate Amygdala.	eNeuro	Putnam, Philip T; Gothard, Katalin M	2019	Not Determined
31527057	Create Study	Social Isolation in Adolescence Disrupts Cortical Development and Goal-Dependent Decision-Making in Adulthood, Despite Social Reintegration.	eNeuro	Hinton, Elizabeth A; Li, Dan C; Allen, Aylet G; Gourley, Shannon L	2019	Not Determined
31509768	Create Study	Conserved features of anterior cingulate networks support observational learning across species.	Neuroscience and biobehavioral reviews	Burgos-Robles, Anthony; Gothard, Katalin M; Monfils, Marie H; Morozov, Alexei; Vicentic, Aleksandra	December 2019	Not Determined
31084703	Create Study	Increased anxiety and decreased sociability induced by paternal deprivation involve the PVN-PrL OTergic pathway.	eLife	He Z, Young L, Ma XM, Guo Q, Wang L, Yang Y, Luo L, Yuan W, Li L, Zhang J, Hou W, Qiao H, Jia R, Tai F	May 2019	Not Determined
30858163	Create Study	Multisensory Neurons in the Primate Amygdala.	The Journal of neuroscience : the official journal of the Society for Neuroscience	Morrow J, Mosher C, Gothard K	May 2019	Not Determined
30713102	Create Study	Oxytocin receptor knockout prairie voles generated by CRISPR/Cas9 editing show reduced preference for social novelty and exaggerated repetitive behaviors.	Hormones and behavior	Horie, Kengo; Inoue, Kiyoshi; Suzuki, Shingo; Adachi, Saki; Yada, Saori; Hirayama, Takashi; Hidema, Shizu; Young, Larry J; Nishimori, Katsuhiko	May 2019	Not Determined
30514927	Create Study	Effect of age and autism spectrum disorder on oxytocin receptor density in the human basal forebrain and midbrain.	Translational psychiatry	Freeman, Sara M; Palumbo, Michelle C; Lawrence, Rebecca H; Smith, Aaron L; Goodman, Mark M; Bales, Karen L	December 2018	Not Determined
30378456	Create Study	Oxytocin increases eye-gaze towards novel social and non-social stimuli.	Social neuroscience	Eckstein, Monika; Bamert, Vera; Stephens, Shannon; Wallen, Kim; Young, Larry J; Ehlert, Ulrike; Ditzen, Beate	October 2019	Not Determined
30301953	Create Study	The neural mechanisms and circuitry of the pair bond.	Nature reviews. Neuroscience	Walum, Hasse; Young, Larry J	November 2018	Not Determined
30295946	Create Study	Intranasal oxytocin in rhesus monkeys alters brain networks that detect social salience and reward.	American journal of primatology	Parr, Lisa A; Mitchell, Thomas; Hecht, Erin	October 2018	Not Determined
30283367	Create Study	The Role of Amygdala in Patients With Euthymic Bipolar Disorder During Resting State.	Frontiers in psychiatry	Li, Gaizhi; Liu, Penghong; Andari, Elissar; Zhang, Aixia; Zhang, Kerang	January 2018	Not Determined
30215032	Create Study	Heritability of the human connectome: A connectotyping study.	Network neuroscience (Cambridge, Mass.)	Miranda-Dominguez, Oscar; Feczko, Eric; Grayson, David S; Walum, Hasse; Nigg, Joel T; Fair, Damien A	January 2018	Not Determined
29923206	Create Study	Bridging the gap between rodents and humans: The role of non-human primates in oxytocin research.	American journal of primatology	Putnam, Philip T; Young, Larry J; Gothard, Katalin M	October 2018	Not Determined
29851879	Create Study	Mood Disorders.	Continuum (Minneapolis, Minn.)	Rakofsky J, Rapaport M	June 2018	Not Determined
29851228	Create Study	Evolutionary diversity as a catalyst for biological discovery.	Integrative zoology	Johnson ZV, Young LJ	May 2018	Not Determined
29842887	Create Study	Thalamic integration of social stimuli regulating parental behavior and the oxytocin system.	Frontiers in neuroendocrinology	Dobolyi, Arpad; Cservenák, Melinda; Young, Larry J	October 2018	Not Determined
29797339	Create Study	Oxytocin- and arginine vasopressin-containing fibers in the cortex of humans, chimpanzees, and rhesus macaques.	American journal of primatology	Rogers, Christina N; Ross, Amy P; Sahu, Shweta P; Siegel, Ethan R; Dooyema, Jeromy M; Cree, Mary Ann; Stopa, Edward G; Young, Larry J; Rilling, James K; Albers, H Elliott; Preuss, Todd M	October 2018	Not Determined
