NIMH Data Archive - Data

Genomics

Neuroimaging

Phenotype¹

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Clinical Trial

¹ Numbers reported are subjects by age

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Grant/Project Number

Format should be in the following format: Activity Code, Institute Abbreviation, and Serial Number. Grant Type, Support Year, and Suffix should be excluded. For example, grant 1R01MH123456-01A1 should be entered R01MH123456

Collection - Use Existing Experiment

To associate an experiment to the current collection, just select an axperiment from the table below then click the associate experiment button to persist your changes (saving the collection is not required). Note that once an experiment has been associated to two or more collections, the experiment will not longer be editable.

The table search feature is case insensitive and targets the experiment id, experiment name and experiment type columns. The experiment id is searched only when the search term entered is a number, and filtered using a startsWith comparison. When the search term is not numeric the experiment name is used to filter the results.

Select	Experiment Id	Experiment Name	Experiment Type	Created On

24	HI-NGS_R1	Omics	02/16/2011
475	MB1-10 (CHOP)	Omics	06/07/2016
490	Illumina Infinium PsychArray BeadChip Assay	Omics	07/07/2016
501	PharmacoBOLD Resting State	fMRI	07/27/2016
506	PVPREF	Omics	08/05/2016
509	ABC-CT Resting v2	EEG	08/18/2016
13	Comparison of FI expression in Autistic and Neurotypical Homo Sapiens	Omics	12/28/2010
18	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	01/06/2011
22	Stitching PCR Sequencing	Omics	02/14/2011
26	ASD_Methylation	Omics	03/01/2011
29	Microarray family 03 (father, mother, sibling)	Omics	03/24/2011
37	Standard paired-end sequencing of BCRs	Omics	04/19/2011
38	Illumina Mate-Pair BCR sequencing	Omics	04/19/2011
39	Custom Jumping Libraries	Omics	04/19/2011
40	Custom CapBP	Omics	04/19/2011
41	Immunofluorescence	Omics	05/11/2011
43	Autism brain sample genotyping, Illumina	Omics	05/16/2011
47	ARRA Autism Sequencing Collaboration at Baylor. SOLiD 4 System	Omics	08/01/2011
53	AGRE Omni1-quad	Omics	10/11/2011
59	AGP genotyping	Omics	04/03/2012
60	Ultradeep 454 sequencing of synaptic genes from postmortem cerebella of individuals with ASD and neurotypical controls	Omics	06/23/2012
63	Microemulsion PCR and Targeted Resequencing for Variant Detection in ASD	Omics	07/20/2012
76	Whole Genome Sequencing in Autism Families	Omics	01/03/2013
519	Resting	fMRI	11/08/2016
90	Genotyped IAN Samples	Omics	07/09/2013
91	NJLAGS Axiom Genotyping Array	Omics	07/16/2013
93	AGP genotyping (CNV)	Omics	09/06/2013
106	Longitudinal Sleep Study. H20 200. Channel set 2	EEG	11/07/2013
107	Longitudinal Sleep Study. H20 200. Channel set 3	EEG	11/07/2013
108	Longitudinal Sleep Study. AURA 200	EEG	11/07/2013
105	Longitudinal Sleep Study. H20 200. Channel set 1	EEG	11/07/2013
109	Longitudinal Sleep Study. AURA 400	EEG	11/07/2013
116	Gene Expression Analysis WG-6	Omics	01/07/2014
131	Jeste Lab UCLA ACEii: Charlie Brown and Sesame Street - Project 1	Eye Tracking	02/27/2014
132	Jeste Lab UCLA ACEii: Animacy - Project 1	Eye Tracking	02/27/2014
133	Jeste Lab UCLA ACEii: Mom Stranger - Project 2	Eye Tracking	02/27/2014
134	Jeste Lab UCLA ACEii: Face Emotion - Project 3	Eye Tracking	02/27/2014
145	AGRE/FMR1_Illumina.JHU	Omics	04/14/2014
146	AGRE/MECP2_Sanger.JHU	Omics	04/14/2014
147	AGRE/MECP2_Junior.JHU	Omics	04/14/2014
151	Candidate Gene Identification in familial Autism	Omics	06/09/2014
152	NJLAGS Whole Genome Sequencing	Omics	07/01/2014
154	Math Autism Study - Vinod Menon	fMRI	07/15/2014
155	Resting	fMRI	07/25/2014
156	Speech	fMRI	07/25/2014
159	Emotion	fMRI	07/25/2014
160	syllable contrast	EEG	07/29/2014
167	School-age naturalistic stimuli	Eye Tracking	09/19/2014
44	AGRE/Broad Affymetrix 5.0 Genotype Experiment	Omics	06/27/2011
45	Exome Sequencing of 20 Sporadic Cases of Autism Spectrum Disorder	Omics	07/15/2011

Collection - Add Experiment

Add Supporting Documentation

Funding Source:
URL:

To add an existing Data Structure, enter its title in the search bar. If you need to request changes, select the indicator "No, it requires changes to meet research needs" after selecting the Structure, and upload the file with the request changes specific to the selected Data Structure. Your file should follow the Request Changes Procedure. If the Data Structure does not exist, select "Request New Data Structure" and upload the appropriate zip file.

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Please confirm that you will not be enrolling any more subjects and that all raw data has been collected and submitted.

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Your Collection is now in Data Analysis phase and exempt from biannual submissions. Analyzed data is still expected prior to publication or no later than the project end date.

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Longitudinal MRI Study of Infants at Risk for Autism #19

General
Experiments (1)
Shared Data
Publications (171)
Data Expected (19)
Associated Studies (24)

Collection Title	Collection Investigators	Collection Description
Collection Title:	Longitudinal MRI Study of Infants at Risk for Autism
Collection Investigators:	Joe Piven
Collection Description:	Research data for the IBIS Autism project. Autism Centers of Excellence (ACE) Network is a collaborative effort by investigators at four clinical sites: University of North Carolina (UNC), University of Washington (UW), Washington University (WU), and Yale University; and one data coordinating center (DCC) at the Montreal Neurological Institute (MNI) to conduct a longitudinal MRI/DTI and behavioral study of infants at high risk for autism (i.e., siblings of autistic individuals) at 6, 12 and 24 months (m) of age.
Data Repository:	NIMH Data Archive
Permission Group:
Collection Creation Date:	04/01/2008
NIH Research Initiatives:	Autism Centers of Excellence (ACE), NIMH Repository & Genomics Resource (NRGR)
Collection Phase:	Funding Completed
Collection Sub-Phase:	Close Out
Blinded Clinical Trial:	No
Total Funded Amount:	$6,179,607.00
Subjects Shared:	1,039

{"values":[]}

{"values":[["DTI",335],["fMRI",2],["MRI",356]]}

{"values":[["Autism Spectrum Affected",580],["Sibling Control",1676],["Typical Control",3],["Not Defined",70],["Autism Spectrum Mildly Affected",134],["Autism Spectrum Severely Affected",920]]}

Loading Chart...

Funding Sources:

Funding Source Name	Funding Source URL
NIH - Extramural	None

Supporting Documentation:

Grant Information:

Project Number	Project Title	Start Date	End Date	Planned Enrollment	Actual Enrollment	Organization	Funds Obligated
R01HD055741-01	A Longitudinal MRI Study of Infants at Risk for Autism	07/01/2007	06/30/2013	664	526	UNIV OF NORTH CAROLINA CHAPEL HILL	$6,179,607.00

Clinical Trials:

helpcenter.collection.general-tab

Collection - General Tab

Fields available for edit on the top portion of the page include:

Collection Title
Investigators
Collection Description
Collection Phase
Funding Source
Clinical Trials

Collection Phase: The current status of a research project submitting data to an NDA Collection, based on the timing of the award and/or the data that have been submitted.

Pre-Enrollment: The default entry made when the NDA Collection is created.
Enrolling: Data have been submitted to the NDA Collection or the NDA Data Expected initial submission date has been reached for at least one data structure category in the NDA Collection.
Data Analysis: Subject level data collection for the research project is completed and has been submitted to the NDA Collection. The NDA Collection owner or the NDA Help Desk may set this phase when they’ve confirmed data submission is complete and submitted subject counts match at least 90% of the target enrollment numbers in the NDA Data Expected. Data submission reminders will be turned off for the NDA Collection.
Funding Completed: The NIH grant award (or awards) associated with the NDA Collection has reached its end date. NDA Collections in Funding Completed phase are assigned a subphase to indicate the status of data submission.
- The Data Expected Subphase indicates that NDA expects more data will be submitted
- The Closeout Subphase indicates the data submission is complete.
- The Sharing Not Met Subphase indicates that data submission was not completed as expected.

Blinded Clinical Trial Status:

This status is set by a Collection Owner and indicates the research project is a double blinded clinical trial. When selected, the public view of Data Expected will show the Data Expected items and the Submission Dates, but the targeted enrollment and subjects submitted counts will not be displayed.
Targeted enrollment and subjects submitted counts are visible only to NDA Administrators and to the NDA Collection or as the NDA Collection Owner.
When an NDA Collection that is flagged Blinded Clinical Trial reaches the maximum data sharing date for that Data Repository (see https://nda.nih.gov/nda/sharing-regimen.html), the embargo on Data Expected information is released.

Funding Source

The organization(s) responsible for providing the funding is listed here.

Supporting Documentation

Users with Submission privileges, as well as Collection Owners, Program Officers, and those with Administrator privileges, may upload and attach supporting documentation. By default, supporting documentation is shared to the general public, however, the option is also available to limit this information to qualified researchers only.

Grant Information

Identifiable details are displayed about the Project of which the Collection was derived from. You may click in the Project Number to view a full report of the Project captured by the NIH.

Clinical Trials

Any data that is collected to support or further the research of clinical studies will be available here. Collection Owners and those with Administrator privileges may add new clinical trials.

Frequently Asked Questions

How does the NIMH Data Archive (NDA) determine which Permission Group data are submitted into?

During Collection creation, NDA staff determine the appropriate Permission Group based on the type of data to be submitted, the type of access that will be available to data access users, and the information provided by the Program Officer during grant award.
How do I know when a NDA Collection has been created?

When a Collection is created by NDA staff, an email notification will automatically be sent to the PI(s) of the grant(s) associated with the Collection to notify them.
Is a single grant number ever associated with more than one Collection?

The NDA system does not allow for a single grant to be associated with more than one Collection; therefore, a single grant will not be listed in the Grant Information section of a Collection for more than one Collection.
Why is there sometimes more than one grant included in a Collection?

In general, each Collection is associated with only one grant; however, multiple grants may be associated if the grant has multiple competing segments for the same grant number or if multiple different grants are all working on the same project and it makes sense to hold the data in one Collection (e.g., Cooperative Agreements).

Glossary

Administrator Privilege

A privilege provided to a user associated with an NDA Collection or NDA Study whereby that user can perform a full range of actions including providing privileges to other users.
Collection Owner

Generally, the Collection Owner is the contact PI listed on a grant. Only one NDA user is listed as the Collection owner. Most automated emails are primarily sent to the Collection Owner.
Collection Phase
The Collection Phase provides information on data submission as opposed to grant/project completion so while the Collection phase and grant/project phase may be closely related they are often different. Collection users with Administrative Privileges are encouraged to edit the Collection Phase. The Program Officer as listed in eRA (for NIH funded grants) may also edit this field. Changes must be saved by clicking the Save button at the bottom of the page. This field is sortable alphabetically in ascending or descending order. Collection Phase options include:
- Pre-Enrollment: A grant/project has started, but has not yet enrolled subjects.
- Enrolling: A grant/project has begun enrolling subjects. Data submission is likely ongoing at this point.
- Data Analysis: A grant/project has completed enrolling subjects and has completed all data submissions.
- Funding Completed: A grant/project has reached the project end date.
Collection Title

An editable field with the title of the Collection, which is often the title of the grant associated with the Collection.
Grant

Provides the grant number(s) for the grant(s) associated with the Collection. The field is a hyperlink so clicking on the Grant number will direct the user to the grant information in the NIH Research Portfolio Online Reporting Tools (RePORT) page.
Supporting Documentation

Various documents and materials to enable efficient use of the data by investigators unfamiliar with the project and may include the research protocol, questionnaires, and study manuals.
NIH Research Initiative

NDA Collections may be organized by scientific similarity into NIH Research Initiatives, to facilitate query tool user experience. NIH Research Initiatives map to one or multiple Funding Opportunity Announcements.
Permission Group

Access to shared record-level data in NDA is provisioned at the level of a Permission Group. NDA Permission Groups consist of one or multiple NDA Collections that contain data with the same subject consents.
Planned Enrollment

Number of human subject participants to be enrolled in an NIH-funded clinical research study. The data is provided in competing applications and annual progress reports.
Actual Enrollment

Number of human subjects enrolled in an NIH-funded clinical research study. The data is provided in annual progress reports.
NDA Collection

A virtual container and organization structure for data and associated documentation from one grant or one large project/consortium. It contains tools for tracking data submission and allows investigators to define a wide array of other elements that provide context for the data, including all general information regarding the data and source project, experimental parameters used to collect any event-based data contained in the Collection, methods, and other supporting documentation. They also allow investigators to link underlying data to an NDA Study, defining populations and subpopulations specific to research aims.
Data Use Limitations

Data Use Limitations (DULs) describe the appropriate secondary use of a dataset and are based on the original informed consent of a research participant. NDA only accepts consent-based data use limitations defined by the NIH Office of Science Policy.
Total Subjects Shared

The total number of unique subjects for whom data have been shared and are available for users with permission to access data.

Contact NDA Help Desk

ID	Name	Created Date	Status	Type
370	Longitudinal MRI Study of Infants at Risk for Autism	08/11/2015	Approved	fMRI

helpcenter.collection.experiments-tab

Collection - Experiments

The number of Experiments included is displayed in parentheses next to the tab name. You may download all experiments associated with the Collection via the Download button. You may view individual experiments by clicking the Experiment Name and add them to the Filter Cart via the Add to Cart button.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may create or edit an Experiment.

Please note: The creation of an NDA Experiment does not necessarily mean that data collected, according to the defined Experiment, has been submitted or shared.

Frequently Asked Questions

Can an Experiment be associated with more than one Collection?
Yes -see the “Copy” button in the bottom left when viewing an experiment. There are two actions that can be performed via this button:
1. Copy the experiment with intent for modifications.
2. Associate the experiment to the collection. No modifications can be made to the experiment.

Glossary

Experiment Status

An Experiment must be Approved before data using the associated Experiment_ID may be uploaded.
Experiment ID

The ID number automatically generated by NDA which must be included in the appropriate file when uploading data to link the Experiment Definition to the subject record.

Contact NDA Help Desk

Shared Data:

Title	Type	Number of Subjects
Autism Diagnostic Interview, Revised (ADI-R)	Clinical Assessments	350
Autism Diagnostic Observation Schedule (ADOS)- Module 1	Clinical Assessments	312
Autism Diagnostic Observation Schedule (ADOS)- Module 2	Clinical Assessments	34
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 1	Clinical Assessments	63
Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) - Module 2	Clinical Assessments	2
Autism Observation Scale for Infants	Clinical Assessments	481
CHARGE Medical History	Clinical Assessments	487
CHARGE Physical Exam	Clinical Assessments	370
CSBS DP Behavior Sample	Clinical Assessments	420
Early Development Interview	Clinical Assessments	479
First Year Inventory	Clinical Assessments	375
Height and Weight	Clinical Assessments	485
Image	Imaging	456
Infant Behavior Questionnaire Revised	Clinical Assessments	449
M-CHAT	Clinical Assessments	17
MacArthur-Bates CDI - Words and Gestures Form	Clinical Assessments	420
Modified Checklist for Autism in Toddlers (M-CHAT)	Clinical Assessments	2
Mullen Scales of Early Learning	Clinical Assessments	519
Prefrontal task	Clinical Assessments	301
Repetitive Behavior Scale - Revised (RBS-R)	Clinical Assessments	422
Research Subject	Clinical Assessments	934
Sensory Experiences Questionnaire	Clinical Assessments	417
Social Communication Questionnaire (SCQ) - Current Form	Clinical Assessments	134
Social Communication Questionnaire (SCQ) - Lifetime	Clinical Assessments	282
Vineland-II - Survey Form (2005)	Clinical Assessments	832

helpcenter.collection.shared-data-tab

Collection - Shared Data

This tab provides a quick overview of the Data Structure title, Data Type, and Number of Subjects that are currently Shared for the Collection. The information presented in this tab is automatically generated by NDA and cannot be edited. If no information is visible on this tab, this would indicate the Collection does not have shared data or the data is private.

