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Description
Value Range
Notes
Data Structures with shared data
Phillip Gorrindo
Shared
Levitt P; Gorrindo P, Williams KC, Lee EB, Walker LS, McGrew SG
The objectives of this study were to characterize gastrointestinal dysfunction (GID) in autism spectrum disorder (ASD), to examine parental reports of GID relative to evaluations by pediatric gastroenterologists, and to explore factors associated with GID in ASD. One hundred twenty-one children were recruited into three groups: co-occurring ASD and GID, ASD without GID, and GID without ASD. A pediatric gastroenterologist evaluated both GID groups. Parents in all three groups completed questionnaires about their child`s behavior and GI symptoms, and a dietary journal. Functional constipation was the most common type of GID in children with ASD (85.0%). Parental report of any GID was highly concordant with a clinical diagnosis of any GID (92.1%). Presence of GID in children with ASD was not associated with distinct dietary habits or medication status. Odds of constipation were associated with younger age, increased social impairment, and lack of expressive language (adjusted odds ratio in nonverbal children: 11.98, 95% confidence interval 2.54-56.57). This study validates parental concerns for GID in children with ASD, as parents were sensitive to the existence, although not necessarily the nature, of GID. The strong association between constipation and language impairment highlights the need for vigilance by health-care providers to detect and treat GID in children with ASD. Medications and diet, commonly thought to contribute to GID in ASD, were not associated with GID status. These findings are consistent with a hypothesis that GID in ASD represents pleiotropic expression of genetic risk factors.
info icon 10.15154/1163508
info icon Primary Analysis
()
Age: 60 to 215 months
Gender: Both
()
Age: 60 to 215 months
Gender: Both
()
Age: 60 to 215 months
Gender: Both
()
()
Statistical
   Method: ANOVA, Chi-square test, Regression analysis
   Significance
      p-value: <0.05
   Software: SPSS

Summary information about the study.

ID Type Name Gender Age From Age To Comments SubjectsView
16 Control ASD-only Both 60 215 Please note: one family opted-out of submitting their data to NDAR, thus n=44 in NDAR, but the paper based on these data has n=45 for this cohort. 44
16
View Cohort
17 Control GID-only Both 60 215 Please note: 8 families opted-out of submitting their data to NDAR, thus n=28 in NDAR, but the paper based on these data has n=36 for this cohort. 28
17
View Cohort
18 Test ASD-GID Both 60 215 40
18
View Cohort
info icon
Aicardi Syndrome
Anxiety
Anxiety Disorders in Youth With Autism
Asthma
Attention Deficit Hyperactivity Disorder
Attention Deficit and Disruptive Behavior Disorders
Attention Deficit Disorder With Hyperactivity
Autoimmune Disease
Bipolar Disorder
Brain Disorders
Cerebral Palsy
Childhood Disintegrative Disorder
Childhood Obsessive-Compulsive Disorder
Chromosome 22q11.2 Deletion Syndrome
Cognition
Congenital Adrenal Hyperplasia
Depressive Disorder Not Otherwise Specified
Developmental Coordination Disorder
Developmental Disabilities
Developmental Delay
Diabetes
Down Syndrome
Food Allergies
Gastrointestinal Symptoms
Generalized Anxiety Disorder
Healthy
High Functioning Autism
Huntington Disease
Inflammation
Insomnia
Intellectual Disabilities
Language Disorder
Major Depressive Disorder
Maternal Depression
Mental Disorder Diagnosed in Childhood
Mental Retardation
Mental Health
Mood Disorder Not Otherwise Specified
Mood Disorders
Neurodevelopmental Disorders
Neurologic Manifestation
Neuromuscular Diseases
Normal Physiology
Obesity
Obsessive-Compulsive Disorder
Oxidative Stress
Parkinson Disease
Pervasive Developmental Disorder
Pervasive Child Development Disorders
Premature Birth
Prodromal Schizophrenia
Psychiatric Disorders
Psychotic Disorder Not Otherwise Specified
Rett Syndrome
Schizoaffective Disorder
Schizophrenia
Schizophreniform Disorder
Separation Anxiety Disorder
Severe Behavior Disorder
Sleep Disorders
Sleep Problems
Social Phobia
Tuberous Sclerosis Complex
Autism Spectrum
Affected
Mildly Affected
Severely Affected
Non-ASD Control
Neurological Disorder (Non-ASD)
Parental
Sibling
Typical
Other Disorders
Anxiety
Anxiety Disorder Not Otherwise Specified
Anxiety Disorders in Youth With Autism
Generalized Anxiety Disorder
Separation Anxiety Disorder
Social Phobia
Attention Deficit and Disruptive Behavior Disorders
Attention Deficit Hyperactivity Disorder
Attention Deficit Disorder With Hyperactivity
Mood Disorders
Depressive Disorder Not Otherwise Specified
Major Depressive Disorder
Maternal Depression
Mood Disorder Not Otherwise Specified
Neurodevelopmental Disorders
Childhood Disintegrative Disorder
Chromosome 22q11.2 Deletion Syndrome
Developmental Coordination Disorder
Developmental Disabilities
Developmental Delay
Down Syndrome
Obsessive-Compulsive Disorder
Childhood Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder
Psychiatric Disorders
Bipolar Disorder
Prodromal Schizophrenia
Psychotic Disorder Not Otherwise Specified
Schizoaffective Disorder
Schizophrenia
Schizophreniform Disorder
Fragile X
Gastro Intestinal Disorder
High IQ
Immunological
Low IQ
Minimally Verbal
Non-Verbal
Seizures
Verbal