29660417	Create Study	RDoC-based categorization of amygdala functions and its implications in autism.	Neuroscience and biobehavioral reviews	Hennessey, Thomas; Andari, Elissar; Rainnie, Donald G	July 2018	Not Determined
29352154	Create Study	Resting state brain networks in the prairie vole.	Scientific reports	Ortiz JJ, Portillo W, Paredes RG, Young LJ, Alcauter S	January 2018	Not Determined
29330007	Create Study	Lost connections: Oxytocin and the neural, physiological, and behavioral consequences of disrupted relationships.	International journal of psychophysiology : official journal of the International Organization of Psychophysiology	Pohl, Tobias T; Young, Larry J; Bosch, Oliver J	February 2019	Not Determined
28875421	Create Study	Brief Report: Relationship Between ADOS-2, Module 4 Calibrated Severity Scores (CSS) and Social and Non-Social Standardized Assessment Measures in Adult Males with Autism Spectrum Disorder (ASD).	Journal of autism and developmental disorders	Morrier, Michael J; Ousley, Opal Y; Caceres-Gamundi, Gabriella A; Segall, Matthew J; Cubells, Joseph F; Young, Larry J; Andari, Elissar	December 2017	Relevant
28872575	Create Study	Partner Loss in Monogamous Rodents: Modulation of Pain and Emotional Behavior in Male Prairie Voles.	Psychosomatic medicine	Osako Y, Nobuhara R, Arai YP, Tanaka K, Young LJ, Nishihara M, Mitsui S, Yuri K	September 2017	Not Relevant
28812273	Create Study	A Precision Medicine Approach to Oxytocin Trials.	Current topics in behavioral neurosciences	Andari E, Hurlemann R, Young LJ	August 2017	Not Determined
28812266	Create Study	Oxytocin and Social Relationships: From Attachment to Bond Disruption.	Current topics in behavioral neurosciences	Bosch OJ, Young LJ	August 2017	Not Determined
28800678	Create Study	New perspectives on the neurophysiology of primate amygdala emerging from the study of naturalistic social behaviors.	Wiley interdisciplinary reviews. Cognitive science	Gothard KM, Mosher CP, Zimmerman PE, Putnam PT, Morrow JK, Fuglevand AJ	August 2017	Not Relevant
28775827	Create Study	Developmental disruption of amygdala transcriptome and socioemotional behavior in rats exposed to valproic acid prenatally.	Molecular autism	Barrett CE, Hennessey TM, Gordon KM, Ryan SJ, Mcnair ML, Ressler KJ, Rainnie DG	January 2017	Not Relevant
28562592	Create Study	Dynamic corticostriatal activity biases social bonding in monogamous female prairie voles.	Nature	Amadei, Elizabeth A; Johnson, Zachary V; Jun Kwon, Yong; Shpiner, Aaron C; Saravanan, Varun; Mays, Wittney D; Ryan, Steven J; Walum, Hasse; Rainnie, Donald G; Young, Larry J; Liu, Robert C	June 2017	Not Relevant
28460185	Create Study	Establishing Wiring Specificity in Visual System Circuits: From the Retina to the Brain.	Annual review of neuroscience	Zhang C, Kolodkin AL, Wong RO, James RE	July 2017	Not Determined
28434591	Create Study	Oxytocin and vasopressin neural networks: Implications for social behavioral diversity and translational neuroscience.	Neuroscience and biobehavioral reviews	Johnson, Zachary V; Young, Larry J	May 2017	Not Relevant
28122239	Create Study	Fixations Gate Species-Specific Responses to Free Viewing of Faces in the Human and Macaque Amygdala.	Cell reports	Minxha J, Mosher C, Morrow JK, Mamelak AN, Adolphs R, Gothard KM, Rutishauser U	January 2017	Relevant
27922101	Create Study	Social determinants of eyeblinks in adult male macaques.	Scientific reports	Ballesta S, Mosher CP, Szep J, Fischl KD, Gothard KM	December 2016	Not Relevant
27838170	Create Study	An evaluation of central penetration from a peripherally administered oxytocin receptor selective antagonist in nonhuman primates.	Bioorganic & medicinal chemistry	Smith AL, Walum H, Connor-Stroud F, Freeman SM, Inoue K, Parr LA, Goodman MM, Young LJ	January 2017	Not Relevant