The shared data is available to other researchers who have permission to access data in the Collection's designated Permission Group(s). Use the Download button to get all shared data from the Collection to the Filter Cart.

Frequently Asked Questions

How will I know if another researcher uses data that I shared through the NIMH Data Archive (NDA)?

To see what data your project have submitted are being used by a study, simply go the Associated Studies tab of your collection. Alternatively, you may review an NDA Study Attribution Report available on the General tab.
Can I get a supplement to share data from a completed research project?

Often it becomes more difficult to organize and format data electronically after the project has been completed and the information needed to create a GUID may not be available; however, you may still contact a program staff member at the appropriate funding institution for more information.
Can I get a supplement to share data from a research project that is still ongoing?

Unlike completed projects where researchers may not have the information needed to create a GUID and/or where the effort needed to organize and format data becomes prohibitive, ongoing projects have more of an opportunity to overcome these challenges. Please contact a program staff member at the appropriate funding institution for more information.

Glossary

Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Type

A grouping of data by similar characteristics such as Clinical Assessments, Omics, or Neurosignal data.
Shared

The term 'Shared' generally means available to others; however, there are some slightly different meanings based on what is Shared. A Shared NDA Study is viewable and searchable publicly regardless of the user's role or whether the user has an NDA account. A Shared NDA Study does not necessarily mean that data used in the NDA Study have been shared as this is independently determined. Data are shared according the schedule defined in a Collection's Data Expected Tab and/or in accordance with data sharing expectations in the NDA Data Sharing Terms and Conditions. Additionally, Supporting Documentation uploaded to a Collection may be shared independent of whether data are shared.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Publications

Publications relevant to NDA data are listed below. Most displayed publications have been associated with the grant within Pubmed. Use the "+ New Publication" button to add new publications. Publications relevant/not relevant to data expected are categorized. Relevant publications are then linked to the underlying data by selecting the Create Study link. Study provides the ability to define cohorts, assign subjects, define outcome measures and lists the study type, data analysis and results. Analyzed data and results are expected in this way.