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Data Structure Status
Autism Diagnostic Observation Schedule (ADOS) - Module 4 - V02
scoresumm_atotal Secondary
scoresumm_btotal Secondary
scoresumm_abtotal Secondary
scoresumm_adosdiag Secondary
scoresumm_overalldiag Secondary
Autism Diagnostic Observation Schedule (ADOS)- Module 1 - V02
scoresumm_atotal Secondary
scoresumm_btotal Secondary
scoresumm_abtotal Secondary
scoresumm_adosdiag Secondary
scoresumm_overalldiag Secondary
Autism Diagnostic Observation Schedule (ADOS)- Module 2 - V02
scoresumm_atotal Secondary
scoresumm_btotal Secondary
scoresumm_abtotal Secondary
scoresumm_adosdiag Secondary
scoresumm_overalldiag Secondary
Autism Diagnostic Observation Schedule (ADOS)- Module 3 - V02
scoresumm_atotal Secondary
scoresumm_btotal Secondary
scoresumm_abtotal Secondary
scoresumm_adosdiag Secondary
scoresumm_overalldiag Secondary
Secondary
Primary
Social Responsiveness Scale (SRS) - V02
male_tscore1 Primary
male_tscore2 Primary
male_tscore3 Primary
male_tscore4 Primary
male_tscore5 Primary
male_tscoreall Primary
female_tscore1 Primary
female_tscore2 Primary
female_tscore3 Primary
female_tscore4 Primary
female_tscore5 Primary
female_tscoreall Primary
phenotype Primary
- V
Data Element Primary/Secondary
Description:

Value Range:

None specified

Notes:

Based upon the subjects and collections defined in Cohorts, NDAR will show the available outcome measures. You can select a measure as either primary or secondary outcome measures. A minimum of one primary measure is needed to share the study. Only the measures chosen will be available for download when the study is shared.

Selection the Study Description, Study Arms/Comparison Groups, and Intervention types for either a Controlled or Observational Study. If your study arms/comparison groups or intervention type is not listed, select Add New.