27793769	Create Study	Oxytocin receptors modulate a social salience neural network in male prairie voles.	Hormones and behavior	Johnson ZV, Walum H, Xiao Y, Riefkohl PC, Young LJ	January 2017	Not Relevant
27752543	Create Study	Tactile Stimulation of the Face and the Production of Facial Expressions Activate Neurons in the Primate Amygdala.	eNeuro	Mosher, Clayton P; Zimmerman, Prisca E; Fuglevand, Andrew J; Gothard, Katalin M	September 2016	Not Relevant
27522019	Create Study	A single prolonged stress paradigm produces enduring impairments in social bonding in monogamous prairie voles.	Behavioural brain research	Arai A, Hirota Y, Miyase N, Miyata S, Young LJ, Osako Y, Yuri K, Mitsui S	December 2016	Not Relevant
27453637	Create Study	Distributions of oxytocin and vasopressin 1a receptors in the Taiwan vole and their role in social monogamy.	Journal of zoology (London, England : 1987)	Chappell, A R; Freeman, S M; Lin, Y K; LaPrairie, J L; Inoue, K; Young, L J; Hayes, L D	June 2016	Not Relevant
27343726	Create Study	Oxytocin enhances gaze-following responses to videos of natural social behavior in adult male rhesus monkeys.	Psychoneuroendocrinology	Putnam, P T; Roman, J M; Zimmerman, P E; Gothard, K M	October 2016	Not Relevant
27209233	Create Study	Initial investigation of three selective and potent small molecule oxytocin receptor PET ligands in New World monkeys.	Bioorganic & medicinal chemistry letters	Smith AL, Freeman SM, Barnhart TE, Abbott DH, Ahlers EO, Kukis DL, Bales KL, Goodman MM, Young LJ	July 15, 2016	Not Relevant
26940141	Create Study	Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications.	Journal of neuroendocrinology	Freeman SM, Young LJ	April 2016	Not Relevant
26893121	Create Study	Variation in the Oxytocin Receptor Gene Predicts Brain Region-Specific Expression and Social Attachment.	Biological psychiatry	King LB, Walum H, Inoue K, Eyrich NW, Young LJ	December 15, 2015	Not Relevant
26798013	Create Study	Oxytocin-dependent consolation behavior in rodents.	Science (New York, N.Y.)	Burkett JP, Andari E, Johnson ZV, Curry DC, de Waal FB, Young LJ	January 22, 2016	Not Relevant
26731103	Create Study	The Macaque Social Responsiveness Scale (mSRS): A Rapid Screening Tool for Assessing Variability in the Social Responsiveness of Rhesus Monkeys (Macaca mulatta).	PloS one	Feczko, Eric J; Bliss-Moreau, Eliza; Walum, Hasse; Pruett Jr, John R; Parr, Lisa A	2016	Not Relevant
26723109	Create Study	The Need for a Theoretical Framework of Social Functioning to Optimize Targeted Therapies in Psychiatric Disorders.	Biological psychiatry	Andari E	February 1, 2016	Not Relevant
26723107	Create Study	Understanding the Oxytocin System and Its Relevance to Psychiatry.	Biological psychiatry	Shamay-Tsoory S, Young LJ	February 1, 2016	Not Relevant
26643557	Create Study	Central oxytocin receptors mediate mating-induced partner preferences and enhance correlated activation across forebrain nuclei in male prairie voles.	Hormones and behavior	Johnson ZV, Walum H, Jamal YA, Xiao Y, Keebaugh AC, Inoue K, Young LJ	March 2016	Not Relevant
26615473	Create Study	Oxytocin in the nucleus accumbens shell reverses CRFR2-evoked passive stress-coping after partner loss in monogamous male prairie voles.	Psychoneuroendocrinology	Bosch OJ, Dabrowska J, Modi ME, Johnson ZV, Keebaugh AC, Barrett CE, Ahern TH, Guo J, Grinevich V, Rainnie DG, Neumann ID, Young LJ	February 2016	Not Relevant
26392632	Create Study	Establishing the reliability of rhesus macaque social network assessment from video observations.	Animal behaviour	Feczko E, Mitchell TA, Walum H, Brooks JM, Heitz TR, Young LJ, Parr LA	September 1, 2015	Not Determined
26379517	Create Study	Editorial: Oxytocin''s routes in social behavior: into the 21st century.	Frontiers in behavioral neuroscience	Andari, Elissar	2015	Not Relevant