PubMed ID	Study	Title	Journal	Authors	Date	Status
38419749	Create Study	E(3) × SO(3)-Equivariant Networks for Spherical Deconvolution in Diffusion MRI.	Proceedings of machine learning research	Elaldi, Axel; Gerig, Guido; Dey, Neel	January 1, 2024	Not Determined
38204321	Create Study	Infants who develop autism show smaller inventories of deictic and symbolic gestures at 12 months of age.	Autism research : official journal of the International Society for Autism Research	Wu, Dennis; Wolff, Jason J; Ravi, Shruthi; Elison, Jed T; Estes, Annette; Paterson, Sarah; St John, Tanya; Abdi, Hervé; Moraglia, Luke E; Piven, Joseph; Swanson, Meghan R; IBIS Network	January 10, 2024	Not Determined
37996530	Create Study	A global multicohort study to map subcortical brain development and cognition in infancy and early childhood.	Nature neuroscience	Alex, Ann M; Aguate, Fernando; Botteron, Kelly; Buss, Claudia; Chong, Yap-Seng; Dager, Stephen R; Donald, Kirsten A; Entringer, Sonja; Fair, Damien A; Fortier, Marielle V; Gaab, Nadine; Gilmore, John H; Girault, Jessica B; Graham, Alice M; Groenewold, Nynke A; Hazlett, Heather; Lin, Weili; Meaney, Michael J; Piven, Joseph; Qiu, Anqi; Rasmussen, Jerod M; Roos, Annerine; Schultz, Robert T; Skeide, Michael A; Stein, Dan J; Styner, Martin; Thompson, Paul M; Turesky, Ted K; Wadhwa, Pathik D; Zar, Heather J; Zöllei, Lilla; de Los Campos, Gustavo; Knickmeyer, Rebecca C; ENIGMA ORIGINs group	January 1, 2024	Not Determined
37898019	Create Study	Structural and functional connectome relationships in early childhood.	Developmental cognitive neuroscience	Hong, Yoonmi; Cornea, Emil; Girault, Jessica B; Bagonis, Maria; Foster, Mark; Kim, Sun Hyung; Prieto, Juan Carlos; Chen, Haitao; Gao, Wei; Styner, Martin A; Gilmore, John H	December 1, 2023	Not Determined
37614415	Create Study	Local Spatiotemporal Representation Learning for Longitudinally-consistent Neuroimage Analysis.	Advances in neural information processing systems	Ren, Mengwei; Dey, Neel; Styner, Martin A; Botteron, Kelly N; Gerig, Guido	December 1, 2022	Not Determined
37576905	Create Study	Equivariant Spherical Deconvolution: Learning Sparse Orientation Distribution Functions from Spherical Data.	Information processing in medical imaging : proceedings of the ... conference	Elaldi, Axel; Dey, Neel; Kim, Heejong; Gerig, Guido	June 1, 2021	Not Determined
37168581	Create Study	Are early social communication skills a harbinger for language development in infants later diagnosed autistic?-A longitudinal study using a standardized social communication assessment.	Frontiers in communication	Ravi, Shruthi; Bradshaw, Allison; Abdi, Hervé; Meera, Shoba Sreenath; Parish-Morris, Julia; Yankowitz, Lisa; Paterson, Sarah; Dager, Stephen R; Burrows, Catherine A; Chappell, Chad; St John, Tanya; Estes, Annette M; Piven, Joseph; Swanson, Meghan R; IBIS Network	January 1, 2022	Not Determined
37140923	Create Study	Association of Sex With Neurobehavioral Markers of Executive Function in 2-Year-Olds at High and Low Likelihood of Autism.	JAMA network open	St John, Tanya; Estes, Annette M; Hazlett, Heather C; Marrus, Natasha; Burrows, Catherine A; Donovan, Kevin; Torres Gomez, Santiago; Grzadzinski, Rebecca L; Parish-Morris, Julia; Smith, Rachel; Styner, Martin; Garic, Dea; Pandey, Juhi; Lee, Chimei M; Schultz, Robert T; Botteron, Kelly N; Zwaigenbaum, Lonnie; Piven, Joseph; Dager, Stephen R; IBIS Network	May 1, 2023	Not Determined
37089869	Create Study	Dmriprep: open-source diffusion MRI quality control framework with graphical user interface.	Proceedings of SPIE--the International Society for Optical Engineering	Dubos, Johanna; Park, Sang Kyoon; Vlasova, Roza; Prieto, Juan Carlos; Styner, Martin	February 1, 2023	Not Determined
37076628	Create Study	A somato-cognitive action network alternates with effector regions in motor cortex.	Nature	Gordon, Evan M; Chauvin, Roselyne J; Van, Andrew N; Rajesh, Aishwarya; Nielsen, Ashley; Newbold, Dillan J; Lynch, Charles J; Seider, Nicole A; Krimmel, Samuel R; Scheidter, Kristen M; Monk, Julia; Miller, Ryland L; Metoki, Athanasia; Montez, David F; Zheng, Annie; Elbau, Immanuel; Madison, Thomas; Nishino, Tomoyuki; Myers, Michael J; Kaplan, Sydney; Badke D'Andrea, Carolina; Demeter, Damion V; Feigelis, Matthew; Ramirez, Julian S B; Xu, Ting; Barch, Deanna M; Smyser, Christopher D; Rogers, Cynthia E; Zimmermann, Jan; Botteron, Kelly N; Pruett, John R; Willie, Jon T; Brunner, Peter; Shimony, Joshua S; Kay, Benjamin P; Marek, Scott; Norris, Scott A; Gratton, Caterina; Sylvester, Chad M; Power, Jonathan D; Liston, Conor; Greene, Deanna J; Roland, Jarod L; Petersen, Steven E; Raichle, Marcus E; Laumann, Timothy O; Fair, Damien A; Dosenbach, Nico U F	May 1, 2023	Not Determined
37060675	Create Study	Language exposure during infancy is negatively associated with white matter microstructure in the arcuate fasciculus.	Developmental cognitive neuroscience	Estrada, Katiana A; Govindaraj, Sharnya; Abdi, Hervé; Moraglia, Luke E; Wolff, Jason J; Meera, Shoba Sreenath; Dager, Stephen R; McKinstry, Robert C; Styner, Martin A; Zwaigenbaum, Lonnie; Piven, Joseph; Swanson, Meghan R; IBIS Network	June 1, 2023	Not Determined
37017863	Create Study	Sensory Profiles in Relation to Later Adaptive Functioning Among Toddlers at High-Familial Likelihood for Autism.	Journal of autism and developmental disorders	Worthley, Emma; Grzadzinski, Rebecca; Zwaigenbaum, Lonnie; Dager, Stephen R; Estes, Annette M; Hazlett, Heather C; Schultz, Robert T; Piven, Joseph; Wolff, Jason J; IBIS Network	April 5, 2023	Not Determined
36968615	Create Study	Learning Strategies for Contrast-agnostic Segmentation via SynthSeg for Infant MRI data.	Proceedings of machine learning research	Shang, Ziyao; Turja, Md Asadullah; Feczko, Eric; Houghton, Audrey; Rueter, Amanda; Moore, Lucille A; Snider, Kathy; Hendrickson, Timothy; Reiners, Paul; Stoyell, Sally; Kardan, Omid; Rosenberg, Monica; Elison, Jed T; Fair, Damien A; Styner, Martin A	July 1, 2022	Not Determined
36932005	Create Study	Genetic Influences on the Developing Young Brain and Risk for Neuropsychiatric Disorders.	Biological psychiatry	Alex, Ann M; Buss, Claudia; Davis, Elysia Poggi; Campos, Gustavo de Los; Donald, Kirsten A; Fair, Damien A; Gaab, Nadine; Gao, Wei; Gilmore, John H; Girault, Jessica B; Grewen, Karen; Groenewold, Nynke A; Hankin, Benjamin L; Ipser, Jonathan; Kapoor, Shreya; Kim, Pilyoung; Lin, Weili; Luo, Shan; Norton, Elizabeth S; O'Connor, Thomas G; Piven, Joseph; Qiu, Anqi; Rasmussen, Jerod M; Skeide, Michael A; Stein, Dan J; Styner, Martin A; Thompson, Paul M; Wakschlag, Laurie; Knickmeyer, Rebecca; ENIGMA ORIGINs group	May 15, 2023	Not Determined
36573033	Create Study	Confirmatory factor analysis of the BRIEF2 in a sample of youth with Down syndrome.	Journal of intellectual disability research : JIDR	Soltani, A; Schworer, E K; Jacobson, L A; Channell, M M; Lee, N R; Faught, G G; Grzadzinski, R; Fidler, D; Esbensen, A J	February 1, 2023	Not Determined
36517753	Create Study	Social attention during object engagement: toward a cross-species measure of preferential social orienting.	Journal of neurodevelopmental disorders	Weichselbaum, Claire; Hendrix, Nicole; Albright, Jordan; Dougherty, Joseph D; Botteron, Kelly N; Constantino, John N; Marrus, Natasha	December 14, 2022	Not Determined
36495600	Create Study	Optimal transport features for morphometric population analysis.	Medical image analysis	Gerber, Samuel; Niethammer, Marc; Ebrahim, Ebrahim; Piven, Joseph; Dager, Stephen R; Styner, Martin; Aylward, Stephen; Enquobahrie, Andinet	February 1, 2023	Not Determined
36383495	Create Study	Q-space Conditioned Translation Networks for Directional Synthesis of Diffusion Weighted Images from Multi-modal Structural MRI.	Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention	Ren, Mengwei; Kim, Heejong; Dey, Neel; Gerig, Guido	January 1, 2021	Not Determined
36222317	Create Study	Quantifying latent social motivation and its associations with joint attention and language in infants at high and low likelihood for autism spectrum disorder.	Developmental science	Stallworthy, Isabella C; Berry, Daniel; Davis, Savannah; Wolff, Jason J; Burrows, Catherine A; Swanson, Meghan R; Grzadzinski, Rebecca L; Botteron, Kelly; Dager, Stephen R; Estes, Annette M; Schultz, Robert T; Piven, Joseph; Elison, Jed T; Pruett Jr, John R; Marrus, Natasha; IBIS Network	May 1, 2023	Not Determined
36189644	Create Study	Social motivation in infancy is associated with familial recurrence of ASD.	Development and psychopathology	Marrus, Natasha; Botteron, Kelly N; Hawks, Zoë; Pruett Jr, John R; Elison, Jed T; Jackson, Joshua J; Markson, Lori; Eggebrecht, Adam T; Burrows, Catherine A; Zwaigenbaum, Lonnie; Dager, Stephen R; Estes, Annette M; Hazlett, Heather Cody; Schultz, Robert T; Piven, Joseph; Constantino, John N	February 1, 2024	Not Determined
36108328	Create Study	Trajectories from Distribution-valued Functional Curves: A Unified Wasserstein Framework★.	Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention	Sharma, Anuja; Gerig, Guido	October 1, 2020	Not Determined
36108321	Create Study	Hierarchical Multi-Geodesic Model for Longitudinal Analysis of Temporal Trajectories of Anatomical Shape and Covariates.	Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention	Hong, Sungmin; Fishbaugh, James; Wolff, Jason J; Styner, Martin A; Gerig, Guido	October 1, 2019	Not Determined
35965107	Create Study	A Data-Driven Approach in an Unbiased Sample Reveals Equivalent Sex Ratio of Autism Spectrum Disorder-Associated Impairment in Early Childhood.	Biological psychiatry	Burrows, Catherine A; Grzadzinski, Rebecca L; Donovan, Kevin; Stallworthy, Isabella C; Rutsohn, Joshua; St John, Tanya; Marrus, Natasha; Parish-Morris, Julia; MacIntyre, Leigh; Hampton, Jacqueline; Pandey, Juhi; Shen, Mark D; Botteron, Kelly N; Estes, Annette M; Dager, Stephen R; Hazlett, Heather C; Pruett Jr, John R; Schultz, Robert T; Zwaigenbaum, Lonnie; Truong, Kinh N; Piven, Joseph; Elison, Jed T; IBIS Network	October 15, 2022	Not Determined
35761377	Create Study	Infants later diagnosed with autism have lower canonical babbling ratios in the first year of life.	Molecular autism	Yankowitz, L D; Petrulla, V; Plate, S; Tunc, B; Guthrie, W; Meera, S S; Tena, K; Pandey, J; Swanson, M R; Pruett Jr, J R; Cola, M; Russell, A; Marrus, N; Hazlett, H C; Botteron, K; Constantino, J N; Dager, S R; Estes, A; Zwaigenbaum, L; Piven, J; Schultz, R T; Parish-Morris, J; IBIS Network	June 27, 2022	Not Determined
35720673	Create Study	Local Extraction of Extra-Axial CSF from structural MRI.	Proceedings of SPIE--the International Society for Optical Engineering	Deddah, Tahya; Styner, Martin; Prieto, Juan	February 1, 2022	Not Determined
35720672	Create Study	CONTINUITY: CONnectivity Tool with INtegration of sUbcortical regions, regIstration and visualization of TractographY.	Proceedings of SPIE--the International Society for Optical Engineering	Piot, Elodie; Bagonis, Maria; Prieto, Juan C; Styner, Martin	February 1, 2022	Not Determined
35615814	Create Study	Infant Visual Brain Development and Inherited Genetic Liability in Autism.	The American journal of psychiatry	Girault, Jessica B; Donovan, Kevin; Hawks, Zoë; Talovic, Muhamed; Forsen, Elizabeth; Elison, Jed T; Shen, Mark D; Swanson, Meghan R; Wolff, Jason J; Kim, Sun Hyung; Nishino, Tomoyuki; Davis, Savannah; Snyder, Abraham Z; Botteron, Kelly N; Estes, Annette M; Dager, Stephen R; Hazlett, Heather C; Gerig, Guido; McKinstry, Robert; Pandey, Juhi; Schultz, Robert T; St John, Tanya; Zwaigenbaum, Lonnie; Todorov, Alexandre; Truong, Young; Styner, Martin; Pruett Jr, John R; Constantino, John N; Piven, Joseph; IBIS Network	August 1, 2022	Not Determined
35485579	Create Study	Examining the factor structure and discriminative utility of the Infant Behavior Questionnaire-Revised in infant siblings of autistic children.	Child development	Sung, Sooyeon; Fenoglio, Angela; Wolff, Jason J; Schultz, Robert T; Botteron, Kelly N; Dager, Stephen R; Estes, Annette M; Hazlett, Heather C; Zwaigenbaum, Lonnie; Piven, Joseph; Elison, Jed T; IBIS Network	September 1, 2022	Not Determined
35331012	Create Study	Subcortical Brain Development in Autism and Fragile X Syndrome: Evidence for Dynamic, Age- and Disorder-Specific Trajectories in Infancy.	The American journal of psychiatry	Shen, Mark D; Swanson, Meghan R; Wolff, Jason J; Elison, Jed T; Girault, Jessica B; Kim, Sun Hyung; Smith, Rachel G; Graves, Michael M; Weisenfeld, Leigh Anne H; Flake, Lisa; MacIntyre, Leigh; Gross, Julia L; Burrows, Catherine A; Fonov, Vladimir S; Collins, D Louis; Evans, Alan C; Gerig, Guido; McKinstry, Robert C; Pandey, Juhi; St John, Tanya; Zwaigenbaum, Lonnie; Estes, Annette M; Dager, Stephen R; Schultz, Robert T; Styner, Martin A; Botteron, Kelly N; Hazlett, Heather C; Piven, Joseph; IBIS Network	August 1, 2022	Not Determined
34708871	Create Study	Infant vocalizing and phenotypic outcomes in autism: Evidence from the first 2 years.	Child development	Plate, Samantha; Yankowitz, Lisa; Resorla, Leslie; Swanson, Meghan R; Meera, Shoba Sreenath; Estes, Annette; Marrus, Natasha; Cola, Meredith; Petrulla, Victoria; Faggen, Aubrey; Pandey, Juhi; Paterson, Sarah; Pruett Jr, John R; Hazlett, Heather; Dager, Stephen; St John, Tanya; Botteron, Kelly; Zwaigenbaum, Lonnie; Piven, Joseph; Schultz, Robert T; Parish-Morris, Julia; IBIS Network	March 1, 2022	Not Determined
34368815	Create Study	A framework to construct a longitudinal DW-MRI infant atlas based on mixed effects modeling of dODF coefficients.	Computational diffusion MRI : MICCAI Workshop	Kim, Heejong; Styner, Martin; Piven, Joseph; Gerig, Guido	January 1, 2020	Not Determined
34327517	Create Study	Hierarchical geodesic modeling on the diffusion orientation distribution function for longitudinal DW-MRI analysis.	Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention	Kim, Heejong; Hong, Sungmin; Styner, Martin; Piven, Joseph; Botteron, Kelly; Gerig, Guido	October 1, 2020	Not Determined
34145789	Create Study	Social and non-social sensory responsivity in toddlers at high-risk for autism spectrum disorder.	Autism research : official journal of the International Society for Autism Research	Gunderson, Jaclyn; Worthley, Emma; Grzadzinski, Rebecca; Burrows, Catherine; Estes, Annette; Zwaigenbaum, Lonnie; Botteron, Kelly; Dager, Stephen; Hazlett, Heather; Schultz, Robert; Piven, Joseph; Wolff, Jason; IBIS Network	October 1, 2021	Not Determined
34021722	Create Study	Cataloguing and characterizing interests in typically developing toddlers and toddlers who develop ASD.	Autism research : official journal of the International Society for Autism Research	Burrows, Catherine A; Bodfish, James W; Wolff, Jason J; Vollman, Elayne P; Altschuler, Melody R; Botteron, Kelly N; Dager, Stephen R; Estes, Annette M; Hazlett, Heather C; Pruett Jr, John R; Schultz, Robert T; Zwaigenbaum, Lonnie; Piven, Joseph; Elison, Jed T; IBIS Network	August 1, 2021	Not Determined
34020453	Create Study	Human milk 3''-Sialyllactose is positively associated with language development during infancy.	The American journal of clinical nutrition	Cho, Seoyoon; Zhu, Ziliang; Li, Tengfei; Baluyot, Kristine; Howell, Brittany R; Hazlett, Heather C; Elison, Jed T; Hauser, Jonas; Sprenger, Norbert; Wu, Di; Lin, Weili	August 2, 2021	Not Determined
33965519	Create Study	Variability in Responding to Joint Attention Cues in the First Year is Associated With Autism Outcome.	Journal of the American Academy of Child and Adolescent Psychiatry	Stallworthy, Isabella C; Lasch, Carolyn; Berry, Daniel; Wolff, Jason J; Pruett Jr, John R; Marrus, Natasha; Swanson, Meghan R; Botteron, Kelly N; Dager, Stephen R; Estes, Annette M; Hazlett, Heather C; Schultz, Robert T; Zwaigenbaum, Lonnie; Piven, Joseph; Elison, Jed T; IBIS Network	March 1, 2022	Not Determined
33956255	Create Study	Relations of Restricted and Repetitive Behaviors to Social Skills in Toddlers with Autism.	Journal of autism and developmental disorders	Chaxiong, Pang; Burrows, Catherine; Botteron, Kelly N; Dager, Stephen R; Estes, Annette M; Hazlett, Heather C; Schultz, Robert T; Zwaigenbaum, Lonnie; Piven, Joseph; Wolff, Jason; IBIS Network	April 1, 2022	Not Determined
33826159	Create Study	Diagnostic shifts in autism spectrum disorder can be linked to the fuzzy nature of the diagnostic boundary: a data-driven approach.	Journal of child psychology and psychiatry, and allied disciplines	Tunç, Birkan; Pandey, Juhi; St John, Tanya; Meera, Shoba S; Maldarelli, Jennifer E; Zwaigenbaum, Lonnie; Hazlett, Heather C; Dager, Stephen R; Botteron, Kelly N; Girault, Jessica B; McKinstry, Robert C; Verma, Ragini; Elison, Jed T; Pruett Jr, John R; Piven, Joseph; Estes, Annette M; Schultz, Robert T; IBIS Network	October 1, 2021	Not Determined
33591913	Create Study	Segmentation-Renormalized Deep Feature Modulation for Unpaired Image Harmonization.	IEEE transactions on medical imaging	Ren, Mengwei; Dey, Neel; Fishbaugh, James; Gerig, Guido	June 1, 2021	Not Determined
33421871	Create Study	A voxel-wise assessment of growth differences in infants developing autism spectrum disorder.	NeuroImage. Clinical	Cárdenas-de-la-Parra, A; Lewis, J D; Fonov, V S; Botteron, K N; McKinstry, R C; Gerig, G; Pruett Jr, J R; Dager, S R; Elison, J T; Styner, M A; Evans, A C; Piven, J; Collins, D L; IBIS Network	January 1, 2021	Not Determined
33161063	Create Study	Towards a Data-Driven Approach to Screen for Autism Risk at 12 Months of Age.	Journal of the American Academy of Child and Adolescent Psychiatry	Meera, Shoba S; Donovan, Kevin; Wolff, Jason J; Zwaigenbaum, Lonnie; Elison, Jed T; Kinh, Truong; Shen, Mark D; Estes, Annette M; Hazlett, Heather C; Watson, Linda R; Baranek, Grace T; Swanson, Meghan R; St John, Tanya; Burrows, Catherine A; Schultz, Robert T; Dager, Stephen R; Botteron, Kelly N; Pandey, Juhi; Piven, Joseph; IBIS Network	August 1, 2021	Not Determined
33161062	Create Study	Predicting Autism in Infancy.	Journal of the American Academy of Child and Adolescent Psychiatry	Wolff, Jason J; Piven, Joseph	August 1, 2021	Not Determined
33132824	Create Study	A Novel Method for High-Dimensional Anatomical Mapping of Extra-Axial Cerebrospinal Fluid: Application to the Infant Brain.	Frontiers in neuroscience	Mostapha, Mahmoud; Kim, Sun Hyung; Evans, Alan C; Dager, Stephen R; Estes, Annette M; McKinstry, Robert C; Botteron, Kelly N; Gerig, Guido; Pizer, Stephen M; Schultz, Robert T; Hazlett, Heather C; Piven, Joseph; Girault, Jessica B; Shen, Mark D; Styner, Martin A	January 1, 2020	Not Determined
32944847	Create Study	Distributional Properties and Criterion Validity of a Shortened Version of the Social Responsiveness Scale: Results from the ECHO Program and Implications for Social Communication Research.	Journal of autism and developmental disorders	Lyall, Kristen; Hosseini, Mina; Ladd-Acosta, Christine; Ning, Xuejuan; Catellier, Diane; Constantino, John N; Croen, Lisa A; Kaat, Aaron J; Botteron, Kelly; Bush, Nicole R; Dager, Stephen R; Duarte, Cristiane S; Fallin, M Daniele; Hazlett, Heather; Hertz-Picciotto, Irva; Joseph, Robert M; Karagas, Margaret R; Korrick, Susan; Landa, Rebecca; Messinger, Daniel; Oken, Emily; Ozonoff, Sally; Piven, Joseph; Pandey, Juhi; Sathyanarayana, Sheela; Schultz, Robert T; St John, Tanya; Schmidt, Rebecca; Volk, Heather; Newschaffer, Craig J; program collaborators for Environmental influences on Child Health Outcomes	July 1, 2021	Not Determined
32728309	Create Study	Automatic Measurement of Extra-Axial CSF from Infant MRI Data.	Proceedings of SPIE--the International Society for Optical Engineering	LeMaout, Arthur; Yoon, Han Bit; Kim, Sun Hyung; Mostapha, Mahmoud; Shen, Mark D; Prieto, Juan; Styner, Martin	February 2020	Not Determined
32375538	Create Study	Sleep Onset Problems and Subcortical Development in Infants Later Diagnosed With Autism Spectrum Disorder.	The American journal of psychiatry	MacDuffie, Katherine E; Shen, Mark D; Dager, Stephen R; Styner, Martin A; Kim, Sun Hyung; Paterson, Sarah; Pandey, Juhi; St John, Tanya; Elison, Jed T; Wolff, Jason J; Swanson, Meghan R; Botteron, Kelly N; Zwaigenbaum, Lonnie; Piven, Joseph; Estes, Annette M	June 2020	Not Determined