Data Transformation, QA/QC
QA Filtering
Call rates
HWE
Minor Allele Frequency (MAF)
Autosome Heterozygosity
Chromosomal Aberration Screening
Cluster Plots of Probe Intensities
Derivative Log Ratio Spread
Family-Based QC
Gender Misidentification
LD pruning
Multidimensional Outlier Detection
Percentile-Based Winsorizing
Population Stratification Correction
Quartile Summary Statistics
Wave Detection and Correction
Genetic Model
Additive model
Allele test
Dominant model
Genotypic test
Recessive model
Genotype Statistics by Marker and Sample
Allele count
Call rate
FIsher's exact test for HWE p-value
Genotype count
Global sample test
Hardy-Weinberg Equilibrium (HWE) p-value
Minor allele frequency
Signed HWE Correlation R
Linkage and Haplotype Analysis
Haplotype frequency estimation
Case/Control Association
Composite Haplotype Method
Expectation Maximization
Haplotype Association Testing
Haplotype Block analysis
LD plot
NGS Analysis
RNA-seq
Gene expression
Variant annotation
SnpEff Annotations
dbNSFP Annotations
Variant filtering
Annotation tracks
De novo variants
Functional prediction
GERP Score
Gene tracks
Grantham Score
Inherited variants
PolyPhen-2 Prediction
Probe tracks
SIFT
phyloP
Variant validation
Independent microarray experiments
Long-range PCR
Multiplex ligation-dependent probe amplification
PCR
Sanger sequencing
Sequenom assay
Targeted aCGH
qPCR
Rare Variant Burden and Association Testing
Software
BWA
BeadStudio
CASAVA
CNAM
CNV Prediction
CNVnator
CoNIFER
DNAStar
FBAT
FreeBayes
GATK
GCTA
Golden Helix
OmicSoft
PLINK
PennCNV
Picard Tools
QuantiSNP
SAMtools
SPLIT-READ
Sequencher
SnpEff
SpectralGEM
XHMM
dbNSFP
iPattern
mrsFAST
Test Correction
Benjamini-Hochberg
Bonferroni adjustment
FDR
Full scan permutation
Single value permutation
Test Statistics
Analysis of deviance
Cohran-Armitage test
Correlation/Trend test
F-test
Fisher's exact test
Kolmogorov-Smirnov
Linear regression
Logistic regression
Odds ratio
Pearson's chi-square test
Type
RNA-Seq
Splice isoform assembly and annotation
Strand-specific dUTP
CNV
Exome Sequencing
GWAS
Haplotype
Linkage
ROH
SNP
Targeted Sequencing
Whole Genome sequencing
Algorithm
Cluster Analysis
Hierarchical
Partition
ANOVA
Bayesian Method
Mann-Whitney U test
Pearson's correlation
Permutation
Two Group Comparison
Normalization Method
Global
LOWESS
Robust-Linear model
Pathway Analysis
Genetic
Identification of co-expressed gene pairs
Identification of co-regulated gene pairs
Metabolic
Neural
Protein Interaction
Significance
FDR
<1%
<10%
<5%
p-value
<0.001
<0.01
<0.05
Software
ADM-2 Algorithm
Acuity
DAPPLE
GeneMANIA
GeneSpring
GenomeStudio
IPA
MatLab
SAM
TM4 - MeV MultiExperiment Viewer
Type
Antibody
Comparative Genomic Hybridization
Gene Expression
Methylation
RPPM
Criteria
Anatomical
Functional
Experiment
BOLD Contrast
Echo planar T2-weighted gradient echo sequence
T2-sensitive echo planar imaging pulse sequence
High resolution anatomical volume
Coplanar high-resolution T2-weighted echo planar imaging volume
T1-weighted 3D-MPRAGE pulse sequence
Number of Scans
4
6
Order
Non-random
Randon
Stimuli
Still images
Image description
Video clips of movements
Timing
Image
750ms/750ms blank
Visual Stimulation
9s/6s blank
Type
Motor
Action Execution
Imitation
Visual
Movement Observation Experiment
Visual Field
Left
Right
Method
General linear model
Region of Interest
Statistical Parameter Mapping
Model
Expected hemodynamic response
Mean percentage signal change
Single response time-course
Within-subject response variability
Preprocessing and correction
Inflating
Gray matter
Segmenting
Gray matter
White matter
Temporal high-pass filtering
Cutoff frequency
10 cycles/scan
6 cycles/scan
Orthogonal projection
Trilinear interpolation
3D motion correction
Gaussian filter
Processing
Alignment / Orientation
Image reorientation to match standard template images
Rigid-body linear registration algorithm
Image Normalization
Fifth-order polynomial nonlinear warping
Scanner
General Electric 3.0T MRI with an Advanced Magnetic Resonance Imaging upgrade for echo planar imaging (EPI)
Siemens 3T Allegra MRI
Significance, correction
FDR
0.01
0.05
Percentile
above 95th
below 5th
p-value
0.001
0.01
0.05
Bonferroni method
Software
BXH/XCEDE Tools
Brain Voyager
FSL
FreeSurfer
Statistical Test
T-test
paired
unpaired
ANOVA
Linear regression
Randomization test
Transformation
Talairach coordinate system
Type
CT
DOT
EEG
Eye Tracking
MRI
Magnetoencephalography
PET
Spectroscopy
fMRI
Initial Transformation
Categorical
Inverse
Log
Square root
Method
Mixed Effects model
Linear mixed effects regression model
ANOVA
Binomial test
Chi-square test
Correlation
Factor analysis
Hidden Markov model
MSWD
Mann-Whitney U
Pearson correlation
Positive Predictive Value
Regression analysis
Sensitivity/Specificity
Spearman's rank correlation
Student's t-test
Time series analysis
Weighted Least Squares Estimation
Significance
FDR
<1%
<10%
<15%
<5%
Sensitivity
90%
95%
Specificity
90%
95%
p-value
<0.001
<0.01
<0.05
Software
Bioconductor
DIFAS v.5.0
MS' Excel
MatLab
Mplus v6.0
R-project
SAS
SPSS

Select at least one type of data analysis. If the type of data analysis for your study is not provided, please select Add New.

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