26210057	Create Study	Statistical and Methodological Considerations for the Interpretation of Intranasal Oxytocin Studies.	Biological psychiatry	Walum, Hasse; Waldman, Irwin D; Young, Larry J	February 1, 2016	Not Relevant
26196439	Create Study	The oxytocin system promotes resilience to the effects of neonatal isolation on adult social attachment in female prairie voles.	Translational psychiatry	Barrett CE, Arambula SE, Young LJ	2015	Not Relevant
26146650	Create Study	Neurobiological mechanisms of social attachment and pair bonding.	Current opinion in behavioral sciences	Johnson, Zachary V; Young, Larry J	June 2015	Not Relevant
26062432	Create Study	Neural mechanisms of mother-infant bonding and pair bonding: Similarities, differences, and broader implications.	Hormones and behavior	Numan M, Young LJ	January 2016	Not Relevant
25874849	Create Study	RNAi knockdown of oxytocin receptor in the nucleus accumbens inhibits social attachment and parental care in monogamous female prairie voles.	Social neuroscience	Keebaugh AC, Barrett CE, Laprairie JL, Jenkins JJ, Young LJ	2015	Not Relevant
25874677	Create Study	Sensory systems: The yin and yang of cortical oxytocin.	Nature	Liu, Robert C	April 23, 2015	Not Relevant
25700501	Create Study	Neuroscience. Can oxytocin treat autism?	Science (New York, N.Y.)	Young LJ, Barrett CE	February 20, 2015	Not Relevant
25652247	Create Study	Melanocortin Receptor Agonists Facilitate Oxytocin-Dependent Partner Preference Formation in the Prairie Vole.	Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology	Modi ME, Inoue K, Barrett CE, Kittelberger KA, Smith DG, Landgraf R, Young LJ	July 2015	Not Relevant
25482173	Create Study	Oxytocin, social cognition and psychiatry.	Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology	Young LJ	January 2015	Not Relevant
25414633	Create Study	Social relevance drives viewing behavior independent of low-level salience in rhesus macaques.	Frontiers in neuroscience	Solyst, James A; Buffalo, Elizabeth A	2014	Not Relevant
25283782	Create Study	Neurons in the monkey amygdala detect eye contact during naturalistic social interactions.	Current biology : CB	Mosher CP, Zimmerman PE, Gothard KM	October 20, 2014	Not Relevant
25124431	Create Study	The biology of mammalian parenting and its effect on offspring social development.	Science (New York, N.Y.)	Rilling, James K; Young, Larry J	August 15, 2014	Not Relevant
25072016	Create Study	Autism Spectrum Disorder: Defining Dimensions and Subgroups.	Current developmental disorders reports	Ousley, Opal; Cermak, Tracy	March 1, 2014	Not Relevant
24845184	Create Study	The neuroanatomical distribution of oxytocin receptor binding and mRNA in the male rhesus macaque (Macaca mulatta).	Psychoneuroendocrinology	Freeman SM, Inoue K, Smith AL, Goodman MM, Young LJ	July 2014	Not Relevant
24845176	Create Study	Aerosolized oxytocin increases cerebrospinal fluid oxytocin in rhesus macaques.	Psychoneuroendocrinology	Modi ME, Connor-Stroud F, Landgraf R, Young LJ, Parr LA	July 2014	Not Relevant
24814726	Create Study	Neuroanatomical distribution of oxytocin and vasopressin 1a receptors in the socially monogamous coppery titi monkey (Callicebus cupreus).	Neuroscience	Freeman SM, Walum H, Inoue K, Smith AL, Goodman MM, Bales KL, Young LJ	July 25, 2014	Not Relevant
24509130	Create Study	A nonparametric method for detecting fixations and saccades using cluster analysis: removing the need for arbitrary thresholds.	Journal of neuroscience methods	König SD, Buffalo EA	April 30, 2014	Not Relevant
24367110	Create Study	Common polymorphism in the oxytocin receptor gene (OXTR) is associated with human social recognition skills.	Proceedings of the National Academy of Sciences of the United States of America	Skuse DH, Lori A, Cubells JF, Lee I, Conneely KN, Puura K, Lehtimäki T, Binder EB, Young LJ	February 4, 2014	Not Determined