32314879	Create Study	The Association Between Parental Age and Autism-Related Outcomes in Children at High Familial Risk for Autism.	Autism research : official journal of the International Society for Autism Research	Lyall, Kristen; Song, Lanxin; Botteron, Kelly; Croen, Lisa A; Dager, Stephen R; Fallin, M Daniele; Hazlett, Heather C; Kauffman, Elizabeth; Landa, Rebecca; Ladd-Acosta, Christine; Messinger, Daniel S; Ozonoff, Sally; Pandey, Juhi; Piven, Joseph; Schmidt, Rebecca J; Schultz, Robert T; Stone, Wendy L; Newschaffer, Craig J; Volk, Heather E	June 2020	Not Determined
32276067	Create Study	Sex differences associated with corpus callosum development in human infants: A longitudinal multimodal imaging study.	NeuroImage	Schmied, Astrid; Soda, Takahiro; Gerig, Guido; Styner, Martin; Swanson, Meghan R; Elison, Jed T; Shen, Mark D; McKinstry, Robert C; Pruett Jr, John R; Botteron, Kelly N; Estes, Annette M; Dager, Stephen R; Hazlett, Heather C; Schultz, Robert T; Piven, Joseph; Wolff, Jason J; IBIS Network	July 2020	Not Determined
32140983	Create Study	Sleep Problems and Trajectories of Restricted and Repetitive Behaviors in Children with Neurodevelopmental Disabilities.	Journal of autism and developmental disorders	MacDuffie, Katherine E; Munson, Jeffrey; Greenson, Jessica; Ward, Teresa M; Rogers, Sally J; Dawson, Geraldine; Estes, Annette	November 1, 2020	Not Determined
32024459	Create Study	Quantitative trait variation in ASD probands and toddler sibling outcomes at 24 months.	Journal of neurodevelopmental disorders	Girault, Jessica B; Swanson, Meghan R; Meera, Shoba S; Grzadzinski, Rebecca L; Shen, Mark D; Burrows, Catherine A; Wolff, Jason J; Pandey, Juhi; John, Tanya St; Estes, Annette; Zwaigenbaum, Lonnie; Botteron, Kelly N; Hazlett, Heather C; Dager, Stephen R; Schultz, Robert T; Constantino, John N; Piven, Joseph; IBIS Network	February 2020	Not Determined
31839003	Create Study	White matter as a monitoring biomarker for neurodevelopmental disorder intervention studies.	Journal of neurodevelopmental disorders	Swanson, Meghan R; Hazlett, Heather C	December 2019	Not Determined
31764985	Create Study	"If He Has it, We Know What to Do": Parent Perspectives on Familial Risk for Autism Spectrum Disorder.	Journal of pediatric psychology	MacDuffie, Katherine E; Turner-Brown, Lauren; Estes, Annette M; Wilfond, Benjamin S; Dager, Stephen R; Pandey, Juhi; Zwaigenbaum, Lonnie; Botteron, Kelly N; Pruett, John R; Piven, Joseph; Peay, Holly L; IBIS Network	March 2020	Not Determined
31759576	Create Study	The Neurodevelopment of Autism from Infancy Through Toddlerhood.	Neuroimaging clinics of North America	Girault, Jessica B; Piven, Joseph	February 2020	Not Determined
31254329	Create Study	Early language exposure supports later language skills in infants with and without autism.	Autism research : official journal of the International Society for Autism Research	Swanson, Meghan R; Donovan, Kevin; Paterson, Sarah; Wolff, Jason J; Parish-Morris, Julia; Meera, Shoba S; Watson, Linda R; Estes, Annette M; Marrus, Natasha; Elison, Jed T; Shen, Mark D; McNeilly, Heidi B; MacIntyre, Leigh; Zwaigenbaum, Lonnie; St John, Tanya; Botteron, Kelly; Dager, Stephen; Piven, Joseph; IBIS Network	December 2019	Not Determined
31229667	Create Study	Role of deep learning in infant brain MRI analysis.	Magnetic resonance imaging	Mostapha, Mahmoud; Styner, Martin	December 2019	Not Determined
31172134	Create Study	Exploratory Population Analysis with Unbalanced Optimal Transport.	Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention	Gerber S, Niethammer M, Styner M, Aylward S	September 2018	Not Determined
30993502	Create Study	The Importance of Temperament for Understanding Early Manifestations of Autism Spectrum Disorder in High-Risk Infants.	Journal of autism and developmental disorders	Paterson, Sarah J; Wolff, Jason J; Elison, Jed T; Winder-Patel, Breanna; Zwaigenbaum, Lonnie; Estes, Annette; Pandey, Juhi; Schultz, Robert T; Botteron, Kelly; Dager, Stephen R; Hazlett, Heather C; Piven, Joseph; IBIS Network	July 1, 2019	Not Determined
30628809	Create Study	Early motor abilities in infants at heightened versus low risk for ASD: A Baby Siblings Research Consortium (BSRC) study.	Journal of abnormal psychology	Iverson, Jana M; Shic, Frederick; Wall, Carla A; Chawarska, Katarzyna; Curtin, Suzanne; Estes, Annette; Gardner, Judith M; Hutman, Ted; Landa, Rebecca J; Levin, April R; Libertus, Klaus; Messinger, Daniel S; Nelson, Charles A; Ozonoff, Sally; Sacrey, Lori-Ann R; Sheperd, Kelly; Stone, Wendy L; Tager-Flusberg, Helen B; Wolff, Jason J; Yirmiya, Nurit; Young, Gregory S	January 2019	Not Determined
30541429	Create Study	Cerebrospinal fluid and the early brain development of autism.	Journal of neurodevelopmental disorders	Shen, Mark D	December 2018	Not Relevant
30446435	Create Study	Restricted and Repetitive Behavior and Brain Functional Connectivity in Infants at Risk for Developing Autism Spectrum Disorder.	Biological psychiatry. Cognitive neuroscience and neuroimaging	Mckinnon CJ, Eggebrecht AT, Todorov A, Wolff JJ, Elison JT, Adams CM, Snyder AZ, Estes AM, Zwaigenbaum L, Botteron KN, Mckinstry RC, Marrus N, Evans A, Hazlett HC, Dager SR, Paterson SJ, Pandey J, Schultz RT, Styner MA, Gerig G, Schlaggar BL, Petersen SE, Piven J, Pruett JR,	January 2019	Not Determined
30364770	Create Study	NON-EUCLIDEAN, CONVOLUTIONAL LEARNING ON CORTICAL BRAIN SURFACES.	Proceedings. IEEE International Symposium on Biomedical Imaging	Mostapha, Mahmoud; Kim, SunHyung; Wu, Guorong; Zsembik, Leo; Pizer, Stephen; Styner, Martin	April 2018	Not Relevant
30364673	Create Study	A Novel Framework for the Local Extraction of Extra-Axial Cerebrospinal Fluid from MR Brain Images.	Proceedings of SPIE--the International Society for Optical Engineering	Mostapha, Mahmoud; Shen, Mark D; Kim, SunHyung; Swanson, Meghan; Collins, D Louis; Fonov, Vladimir; Gerig, Guido; Piven, Joseph; Styner, Martin A; IBIS Network	March 2018	Not Relevant
30350375	Create Study	A longitudinal study of parent-reported sensory responsiveness in toddlers at-risk for autism.	Journal of child psychology and psychiatry, and allied disciplines	Wolff, Jason J; Dimian, Adele F; Botteron, Kelly N; Dager, Stephen R; Elison, Jed T; Estes, Annette M; Hazlett, Heather C; Schultz, Robert T; Zwaigenbaum, Lonnie; Piven, Joseph; IBIS Network	March 2019	Not Relevant
30348077	Create Study	Language delay aggregates in toddler siblings of children with autism spectrum disorder.	Journal of neurodevelopmental disorders	Marrus, N; Hall, L P; Paterson, S J; Elison, J T; Wolff, J J; Swanson, M R; Parish-Morris, J; Eggebrecht, A T; Pruett Jr, J R; Hazlett, H C; Zwaigenbaum, L; Dager, S; Estes, A M; Schultz, R T; Botteron, K N; Piven, J; Constantino, J N; IBIS Network	October 2018	Not Relevant
30153278	Create Study	Rapid face orienting in infants and school-age children with and without autism: Exploring measurement invariance in eye-tracking.	PloS one	Dalrymple, Kirsten A; Wall, Natalie; Spezio, Michael; Hazlett, Heather C; Piven, Joseph; Elison, Jed T	January 2018	Not Determined
29780197	Create Study	TRAFIC: Fiber Tract Classification Using Deep Learning.	Proceedings of SPIE--the International Society for Optical Engineering	Ngattai Lam, Prince D; Belhomme, Gaetan; Ferrall, Jessica; Patterson, Billie; Styner, Martin; Prieto, Juan C	February 2018	Not Relevant
29617515	Create Study	Development of White Matter Circuitry in Infants With Fragile X Syndrome.	JAMA psychiatry	Swanson, Meghan R; Wolff, Jason J; Shen, Mark D; Styner, Martin; Estes, Annette; Gerig, Guido; McKinstry, Robert C; Botteron, Kelly N; Piven, Joseph; Hazlett, Heather C; Infant Brain Imaging Study (IBIS) Network	May 2018	Not Relevant
29560900	Create Study	Subcortical Brain and Behavior Phenotypes Differentiate Infants With Autism Versus Language Delay.	Biological psychiatry. Cognitive neuroscience and neuroimaging	Swanson, Meghan R; Shen, Mark D; Wolff, Jason J; Elison, Jed T; Emerson, Robert W; Styner, Martin A; Hazlett, Heather C; Truong, Kinh; Watson, Linda R; Paterson, Sarah; Marrus, Natasha; Botteron, Kelly N; Pandey, Juhi; Schultz, Robert T; Dager, Stephen R; Zwaigenbaum, Lonnie; Estes, Annette M; Piven, Joseph; IBIS Network	November 2017	Not Relevant
29492184	Create Study	Compressive Sensing Based Q-Space Resampling for Handling Fast Bulk Motion in Hardi Acquisitions.	Proceedings. IEEE International Symposium on Biomedical Imaging	Elhabian, Shireen; Vachet, Clement; Piven, Joseph; for IBIS; Styner, Martin; Gerig, Guido	January 2016	Not Relevant
29398928	Create Study	Brain and behavior development in autism from birth through infancy.	Dialogues in clinical neuroscience	Shen, Mark D; Piven, Joseph	December 2017	Not Relevant
29353953	Create Study	A Segmentation Editing Framework Based on Shape Change Statistics.	Proceedings of SPIE--the International Society for Optical Engineering	Mostapha, Mahmoud; Vicory, Jared; Styner, Martin; Pizer, Stephen	January 2017	Not Relevant
29296026	Create Study	Toward a conceptual framework for early brain and behavior development in autism.	Molecular psychiatry	Piven, J; Elison, J T; Zylka, M J	January 2018	Not Relevant
29186388	Create Study	Walking, Gross Motor Development, and Brain Functional Connectivity in Infants and Toddlers.	Cerebral cortex (New York, N.Y. : 1991)	Marrus, Natasha; Eggebrecht, Adam T; Todorov, Alexandre; Elison, Jed T; Wolff, Jason J; Cole, Lyndsey; Gao, Wei; Pandey, Juhi; Shen, Mark D; Swanson, Meghan R; Emerson, Robert W; Klohr, Cheryl L; Adams, Chloe M; Estes, Annette M; Zwaigenbaum, Lonnie; Botteron, Kelly N; McKinstry, Robert C; Constantino, John N; Evans, Alan C; Hazlett, Heather C; Dager, Stephen R; Paterson, Sarah J; Schultz, Robert T; Styner, Martin A; Gerig, Guido; IBIS Network; Schlaggar, Bradley L; Piven, Joseph; Pruett Jr, John R	February 2018	Not Relevant
29149191	Create Study	Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness.	PloS one	Mitra, Anish; Snyder, Abraham Z; Tagliazucchi, Enzo; Laufs, Helmut; Elison, Jed; Emerson, Robert W; Shen, Mark D; Wolff, Jason J; Botteron, Kelly N; Dager, Stephen; Estes, Annette M; Evans, Alan; Gerig, Guido; Hazlett, Heather C; Paterson, Sarah J; Schultz, Robert T; Styner, Martin A; Zwaigenbaum, Lonnie; IBIS Network; Schlaggar, Bradley L; Piven, Joseph; Pruett Jr, John R; Raichle, Marcus	January 2017	Not Relevant
29090080	Create Study	Critical region within 22q11.2 linked to higher rate of autism spectrum disorder.	Molecular autism	Clements, Caitlin C; Wenger, Tara L; Zoltowski, Alisa R; Bertollo, Jennifer R; Miller, Judith S; de Marchena, Ashley B; Mitteer, Lauren M; Carey, John C; Yerys, Benjamin E; Zackai, Elaine H; Emanuel, Beverly S; McDonald-McGinn, Donna M; Schultz, Robert T	January 2017	Not Relevant
28937691	Create Study	Toward a conceptual framework for early brain and behavior development in autism.	Molecular psychiatry	Piven, J; Elison, J T; Zylka, M J	October 2017	Not Relevant
28931307	Create Study	Autism spectrum disorder screening with the CBCL/1½-5: Findings for young children at high risk for autism spectrum disorder.	Autism : the international journal of research and practice	Rescorla, Leslie A; Winder-Patel, Breanna M; Paterson, Sarah J; Pandey, Juhi; Wolff, Jason J; Schultz, Robert T; Piven, Joseph	January 2019	Not Relevant
28889315	Create Study	Brief Report: Executive Function as a Predictor of Academic Achievement in School-Aged Children with ASD.	Journal of autism and developmental disorders	St John, Tanya; Dawson, Geraldine; Estes, Annette	January 2018	Not Relevant
28838582	Create Study	Cost Offset Associated With Early Start Denver Model for Children With Autism.	Journal of the American Academy of Child and Adolescent Psychiatry	Cidav Z, Munson J, Estes A, Dawson G, Rogers S, Mandell D	September 2017	Not Determined
28705497	Create Study	Quicksilver: Fast predictive image registration - A deep learning approach.	NeuroImage	Yang, Xiao; Kwitt, Roland; Styner, Martin; Niethammer, Marc	September 2017	Not Relevant
28634707	Create Study	Parent Support of Preschool Peer Relationships in Younger Siblings of Children with Autism Spectrum Disorder.	Journal of autism and developmental disorders	Estes, Annette; Munson, Jeffrey; John, Tanya St; Dager, Stephen R; Rodda, Amy; Botteron, Kelly; Hazlett, Heather; Schultz, Robert T; Zwaigenbaum, Lonnie; Piven, Joseph; Guralnick, Michael J; IBIS network	April 2018	Not Relevant
28592562	Create Study	Functional neuroimaging of high-risk 6-month-old infants predicts a diagnosis of autism at 24 months of age.	Science translational medicine	Emerson, Robert W; Adams, Chloe; Nishino, Tomoyuki; Hazlett, Heather Cody; Wolff, Jason J; Zwaigenbaum, Lonnie; Constantino, John N; Shen, Mark D; Swanson, Meghan R; Elison, Jed T; Kandala, Sridhar; Estes, Annette M; Botteron, Kelly N; Collins, Louis; Dager, Stephen R; Evans, Alan C; Gerig, Guido; Gu, Hongbin; McKinstry, Robert C; Paterson, Sarah; Schultz, Robert T; Styner, Martin; IBIS Network; Schlaggar, Bradley L; Pruett Jr, John R; Piven, Joseph	June 2017	Not Relevant
28460842	Create Study	The Emergence of Network Inefficiencies in Infants With Autism Spectrum Disorder.	Biological psychiatry	Lewis, John D; Evans, Alan C; Pruett Jr, John R; Botteron, Kelly N; McKinstry, Robert C; Zwaigenbaum, Lonnie; Estes, Annette M; Collins, D Louis; Kostopoulos, Penelope; Gerig, Guido; Dager, Stephen R; Paterson, Sarah; Schultz, Robert T; Styner, Martin A; Hazlett, Heather C; Piven, Joseph; Infant Brain Imaging Study Network	August 1, 2017	Not Relevant
28399476	Create Study	Geodesic shape regression with multiple geometries and sparse parameters.	Medical image analysis	Fishbaugh J, Durrleman S, Prastawa M, Gerig G	July 2017	Not Relevant
28392081	Create Study	Increased Extra-axial Cerebrospinal Fluid in High-Risk Infants Who Later Develop Autism.	Biological psychiatry	Shen, Mark D; Kim, Sun Hyung; McKinstry, Robert C; Gu, Hongbin; Hazlett, Heather C; Nordahl, Christine W; Emerson, Robert W; Shaw, Dennis; Elison, Jed T; Swanson, Meghan R; Fonov, Vladimir S; Gerig, Guido; Dager, Stephen R; Botteron, Kelly N; Paterson, Sarah; Schultz, Robert T; Evans, Alan C; Estes, Annette M; Zwaigenbaum, Lonnie; Styner, Martin A; Amaral, David G; Piven, J; Hazlett, H C; Chappell, C; Dager, S; Estes, A; Shaw, D; Botteron, K; McKinstry, R; Constantino, J; Pruett, J; Schultz, R; Zwaigenbaum, L; Elison, J; Evans, A C; Collins, D L; Pike, G B; Fonov, V; Kostopoulos, P; Das, S; Gerig, G; Styner, M; Gu, H; Piven, Joseph; Infant Brain Imaging Study Network	August 2017	Not Relevant
28316772	Create Study	Neural circuitry at age 6 months associated with later repetitive behavior and sensory responsiveness in autism.	Molecular autism	Wolff, Jason J; Swanson, Meghan R; Elison, Jed T; Gerig, Guido; Pruett Jr, John R; Styner, Martin A; Vachet, Clement; Botteron, Kelly N; Dager, Stephen R; Estes, Annette M; Hazlett, Heather C; Schultz, Robert T; Shen, Mark D; Zwaigenbaum, Lonnie; Piven, Joseph; IBIS Network	January 2017	Not Relevant
28295208	Create Study	Naturalistic Language Recordings Reveal "Hypervocal" Infants at High Familial Risk for Autism.	Child development	Swanson, Meghan R; Shen, Mark D; Wolff, Jason J; Boyd, Brian; Clements, Mark; Rehg, James; Elison, Jed T; Paterson, Sarah; Parish-Morris, Julia; Chappell, J Chad; Hazlett, Heather C; Emerson, Robert W; Botteron, Kelly; Pandey, Juhi; Schultz, Robert T; Dager, Stephen R; Zwaigenbaum, Lonnie; Estes, Annette M; Piven, Joseph; IBIS Network	March 2018	Not Relevant
28202961	Create Study	Early brain development in infants at high risk for autism spectrum disorder.	Nature	Hazlett, Heather Cody; Gu, Hongbin; Munsell, Brent C; Kim, Sun Hyung; Styner, Martin; Wolff, Jason J; Elison, Jed T; Swanson, Meghan R; Zhu, Hongtu; Botteron, Kelly N; Collins, D Louis; Constantino, John N; Dager, Stephen R; Estes, Annette M; Evans, Alan C; Fonov, Vladimir S; Gerig, Guido; Kostopoulos, Penelope; McKinstry, Robert C; Pandey, Juhi; Paterson, Sarah; Pruett, John R; Schultz, Robert T; Shaw, Dennis W; Zwaigenbaum, Lonnie; Piven, Joseph; IBIS Network; Clinical Sites; Data Coordinating Center; Image Processing Core; Statistical Analysis	February 2017	Not Relevant
27791287	Create Study	Diffusion tensor spectroscopic imaging of the human brain in children and adults.	Magnetic resonance in medicine	Fotso K, Dager SR, Landow A, Ackley E, Myers O, Dixon M, Shaw D, Corrigan NM, Posse S	October 2016	Not Relevant
27497283	Create Study	A touchscreen based global motion perception task for mice.	Vision research	Stirman JN, Townsend LB, Smith SL	October 2016	Not Relevant
27344938	Create Study	Longitudinal modeling of appearance and shape and its potential for clinical use.	Medical image analysis	Gerig, Guido; Fishbaugh, James; Sadeghi, Neda	October 2016	Not Relevant
27150231	Create Study	Development of cortical shape in the human brain from 6 to 24months of age via a novel measure of shape complexity.	NeuroImage	Kim, Sun Hyung; Lyu, Ilwoo; Fonov, Vladimir S; Vachet, Clement; Hazlett, Heather C; Smith, Rachel G; Piven, Joseph; Dager, Stephen R; Mckinstry, Robert C; Pruett Jr, John R; Evans, Alan C; Collins, D Louis; Botteron, Kelly N; Schultz, Robert T; Gerig, Guido; Styner, Martin A; IBIS Network	July 15, 2016	Not Relevant
27065227	Create Study	Autotract: Automatic cleaning and tracking of fibers.	Proceedings of SPIE--the International Society for Optical Engineering	Prieto, Juan C; Yang, Jean Y; Budin, François; Styner, Martin	February 27, 2016	Not Relevant
26731103	Create Study	The Macaque Social Responsiveness Scale (mSRS): A Rapid Screening Tool for Assessing Variability in the Social Responsiveness of Rhesus Monkeys (Macaca mulatta).	PloS one	Feczko, Eric J; Bliss-Moreau, Eliza; Walum, Hasse; Pruett Jr, John R; Parr, Lisa A	2016	Not Relevant
26612964	Create Study	Early Postnatal Myelin Content Estimate of White Matter via T1w/T2w Ratio.	Proceedings of SPIE--the International Society for Optical Engineering	Lee, Kevin; Cherel, Marie; Budin, Francois; Gilmore, John; Consing, Kirsten Zaldarriaga; Rasmussen, Jerod; Wadhwa, Pathik D; Entringer, Sonja; Glasser, Matthew F; Van Essen, David C; Buss, Claudia; Styner, Martin	2015	Not Relevant
26490257	Create Study	Splenium development and early spoken language in human infants.	Developmental science	Swanson MR, Wolff JJ, Elison JT, Gu H, Hazlett HC, Botteron K, Styner M, Paterson S, Gerig G, Constantino J, Dager S, Estes A, Vachet C, Piven J, IBIS Network	October 21, 2015	Not Relevant
26203305	Create Study	Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life.	Journal of neurodevelopmental disorders	Estes, Annette; Zwaigenbaum, Lonnie; Gu, Hongbin; St John, Tanya; Paterson, Sarah; Elison, Jed T; Hazlett, Heather; Botteron, Kelly; Dager, Stephen R; Schultz, Robert T; Kostopoulos, Penelope; Evans, Alan; Dawson, Geraldine; Eliason, Jordana; Alvarez, Shanna; Piven, Joseph; IBIS network	2015	Not Relevant
26113807	Create Study	Robust estimation of group-wise cortical correspondence with an application to macaque and human neuroimaging studies.	Frontiers in neuroscience	Lyu, Ilwoo; Kim, Sun H; Seong, Joon-Kyung; Yoo, Sang W; Evans, Alan; Shi, Yundi; Sanchez, Mar; Niethammer, Marc; Styner, Martin A	January 1, 2015	Not Determined
26089584	Create Study	Automatic Tissue Segmentation of Neonate Brain MR Images with Subject-specific Atlases.	Proceedings of SPIE--the International Society for Optical Engineering	Cherel, Marie; Budin, Francois; Prastawa, Marcel; Gerig, Guido; Lee, Kevin; Buss, Claudia; Lyall, Amanda; Consing, Kirsten Zaldarriaga; Styner, Martin	February 21, 2015	Not Relevant
26088663	Create Study	Long-Term Outcomes of Early Intervention in 6-Year-Old Children With Autism Spectrum Disorder.	Journal of the American Academy of Child and Adolescent Psychiatry	Estes, Annette; Munson, Jeffrey; Rogers, Sally J; Greenson, Jessica; Winter, Jamie; Dawson, Geraldine	July 2015	Not Relevant
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26028803	Create Study	Shape index distribution based local surface complexity applied to the human cortex.	Proceedings of SPIE--the International Society for Optical Engineering	Kim, Sun Hyung; Fonov, Vladimir; Collins, D Louis; Gerig, Guido; IBIS Network; Styner, Martin A	2015	Not Relevant
26028801	Create Study	Automatic Sulcal Curve Extraction on the Human Cortical Surface.	Proceedings of SPIE--the International Society for Optical Engineering	Lyu, Ilwoo; Kim, Sun Hyung; Styner, Martin	2015	Not Relevant
25937563	Create Study	Altered corpus callosum morphology associated with autism over the first 2 years of life.	Brain : a journal of neurology	Wolff JJ, Gerig G, Lewis JD, Soda T, Styner MA, Vachet C, Botteron KN, Elison JT, Dager SR, Estes AM, Hazlett HC, Schultz RT, Zwaigenbaum L, Piven J,	July 2015	Not Relevant
25704288	Create Study	Accurate age classification of 6 and 12 month-old infants based on resting-state functional connectivity magnetic resonance imaging data.	Developmental cognitive neuroscience	Pruett Jr, John R; Kandala, Sridhar; Hoertel, Sarah; Snyder, Abraham Z; Elison, Jed T; Nishino, Tomoyuki; Feczko, Eric; Dosenbach, Nico U F; Nardos, Binyam; Power, Jonathan D; Adeyemo, Babatunde; Botteron, Kelly N; McKinstry, Robert C; Evans, Alan C; Hazlett, Heather C; Dager, Stephen R; Paterson, Sarah; Schultz, Robert T; Collins, D Louis; Fonov, Vladimir S; Styner, Martin; Gerig, Guido; Das, Samir; Kostopoulos, Penelope; Constantino, John N; Estes, Annette M; IBIS Network; Petersen, Steven E; Schlaggar, Bradley L; Piven, Joseph	April 2015	Not Relevant
25664349	Create Study	Geodesic image regression with a sparse parameterization of diffeomorphisms.	Geometric science of information : first international conference, GSI 2013, Paris, France, August 28-30, 2013 : proceedings. Geometric Science of Information (1st : 2013 : Paris, France)	Fishbaugh, James; Prastawa, Marcel; Gerig, Guido; Durrleman, Stanley	2013	Not Relevant
25538672	Create Study	Subject-Motion Correction in HARDI Acquisitions: Choices and Consequences.	Frontiers in neurology	Elhabian, Shireen; Gur, Yaniv; Vachet, Clement; Piven, Joseph; Styner, Martin; Leppert, Ilana R; Pike, G Bruce; Gerig, Guido	2014	Not Relevant
25506622	Create Study	Mixed-Effects Shape Models for Estimating Longitudinal Changes in Anatomy.	Spatio-temporal image analysis for longitudinal and time-series image data : Second International Workshop, STIA 2012, held in conjunction with MICCAI 2012, Nice, France, October 1, 2012, proceedings. STIA (Conference) (2nd : 2012 : Nic...	Datar, Manasi; Muralidharan, Prasanna; Kumar, Abhishek; Gouttard, Sylvain; Piven, Joseph; for the IBIS Network; Gerig, Guido; Whitaker, Ross; Fletcher, P Thomas	October 2012	Not Relevant
25440311	Create Study	Repetitive behavior in 12-month-olds later classified with autism spectrum disorder.	Journal of the American Academy of Child and Adolescent Psychiatry	Elison JT, Wolff JJ, Reznick JS, Botteron KN, Estes AM, Gu H, Hazlett HC, Meadows AJ, Paterson SJ, Zwaigenbaum L, Piven J, Infant Brain Imaging Study (IBIS) Network	November 2014	Not Relevant
25356196	Create Study	A JOINT FRAMEWORK FOR 4D SEGMENTATION AND ESTIMATION OF SMOOTH TEMPORAL APPEARANCE CHANGES.	Proceedings. IEEE International Symposium on Biomedical Imaging	Gao, Yang; Prastawa, Marcel; Styner, Martin; Piven, Joseph; Gerig, Guido	April 2014	Not Relevant
25356195	Create Study	A PRELIMINARY STUDY ON THE EFFECT OF MOTION CORRECTION ON HARDI RECONSTRUCTION.	Proceedings. IEEE International Symposium on Biomedical Imaging	Elhabian, Shireen; Gur, Yaniv; Vachet, Clement; Piven, Joseph; Styner, Martin; Leppert, Ilana; Pike, G Bruce; Gerig, Guido	April 2014	Not Relevant
25356194	Create Study	PARAMETRIC REGRESSION SCHEME FOR DISTRIBUTIONS: ANALYSIS OF DTI FIBER TRACT DIFFUSION CHANGES IN EARLY BRAIN DEVELOPMENT.	Proceedings. IEEE International Symposium on Biomedical Imaging	Sharma, Anuja; Fletcher, P Thomas; Gilmore, John H; Escolar, Maria L; Gupta, Aditya; Styner, Martin; Gerig, Guido	April 2014	Not Relevant
25356192	Create Study	GEODESIC REGRESSION OF IMAGE AND SHAPE DATA FOR IMPROVED MODELING OF 4D TRAJECTORIES.	Proceedings. IEEE International Symposium on Biomedical Imaging	Fishbaugh, James; Prastawa, Marcel; Gerig, Guido; Durrleman, Stanley	April 2014	Not Relevant
25320779	Create Study	Subject-specific prediction using nonlinear population modeling: application to early brain maturation from DTI.	Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention	Sadeghi N, Fletcher PT, Prastawa M, Gilmore JH, Gerig G	2014	Not Relevant
25312279	Create Study	Brief Report: Chimpanzee Social Responsiveness Scale (CSRS) Detects Individual Variation in Social Responsiveness for Captive Chimpanzees.	Journal of autism and developmental disorders	Faughn, Carley; Marrus, Natasha; Shuman, Jeremy; Ross, Stephen R; Constantino, John N; Pruett Jr, John R; Povinelli, Daniel J	May 2015	Not Relevant
25309699	Create Study	Characterizing growth patterns in longitudinal MRI using image contrast.	Proceedings of SPIE--the International Society for Optical Engineering	Vardhan, Avantika; Prastawa, Marcel; Vachet, Clement; Piven, Joseph; Gerig, Guido	March 21, 2014	Not Relevant
25103541	Create Study	Striatal development in autism: repetitive behaviors and the reward circuitry.	Biological psychiatry	Kohls G, Yerys BE, Schultz RT	September 1, 2014	Not Relevant
24802306	Create Study	Network inefficiencies in autism spectrum disorder at 24 months.	Translational psychiatry	Lewis, J D; Evans, A C; Pruett, J R; Botteron, K; Zwaigenbaum, L; Estes, A; Gerig, G; Collins, L; Kostopoulos, P; McKinstry, R; Dager, S; Paterson, S; Schultz, R T; Styner, M; Hazlett, H; Piven, J	2014	Not Relevant
24684012	Create Study	Geodesic shape regression in the framework of currents.	Information processing in medical imaging : proceedings of the ... conference	Fishbaugh, James; Prastawa, Marcel; Gerig, Guido; Durrleman, Stanley	2013	Not Relevant
24655647	Create Study	BAP: not-quite-autism in infants.	Journal of the American Academy of Child and Adolescent Psychiatry	Pruett JR	April 2014	Not Relevant
24567717	Create Study	Multi-atlas segmentation of subcortical brain structures via the AutoSeg software pipeline.	Frontiers in neuroinformatics	Wang, Jiahui; Vachet, Clement; Rumple, Ashley; Gouttard, Sylvain; Ouziel, Clémentine; Perrot, Emilie; Du, Guangwei; Huang, Xuemei; Gerig, Guido; Styner, Martin	2014	Not Relevant
24552513	Create Study	Longitudinal patterns of repetitive behavior in toddlers with autism.	Journal of child psychology and psychiatry, and allied disciplines	Wolff JJ, Botteron KN, Dager SR, Elison JT, Estes AM, Gu H, Hazlett HC, Pandey J, Paterson SJ, Schultz RT, Zwaigenbaum L, Piven J, IBIS Network	August 2014	Not Relevant
24523693	Create Study	DTIPrep: quality control of diffusion-weighted images.	Frontiers in neuroinformatics	Oguz, Ipek; Farzinfar, Mahshid; Matsui, Joy; Budin, Francois; Liu, Zhexing; Gerig, Guido; Johnson, Hans J; Styner, Martin	2014	Not Relevant
24466504	Create Study	Uncertainty Visualization in HARDI based on Ensembles of ODFs.	IEEE Pacific Visualization Symposium : [proceedings]. IEEE Pacific Visualisation Symposium	Jiao, Fangxiang; Phillips, Jeff M; Gur, Yaniv; Johnson, Chris R	December 31, 2012	Not Determined
24443698	Create Study	MODELING LONGITUDINAL MRI CHANGES IN POPULATIONS USING A LOCALIZED, INFORMATION-THEORETIC MEASURE OF CONTRAST.	Proceedings. IEEE International Symposium on Biomedical Imaging	Vardhan, Avantika; Prastawa, Marcel; Sharma, Anuja; Piven, Joseph; Gerig, Guido	December 31, 2013	Not Relevant
24443688	Create Study	SPATIOTEMPORAL MODELING OF DISCRETE-TIME DISTRIBUTION-VALUED DATA APPLIED TO DTI TRACT EVOLUTION IN INFANT NEURODEVELOPMENT.	Proceedings. IEEE International Symposium on Biomedical Imaging	Sharma, Anuja; Fletcher, P Thomas; Gilmore, John H; Escolar, Maria L; Gupta, Aditya; Styner, Martin; Gerig, Guido	December 31, 2013	Not Relevant
24443681	Create Study	LONGITUDINAL GROWTH MODELING OF DISCRETE-TIME FUNCTIONS WITH APPLICATION TO DTI TRACT EVOLUTION IN EARLY NEURODEVELOPMENT.	Proceedings. IEEE International Symposium on Biomedical Imaging	Sharma, Anuja; Durrleman, Stanley; Gilmore, John H; Gerig, Guido	December 31, 2013	Not Relevant
24409141	Create Study	UNC-Utah NA-MIC framework for DTI fiber tract analysis.	Frontiers in neuroinformatics	Verde, Audrey R; Budin, Francois; Berger, Jean-Baptiste; Gupta, Aditya; Farzinfar, Mahshid; Kaiser, Adrien; Ahn, Mihye; Johnson, Hans; Matsui, Joy; Hazlett, Heather C; Sharma, Anuja; Goodlett, Casey; Shi, Yundi; Gouttard, Sylvain; Vachet, Clement; Piven, Joseph; Zhu, Hongtu; Gerig, Guido; Styner, Martin	2014	Not Relevant
24392201	Create Study	A framework for longitudinal data analysis via shape regression.	Proceedings of SPIE--the International Society for Optical Engineering	Fishbaugh, James; Durrleman, Stanley; Piven, Joseph; Gerig, Guido	February 23, 2012	Not Relevant
24386543	Create Study	UNC-Utah NA-MIC DTI framework: Atlas Based Fiber Tract Analysis with Application to a Study of Nicotine Smoking Addiction.	Proceedings of SPIE--the International Society for Optical Engineering	Verde, Audrey R; Berger, Jean-Baptiste; Gupta, Aditya; Farzinfar, Mahshid; Kaiser, Adrien; Chanon, Vicki W; Boettiger, Charlotte; Goodlett, Casey; Shi, Yundi; Zhu, Hongtu; Gerig, Guido; Gouttard, Sylvain; Vachet, Clement; Styner, Martin	March 13, 2013	Not Relevant
24353382	Create Study	Automatic corpus callosum segmentation using a deformable active Fourier contour model.	Proceedings of SPIE--the International Society for Optical Engineering	Vachet, Clement; Yvernault, Benjamin; Bhatt, Kshamta; Smith, Rachel G; Gerig, Guido; Hazlett, Heather Cody; Styner, Martin	March 23, 2012	Not Relevant
24353381	Create Study	Measures for Validation of DTI Tractography.	Proceedings of SPIE--the International Society for Optical Engineering	Gouttard, Sylvain; Goodlett, Casey B; Kubicki, Marek; Gerig, Guido	February 23, 2012	Not Relevant
24353379	Create Study	Quality Control of Diffusion Weighted Images.	Proceedings of SPIE--the International Society for Optical Engineering	Liu, Zhexing; Wang, Yi; Gerig, Guido; Gouttard, Sylvain; Tao, Ran; Fletcher, Thomas; Styner, Martin	March 11, 2010	Not Relevant
24353378	Create Study	Changes of MR and DTI appearance in early human brain development.	Proceedings of SPIE--the International Society for Optical Engineering	Marc, Cassian; Vachet, Clement; Gerig, Guido; Blocher, Joseph; Gilmore, John; Styner, Martin	March 12, 2010	Not Relevant
24353377	Create Study	Evaluation of DTI Property Maps as Basis of DTI Atlas Building.	Proceedings of SPIE--the International Society for Optical Engineering	Liu, Zhexing; Goodlett, Casey; Gerig, Guido; Styner, Martin	March 12, 2010	Not Relevant
24353376	Create Study	Towards Analysis of Growth Trajectory through Multi-modal Longitudinal MR Imaging.	Proceedings of SPIE--the International Society for Optical Engineering	Sadeghi, Neda; Prastawa, Marcel; Gilmore, John H; Lin, Weili; Gerig, Guido	March 12, 2010	Not Relevant
24069234	Create Study	Age-specific average head template for typically developing 6-month-old infants.	PloS one	Akiyama, Lisa F; Richards, Todd R; Imada, Toshiaki; Dager, Stephen R; Wroblewski, Liv; Kuhl, Patricia K	2013	Not Relevant
23959506	Create Study	MULTIVARIATE MODELING OF LONGITUDINAL MRI IN EARLY BRAIN DEVELOPMENT WITH CONFIDENCE MEASURES.	Proceedings. IEEE International Symposium on Biomedical Imaging	Sadeghi, Neda; Prastawa, Marcel; Fletcher, P Thomas; Vachet, Clement; Wang, Bo; Gilmore, John; Gerig, Guido	2013	Not Relevant
23959442	Create Study	A NEW FRAMEWORK FOR ANALYZING WHITE MATTER MATURATION IN EARLY BRAIN DEVELOPMENT.	Proceedings. IEEE International Symposium on Biomedical Imaging	Prastawa, Marcel; Sadeghi, Neda; Gilmore, John H; Lin, Weili; Gerig, Guido	2010	Not Relevant
23958630	Create Study	QUANTIFYING REGIONAL GROWTH PATTERNS THROUGH LONGITUDINAL ANALYSIS OF DISTANCES BETWEEN MULTIMODAL MR INTENSITY DISTRIBUTIONS.	Proceedings. IEEE International Symposium on Biomedical Imaging	Vardhan, Avantika; Prastawa, Marcel; Gouttard, Sylvain; Piven, Joseph; Gerig, Guido	2012	Not Relevant
23956495	Create Study	Toward a comprehensive framework for the spatiotemporal statistical analysis of longitudinal shape data.	International journal of computer vision	Durrleman, S; Pennec, X; Trouvé, A; Braga, J; Gerig, G; Ayache, N	May 2013	Not Relevant
23846465	Create Study	Longitudinal image registration with temporally-dependent image similarity measure.	IEEE transactions on medical imaging	Csapo I, Davis B, Shi Y, Sanchez M, Styner M, Niethammer M	October 2013	Not Relevant
23833547	Create Study	DTI Quality Control Assessment via Error Estimation From Monte Carlo Simulations.	Proceedings of SPIE--the International Society for Optical Engineering	Farzinfar, Mahshid; Li, Yin; Verde, Audrey R; Oguz, Ipek; Gerig, Guido; Styner, Martin A	March 13, 2013	Not Relevant
23684874	Create Study	Diffusion imaging quality control via entropy of principal direction distribution.	NeuroImage	Farzinfar M, Oguz I, Smith RG, Verde AR, Dietrich C, Gupta A, Escolar ML, Piven J, Pujol S, Vachet C, Gouttard S, Gerig G, Dager S, McKinstry RC, Paterson S, Evans AC, IBIS network, Styner MA	November 15, 2013	Not Relevant
23595508	Create Study	ENTROPY BASED DTI QUALITY CONTROL VIA REGIONAL ORIENTATION DISTRIBUTION.	Proceedings. IEEE International Symposium on Biomedical Imaging	Farzinfar, M; Dietrich, C; Smith, Rg; Li, Y; Gupta, A; Liu, Z; Styner, Ma	2012	Not Relevant
23568185	Create Study	Building Spatiotemporal Anatomical Models using Joint 4-D Segmentation, Registration, and Subject-Specific Atlas Estimation.	Proceedings. Workshop on Mathematical Methods in Biomedical Image Analysis	Prastawa, Marcel; Awate, Suyash P; Gerig, Guido	2012	Not Relevant
23511344	Create Study	White matter microstructure and atypical visual orienting in 7-month-olds at risk for autism.	The American journal of psychiatry	Elison JT, Paterson SJ, Wolff JJ, Reznick JS, Sasson NJ, Gu H, Botteron KN, Dager SR, Estes AM, Evans AC, Gerig G, Hazlett HC, Schultz RT, Styner M, Zwaigenbaum L, Piven J, IBIS Network	August 2013	Not Relevant
23432829	Create Study	Frontolimbic neural circuitry at 6 months predicts individual differences in joint attention at 9 months.	Developmental science	Elison JT, Wolff JJ, Heimer DC, Paterson SJ, Gu H, Hazlett HC, Styner M, Gerig G, Piven J,	March 2013	Not Relevant
23285617	Create Study	Analysis of longitudinal shape variability via subject specific growth modeling.	Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention	Fishbaugh J, Prastawa M, Durrleman S, Piven J, Gerig G, IBIS Network	2012	Not Relevant
23235270	Create Study	Regional characterization of longitudinal DT-MRI to study white matter maturation of the early developing brain.	NeuroImage	Sadeghi, Neda; Prastawa, Marcel; Fletcher, P Thomas; Wolff, Jason; Gilmore, John H; Gerig, Guido	March 2013	Not Relevant
23223157	Create Study	SPATIAL INTENSITY PRIOR CORRECTION FOR TISSUE SEGMENTATION IN THE DEVELOPING HUMAN BRAIN.	Proceedings. IEEE International Symposium on Biomedical Imaging	Kim, Sun Hyung; Fonov, Vladimir; Piven, Joe; Gilmore, John; Vachet, Clement; Gerig, Guido; Collins, D Louis; Styner, Martin; The IBIS Network	2011	Not Relevant
23032117	Create Study	Adaptive prior probability and spatial temporal intensity change estimation for segmentation of the one-year-old human brain.	Journal of neuroscience methods	Kim SH, Fonov VS, Dietrich C, Vachet C, Hazlett HC, Smith RG, Graves MM, Piven J, Gilmore JH, Dager SR, Mckinstry RC, Paterson S, Evans AC, Collins DL, Gerig G, Styner MA,	January 2013	Not Relevant
22684595	Create Study	Brain volume findings in 6-month-old infants at high familial risk for autism.	The American journal of psychiatry	Hazlett HC, Gu H, McKinstry RC, Shaw DW, Botteron KN, Dager SR, Styner M, Vachet C, Gerig G, Paterson SJ, Schultz RT, Estes AM, Evans AC, Piven J, IBIS Network	June 2012	Not Relevant
22370873	Create Study	Consensus paper: pathological role of the cerebellum in autism.	Cerebellum (London, England)	Fatemi, S Hossein; Aldinger, Kimberly A; Ashwood, Paul; Bauman, Margaret L; Blaha, Charles D; Blatt, Gene J; Chauhan, Abha; Chauhan, Ved; Dager, Stephen R; Dickson, Price E; Estes, Annette M; Goldowitz, Dan; Heck, Detlef H; Kemper, Thomas L; King, Bryan H; Martin, Loren A; Millen, Kathleen J; Mittleman, Guy; Mosconi, Matthew W; Persico, Antonio M; Sweeney, John A; Webb, Sara J; Welsh, John P	September 2012	Not Relevant
22362397	Create Study	Differences in white matter fiber tract development present from 6 to 24 months in infants with autism.	The American journal of psychiatry	Wolff JJ, Gu H, Gerig G, Elison JT, Styner M, Gouttard S, Botteron KN, Dager SR, Dawson G, Estes AM, Evans AC, Hazlett HC, Kostopoulos P, Mckinstry RC, Paterson SJ, Schultz RT, Zwaigenbaum L, Piven J,	June 2012	Not Relevant
21995056	Create Study	Iterative refinement of point correspondences for 3D statistical shape models.	Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention	Seshamani S, Chintalapani G, Taylor R	2011	Not Relevant
21995054	Create Study	Estimation of smooth growth trajectories with controlled acceleration from time series shape data.	Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention	Fishbaugh J, Durrleman S, Gerig G	2011	Not Relevant
21761651	Create Study	Optimal data-driven sparse parameterization of diffeomorphisms for population analysis.	Information processing in medical imaging : proceedings of the ... conference	Durrleman, Sandy; Prastawa, Marcel; Gerig, Guido; Joshi, Sarang	January 2011	Not Relevant
21438139	Create Study	Mutations in the TSGA14 gene in families with autism spectrum disorders.	American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics	Korvatska, O; Estes, A; Munson, J; Dawson, G; Bekris, L M; Kohen, R; Yu, C-E; Schellenberg, G D; Raskind, W H	April 2011	Not Relevant
21256236	Create Study	DTI registration in atlas based fiber analysis of infantile Krabbe disease.	NeuroImage	Wang, Yi; Gupta, Aditya; Liu, Zhexing; Zhang, Hui; Escolar, Maria L; Gilmore, John H; Gouttard, Sylvain; Fillard, Pierre; Maltbie, Eric; Gerig, Guido; Styner, Martin	April 2011	Not Relevant
21244423	Create Study	Poor fine-motor and visuospatial skills predict persistence of pediatric-onset obsessive-compulsive disorder into adulthood.	Journal of child psychology and psychiatry, and allied disciplines	Bloch MH, Sukhodolsky DG, Dombrowski PA, Panza KE, Craiglow BG, Landeros-Weisenberger A, Leckman JF, Peterson BS, Schultz RT	September 2011	Not Relevant
21042871	Create Study	Discrepancies between academic achievement and intellectual ability in higher-functioning school-aged children with autism spectrum disorder.	Journal of autism and developmental disorders	Estes, Annette; Rivera, Vanessa; Bryan, Matthew; Cali, Philip; Dawson, Geraldine	August 2011	Not Relevant
21041620	Create Study	Laterobasal amygdalar enlargement in 6- to 7-year-old children with autism spectrum disorder.	Archives of general psychiatry	Kim, Jieun E; Lyoo, In Kyoon; Estes, Annette M; Renshaw, Perry F; Shaw, Dennis W; Friedman, Seth D; Kim, Dajung J; Yoon, Sujung J; Hwang, Jaeuk; Dager, Stephen R	November 2010	Not Relevant
20426000	Create Study	Spatiotemporal atlas estimation for developmental delay detection in longitudinal datasets.	Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention	Durrleman, Stanley; Pennec, Xavier; Trouvé, Alain; Gerig, Guido; Ayache, Nicholas	2009	Not Relevant
19819542	Create Study	Autism.	Lancet (London, England)	Levy, Susan E; Mandell, David S; Schultz, Robert T	November 7, 2009	Not Relevant
19243924	Create Study	Cerebellar vermal volumes and behavioral correlates in children with autism spectrum disorder.	Psychiatry research	Webb, Sara Jane; Sparks, Bobbi-Faun; Friedman, Seth D; Shaw, Dennis W W; Giedd, Jay; Dawson, Geraldine; Dager, Stephen R	April 30, 2009	Not Relevant
18982614	Create Study	Assessment of reliability of multi-site neuroimaging via traveling phantom study.	Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention	Gouttard S, Styner M, Prastawa M, Piven J, Gerig G	2008	Not Relevant
18606031	Create Study	Early behavioral intervention, brain plasticity, and the prevention of autism spectrum disorder.	Development and psychopathology	Dawson, Geraldine	2008	Not Relevant
18058011	Create Study	Head circumference as an early predictor of autism symptoms in younger siblings of children with autism spectrum disorder.	Journal of autism and developmental disorders	Elder, Lauren M; Dawson, Geraldine; Toth, Karen; Fein, Deborah; Munson, Jeff	July 2008	Not Relevant
17975722	Create Study	Characteristics associated with presence of depressive symptoms in adults with autism spectrum disorder.	Journal of autism and developmental disorders	Sterling, Lindsey; Dawson, Geraldine; Estes, Annette; Greenson, Jessica	July 2008	Not Relevant
17963435	Create Study	Level of intellectual functioning predicts patterns of associated symptoms in school-age children with autism spectrum disorder.	American journal of mental retardation : AJMR	Estes AM, Dawson G, Sterling L, Munson J	November 2007	Not Relevant