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Data Expected List: Mandatory Data Structures

These data structures are mandatory for your NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

For NIMH HIV-related research that involves human research participants: Select the dictionary or dictionaries most appropriate for your research. If your research does not require all three data dictionaries, just ignore the ones you do not need. There is no need to delete extra data dictionaries from your NDA Collection. You can adjust the Targeted Enrollment column in the Data Expected tab to “0” for those unnecessary data dictionaries. At least one of the three data dictionaries must have a non-zero value.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
Research Subject and Pedigree	40	07/15/2014	0	11/15/2014	0	Approved

To create your project's Data Expected list, use the "+New Data Expected" to add or request existing structures and to request new Data Structures that are not in the NDA Data Dictionary.

If the Structure you need already exists, locate it and specify your dates and enrollment when adding it to your Data Expected list. If you require changes to the Structure you need, select the indicator stating "No, it requires changes to meet research needs," and upload a file containing your requested changes.

If the structure you need is not yet defined in the Data Dictionary, you can select "Upload Definition" and attach the necessary materials to request its creation.

When selecting the expected dates for your data, make sure to follow the standard Data Sharing Regimen and choose dates within the date ranges that correspond to your project start and end dates.

Please visit the Completing Your Data Expected Tutorial for more information.

Data Expected List: Data Structures per Research Aims

These data structures are specific to your research aims and should list all data structures in which data will be collected and submitted for this NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
ADOS	40	07/15/2014	12	11/15/2014	12	Approved
ADI-R	40	07/15/2014	20	11/15/2014	20	Approved
Wechsler Abbreviated Scale of Intelligence (WASI)	38	07/15/2014	38	11/15/2014	38	Approved
Autistic Spectrum Quotient	40	07/15/2014	0	11/15/2014	0	Approved
Wechsler Memory Scale, Third Edition (WMS-III)	21	07/15/2014	21	11/15/2014	21	Approved

Structure not yet defined

No Status history for this Data Expected has been recorded yet

helpcenter.collection.data-expected-tab

Collection - Data Expected

The Data Expected tab displays the list of all data that NDA expects to receive in association with the Collection as defined by the contributing researcher, as well as the dates for the expected initial upload of the data, and when it is first expected to be shared, or with the research community. Above the primary table of Data Expected, any publications determined to be relevant to the data within the Collection are also displayed - members of the contributing research group can use these to define NDA Studies, connecting those papers to underlying data in NDA.

The tab is used both as a reference for those accessing shared data, providing information on what is expected and when it will be shared, and as the primary tracking mechanism for contributing projects. It is used by both contributing primary researchers, secondary researchers, and NIH Program and Grants Management staff.

Researchers who are starting their project need to update their Data Expected list to include all the Data Structures they are collecting under their grant and set their initial submission and sharing schedule according to the NDA Data Sharing Regimen.

To add existing Data Structures from the Data Dictionary, to request new Data Structure that are not in the Dictionary, or to request changes to existing Data Structures, click "+New Data Expected".

For step-by-step instructions on how to add existing Data Structures, request changes to an existing Structure, or request a new Data Structure, please visit the Completing Your Data Expected Tutorial.

If you are a contributing researcher creating this list for the first time, or making changes to the list as your project progress, please note the following:

Although items you add to the list and changes you make are displayed, they are not committed to the system until you Save the entire page using the "Save" button at the bottom of your screen. Please Save after every change to ensure none of your work is lost.
If you attempt to add a new structure, the title you provide must be unique - if another structure exists with the same name your change will fail.
Adding a new structure to this list is the only way to request the creation of a new Data Dictionary definition.

Frequently Asked Questions

What is an NDA Data Structure?

An NDA Data Structure is comprised of multiple Data Elements to make up an electronic definition of an assessment, measure, questionnaire, etc will have a corresponding Data Structure.
What is the NDA Data Dictionary?

The NDA Data Dictionary is comprised of electronic definitions known as Data Structures.

Glossary

Analyzed Data

Data specific to the primary aims of the research being conducted (e.g. outcome measures, other dependent variables, observations, laboratory results, analyzed images, volumetric data, etc.) including processed images.
Data Item

Items listed on the Data Expected list in the Collection which may be an individual and discrete Data Structure, Data Structure Category, or Data Structure Group.
Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Structure Category

An NDA term describing the affiliation of a Data Structure to a Category, which may be disease/disorder or diagnosis related (Depression, ADHD, Psychosis), specific to data type (MRI, eye tracking, omics), or type of data (physical exam, IQ).
Data Structure Group