helpcenter.collection.publications-tab

Collection - Publications

The number of Publications is displayed in parentheses next to the tab name. Clicking on any of the Publication Titles will open the Publication in a new internet browsing tab.

Collection Owners, Program Officers, and users with Submission or Administrative Privileges for the Collection may mark a publication as either Relevant or Not Relevant in the Status column.

Frequently Asked Questions

How can I determine if a publication is relevant?

Publications are considered relevant to a collection when the data shared is directly related to the project or collection.
Where does the NDA get the publications?

PubMed, an online library containing journals, articles, and medical research. Sponsored by NiH and National Library of Medicine (NLM).

Glossary

Create Study

A link to the Create an NDA Study page that can be clicked to start creating an NDA Study with information such as the title, journal and authors automatically populated.
Not Determined Publication

Indicates that the publication has not yet been reviewed and/or marked as Relevant or Not Relevant so it has not been determined whether an NDA Study is expected.
Not Relevant Publication

A publication that is not based on data related to the aims of the grant/project associated with the Collection or not based on any data such as a review article and, therefore, an NDA Study is not expected to be created.
PubMed

PubMed provides citation information for biomedical and life sciences publications and is managed by the U.S. National Institutes of Health's National Library of Medicine.
PubMed ID

The PUBMed ID is the unique ID number for the publication as recorded in the PubMed database.
Relevant Publication

A publication that is based on data related to the aims of the grant/project associated with the Collection and, therefore, an NDA Study is expected to be created.

Contact NDA Help Desk

Data Expected List: Mandatory Data Structures

These data structures are mandatory for your NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

For NIMH HIV-related research that involves human research participants: Select the dictionary or dictionaries most appropriate for your research. If your research does not require all three data dictionaries, just ignore the ones you do not need. There is no need to delete extra data dictionaries from your NDA Collection. You can adjust the Targeted Enrollment column in the Data Expected tab to “0” for those unnecessary data dictionaries. At least one of the three data dictionaries must have a non-zero value.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
Research Subject and Pedigree	526	07/31/2014	934	11/30/2014	934	Approved

To create your project's Data Expected list, use the "+New Data Expected" to add or request existing structures and to request new Data Structures that are not in the NDA Data Dictionary.

If the Structure you need already exists, locate it and specify your dates and enrollment when adding it to your Data Expected list. If you require changes to the Structure you need, select the indicator stating "No, it requires changes to meet research needs," and upload a file containing your requested changes.

If the structure you need is not yet defined in the Data Dictionary, you can select "Upload Definition" and attach the necessary materials to request its creation.

When selecting the expected dates for your data, make sure to follow the standard Data Sharing Regimen and choose dates within the date ranges that correspond to your project start and end dates.

Please visit the Completing Your Data Expected Tutorial for more information.

Data Expected List: Data Structures per Research Aims

These data structures are specific to your research aims and should list all data structures in which data will be collected and submitted for this NDA Collection. Please update the Targeted Enrollment number to accurately represent the number of subjects you expect to submit for the entire study.

Data Expected	Targeted Enrollment	Initial Submission	Subjects Submitted	Initial Share	Subjects Shared	Status
Mullen Scales of Early Learning	525	07/31/2014	519	11/30/2014	519	Approved
ADOS	411	08/31/2012	410	12/31/2012	410	Approved
Early Development Inventory (EDI)	481	07/31/2014	479	11/30/2014	479	Approved
ADI-R	350	07/31/2014	350	11/30/2014	350	Approved
Medical History	490	01/15/2009	487	05/15/2009	487	Approved
Sensory Experiences Questionnaire (SEQ)	418	07/31/2014	417	11/30/2014	417	Approved
Infant Behavior Questionnaire (IBQ)	451	07/31/2014	449	11/30/2014	449	Approved
Social Communication Questionnaire (SCQ)	378	07/31/2014	371	11/30/2014	371	Approved
M-CHAT	19	07/31/2014	17	11/30/2014	17	Approved
Autism Observation Scale for Infants (AOSI)	350	07/15/2015	481	05/15/2011	481	Approved
Communication and Symbolic Behavior Scales (CSBS)	421	01/15/2014	420	05/15/2011	420	Approved
Prefrontal Task	300	01/15/2011	301	05/15/2011	301	Approved
MacArthur Bates Communicative Development Inventory	421	07/31/2014	420	11/30/2014	420	Approved
Repetitive Behavior Scale - Revised (RBS-R)	423	07/31/2014	422	11/30/2014	422	Approved
First Year Inventory (FYI)	375	07/31/2014	375	11/30/2014	375	Approved
Physical Exam	491	07/31/2014	490	11/30/2014	490	Approved
Vineland (Parent and Caregiver)	526	01/15/2009	832	05/15/2009	832	Approved
Imaging (Structural, fMRI, DTI, PET, microscopy)	500	08/31/2012	456	12/31/2012	456	Approved

Structure not yet defined

No Status history for this Data Expected has been recorded yet

helpcenter.collection.data-expected-tab

Collection - Data Expected

The Data Expected tab displays the list of all data that NDA expects to receive in association with the Collection as defined by the contributing researcher, as well as the dates for the expected initial upload of the data, and when it is first expected to be shared, or with the research community. Above the primary table of Data Expected, any publications determined to be relevant to the data within the Collection are also displayed - members of the contributing research group can use these to define NDA Studies, connecting those papers to underlying data in NDA.

The tab is used both as a reference for those accessing shared data, providing information on what is expected and when it will be shared, and as the primary tracking mechanism for contributing projects. It is used by both contributing primary researchers, secondary researchers, and NIH Program and Grants Management staff.

Researchers who are starting their project need to update their Data Expected list to include all the Data Structures they are collecting under their grant and set their initial submission and sharing schedule according to the NDA Data Sharing Regimen.

To add existing Data Structures from the Data Dictionary, to request new Data Structure that are not in the Dictionary, or to request changes to existing Data Structures, click "+New Data Expected".

For step-by-step instructions on how to add existing Data Structures, request changes to an existing Structure, or request a new Data Structure, please visit the Completing Your Data Expected Tutorial.

If you are a contributing researcher creating this list for the first time, or making changes to the list as your project progress, please note the following:

Although items you add to the list and changes you make are displayed, they are not committed to the system until you Save the entire page using the "Save" button at the bottom of your screen. Please Save after every change to ensure none of your work is lost.
If you attempt to add a new structure, the title you provide must be unique - if another structure exists with the same name your change will fail.
Adding a new structure to this list is the only way to request the creation of a new Data Dictionary definition.

Frequently Asked Questions

What is an NDA Data Structure?

An NDA Data Structure is comprised of multiple Data Elements to make up an electronic definition of an assessment, measure, questionnaire, etc will have a corresponding Data Structure.
What is the NDA Data Dictionary?

The NDA Data Dictionary is comprised of electronic definitions known as Data Structures.

Glossary

Analyzed Data

Data specific to the primary aims of the research being conducted (e.g. outcome measures, other dependent variables, observations, laboratory results, analyzed images, volumetric data, etc.) including processed images.
Data Item

Items listed on the Data Expected list in the Collection which may be an individual and discrete Data Structure, Data Structure Category, or Data Structure Group.
Data Structure

A defined organization and group of Data Elements to represent an electronic definition of a measure, assessment, questionnaire, or collection of data points. Data structures that have been defined in the NDA Data Dictionary are available at https://nda.nih.gov/general-query.html?q=query=data-structure
Data Structure Category

An NDA term describing the affiliation of a Data Structure to a Category, which may be disease/disorder or diagnosis related (Depression, ADHD, Psychosis), specific to data type (MRI, eye tracking, omics), or type of data (physical exam, IQ).
Data Structure Group

A Data Item listed on the Data Expected tab of a Collection that indicates a group of Data Structures (e.g., ADOS or SCID) for which data may be submitted instead of a specific Data Structure identified by version, module, edition, etc. For example, the ADOS Data Structure Category includes every ADOS Data Structure such as ADOS Module 1, ADOS Module 2, ADOS Module 1 - 2nd Edition, etc. The SCID Data Structure Group includes every SCID Data Structure such as SCID Mania, SCID V Mania, SCID PTSD, SCID-V Diagnosis, and more.
Evaluated Data

A new Data Structure category, Evaluated Data is analyzed data resulting from the use of computational pipelines in the Cloud and can be uploaded directly back to a miNDAR database. Evaluated Data is expected to be listed as a Data Item in the Collection's Data Expected Tab.
Imaging Data

Imaging+ is an NDA term which encompasses all imaging related data including, but not limited to, images (DTI, MRI, PET, Structural, Spectroscopy, etc.) as well as neurosignal data (EEG, fMRI, MEG, EGG, eye tracking, etc.) and Evaluated Data.
Initial Share Date

Initial Submission and Initial Share dates should be populated according to the NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data will be shared with authorized users upon publication (via an NDA Study) or 1-2 years after the grant end date specified on the first Notice of Award, as defined in the applicable Data Sharing Terms and Conditions.
Initial Submission Date

Initial Submission and Initial Share dates should be populated according to these NDA Data Sharing Terms and Conditions. Any modifications to these will go through the approval processes outlined above. Data for all subjects is not expected on the Initial Submission Date and modifications may be made as necessary based on the project's conduct.
Research Subject and Pedigree

An NDA created Data Structure used to convey basic information about the subject such as demographics, pedigree (links family GUIDs), diagnosis/phenotype, and sample location that are critical to allow for easier querying of shared data.
Submission Cycle

The NDA has two Submission Cycles per year - January 15 and July 15.
Submission Exemption

An interface to notify NDA that data may not be submitted during the upcoming/current submission cycle.

Contact NDA Help Desk

Collection Owners and those with Collection Administrator permission, may edit a collection. The following is currently available for Edit on this page:

Associated Studies

Studies that have been defined using data from a Collection are important criteria to determine the value of data shared. The number of subjects column displays the counts from this Collection that are included in a Study, out of the total number of subjects in that study. The Data Use column represents whether or not the study is a primary analysis of the data or a secondary analysis. State indicates whether the study is private or shared with the research community.