A Data Item listed on the Data Expected tab of a Collection that indicates a group of Data Structures (e.g., ADOS or SCID) for which data may be submitted instead of a specific Data Structure identified by version, module, edition, etc. For example, the ADOS Data Structure Category includes every ADOS Data Structure such as ADOS Module 1, ADOS Module 2, ADOS Module 1 - 2nd Edition, etc. The SCID Data Structure Group includes every SCID Data Structure such as SCID Mania, SCID V Mania, SCID PTSD, SCID-V Diagnosis, and more.
Evaluated Data

A new Data Structure category, Evaluated Data is analyzed data resulting from the use of computational pipelines in the Cloud and can be uploaded directly back to a miNDAR database. Evaluated Data is expected to be listed as a Data Item in the Collection's Data Expected Tab.
Imaging Data

Imaging+ is an NDA term which encompasses all imaging related data including, but not limited to, images (DTI, MRI, PET, Structural, Spectroscopy, etc.) as well as neurosignal data (EEG, fMRI, MEG, EGG, eye tracking, etc.) and Evaluated Data.
Initial Share Date

Initial Submission and Initial Share dates should be populated according to the NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data will be shared with authorized users upon publication (via an NDA Study) or 1-2 years after the grant end date specified on the first Notice of Award, as defined in the applicable Data Sharing Terms and Conditions.
Initial Submission Date

Initial Submission and Initial Share dates should be populated according to these NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data for all subjects is not expected on the Initial Submission Date and modifications may be made as necessary based on the project's conduct.
Research Subject and Pedigree

An NDA created Data Structure used to convey basic information about the subject such as demographics, pedigree (links family GUIDs), diagnosis/phenotype, and sample location that are critical to allow for easier querying of shared data.
Submission Cycle

The NDA has two Submission Cycles per year - January 15 and July 15.
Submission Exemption

An interface to notify NDA that data may not be submitted during the upcoming/current submission cycle.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study NameFilter by Study Name	AbstractFilter by Abstract	Collection/Study SubjectsFilter by Collection/Study Subjects	Data UsageFilter by Data Usage	StateFilter by State
Investigating autism etiology and heterogeneity by decision tree algorithm	Autism spectrum disorder (ASD) is a neurodevelopmental disorder that causes deficits in cognition, communication and social skills. ASD, however, is a highly heterogeneous disorder. This heterogeneity has made identifying the etiology of ASD a particularly difficult challenge, as patients exhibit a wide spectrum of symptoms without any unifying genetic or environmental factors to account for the disorder. For better understanding of ASD, it is paramount to identify potential genetic and environmental risk factors that are comorbid with it. Identifying such factors is of great importance to determine potential causes for the disorder, and understand its heterogeneity. Existing large-scale datasets offer an opportunity for computer scientists to undertake this task by utilizing machine learning to reliably and efficiently obtain insight about potential ASD risk factors, which would in turn assist in guiding research in the field. In this study, decision tree algorithms were utilized to analyze related factors in datasets obtained from the National Database for Autism Research (NDAR) consisting of nearly 3000 individuals. We were able to identify 15 medical conditions that were highly associated with ASD diagnoses in patients; furthermore, we extended our analysis to the family medical history of patients and we report six potentially hereditary medical conditions associated with ASD. Associations reported had a 90% accuracy. Meanwhile, gender comparisons highlighted conditions that were unique to each gender and others that overlapped. Those findings were validated by the academic literature, thus opening the way for new directions for the use of decision tree algorithms to further understand the etiology of autism.	12/3382	Secondary Analysis	Shared

* Data not on individual level

helpcenter.collection.associated-studies-tab

Collection - Associated Studies

Clicking on the Study Title will open the study details in a new internet browser tab. The Abstract is available for viewing, providing the background explanation of the study, as provided by the Collection Owner.

Primary v. Secondary Analysis: The Data Usage column will have one of these two choices. An associated study that is listed as being used for Primary Analysis indicates at least some and potentially all of the data used was originally collected by the creator of the NDA Study. Secondary Analysis indicates the Study owner was not involved in the collection of data, and may be used as supporting data.

Private v. Shared State: Studies that remain private indicate the associated study is only available to users who are able to access the collection. A shared study is accessible to the general public.

Frequently Asked Questions

How do I associate a study to my collection?

Studies are associated to the Collection automatically when the data is defined in the Study.

Glossary

Associated Studies Tab

A tab in a Collection that lists the NDA Studies that have been created using data from that Collection including both Primary and Secondary Analysis NDA Studies.

Contact NDA Help Desk

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Frequently Asked Questions

Glossary