Study NameFilter by Study Name	AbstractFilter by Abstract	Collection/Study SubjectsFilter by Collection/Study Subjects	Data UsageFilter by Data Usage	StateFilter by State
Examining the validity of the use of ratio IQs in psychological assessments	IQ tests are amongst the most used psychological assessments, both in research and clinical settings. For participants who cannot complete IQ tests normed for their age, ratio IQ scores (RIQ) are routinely computed and used as a proxy of IQ, especially in large research databases to avoid missing data points. However, because it has never been scientifically validated, this practice is questionable. In the era of big data, it is important to examine the validity of this widely used practice. In this paper, we use the case of autism to examine the differences between standard full-scale IQ (FSIQ) and RIQ. Data was extracted from four databases in which ages, FSIQ scores and subtests raw scores were available for autistic participants between 2 and 17 years old. The IQ tests included were the MSEL (N=12033), DAS-II early years (N=1270), DAS-II school age (N=2848), WISC-IV (N=471) and WISC-V (N=129). RIQs were computed for each participant as well as the discrepancy (DSC) between RIQ and FSIQ. We performed two linear regressions to respectively assess the effect of FSIQ and of age on the DSC for each IQ test, followed by additional analyses comparing age subgroups as well as FSIQ subgroups on DSC. Participants at the extremes of the FSIQ distribution tended to have a greater DSC than participants with average FSIQ. Furthermore, age significantly predicted the DSC, with RIQ superior to FSIQ for younger participants while the opposite was found for older participants. These results question the validity of this widely used alternative scoring method, especially for individuals at the extremes of the normal distribution, with whom RIQs are most often employed.	519/17423	Secondary Analysis	Shared
The importance of low IQ to early diagnosis of autism	Some individuals can flexibly adapt to life’s changing demands while others, in particular those with Autism Spectrum Disorder (ASD), find it challenging. The origin of early individual differences in cognitive abilities, the putative tools with which to navigate novel information in life, including in infants later diagnosed with ASD remains unexplored. Moreover, the role of intelligence quotient (IQ) vis-à-vis core features of autism remains debated. We systematically investigate the contribution of early IQ in future autism outcomes in an extremely large, population-based study of 8,000 newborns, infants, and toddlers from the US between 2 and 68 months with over 15,000 cross-sectional and longitudinal assessments, and for whom autism outcomes are ascertained or ruled out by about 2-4 years. This population is representative of subjects involved in the National Institutes of Health (NIH)-funded research, mainly on atypical development, in the US. Analyses using predetermined age bins showed that IQ scores are consistently lower in ASD relative to TD at all ages (p<0.001), and IQ significantly correlates with calibrated severity scores (total CSS, as well as non-verbal and verbal CSS) on the ADOS. Note, VIQ is no better than the full-scale IQ to predict ASD cases. These findings raise new, compelling questions about potential atypical brain circuitry affecting performance in both verbal and nonverbal abilities and that precede an ASD diagnosis. This study is the first to establish prospectively that low early IQ is a major feature of ASD in early childhood.	491/6323	Secondary Analysis	Shared
Prognostic early snapshot stratification of autism based on adaptive functioning	A major goal of precision medicine is to predict prognosis based on individualized information at the earliest possible points in development. Using early snapshots of adaptive functioning and unsupervised data- driven discovery methods, we uncover highly stable early autism subtypes that yield information relevant to later prognosis. Data from the National Institute of Mental Health Data Archive (NDA) (n = 1,098) was used to uncover three early subtypes (<72 months) that generalize with 96% accuracy. Outcome data from NDA (n = 2,561; mean age, 13 years) also reproducibly clusters into three subtypes with 99% generalization accuracy. Early snapshot subtypes predict developmental trajectories in non-verbal cognitive, language and motor domains and are predictive of membership in different adaptive functioning outcome subtypes. Robust and prognosis- relevant subtyping of autism based on early snapshots of adaptive functioning may aid future research work via prediction of these subtypes with our reproducible stratification model.	1/3517	Secondary Analysis	Shared
Investigating autism etiology and heterogeneity by decision tree algorithm	Autism spectrum disorder (ASD) is a neurodevelopmental disorder that causes deficits in cognition, communication and social skills. ASD, however, is a highly heterogeneous disorder. This heterogeneity has made identifying the etiology of ASD a particularly difficult challenge, as patients exhibit a wide spectrum of symptoms without any unifying genetic or environmental factors to account for the disorder. For better understanding of ASD, it is paramount to identify potential genetic and environmental risk factors that are comorbid with it. Identifying such factors is of great importance to determine potential causes for the disorder, and understand its heterogeneity. Existing large-scale datasets offer an opportunity for computer scientists to undertake this task by utilizing machine learning to reliably and efficiently obtain insight about potential ASD risk factors, which would in turn assist in guiding research in the field. In this study, decision tree algorithms were utilized to analyze related factors in datasets obtained from the National Database for Autism Research (NDAR) consisting of nearly 3000 individuals. We were able to identify 15 medical conditions that were highly associated with ASD diagnoses in patients; furthermore, we extended our analysis to the family medical history of patients and we report six potentially hereditary medical conditions associated with ASD. Associations reported had a 90% accuracy. Meanwhile, gender comparisons highlighted conditions that were unique to each gender and others that overlapped. Those findings were validated by the academic literature, thus opening the way for new directions for the use of decision tree algorithms to further understand the etiology of autism.	2/3382	Secondary Analysis	Shared
Psychometric Analysis of the Social Communication Questionnaire Using an Item-Response Theory Framework: Implications for the Use of the Lifetime and Current Forms	The Social Communication Questionnaire (SCQ) was developed as a screener of Autism Spectrum Disorder (ASD). To date, the majority of the SCQ utility studies focused on its external validity (e.g., ROC curve analyses), but very few have addressed the internal validity issues. With samples consisting of 2,134 individuals available from the National Database for Autism Research (NDAR), the current study examined the factor structure, item-level characteristics, and measurement equivalence of the SCQ forms (i.e., Lifetime form and Current form) using both the classical true score theory and the item response theory (IRT). While our findings indicate sufficient psychometric properties of the SCQ Lifetime form, measurement issues emerged with respect to the SCQ Current form. These issues include lower internal consistencies, a weaker factor structure, lower item discriminations, significant pseudo-guessing effects, and subscale-level measurement bias. Thus, we caution researchers and clinicians about the use of the SCQ Current form. In particular, it seems inappropriate to use the Current form as an alternative to the Lifetime form among children younger than 5 years old or under other special situations (e.g., teacher-report data), although such practices were advised by the publisher of the SCQ. Instead, we recommend modifying the wording of the Lifetime form items rather than switching to the Current form where a 3-month timeframe is specified for responding to SCQ items. Future studies may consider investigating the association between the temporality of certain behaviors and the individual’s potential for being diagnosed with ASD, as well as the age neutrality of the SCQ.	240/2054	Secondary Analysis	Shared
Unravelling the Collective Diagnostic Power Behind the Features in the Autism Diagnostic Observation Schedule	Background: Autism is a group of heterogeneous disorders defined by deficits in social interaction and communication. Typically, diagnosis depends on the results of a behavioural examination called the Autism Diagnostic Observation Schedule (ADOS). Unfortunately, administration of the ADOS exam is time-consuming and requires a significant amount of expert intervention, leading to delays in diagnosis and access to early intervention programs. The diagnostic power of each feature in the ADOS exam is currently unknown. Our hypothesis is that certain features could be removed from the exam without a significant reduction in diagnostic accuracy, sensitivity or specificity. Objective: Determine the smallest subset of predictive features in ADOS module-1 (an exam variant for patients with minimal verbal skills). Methodology: ADOS module-1 datasets were acquired from the Autism Genetic Resource Exchange and the National Database for Autism Research. The datasets contained 2572 samples with the following labels: autism (1763), autism spectrum (513), and non-autism (296). The datasets were used as input to 4 different cost-sensitive classifiers in Weka (functional trees, LADTree, logistic model trees, and PART). For each classifier, a 10-fold cross validation was preformed and the number of predictive features, accuracy, sensitivity, and specificity was recorded. Results & Conclusion: Each classifier resulted in a reduction of the number of ADOS features required for autism diagnosis. The LADtree classifier was able to obtain the largest reduction, utilizing only 10 of 29 ADOS module-1 features (96.8% accuracy, 96.9% sensitivity, and 95.9% specificity). Overall, these results are a step towards a more efficient behavioural exam for autism diagnosis.	64/1832	Secondary Analysis	Shared
Imbalanced social-communicative and restricted repetitive behavior subtypes in autism spectrum disorder exhibit different neural circuitry	Social-communication (SC) and restricted repetitive behaviors (RRB) are autism diagnostic symptom domains. SC and RRB severity can markedly differ within and between individuals and may be underpinned by different neural circuitry and genetic mechanisms. Modeling SC-RRB balance could help identify how neural circuitry and genetic mechanisms map onto such phenotypic heterogeneity. Here, we developed a phenotypic stratification model that makes highly accurate (97–99%) out-of-sample SC = RRB, SC > RRB, and RRB > SC subtype predictions. Applying this model to resting state fMRI data from the EU-AIMS LEAP dataset (n = 509), we find that while the phenotypic subtypes share many commonalities in terms of intrinsic functional connectivity, they also show replicable differences within some networks compared to a typically-developing group (TD). Specifically, the somatomotor network is hypoconnected with perisylvian circuitry in SC > RRB and visual association circuitry in SC = RRB. The SC = RRB subtype show hyperconnectivity between medial motor and anterior salience circuitry. Genes that are highly expressed within these networks show a differential enrichment pattern with known autism-associated genes, indicating that such circuits are affected by differing autism-associated genomic mechanisms. These results suggest that SC-RRB imbalance subtypes share many commonalities, but also express subtle differences in functional neural circuitry and the genomic underpinnings behind such circuitry.	7/1708	Secondary Analysis	Shared
Joint attention in infants at high familial risk for autism spectrum disorder and the association with thalamic and hippocampal macrostructure	Autism spectrum disorder (ASD) is a heritable neurodevelopmental disorder. Infants diagnosed with ASD can show impairments in spontaneous gaze-following and will seldom engage in joint attention (JA). The ability to initiate JA (IJA) can be more significantly impaired than the ability to respond to JA (RJA). In a longitudinal study, 101 infants who had a familial risk for ASD were enrolled (62% males). Participants completed magnetic resonance imaging scans at 4 or 6 months of age. Subcortical volumes (thalamus, hippocampus, amygdala, basal ganglia, ventral diencephalon, and cerebellum) were automatically extracted. Early gaze and JA behaviors were assessed with standardized measures. The majority of infants were IJA nonresponders (n = 93, 92%), and over half were RJA nonresponders (n = 50, 52%). In the nonresponder groups, models testing the association of subcortical volumes with later ASD diagnosis accounted for age, sex, and cerebral volumes. In the nonresponder IJA group, using regression method, the left hippocampus (B = -0.009, aOR = 0.991, P = 0.025), the right thalamus (B = -0.016, aOR = 0.984, P = 0.026), as well as the left thalamus (B = 0.015, aOR = 1.015, P = 0.019), predicted later ASD diagnosis. Alterations in thalamic and hippocampal macrostructure in at-risk infants who do not engage in IJA may reflect an enhanced vulnerability and may be the key predictors of later ASD development.	833/950	Secondary Analysis	Shared
Revising the Social Communication Questionnaire scoring procedures for Autism Spectrum Disorder and potential Social Communication Disorder	In analyzing data from the National Database for Autism Research, we examine revising the Social Communication Questionnaire (SCQ), a commonly used screening instrument for Autism Spectrum Disorder. A combination of Item Response Theory and Mokken scaling techniques were utilized to achieve this and abbreviated scoring of the SCQ is suggested. The psychometric sensitivity of this abbreviated SCQ was examined via bootstrapped Receiver Operator Characteristic (ROC) curve analyses. Additionally, we examined the sensitivity of the abbreviated and total scaled SCQ as it relates to a potential diagnosis of Social (Pragmatic) Communication Disorder (SCD). As SCD is a new disorder introduced with the fifth edition of the Diagnostic and Statistical Manual (DSM-5), we identified individuals with potential diagnosis of SCD among individuals with ASD via mixture modeling techniques using the same NDAR data. These analyses revealed two classes or clusters of individuals when considering the two core areas of impairment among individuals with ASD: social communication and restricted, repetitive patterns of behavior.	4/889	Secondary Analysis	Shared
Investigating possible biomarkers of autism in resting EEG	There are no clinically useful biomarkers of autism spectrum disorder (ASD). Electroencephalogram (EEG) can measure ongoing brain dynamics using cheap and widely available technology and is minimally invasive. As such, any measurement drived from EEG that is capable of serving as a biomarker for ASD would be hugely beneficial. Previous research has been conflicting and a large list of EEG measures have been suggested.	1/771	Secondary Analysis	Shared
Identification of Infants at High-Risk for Autism Spectrum Disorder Using Multiparameter Multiscale White Matter Connectivity Networks	Autism spectrum disorder (ASD) is a wide range of disabilities that cause life-long cognitive impairment and social, communication, and behavioral challenges. Early diagnosis and medical intervention are important for improving the life quality of autistic patients. However, in the current practice, diagnosis often has to be delayed until the behavioral symptoms become evident during childhood. In this study, we demonstrate the feasibility of using machine learning techniques for identifying high-risk ASD infants at as early as six months after birth. This is based on the observation that ASD-induced abnormalities in white matter (WM) tracts and whole-brain connectivity have already started to appear within 24 months after birth. In particular, we propose a novel multikernel support vector machine classification framework by using the connectivity features gathered from WM connectivity networks, which are generated via multiscale regions of interest (ROIs) and multiple diffusion statistics such as fractional anisotropy, mean diffusivity, and average fiber length. Our proposed framework achieves an accuracy of 76% and an area of 0.80 under the receiver operating characteristic curve (AUC), in comparison to the accuracy of 70% and the AUC of 70% provided by the best singleparameter single-scale network. The improvement in accuracy is mainly due to the complementary information provided by multiparameter multiscale networks. In addition, our framework also provides the potential imaging connectomic markers and an objective means for early ASD diagnosis.	489/489	Secondary Analysis	Shared
The Sensitivity and Specificity of the Social Communication Questionnaire for Autism Spectrum Disorder with Respect to Age	Scientific Abstract The Social Communication Questionnaire (SCQ) assesses communication skills and social functioning in screening for symptoms of autism-spectrum disorder (ASD). The SCQ is recommended for individuals between 4 to 40 years with a cutoff score of 15 for referral. Mixed findings have been reported regarding the recommended cutoff score’s ability to accurately classify an individual as at-risk for ASD (sensitivity) versus an individual as not at-risk for ASD (specificity). Based on a sample from the National Database for Autism Research (n=344; age: 1.58 to 25.92 years old), the present study examined the SCQ’s sensitivity versus specificity across a range of ages. We recommend that the cutoff scores for the SCQ be re-evaluated with age as a consideration. Lay Abstract The age neutrality of the Social Communication Questionnaire (SCQ) was examined as a common screener for ASD. Mixed findings have been reported regarding the recommended cutoff score’s ability to accurately classify an individual as at-risk for ASD (sensitivity) versus accurately classifying an individual as not at-risk for ASD (specificity). With a sample from the National Database for Autism Research, the present study examined the SCQ’s sensitivity versus specificity. Analyses indicated that the actual sensitivity and specificity scores were lower than initially reported by the creators of the SCQ.	5/339	Secondary Analysis	Shared
Word Learning and Word Features	Vocabulary composition and word-learning biases are closely interrelated in typical development. Learning new words involves attending to certain properties to facilitate word learning. Such word-learning biases are influenced by perceptually and conceptually salient word features, including high imageability, concreteness, and iconicity. This study examined the association of vocabulary knowledge and word features in young children with ASD (n = 280) and typically developing (TD) toddlers (n = 1,054). Secondary analyses were conducted using data from the National Database for Autism Research and the Wordbank database. Expressive vocabulary was measured using the MacArthur-Bates Communicative Development Inventory. Although the trajectories for concreteness, iconicity, and imageability are similar between children with ASD and TD toddlers, divergences were observed. Differences in imageability are seen early but resolve to a common trajectory; differences in iconicity are small but consistent; and differences in concreteness only emerge after both groups reach a simultaneous peak, before converging again. This study reports unique information about the nonlinear growth patterns associated with each word feature for and distinctions in these growth patterns between the groups.	30/280	Primary Analysis	Shared
Examining the Shape Bias in Young Autistic Children: A Vocabulary Composition Analysis	Shape is a salient object property and one of the first that children use to categorize objects under one label. Colunga and Sims (2017) suggest that noun vocabulary composition and word learning biases are closely interrelated in typical development. The current study examined the association between noun vocabulary knowledge and perceptual word features, specifically shape and material features. Participants included 249 autistic children and 1,245 non-autistic toddlers who were matched on expressive noun vocabulary size and gender. Nouns were categorized using the Samuelson and Smith (1999) noun feature database. A simple group comparison revealed no group differences in shape bias; both groups evidenced developing noun vocabularies that favored shape+solid and nonsolid+material nouns. However, the trajectory of evidence of shape bias as a function of vocabulary size differed between the groups, with autistic children demonstrating a reduced shape-bias initially. Future work should examine how children’s learning biases shift over development and whether the shape bias promotes lexical development to the same degree across groups.	30/249	Secondary Analysis	Shared
Deviant vocabulary development in children with Autism Spectrum Disorder	Children diagnosed with autism spectrum disorder (ASD) have core impairments in social communication and have restricted interests and repetitive behaviors. Additionally, the majority of young children with ASD have early language delays. Although these early delays are well-documented, it is remains unclear whether language skills are simply delayed or if they are deviant. The current study aimed to expand on previous studies (e.g., Charman et al., 2003; Luyster, Lopez, & Lord, 2007; Rescorla & Safyer, 2012) to provide a large-scale comparison of early language profiles between typically developing (TD) toddlers and young children with ASD. Specifically, we sought to examine the composition of word classes (i.e., nouns, predicates, and close classed words) and semantic categories (i.e., games and routines, sound effects and animal noises) in the early TD and ASD language profiles. A series of linear regression analyses revealed that children with ASD produced a smaller percentage of nouns, and that the percentage of nouns in a vocabulary decreased as children learned more words, but that this reduction was less steep in the ASD group. When examining predicates, we found that children with ASD produced a significantly higher percentage of predicates. Also, as vocabulary size increased, the percentage of predicates increased; however, the slope was less steep for children with ASD. Lastly, children with SD produced a significantly higher percentage of closed class words and the trajectory of growth of the percentage of closed class words differed between groups. The current findings suggest that children with ASD may employ different word-learning strategies during early lexical development.	30/247	Secondary Analysis	Shared
EVIDENCE FOR THE DIMENSIONAL AND CATEGORIAL ACCOUNTS OF LANGUAGE DEVELOPMENT	This study compared the lexical composition of 216 children with ASD aged 11 to 173 months with that of 7,287 typically developing toddlers with and without language delay aged 8 to 30 months. The children with ASD and late talkers produced a lower proportion of nouns and a higher proportion of predicates than typical talkers. The ASD group produced a higher proportion of action words and place words as well as a lower proportion of sound words than the neurotypical groups. We found that children with ASD produced fewer high-social verbs as rated by adults. We discuss how these differences might be associated with features of ASD in a way that supports the categorical view of language development.	28/216	Secondary Analysis	Shared
Semantic modeling 2023	Although it is well documented that children with ASD are slower to develop their lexicons, we still have a limited understanding of the structure of early lexical knowledge in children with ASD. The current study uses network analysis and differential item functioning anlaysis to examine the structure of semantic knowledge, which may provide insight into the learning processes that influence early word learning.	30/208	Secondary Analysis	Shared
Semantic Network Modeling	Although it is well documented that children with ASD are slower to develop their lexicons, we still have a limited understanding of the structure of early lexical knowledge in children with ASD. The current study uses network analysis to examine the structure of semantic knowledge, which may provide insight into the learning processes that influence early word learning.	30/200	Secondary Analysis	Shared
Semantic Network Modeling in Young Autistic Children	Background: Most young autistic children have delayed vocabulary growth relative to their non-autistic peers. Additionally, previous studies have revealed that autistic children are less likely to encode associated features of novel objects, suggesting inefficient encoding or different processes for acquiring semantic information about words. Recent network analyses of vocabulary growth revealed important relationships between early vocabulary acquisition and the structure of the sematic environment. Methods: We studied the expressive vocabularies of 970 non-autistic toddlers (Mage = 20.82 months) and 194 autistic children (Mage = 54.58 months) in two studies. The groups were vocabulary-matched (words produced: MAutistic = 213.60, MNon-autistic = 213.72). In study 1, we estimated their trajectories of semantic development using network analyses. Network structure was based on child-oriented adult-generated word associations. We compared child semantic networks according to indegree, average shortest path length, and clustering coefficient (features that holistically contribute to well-connected network structure). Then, in study 2, we attempted to relate vocabulary-level effects to word-level learning biases. Results: Study 1 revealed that autistic and non-autistic children are sensitive to the structure of their semantic environment. Both groups demonstrated nonlinear vocabulary trajectories that differed from random acquisition networks. Despite similarities, group differences were observed for each network metric. Differences were most pronounced for clustering coefficient (how closely connected groups of words are), with earlier peaks for autistic children. Study 2 demonstrated that many words differ in their expected vocabulary size of acquisition. Conclusions: Group differences at the vocabulary- and word-levels indicate that, although autistic children are learning from their semantic environment, they may be processing their semantic environment differently. These deviations indicate that autistic children have distinctive learning biases that may align with core autism features.	16/194	Secondary Analysis	Shared
Does Anxiety Mediate the Relationship between Sensory Hyperresponsiveness and Restricted, Repetitive Behaviors during Early Development?	Sensory hyperresponsiveness, anxiety, and restricted, repetitive behaviors are known to be associated with one another, especially in autistic youth, and may be important to the development and presentation of autism over time. Few studies, however, have studied the nature of this three-way relationship prospectively, or in young children at elevated likelihood for autism. The goals of the current study were to gain greater insight into the development of autism from a symptom level before a diagnosis can be made, and specifically, to examine the relationship between sensory hyperresponsiveness, anxiety, and restricted, repetitive behaviors across time during early development in children at elevated likelihood for autism. Extant longitudinal data for a group of children at elevated likelihood for autism (N = 147) were used to conduct path analyses for two mediation model configurations, which included measures of sensory hyperresponsiveness at baseline, and anxiety and restricted and repetitive behaviors at follow-up. Results did not indicate mediating effects for either model; however, higher levels of sensory hyperresponsiveness at baseline were significantly associated with higher levels of anxiety symptoms at follow-up (b = 0.09, SE = 0.04, β = 0.24, p = 0.005, 95% CIs [0.07, 0.40]). Findings suggest that sensory hyperresponsiveness during early development later predicts anxiety symptoms in children at elevated likelihood for autism, which is consistent with prior findings in both autistic (Green et al., 2012) and non-autistic children (Carpenter et al., 2019). Although we are unable to determine whether this is a unidirectional or bidirectional relationship in the current study given the lack of concurrent data on anxiety symptoms at baseline, this result adds to emerging research suggesting that sensory hyperresponsiveness may be a risk factor for later developing anxiety.	2/159	Secondary Analysis	Shared
Early brain development in infants at high risk for autism spectrum disorder	Brain enlargement has been observed in children with autism spectrum disorder (ASD), but the timing of this phenomenon, and the relationship between ASD and the appearance of behavioural symptoms, are unknown. Retrospective head circumference and longitudinal brain volume studies of two-year olds followed up at four years of age have provided evidence that increased brain volume may emerge early in development1, 2. Studies of infants at high familial risk of autism can provide insight into the early development of autism and have shown that characteristic social deficits in ASD emerge during the latter part of the first and in the second year of life3, 4. These observations suggest that prospective brain-imaging studies of infants at high familial risk of ASD might identify early postnatal changes in brain volume that occur before an ASD diagnosis. In this prospective neuroimaging study of 106 infants at high familial risk of ASD and 42 low-risk infants, we show that hyperexpansion of the cortical surface area between 6 and 12 months of age precedes brain volume overgrowth observed between 12 and 24 months in 15 high-risk infants who were diagnosed with autism at 24 months. Brain volume overgrowth was linked to the emergence and severity of autistic social deficits. A deep-learning algorithm that primarily uses surface area information from magnetic resonance imaging of the brain of 6–12-month-old individuals predicted the diagnosis of autism in individual high-risk children at 24 months (with a positive predictive value of 81% and a sensitivity of 88%). These findings demonstrate that early brain changes occur during the period in which autistic behaviours are first emerging.	136/138	Primary Analysis	Shared
Identifying Areas of Overlap and Distinction in Early Lexical Profiles of Children with Autism Spectrum Disorder, Late Talkers, and Typical Talkers	This study compares the lexical composition of 11827 children with autism spectrum disorder (ASD) aged 121 to 84173 months with 4,626 vocabulary-matched typically developing toddlers with and without language delay, aged 8 to 30 months. Children with ASD produced a higher proportion of verbs than typical and late talkers, but a similar number of nouns. Additionally, differences were identified in five four semantic categories, four three of them related to play. Most differences appear to reflect the extent of the language delay between the groups. However, children with ASD produced fewer high-social verbs than neurotypical children. We discuss how these lexical differences might be associated with ASD features and language delay, providing partial support for a categorical view of language delay.	4/118	Secondary Analysis	Shared
Do children with Autism Spectrum Disorder learn words differently?	Children with ASD often are late to start to produce words. However, despite the importance of language abilities for child outcomes in children with ASD, we still have only scratched the surface of understanding these children's early lexicons. Therefore, in the current study we examined the semantic networks of the words that children with ASD have been reported to produce and compared them to typically developing children.	4/82	Secondary Analysis	Shared
Individual variability in the nonlinear development of the corpus callosum during infancy and toddlerhood	The human brain spends several years bootstrapping itself through intrinsic and extrinsic modulation, thus gradually developing both spatial organization and functions. Based on previous studies on developmental patterns and inter-individual variability of the corpus callosum (CC), we hypothesized that inherent variations of CC shape among infants emerge, depending on the position within the CC, along the developmental timeline. Here we used longitudinal magnetic resonance imaging data from infancy to toddlerhood and investigated the area, thickness, and shape of the midsagittal plane of the CC by applying multilevel modeling. The shape characteristics were extracted using the Procrustes method. We found nonlinearity, region- dependency, and inter-individual variability, as well as intra-individual consistencies, in CC development. Overall, the growth rate is faster in the first year than in the second year, and the trajectory differs between infants; the direction of CC formation in individual infants was determined within six months and maintained to two years. The anterior and posterior subregions increase in area and thickness faster than other subregions. Moreover, we clarified that the growth rate of the middle part of the CC is faster in the second year than in the first year in some individuals. Since the division of regions exhibiting different tendencies coincides with previously reported divisions based on the diameter of axons that make up the region, our results suggest that subregion-dependent individual variability occurs due to the increase in the diameter of the axon caliber, myelination partly due to experience and axon elimination during the early developmental period.	34/36	Secondary Analysis	Shared

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